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1. 发明申请

WO2010126703A1 IMPLANTABLE MEDICAL DEVICE WITH MEANS FOR DISTINGUISHING BETWEEN TREATABLE AND NON-TREATABLE HEART RHYTHMS 审中-公开
标题翻译：具有可治疗和不可治疗心脏疾病之间差异的手段的可植入医疗器械
公开(公告)号：WO2010126703A1
公开(公告)日：2010-11-04
申请号：PCT/US2010/030711
申请日：2010-04-12
申请人： MEDTRONIC, INC. , ZHANG, Xusheng , STADLER, Robert W. , GILLBERG, Jeffrey M.
发明人： ZHANG, Xusheng , STADLER, Robert W. , GILLBERG, Jeffrey M.
IPC分类号： A61N1/362
CPC分类号： A61N1/3621 , A61B5/04525 , A61B5/046 , A61B5/0464 , A61B5/726 , A61B5/7264 , A61N1/36507 , A61N1/3962 , G06F19/00
摘要： Techniques are described for distinguishing between treatable and non-treatable heart rhythms. A medical device that operates in accordance with the techniques analyzes characteristics over several cardiac event intervals to detect initiation of a sudden rate onset. After detection of the initiation of the sudden rate onset, the IMD analyzes a morphology of an EGM associated with a selected cardiac event within the first several beats after the initiation of sudden rate onset. In one example, the IMD analyzes the morphology of the EGM associated with the first cardiac event immediately subsequent to the initiation of the sudden rate onset. If the morphology of the EGM of the selected cardiac event is abnormal compared to template EGM, the rhythm is classified as treatable. Otherwise, the rhythm is classified as non-treatable.
摘要翻译：描述了用于区分可治疗和不可治疗的心脏节律的技术。根据该技术操作的医疗装置分析几个心脏事件间隔的特征，以检测突然发生率的起始。在检测到突发性发作起始之后，IMD分析在突然发病起始之后的前几次心跳中与所选心脏事件相关的EGM的形态。在一个实例中，IMD分析与突然发病起始之后紧接着的第一次心脏事件相关的EGM的形态。如果所选心脏事件的EGM的形态与模板EGM相比异常，则将节律分类为可治疗的。否则，节奏被分类为不可治疗。

2. 发明申请

WO2011136926A1 METHOD AND APPARATUS FOR DETECTING AND DISCRIMINATING TACHYCARDIA 审中-公开
标题翻译：用于检测和鉴定TACHYCARDIA的方法和装置
公开(公告)号：WO2011136926A1
公开(公告)日：2011-11-03
申请号：PCT/US2011/032265
申请日：2011-04-13
申请人： MEDTRONIC, INC. , ZHANG, Xusheng , STADLER, Robert W. , GILLBERG, Jeffrey M.
发明人： ZHANG, Xusheng , STADLER, Robert W. , GILLBERG, Jeffrey M.
IPC分类号： A61B5/0464 , A61N1/362
CPC分类号： A61B5/0464 , A61B5/7203 , A61N1/3622 , A61N1/36507 , A61N1/37264
摘要： A medical device and associated method for discriminating cardiac events includes determining whether a first match score is within a first match zone having a first correlation with a non-treatable cardiac event, a second match zone having a second correlation with the non-treatable cardiac event less than the first correlation with the non-treatable event, a third match zone having a first correlation with a treatable cardiac event, and a fourth match zone having a second correlation with the treatable cardiac event greater than the first correlation with the treatable cardiac event. A determination is made as to whether a second match score and a third match score are within the first match zone, the second match zone, the third match zone and the fourth match zone to generate a first adjusting factor, and cardiac event evidence is accumulated in response to the first adjusting factor for discriminating cardiac events.
摘要翻译：用于鉴别心脏事件的医疗装置和相关联的方法包括确定第一匹配得分是否在与不可治疗心脏事件具有第一相关性的第一匹配区域内，与不可治疗心脏事件具有第二相关性的第二匹配区域小于与不可治疗事件的第一相关性，具有与可治疗心脏事件的第一相关性的第三匹配区，以及与可治疗心脏事件具有大于与可治疗心脏事件的第一相关性的第二相关性的第四匹配区。确定第二匹配分数和第三匹配分数是否在第一匹配区域，第二匹配区域，第三匹配区域和第四匹配区域内，以产生第一调整因子，并且累积心脏事件证据响应于用于区分心脏事件的第一调整因子。

