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1. 发明申请

WO2007038557A1 METHOD AND APPARATUS FOR REGULATING A CARDIAC STIMULATION THERAPY 审中-公开
标题翻译：调节心脏刺激治疗的方法和装置
公开(公告)号：WO2007038557A1
公开(公告)日：2007-04-05
申请号：PCT/US2006/037580
申请日：2006-09-27
申请人： MEDTRONIC, INC. , EULER, David, E. , BENNETT, Tommy, D. , MANDA, Ven , DENO, Curtis, D. , SPLETT, Vincent, E.
发明人： EULER, David, E. , BENNETT, Tommy, D. , MANDA, Ven , DENO, Curtis, D. , SPLETT, Vincent, E.
IPC分类号： A61N1/362 , A61N1/365 , A61B5/0215
CPC分类号： A61N1/36564 , A61B5/02028 , A61B5/0215 , A61B5/0422 , A61B5/7285 , A61N1/3627
摘要： A method comprising sensing a blood pressure signal, deriving a hemodynamic measure from the sensed blood pressure signal, adjusting an extra systolic stimulation control parameter in response to the hemodynamic measure, and delivering extra systolic stimulation pulses according to the adjusted control parameter. The sensed blood pressure signal may be a ventricular or arterial blood pressure signal from which an estimated cardiac output, end diastolic pressure, mean pressure or any other hemodynamic measure is derived. Adjusting the extra systolic stimulation control parameter may include adjusting a pacing rate, a pacing interval, an extra systolic stimulation ratio, an extra systolic stimulation interval or enabling or terminating the extra systolic stimulation.
摘要翻译：一种方法，包括感测血压信号，从感测到的血压信号导出血液动力学测量值，响应于血液动力学测量值调整额外的收缩刺激控制参数，以及根据所调节的控制参数递送额外的收缩刺激脉冲。所感测的血压信号可以是心室或动脉血压信号，从其导出估计的心输出量，舒张末期压力，平均压力或任何其它血液动力学测量值。调整额外的收缩刺激控制参数可以包括调整起搏速率，起搏间隔，额外的收缩期刺激比，额外的收缩期刺激间期或启用或终止额外的收缩期刺激。

2. 发明申请

WO2005016449A1 ELECTRICALLY EFFICIENT NEURALLY-EXCITABLE STIMULATION 审中-公开
标题翻译：有效的神经激动刺激
公开(公告)号：WO2005016449A1
公开(公告)日：2005-02-24
申请号：PCT/US2004/025776
申请日：2004-08-10
申请人： MEDTRONIC, INC. , DENO, Curtis, D. , EULER, David, E. , MULLIGAN, Lawrence, J. , DUFFIN, Edwin, G. , IGEL, David, A.
发明人： DENO, Curtis, D. , EULER, David, E. , MULLIGAN, Lawrence, J. , DUFFIN, Edwin, G. , IGEL, David, A.
IPC分类号： A61N1/362
CPC分类号： A61N1/36514 , A61N1/3627 , A61N1/36564 , A61N1/368
摘要： A medical device, e.g., an implantable medical device, delivers one or more neurally-excitable stimulation pulses to myocardial tissue during a period when the tissue is refractory. The width of the pulses is less than or equal to approximately one half millisecond. In some embodiments, the current amplitude of the pulses is less than or equal to approximately twenty milliamps. In exemplary embodiments, the medical device delivers a pulse train of six or fewer pulses separated from each other by an interval that is greater than or equal to approximately ten milliseconds. In some embodiments, the medical device delivers pulses according to a schedule stored in a memory, or as a function of a monitored physiological parameter of a patient, such as an intracardiac pressure. In some embodiments, the medical device suspends or withholds delivery of neurally-excitable based on detection of cardiac ischemia.
摘要翻译：医疗装置，例如可植入医疗装置，在组织是难治性的期间，向心肌组织递送一个或多个神经兴奋的刺激脉冲。脉冲的宽度小于或等于大约一半毫秒。在一些实施例中，脉冲的电流幅度小于或等于大约二十毫安。在示例性实施例中，医疗设备递送彼此间隔大于或等于大约十毫秒的六个或更少个脉冲的脉冲串。在一些实施例中，医疗装置根据存储在存储器中的调度或者作为患者的被监测的生理参数（例如心脏内压力）来递送脉冲。在一些实施方案中，基于心脏缺血的检测，医疗装置暂停或禁止神经可兴奋的递送。

