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1. 发明申请

WO2011070541A1 CYSTEINE PROTEASE INHIBITORS 审中-公开
标题翻译： CYSTEINE PROTEASE抑制剂
公开(公告)号：WO2011070541A1
公开(公告)日：2011-06-16
申请号：PCT/IB2010/055738
申请日：2010-12-10
申请人： MEDIVIR UK LIMITED , AYESA, Susana , CARLQUIST, Peter , ERSMARK, Karolina , GRABOWSKA, Urszula , HEWITT, Ellen , JÖNSSON, Daniel , KAHNBERG, Pia , KLASSON, Björn , LIND, Peter , ODÉN, Lourdes , PARKES, Kevin , WIKTELIUS, Daniel
发明人： AYESA, Susana , CARLQUIST, Peter , ERSMARK, Karolina , GRABOWSKA, Urszula , HEWITT, Ellen , JÖNSSON, Daniel , KAHNBERG, Pia , KLASSON, Björn , LIND, Peter , ODÉN, Lourdes , PARKES, Kevin , WIKTELIUS, Daniel
IPC分类号： C07D231/40 , A61K31/16 , A61K31/415 , A61K31/426 , A61P9/10 , A61P11/06 , A61P17/06 , A61P21/04 , A61P37/02 , A61P37/08 , C07C237/14 , C07D277/46
CPC分类号： C07K5/06078 , A61K38/05 , C07C271/22 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D231/40 , C07D277/46 , C07D405/12 , C07K5/06034 , C07K5/0606 , C07K5/06139
摘要： Compounds of the formula (I) wherein R 1a is H; and R 1b is C 1 -C 6 alkyl, Carbocyclyl or Het; or R 1a and R 1b together define a saturated cyclic amine with 3-6 ring atoms; R 2a and R 2b are independently H, halo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl or C 1 -C 4 alkoxy, or R 2a and R 2b together with the carbon atom to which they are attached form a C 3 -C 6 cycloalkyl; R 3 is a branched C 5 -C 10 alkyl chain, C 2 -C 4 haloalkyl or -CH 2 C 3 -C 7 cycloalkyl; R 4 is C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkylamino or C 1 -C 6 dialkylamino; for use in the prophylaxis or treatment of a disorder characterised by inappropriate expression or activation of cathepsin S.
摘要翻译：式（I）的化合物，其中R 1a是H; 并且R 1b是C 1 -C 6烷基，碳环或Het; 或R 1a和R 1b一起限定具有3-6个环原子的饱和环胺; R2a和R2b独立地为H，卤素，C1-C4烷基，C1-C4卤代烷基或C1-C4烷氧基，或R2a和R2b与它们所连接的碳原子一起形成C 3 -C 6环烷基; R3是支链C 5 -C 10烷基链，C 2 -C 4卤代烷基或-CH 2 C 3 -C 7环烷基; R 4是C 1 -C 6烷基，C 1 -C 6卤代烷基，C 1 -C 6烷基氨基或C 1 -C 6二烷基氨基; 用于预防或治疗以组织蛋白酶S不适当表达或活化为特征的病症。