3. 发明申请

WO2011136923A1 METHOD AND APPARATUS FOR DETECTING AND DISCRIMINATING TACHYCARDIA 审中-公开
标题翻译：用于检测和鉴定TACHYCARDIA的方法和装置
公开(公告)号：WO2011136923A1
公开(公告)日：2011-11-03
申请号：PCT/US2011/032208
申请日：2011-04-13
申请人： MEDTRONIC, INC. , ZHANG, Xusheng , STADLER, Robert W. , GILLBERG, Jeffrey M.
发明人： ZHANG, Xusheng , STADLER, Robert W. , GILLBERG, Jeffrey M.
IPC分类号： A61B5/0464 , A61N1/362
CPC分类号： A61B5/0464 , A61B5/04525 , A61B5/686 , A61B5/6869 , A61B5/7203 , A61N1/3621 , A61N1/3624 , A61N1/3962
摘要： A medical device and associated method for discriminating cardiac events includes determining whether a first match score is within a first match zone having a first correlation with a non-treatable cardiac event, a second match zone having a second correlation with the non-treatable cardiac event less than the first correlation, a third match zone having a first correlation with a treatable cardiac event, and a fourth match zone having a second correlation with the treatable cardiac event greater than the first correlation with the treatable cardiac event. In response to the first match score being within one of the first and second match zones, a determination is made whether consecutive match scores are within the first match zone and whether a break in the treatable cardiac event has occurred. Cardiac evidence is accumulated in response to determining whether a break has occurred and utilized to discriminate cardiac events.
摘要翻译：用于识别心脏事件的医疗装置和相关联的方法包括确定第一匹配得分是否在与不可治疗心脏事件具有第一相关性的第一匹配区域内，与不可治疗心脏事件具有第二相关性的第二匹配区域小于第一相关性，具有与可治疗心脏事件的第一相关性的第三匹配区，以及与可治疗心脏事件具有大于与可治疗心脏事件的第一相关性的第二相关性的第四匹配区。响应于第一匹配分数在第一和第二匹配区域之一内，确定连续匹配分数是否在第一匹配区域内，以及是否发生可治疗心脏事件的中断。响应于确定是否发生休息并利用心脏事件来积累心脏证据。

4. 发明申请

WO2011136920A1 METHOD AND APPARATUS FOR DETECTING AND DISCRIMINATING TACHYCARDIA 审中-公开
标题翻译：用于检测和鉴定TACHYCARDIA的方法和装置
公开(公告)号：WO2011136920A1
公开(公告)日：2011-11-03
申请号：PCT/US2011/032205
申请日：2011-04-13
申请人： MEDTRONIC, INC. , ZHANG, Xusheng , STADLER, Robert, W. , GILLBERG, Jeffrey, M.
发明人： ZHANG, Xusheng , STADLER, Robert, W. , GILLBERG, Jeffrey, M.
IPC分类号： A61B5/0464 , A61N1/362
CPC分类号： A61B5/0464 , A61B5/7203 , A61N1/3962
摘要： A medical device and associated method for discriminating cardiac events sense cardiac signals that includes determining whether a first match score is within one of a first match zone corresponding to a first cardiac event, and a second match zone corresponding to the first cardiac event, and determining whether a second match score is within one of the first match zone, the second match zone, and a third match zone corresponding to a second cardiac event different from the first cardiac event. One of increasing and decreasing an event counter is performed in response to both the determination of whether the first match score is within one of the first match zone and the second match zone and the determination of whether the second match score is within one of the first match zone, the second match zone, and the third match zone.
摘要翻译：用于识别心脏事件的医疗装置和相关联的方法检测心脏信号，所述心脏信号包括确定第一匹配分数是否在对应于第一心脏事件的第一匹配区域之内，以及对应于第一心脏事件的第二匹配区域，以及确定第二匹配得分是否在第一匹配区域，第二匹配区域和对应于不同于第一心脏事件的第二心脏事件的第三匹配区域之一内。响应于第一匹配分数是否在第一匹配区域和第二匹配区域之一的确定以及确定第二匹配分数是否在第一匹配区域之一内的确定来执行增加和减少事件计数器之一匹配区，第二匹配区和第三匹配区。