3. 发明申请

WO2006105140A3 SYSTEM AND METHOD FOR USING ATRIAL PACING TO ENHANCE FUNCTION OF STUNNED ATRIAL MYOCARDIUM FOLLOWING CONVERSION TO NORMAL SINUS RHYTHM 审中-公开
公开(公告)号：WO2006105140A3
公开(公告)日：2006-10-05
申请号：PCT/US2006/011374
申请日：2006-03-30
申请人： MEDTRONIC, INC. , EULER, David, E. , HETTRICK, Douglas, A.
发明人： EULER, David, E. , HETTRICK, Douglas, A.
IPC分类号： A61N1/39 , A61N1/362 , A61N1/365 , A61B5/046
摘要： An implantable medical device (IMD) includes a therapy circuit for delivering atrial pacing and a control circuit for detecting a return to sinus rhythm, determining the duration of atrial arrhythmia preceding the return to sinus rhythm, and controlling the therapy circuit to deliver transient atrial pacing based on the duration. Further, the implantable medical device comprises means for using data from a hemodynamic sensor to select the pacing rate of the transient atrial pacing. The pacing may be overdrive pacing or paired pacing.

4. 发明申请

WO2006004700A1 FIBRILLATION/TACHYCARDIA DISCRIMINATION BASED ON EGM INTRA-CARDIAC PRESSURE 审中-公开
标题翻译：基于临床心脏压力的颤动/ TACHYCARDIA辨别
公开(公告)号：WO2006004700A1
公开(公告)日：2006-01-12
申请号：PCT/US2005/022832
申请日：2005-06-22
申请人： MEDTRONIC, INC. , HETTRICK, Douglas, A. , EULER, David, E. , BROWN, Mark, L.
发明人： HETTRICK, Douglas, A. , EULER, David, E. , BROWN, Mark, L.
IPC分类号： A61B5/0452
CPC分类号： A61B5/6882 , A61B5/0031 , A61B5/0215 , A61B5/0422 , A61B5/046 , A61B5/0464 , A61B5/7257 , A61B5/7264 , A61N1/3622 , A61N1/36564 , A61N1/3956
摘要： A system and method for detecting and classifying cardiac arrhythmias based on cardiac pressure signals or the combination of cardiac electrical and cardiac pressure signals. A cardiac electrogram signal is sensed to derive a cardiac rate from which an arrhythmia detection is made when the cardiac rate meets arrhythmia detection criteria. An intracardiac pressure signal is sensed to derive an indicator of tachycardia based on an analysis of the pressure signal in either the time domain or frequency domain. The detected arrhythmia is classified as tachycardia or fibrillation based on the tachycardia indicator wherein the tachycardia indicator is compared to tachycardia detection criteria and the arrhythmia is classified as tachycardia if tachycardia detection criteria are met and the arrhythmia is classified as fibrillation if the tachycardia detection criteria are not met.
摘要翻译：一种基于心脏压力信号或心脏电压和心脏压力信号的组合来检测和分类心律失常的系统和方法。感测到心电图信号以导出当心率达到心律失常检测标准时进行心律失常检测的心率。基于对时域或频域中的压力信号的分析，感测心内压力信号以导出心动过速的指标。检测到的心律失常根据心动过速指标分类为心动过速指标，其中心动过速指标与心动过速检测标准进行比较，如果心动过速检测标准得到满足，则将心律不齐分类为心动过速，如果心动过速检测标准为没见过。

5. 发明申请

WO2007090031A1 METHOD AND SYSTEM FOR CONTROLLING PULMONARY CAPILLARY PRESSURE 审中-公开
标题翻译：用于控制脉搏毛细血管压力的方法和系统
公开(公告)号：WO2007090031A1
公开(公告)日：2007-08-09
申请号：PCT/US2007/061059
申请日：2007-01-25
申请人： MEDTRONIC, INC. , WARKENTIN, Dwight, H. , EULER, David, E.
发明人： WARKENTIN, Dwight, H. , EULER, David, E.
IPC分类号： A61N1/362 , A61N1/365
CPC分类号： A61N1/3627 , A61N1/36564
摘要： A method of controlling pulmonary capillary pressure is disclosed which includes increasing the output of a first ventricle (V1) (e.g., a left ventricle) relative to second ventricle (e.g., right ventricle) by increasing the magnitude of a post extrasystolic potentiation (PESP) therapy effect in the first ventricle relative to the magnitude of a PESP therapy effect produced in the second ventricle. In certain embodiments of the invention, this may be accomplished by adjusting the extra-stimulus interval (ESI) in either or both of the left ventricle and the right ventricle, for example.
摘要翻译：公开了一种控制肺毛细血管压力的方法，其包括通过增加柱后收缩期增强（PESP）的幅度来增加相对于第二脑室（例如，右心室）的第一脑室（V1）（例如，左心室）的输出，相对于在第二脑室产生的PESP治疗效果的大小，第一脑室的治疗效果。在本发明的某些实施方案中，例如可以通过调整左心室和右心室中的任一者或两者的额外刺激间隔（ESI）来实现。