2. 发明申请

WO2011070539A1 CYSTEINE PROTEASE INHIBITORS 审中-公开
公开(公告)号：WO2011070539A1
公开(公告)日：2011-06-16
申请号：PCT/IB2010/055732
申请日：2010-12-10
申请人： MEDIVIR UK LIMITED , AYESA, Susana , ERSMARK, Karolina , GRABOWSKA, Urszula , HEWITT, Ellen , JÖNSSON, Daniel , KAHNBERG, Pia , KLASSON, Björn , LIND, Peter , LUNDGREN, Stina , ODÉN, Lourdes , PARKES, Kevin , WIKTELIUS, Daniel
发明人： AYESA, Susana , ERSMARK, Karolina , GRABOWSKA, Urszula , HEWITT, Ellen , JÖNSSON, Daniel , KAHNBERG, Pia , KLASSON, Björn , LIND, Peter , LUNDGREN, Stina , ODÉN, Lourdes , PARKES, Kevin , WIKTELIUS, Daniel
IPC分类号： C07D231/40 , A61K31/27 , A61K31/415 , A61K31/4155 , A61K31/4164 , A61K31/42 , A61K31/426 , A61P9/10 , A61P11/06 , A61P17/06 , A61P21/04 , A61P37/02 , A61P37/08 , C07C271/20 , C07D233/88 , C07D261/14 , C07D277/46 , C07D405/12
CPC分类号： C07K5/06078 , A61K38/05 , C07C271/22 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D231/40 , C07D277/46 , C07D405/12 , C07K5/06034 , C07K5/0606 , C07K5/06139
摘要： Compounds of Formula (II) wherein R 1a is H; and R 1b is C 1 -C 6 alkyl, Carbocyclyl or Het; or R 1a and R 1b together define a saturated cyclic amine with 3-6 ring atoms; R 2a and R 2b are independently H, halo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl or C 1 -C 4 alkoxy, or R 2a and R 2b together with the carbon atom to which they are attached form a C 3 -C 6 cycloalkyl; R 3 is a branched C 5 -C 10 alkyl chain, C 2 -C 4 haloalkyl or -CH 2 C 3 -C 7 cycloalkyl; R 4' is C 1 -C 6 alkyl, C 1 -C 6 haloalkyl or oxetany-3-yl. for use in the prophylaxis or treatment of a disorder characterised by inappropriate expression or activation of cathepsin S.
摘要翻译：式（II）的化合物，其中R 1a是H; 并且R 1b是C 1 -C 6烷基，碳环或Het; 或R1a和R1b一起限定具有3-6个环原子的饱和环胺; R2a和R2b独立地为H，卤素，C1-C4烷基，C1-C4卤代烷基或C1-C4烷氧基，或R2a和R2b与它们所连接的碳原子一起形成C 3 -C 6环烷基; R3是支链C 5 -C 10烷基链，C 2 -C 4卤代烷基或-CH 2 C 3 -C 7环烷基; R 4'是C 1 -C 6烷基，C 1 -C 6卤代烷基或氧杂环丁烷-3-基。用于预防或治疗以组织蛋白酶S不适当表达或活化为特征的病症。

3. 发明申请

WO2010070615A1 CYSTEINE PROTEASE INHIBITORS 审中-公开
标题翻译： CYSTEINE PROTEASE抑制剂
公开(公告)号：WO2010070615A1
公开(公告)日：2010-06-24
申请号：PCT/IB2009/055839
申请日：2009-12-18
申请人： MEDIVIR UK LTD , AYESA, Susana , BELFRAGE, Anna, Karin , CLASSON, Björn , GRABOWSKA, Urszula , HEWITT, Ellen , IVANOV, Vladimir , Jönsson, Daniel , KAHNBERG, Pia , LIND, Peter , NILSSON, Magnus , ODÉN, Lourdes , PELCMAN, Mikael , WÄHLING, Horst
发明人： AYESA, Susana , BELFRAGE, Anna, Karin , CLASSON, Björn , GRABOWSKA, Urszula , HEWITT, Ellen , IVANOV, Vladimir , Jönsson, Daniel , KAHNBERG, Pia , LIND, Peter , NILSSON, Magnus , ODÉN, Lourdes , PELCMAN, Mikael , WÄHLING, Horst
IPC分类号： C07D295/20 , A61K31/145 , A61K31/16 , A61K31/341 , A61K31/343 , A61K31/415 , A61K31/4965 , A61K31/5375 , A61P11/00 , A61P17/06 , A61P37/00 , C07C215/20 , C07C235/74 , C07C311/21 , C07D213/71 , C07D215/20 , C07D231/12 , C07D231/40 , C07D233/64 , C07D239/80 , C07D241/12 , C07D275/00 , C07D275/03 , C07D307/46 , C07D307/80
CPC分类号： C07C311/21 , C07C237/24 , C07C271/24 , C07C2601/02 , C07C2601/04 , C07C2601/06 , C07C2601/08 , C07D207/34 , C07D213/40 , C07D213/71 , C07D231/14 , C07D231/40 , C07D239/80 , C07D241/24 , C07D277/36 , C07D277/56 , C07D295/215 , C07D307/68 , C07D307/85 , C07D401/12 , C07D403/12 , C07D405/12 , C07D417/12
摘要： Compounds of the formula I wherein R 1a is H; and R 1b is C 1 -C 6 alkyl, Carbocyclyl or Het; or R 1a and R 1b together define a saturated cyclic amine with 3-6 ring atoms; R 2a and R 2b are H, halo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 alkoxy; or R 2a and R 2b together with the carbon atom to which they are attached form a C 3 -C 6 cycloalkyl; R is a branched C 5 -C 10 alkyl chain, C 2 -C 4 haloalkyl or C 3 -C 7 cycloalkylmethyl, R 4 is Het, Carbocyclyl, optionally substituted as defined in the specification and pharmaceutically acceptable salts, hydrates and N-oxides thereof; are inhibitors of cathepsin S and have utility in the treatment of psoriasis, autoimmune disorders and other disorders such as asthma, arteriosclerosis, COPD and chronic pain
摘要翻译：式Ⅰ化合物，其中R1a是H; 并且R 1b是C 1 -C 6烷基，碳环或Het; 或R 1a和R 1b一起限定具有3-6个环原子的饱和环胺; R2a和R2b是H，卤素，C1-C4烷基，C1-C4卤代烷基，C1-C4烷氧基; 或R 2a和R 2b与它们所连接的碳原子一起形成C 3 -C 6环烷基; R是支链C 5 -C 10烷基链，C 2 -C 4卤代烷基或C 3 -C 7环烷基甲基，R 4是Het，碳环基，如说明书中所定义的任选取代，以及其药学上可接受的盐，水合物和N-氧化物; 是组织蛋白酶S的抑制剂，并且可用于治疗牛皮癣，自身免疫性疾病和其它疾病如哮喘，动脉硬化，COPD和慢性疼痛