5. 发明申请

WO2010114722A1 DETECTING A CONDITION OF A PATIENT USING A PROBABILITY-CORRELATION BASED MODEL 审中-公开
标题翻译：使用基于可靠性相关模型检测患者的状况
公开(公告)号：WO2010114722A1
公开(公告)日：2010-10-07
申请号：PCT/US2010/027991
申请日：2010-03-19
申请人： MEDTRONIC, INC. , ZHANG, Xusheng , STADLER, Robert, W. , GILLBERG, Jeffrey, M.
发明人： ZHANG, Xusheng , STADLER, Robert, W. , GILLBERG, Jeffrey, M.
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452 , A61B5/7203 , A61N1/3621 , A61N1/3702 , A61N1/3962
摘要： Techniques are described for detecting a condition of a patient using a probability-correlation based model that integrates a plurality of parameters associated with the condition. A medical device that operates in accordance with the techniques obtains a plurality of parameters associated with the condition of the patient. The medical device obtains probabilities that the condition of the patient exists based on each single parameter separately and correlations between each of the parameters and the other ones of the parameters. After obtaining the probabilities and correlations associated with each of the parameters, the medical device determines whether the condition of the patient exists based on the determined probabilities and correlations. Such techniques may be particularly effective for use in distinguishing whether a rhythm of a patient is treatable, e.g., VT or VF, or non-treatable, e.g., SVT.
摘要翻译：描述了用于使用集成了与条件相关联的多个参数的基于概率相关的模型来检测患者的状况的技术。根据技术操作的医疗装置获得与患者状况相关联的多个参数。医疗设备根据每个单独的参数获得病人的状况存在的概率，以及每个参数与其他参数之间的相关性。在获得与每个参数相关联的概率和相关性之后，医疗设备基于所确定的概率和相关性来确定患者的状况是否存在。这种技术可能特别有效地用于区分患者的节律是否可治疗，例如VT或VF，或不可治疗的，例如SVT。

6. 发明申请

WO2012051163A1 A SEQUENTIAL DISCRIMINATION APPROACH FOR DETECTING TREATABLE CARDIAC RHYTHMS 审中-公开
标题翻译：用于检测可治疗心脏病的顺序分析方法
公开(公告)号：WO2012051163A1
公开(公告)日：2012-04-19
申请号：PCT/US2011/055732
申请日：2011-10-11
申请人： MEDTRONIC, INC. , ZHANG, Xusheng , STADLER, Robert, W. , GILLBERG, Jeffrey M.
发明人： ZHANG, Xusheng , STADLER, Robert, W. , GILLBERG, Jeffrey M.
IPC分类号： A61B5/0464 , A61N1/39
CPC分类号： A61B5/7267 , A61B5/0422 , A61B5/046 , A61B5/0464 , A61B5/686 , A61B5/7239 , A61N1/3624 , A61N1/3962
摘要： A system and method for use in a medical device for discriminating cardiac events establishes population-based thresholds corresponding to cardiac signal morphology metrics for discriminating between a first cardiac event and a second cardiac event. A population-based threshold criterion for discriminating cardiac events is established. The population-based threshold criterion is applied to a cardiac signal segment and the segment is classified if the criterion is satisfied. A patient-specific threshold is established in response to the sensed cardiac signal segment not being classified after applying the population-based threshold criterion. The sensed signal segment is classified in response to the patient-specific threshold comparison.
摘要翻译：用于辨别心脏事件的医疗装置中的系统和方法建立了对应于心脏信号形态度量的基于群体的阈值，用于区分第一心脏事件和第二心脏事件。建立了基于人群的阈值判别标准，用于辨别心脏事件。基于人群的阈值标准被应用于心脏信号段，并且如果满足标准，则对该段进行分类。响应于在应用基于群体的阈值标准之后未被分类的感测到的心脏信号段建立患者特异性阈值。感测的信号段根据患者特异性阈值比较进行分类。