6. 发明申请

WO2004093975A2 METHODS AND APPARATUS FOE DECREASING INCIDENCES OF EARLY RECURRENCE OF ATRIAL FIBRILLATION 审中-公开
标题翻译：方法和装置减少早期复发的复发
公开(公告)号：WO2004093975A2
公开(公告)日：2004-11-04
申请号：PCT/US2004/011237
申请日：2004-04-09
申请人： MEDTRONIC, INC. , MUSLEY, Shaelesh Kuma V. , EULER, David, E. , WARMAN, Eduardo, N.
发明人： MUSLEY, Shaelesh Kuma V. , EULER, David, E. , WARMAN, Eduardo, N.
IPC分类号： A61N1/00
CPC分类号： A61N1/3956 , A61N1/395 , A61N1/3987
摘要： Implantable cardioverter/defibrillators (ICDs) providing atrial cardioversion/defibrillation (C/D) shock therapies in response to detected atrial tachyarrhythmias, particularly atrial fibrillation (AF) or in response to a patient command generated by a patient experiencing AF symptoms are disclosed. The early recurrence of atrial fibrillation (ERAF) following delivery of an atrial C/D shock is detected and delivery of any subsequent atrial C/D shock therapies is delayed for an ERAF sustained duration.
摘要翻译：公开了用于响应于检测到的心房快速性心律失常，特别是心房颤动（AF）或响应于患有AF症状的患者产生的患者指令的心房复律/除颤（C / D）休克疗法的植入式心律转复器/除颤器（ICD）。检测到心房C / D休克后出现心房颤动（ERAF）的早期复发，并且随后的心房C / D休克疗法的递送延迟了ERAF持续时间。

7. 发明申请

WO2010088116A1 HIGH FREQUENCY STIMULATION TO BLOCK LARYNGEAL STIMULATION DURING VAGAL NERVE STIMULATION 审中-公开
标题翻译：高频刺激在血管神经刺激期间进行块状淋巴结刺激
公开(公告)号：WO2010088116A1
公开(公告)日：2010-08-05
申请号：PCT/US2010/021520
申请日：2010-01-20
申请人： MEDTRONIC, INC. , EULER, David, E. , SCHEINER, Avram
发明人： EULER, David, E. , SCHEINER, Avram
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/0556 , A61B5/4035 , A61B5/4047 , A61B5/7217 , A61N1/36114
摘要： An implantable medical device and associated method deliver a therapy to an autonomic nerve. The therapy delivery includes delivering therapeutic low frequency (LF) electrical stimulation pulses to the autonomic nerve and delivering a high frequency electrical signal to the autonomic nerve during the LF frequency stimulation pulse delivery. The high frequency stimulation signal blocks activation of autonomic nerve fibers innervating a non-targeted tissue during the therapeutic LF stimulation pulse delivery.
摘要翻译：可植入医疗装置和相关方法将治疗递送至自主神经。治疗递送包括在LF频率刺激脉冲传送期间向自主神经递送治疗性低频（LF）电刺激脉冲并将高频电信号传递给自主神经。高频刺激信号阻止在治疗性LF刺激脉冲输送期间支配非目标组织的自主神经纤维的活化。

8. 发明申请

WO2010011553A1 IMPROVEMENTS TO CARDIAC PACING METHODS AND APPARATUS 审中-公开
标题翻译： CARDIAC PACING方法和设备的改进
公开(公告)号：WO2010011553A1
公开(公告)日：2010-01-28
申请号：PCT/US2009/050798
申请日：2009-07-16
申请人： MEDTRONIC, INC. , HETTRICK, Douglas, A. , ZIEGLER, Paul, D. , SHELDON, Todd, J. , EULER, David, E.
发明人： HETTRICK, Douglas, A. , ZIEGLER, Paul, D. , SHELDON, Todd, J. , EULER, David, E.
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/3682
摘要： A method and apparatus is provided for determining whether a current atrial-ventricular (AV) delay during cardiac pacing is appropriate for proper mechanical coupling of the atrium and ventricle. If proper mechanical coupling is determined to not exist, an additional atrial contraction is induced within the same ventricular cycle to maintain atrial-ventricular mechanical coupling.
摘要翻译：提供了一种用于确定心脏起搏期间当前心房（AV）延迟是否适合于心房和心室的适当机械耦合的方法和装置。如果确定不存在适当的机械耦合，则在相同心室周期内诱发另外的心房收缩以维持心房 - 心室机械耦合。