4. 发明申请

WO2017201099A1 MULTI-DEGREE OF FREEDOM RESISTANCE EXERCISE DEVICE 审中-公开
标题翻译：多度自由活动锻炼设备
公开(公告)号：WO2017201099A1
公开(公告)日：2017-11-23
申请号：PCT/US2017/032977
申请日：2017-05-16
申请人： LIND, Peter
发明人： LIND, Peter
IPC分类号： A63B21/02 , A63B21/008
CPC分类号： A63B23/03575 , A63B21/00069 , A63B21/005 , A63B21/0083 , A63B21/0087 , A63B21/012 , A63B21/02 , A63B21/023 , A63B21/154 , A63B21/4015 , A63B21/4029 , A63B21/4034 , A63B21/4035 , A63B21/4037 , A63B21/4043 , A63B21/4047 , A63B21/4049 , A63B22/0012 , A63B23/03541 , A63B23/0405 , A63B23/1209 , A63B2210/50 , A63B2225/09 , A63B2225/093 , A63B2225/10 , A63B2230/06 , A63B2230/207 , A63B2230/30 , A63B2230/50
摘要： A rehabilitative and/or exercise machine that has a frame with attachments to multiple independent bidirectional resistance devices (pneumatic, hydraulic, spring actuated, pulley system, cam, or any other resistance devices) used by the arms and/or legs to provide resistance against movement of the user's appendages in two substantially opposed directions. The resistance devices may have a mechanism such as one or more valves, brakes, springs, or the like that control bi-directional resistance. The action of the arms and/or legs in bi-directional resistance offers near full body exercise of the agonist/antagonist muscles using flexion and extension action of the larger muscle groups in a gait pattern, simultaneously. Hand engaging members attach to the arm resistance devices and foot engaging members attach to the leg resistance devices. The unit may- include an attached inclined backboard, mat, bench, or cushion to fully or partially support the user, such as for the user to sit or lay on. The unit may have separate adjustment mechanism s for adjusting the height and/or length of the various portions of the unit to adjust the range of motion of the appendages. The unit may have devices to monitor pulse, oxygen flow and other vital signs.
摘要翻译：康复和/或运动机器，其具有框架，所述框架具有用于手臂使用的多个独立双向阻力装置（气动，液压，弹簧致动，滑轮系统，凸轮或任何其他阻力装置）的附件和/或腿以提供抵抗使用者的附肢在两个基本相反的方向上的移动的阻力。阻力装置可以具有诸如控制双向阻力的一个或多个阀，制动器，弹簧等的机构。双向阻力中的手臂和/或腿的动作通过同时使用步态模式中的较大肌肉群的弯曲和伸展动作来提供接近全身锻炼的激动剂/拮抗剂肌肉。手接合构件附接到手臂阻力装置并且脚接合构件附接到腿阻力装置。该单元可以包括附接的倾斜背板，垫子，长凳或衬垫以完全或部分地支撑使用者，例如供使用者坐下或躺下。该单元可以具有单独的调节机构，用于调节该单元的各个部分的高度和/或长度，以调节附件的运动范围。该设备可能有监测脉搏，氧气流量和其他生命体征的设备。