7. 发明申请

WO2011139531A1 METHOD AND APPARATUS FOR DETECTING AND DISCRIMINATING TACHYCARDIA 审中-公开
标题翻译：用于检测和鉴定TACHYCARDIA的方法和装置
公开(公告)号：WO2011139531A1
公开(公告)日：2011-11-10
申请号：PCT/US2011/032820
申请日：2011-04-18
申请人： MEDTRONIC, INC. , STADLER, Robert , W. , ZHANG, Xusheng , GILLBERG, Jeffrey, M.
发明人： STADLER, Robert , W. , ZHANG, Xusheng , GILLBERG, Jeffrey, M.
IPC分类号： A61N1/362 , A61B5/0464 , A61N1/39
CPC分类号： A61B5/02405 , A61B5/0031 , A61B5/04011 , A61B5/0464 , A61B5/0468 , A61B5/686 , A61B5/6869 , A61B5/7203 , A61N1/3622 , A61N1/36507 , A61N1/37264
摘要： A medical device and associated method for monitoring a patient's heart rhythm sense cardiac events and detect a sudden change in the heart rhythm in response to the sensed cardiac events. Detecting the sudden change includes determining a variability of intervals between the sensed cardiac events and switching between a low variability mode of operation and a high variability mode of operation in response to the variability of intervals. During the low variability mode, detecting the sudden change includes detecting an increase in the rate of cardiac events. During the high variability mode, detecting the sudden change includes detecting a sudden decrease in the variability of the cardiac event intervals. A concerning cardiac rhythm is detected in response to detecting the sudden change.
摘要翻译：用于监测患者心律的医疗装置和相关联的方法感测心脏事件并且响应于感测到的心脏事件来检测心律的突然变化。检测突然变化包括响应于间隔的可变性来确定所感测的心脏事件之间的间隔的可变性和低变异性操作模式与高变异性操作模式之间的切换。在低变异性模式期间，检测突然变化包括检测心脏事件发生率的增加。在高可变性模式期间，检测突然变化包括检测心脏事件间隔的变异性的突然降低。响应于检测到突然变化而检测到关于心律的A。

8. 发明申请

WO2011136916A1 METHOD AND APPARATUS FOR DETECTING AND DISCRIMINATING TACHYCARDIA 审中-公开
标题翻译：用于检测和鉴定TACHYCARDIA的方法和装置
公开(公告)号：WO2011136916A1
公开(公告)日：2011-11-03
申请号：PCT/US2011/032004
申请日：2011-04-12
申请人： MEDTRONIC, INC. , ZHANG, Xusheng , STADLER, Robert W. , GILLBERG, Jeffrey M.
发明人： ZHANG, Xusheng , STADLER, Robert W. , GILLBERG, Jeffrey M.
IPC分类号： A61N1/39 , A61B5/0452
CPC分类号： A61B5/04525 , A61B5/02405 , A61B5/7203 , A61N1/3962
摘要： A medical device and associated method for discriminating cardiac events includes sensing a cardiac signal spatially located across approximately a full duration of a predetermined sensing window. A match score is determined corresponding to the sensed cardiac signal. A beat feature of multiple beat features across less than the full duration of the sensing window is determined, the beat feature being selected from the multiple beat features in response to the match score. Cardiac event evidence is accumulated in response to the match score and the determined beat feature, and cardiac events are discriminated in response to the accumulated cardiac evidence.
摘要翻译：用于鉴别心脏事件的医疗装置和相关联的方法包括感测在预定感测窗口的大约整个持续时间上空间定位的心脏信号。根据感测的心脏信号确定匹配分数。确定在小于感测窗口的整个持续时间的多个拍子特征的拍子特征，响应于匹配分数，从多拍特征中选择节拍特征。响应于匹配得分和确定的搏动特征累积心脏事件证据，并且响应于累积的心脏证据来区分心脏事件。