9. 发明申请

WO2010051480A1 ELECTRICAL RENAL AUTONOMIC BLOCKADE 审中-公开
标题翻译：电气自动化BLOCKADE
公开(公告)号：WO2010051480A1
公开(公告)日：2010-05-06
申请号：PCT/US2009/062831
申请日：2009-10-30
申请人： MEDTRONIC, INC. , MANDA, Venkatesh , ANDERSON, Kenneth, M. , EULER, David, E. , SCHEINER, Avram
发明人： MANDA, Venkatesh , ANDERSON, Kenneth, M. , EULER, David, E. , SCHEINER, Avram
IPC分类号： A61N1/32
CPC分类号： A61N1/36007 , A61N1/08 , A61N1/32
摘要： Electrical stimulation may be configured to decrease renal sympathetic activity by creating at least a partial functional conduction block in the efferent and/or afferent sympathetic nerve fibers that innervate the kidneys. An electrical stimulator may deliver a stimulation signal to a renal nerve of a patient. The stimulation signal may be a biphasic signal with a frequency of approximately 100 hertz to 20 kilohertz. In some examples, a sensor may sense a physiological parameter of the patient, and the stimulation generator may activate, deactivate, or adjust the stimulation signal based on the physiological parameter. The physiological parameter may be indicative of sympathetic activity within the patient.
摘要翻译：电刺激可以被配置为通过在支配肾脏的传出和/或传入的交感神经纤维中产生至少部分功能性传导阻滞来降低肾交感活性。电刺激器可以向患者的肾神经传递刺激信号。刺激信号可以是频率约为100赫兹到20千赫兹的双相信号。在一些示例中，传感器可以感测患者的生理参数，并且刺激发生器可以基于生理参数激活，去激活或调整刺激信号。生理参数可以指示患者内的交感神经活动。

10. 发明申请

WO2006104869A2 METHOD AND APPARATUS FOR EVALUATING VENTRICULAR PERFORMANCE DURING ISOVOLUMIC CONTRACTION 审中-公开
标题翻译：评价异体收缩时心室功能的方法和装置
公开(公告)号：WO2006104869A2
公开(公告)日：2006-10-05
申请号：PCT/US2006/010713
申请日：2006-03-23
申请人： MEDTRONIC, INC. , HETTRICK, Douglas, A. , EULER, David, E.
发明人： HETTRICK, Douglas, A. , EULER, David, E.
IPC分类号： A61N1/362 , A61B8/00
CPC分类号： A61N1/3627 , A61B8/0858 , A61N1/36528 , A61N1/3684
摘要： A method of evaluating ventricular performance of a heart employing sensors to measure a ventricular dimension signal and deriving indices of ventricular performance therefrom. Premature Shortening (PS) and Isovolumic Lengthening (IL) comprise two indices of ventricular performance determined from analysis of the left ventricular dimension signal during the transition from ventricular filling to ventricular ejection. Measured values of PS and IL are compared to other measured values or reference values to determine if ventricular performance has improved (or worsened). In some embodiments, the dimension sensors may comprise piezoelectric sonomicrometer crystals that operate as ultrasound transmitters and receivers. The sensors may be mounted in relation to a ventricle of the heart either temporarily or permanently, and may be configured either separately from or integrally with cardiac pacing leads.
摘要翻译：一种使用传感器来测量心室尺寸信号并由此导出心室性能指标的心脏心室性能评估方法。过早缩短（PS）和等容延长（IL）包括从心室充盈过渡到心室射血期间通过分析左心室尺寸信号确定的两个心室性能指标。将PS和IL的测量值与其他测量值或参考值进行比较以确定心室功能是否得到改善（或恶化）。在一些实施例中，尺寸传感器可以包括作为超声波发射器和接收器操作的压电超声微结晶体。传感器可临时或永久地相对于心脏的心室安装，并且可以与心脏起搏导线分开或整体配置。

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