5. 发明申请

WO2003002732A1 CITRATE LYASE POLY PEPTIDES 审中-公开
公开(公告)号：WO2003002732A1
公开(公告)日：2003-01-09
申请号：PCT/SE2002/001301
申请日：2002-06-27
申请人： BIOVITRUM AB , LIND, Peter , SÖDERBERG, Charlotte
发明人： LIND, Peter , SÖDERBERG, Charlotte
IPC分类号： C12N9/88
CPC分类号： C12Q1/527 , A01K2217/05 , C12N9/88 , G01N2500/00
摘要： The present invention relates to citrate lyase polypeptides and to nucleic acid molecules coding for such polypeptides. Citrate lyase is transcriptionally regulated in adipose tissue, suggesting involvement in a novel pathway in energy expenditure, downstream of fatty acid metabolism. This makes CitE an attractive drug target for treating and/or preventing diseases such as obesity. Accordingly, the invention refers to the novel mammalian CitE-polypeptide, as well as homologs and functionally equivalent variants thereof. Further, the invention refers to the nucleic acid sequence encoding the novel protein and to vectors for expressing the protein in various organisms. The invention also refers to methods for expressing the protein in said organisms and for purifying the protein upon overexpression. Moreover, the invention refers to a method wherein CitE is used for screening for substances that affect the activity of CitE.
摘要翻译：本发明涉及柠檬酸裂解酶多肽和编码这种多肽的核酸分子。柠檬酸裂合酶在脂肪组织中被转录调节，表明参与能量消耗的新途径，脂肪酸代谢下游。这使得CitE成为治疗和/或预防诸如肥胖症等疾病的有吸引力的药物靶点。因此，本发明涉及新型哺乳动物CitE-多肽，以及其同系物和功能等同变体。此外，本发明涉及编码新蛋白质的核酸序列和用于在各种生物体中表达蛋白质的载体。本发明还涉及用于在所述生物体中表达蛋白质并在过表达时纯化蛋白质的方法。此外，本发明涉及一种方法，其中CitE用于筛选影响CitE活性的物质。

6. 发明申请

WO2002064789A1 PROTEIN-COUPLED RECEPTOR 审中-公开
标题翻译：蛋白偶联受体
公开(公告)号：WO2002064789A1
公开(公告)日：2002-08-22
申请号：PCT/US2001/004641
申请日：2001-02-14
申请人： PHARMACIA & UPJOHN COMPANY , LIND, Peter , PARODI, Luis, A. , VOGELI, Gabriel , WOOD, Linda, S.
发明人： LIND, Peter , PARODI, Luis, A. , VOGELI, Gabriel , WOOD, Linda, S.
IPC分类号： C12N15/12
CPC分类号： C07K14/705
摘要： The present application provides a gene encoding a G protein-coupled receptor termed nGPCR-14; constructs and recombinant host cells incorporating the genes; the nGPCR-14 polypeptides encoded by the gene; antibodies to the nGPCR-x polypeptides; and methods of making and using all of the foregoing.
摘要翻译：本申请提供了编码称为nGPCR-14的G蛋白偶联受体的基因; 构建体和掺入该基因的重组宿主细胞; 由该基因编码的nGPCR-14多肽; 针对nGPCR-x多肽的抗体; 以及制作和使用上述所有方法。

7. 发明申请

WO2001062924A3 HUMAN G PROTEIN-COUPLED RECEPTORS 审中-公开
公开(公告)号：WO2001062924A3
公开(公告)日：2001-08-30
申请号：PCT/US2001/005989
申请日：2001-02-23
申请人： PHARMACIA & UPJOHN COMPANY , VOGELI, Gabriel , WOOD, Linda, S. , PARODI, Luis, A. , LIND, Peter
发明人： VOGELI, Gabriel , WOOD, Linda, S. , PARODI, Luis, A. , LIND, Peter
IPC分类号： C12N15/12
摘要： The present invention provides a gene encoding a G protein-coupled receptor termed nGPCR-x; constructs and recombinant host cells incorporating the genes; the nGPCR-x polypeptides encoded by the gene; antibodies to the nGPCR-x polypeptides; and methods of making and using all of the foregoing.

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