9. 发明申请

WO2011002535A1 HEART SOUND SENSING TO REDUCE INAPPROPRIATE TACHYARRHYTHMIA THERAPY 审中-公开
标题翻译：心脏感觉减少不明显的TACHYARRHYTHMIA治疗
公开(公告)号：WO2011002535A1
公开(公告)日：2011-01-06
申请号：PCT/US2010/030268
申请日：2010-04-07
申请人： MEDTRONIC, INC. , ZHANG, Xusheng , ANDERSON, David, A. , HUSTON, Jeffrey, M. , GILLBERG, Jeffrey, M.
发明人： ZHANG, Xusheng , ANDERSON, David, A. , HUSTON, Jeffrey, M. , GILLBERG, Jeffrey, M.
IPC分类号： A61N1/362 , A61N1/365
CPC分类号： A61N1/3621 , A61N1/3624 , A61N1/36528 , A61N1/36535
摘要： Techniques for detecting heart sounds to reduce inappropriate tachyarrhythmia therapy are described. In some examples, a medical device determines that a cardiac rhythm of the patient is treatable with a therapy, such as a defibrillation pulse, based on a cardiac electrogram (EGM). The medical device analyzes detected heart sounds, and withholds or allows the therapy based on the analysis of the heart sounds.
摘要翻译：描述了用于检测心音以减少不适当的快速性心律失常治疗的技术。在一些示例中，医疗装置通过基于心电图（EGM）的治疗，例如除颤脉冲来确定患者的心律是可治疗的。医疗器械分析检测到的心脏声音，并根据对心脏声音的分析，保留或允许进行治疗。

10. 发明申请

WO2010085524A1 A "BLURRED TEMPLATE" APPROACH FOR ARRHYTHMIA DETECTION 审中-公开
标题翻译：一种用于ARRHYTHMIA检测的“BLEDED TEMPLATE”方法
公开(公告)号：WO2010085524A1
公开(公告)日：2010-07-29
申请号：PCT/US2010/021580
申请日：2010-01-21
申请人： MEDTRONIC, INC. , ZHANG, Xin , BROWN, Mark, L. , ZHANG, Xusheng , GILLBERG, Jeffrey, M.
发明人： ZHANG, Xin , BROWN, Mark, L. , ZHANG, Xusheng , GILLBERG, Jeffrey, M.
IPC分类号： A61B5/0452 , A61N1/39 , A61B5/046 , A61B5/0464 , A61N1/362
CPC分类号： A61N1/3956 , A61B5/04525 , A61B5/046 , A61B5/0464 , A61B5/7264
摘要： An implantable medical device and associated method sense cardiac signals for deriving a template representing a known EGM waveform morphology and for classifying an unknown waveform morphology. A boundary of the template, offset from the template, is computed and compared to an unknown waveform morphology for classifying the unknown waveform morphology.
摘要翻译：可植入医疗装置和相关联的方法感测用于导出表示已知EGM波形形态的模板并用于分类未知波形形态的心脏信号。计算与模板偏移的模板的边界，并将其与未知波形形态进行比较，以对未知波形形态进行分类。

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