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1. 发明申请

WO2009086058A1 THERMAL TREATMENT DEVICE 审中-公开
标题翻译：热处理装置
公开(公告)号：WO2009086058A1
公开(公告)日：2009-07-09
申请号：PCT/US2008/087603
申请日：2008-12-19
申请人： MCNEIL-PPC, INC. , ROBINSON, Ronni L. , SOWDEN, Harry S. , KRIKSUNOV, Leo B.
发明人： ROBINSON, Ronni L. , SOWDEN, Harry S. , KRIKSUNOV, Leo B.
IPC分类号： A61H15/02 , A61F7/02 , A61F7/00 , A61H15/00
CPC分类号： A61F7/02 , A61F7/034 , A61F2007/0071 , A61F2007/0075 , A61F2007/0078 , A61F2007/0086 , A61F2007/0228 , A61F2007/0296 , A61H7/00 , A61H23/02 , A61H23/0254 , A61H2015/0042 , A61H2201/0173 , A61H2201/0207 , A61H2201/0214 , A61H2201/0242 , A61H2201/0257 , A61H2201/0278 , A61H2201/102 , A61H2201/1626 , A61H2201/165 , A61H2201/1688 , A61H2205/081
摘要： The present invention is directed to a reusable pain relieving treatment device, such as a belt, that comprises one or more conductive members that extend from an inner surface of the device and are capable of transferring heat, cold or vibrations from disposable or reusable packs.
摘要翻译：本发明涉及一种可重复使用的止痛治疗装置，例如带，其包括一个或多个导电构件，其从装置的内表面延伸并且能够从一次性或可重复使用的包装传递热，冷或振动。

2. 发明申请

WO2014189971A1 CHILD-RESISTANT PACKAGE 审中-公开
标题翻译：儿童防护包
公开(公告)号：WO2014189971A1
公开(公告)日：2014-11-27
申请号：PCT/US2014/038842
申请日：2014-05-20
申请人： MCNEIL-PPC, INC.
发明人： SOWDEN, Harry S. , MCNALLY, Gerard P. , SHORTS, R. Scott
IPC分类号： B65D77/20
CPC分类号： A61J1/035 , B65D77/2052 , B65D2215/04 , B65D2215/08 , B65D2577/2083
摘要： A package including a container and a cover sheet, the container having a first section and a second section connected at a breakable joint (30), the first section includes a well, and the cover sheet is adhered to at least a portion of the first section and at least a portion of the second section and the cover sheet covers the well. Either the first section or the second section is adapted to pivot at a fulcrum (10) between the cover sheet and the joint to assist in breaking the breakable joint in order to separate the first section and the second section, and allow removal of the cover sheet.
摘要翻译：一种包括容器和覆盖片的包装，所述容器具有连接在可破坏接头（30）上的第一部分和第二部分，所述第一部分包括孔，并且所述覆盖片粘附到所述第一部分的至少一部分并且所述第二部分和所述覆盖片的至少一部分覆盖所述孔。第一部分或第二部分适于在盖片和接头之间的支点（10）处枢转，以帮助破坏可破坏的接头，以便分离第一部分和第二部分，并且允许移除盖片。

3. 发明申请

WO2013166136A1 TABLET COMPRISING A FIRST AND SECOND REGION 审中-公开
标题翻译：包含第一和第二地区的图纸
公开(公告)号：WO2013166136A1
公开(公告)日：2013-11-07
申请号：PCT/US2013/039045
申请日：2013-05-01
申请人： MCNEIL-PPC, INC.
发明人： SOWDEN, Harry S. , MCNALLY, Gerard P. , ANDERSON, Oliver , STUHL, William J. , CHEN, Jen-Chi , DAY, Kenneth , SZYMCZAK, Christopher E.
IPC分类号： A61K9/00 , A61K9/20
CPC分类号： A61K9/209 , A61K9/0056 , A61K9/2072 , A61K9/2086 , A61K31/137 , A61K31/167 , A61K31/4545 , A61K2300/00
摘要： In one aspect, the present invention features a tablet including a first region and a second region, wherein: (i) the first region and the second region each include at least 10%, by volume, of the tablet; (ii) the first region includes a pharmaceutically active agent and the composition of the first region is different from the composition of the second region; (iii) the first region has a density less than about 0.8 g/cc; and (iv) the first region disintegrates in the mouth when placed on the tongue in less than about 30 seconds; wherein the shape of the tablet includes two opposing major faces separated by a side wall, and the interface between the first region and the second region is along at least one major face of the tablet.
摘要翻译：在一个方面，本发明的特征在于包括第一区域和第二区域的片剂，其中：（i）第一区域和第二区域各自包含片剂的至少10体积％（ii）第一区域包括药物活性剂，第一区域的组成与第二区域的组成不同; （iii）第一区域的密度小于约0.8g / cc; 和（iv）第一个区域在不到约30秒内放置在舌头上时在口中分解; 其中所述片剂的形状包括由侧壁分开的两个相对的主面，并且所述第一区域和所述第二区域之间的界面沿着所述片剂的至少一个主面。

4. 发明申请

WO2013166144A1 METHOD OF MANUFACTURING SOLID DOSAGE FORM 审中-公开
标题翻译：制造固体剂型的方法
公开(公告)号：WO2013166144A1
公开(公告)日：2013-11-07
申请号：PCT/US2013/039061
申请日：2013-05-01
申请人： MCNEIL-PPC, INC.
发明人： ANDERSON, Oliver , SOWDEN, Harry S. , MCNALLY, Gerard P. , STUHL, William J.
IPC分类号： B30B15/30 , B30B11/02 , A61K9/20
CPC分类号： A61J3/10 , A61J3/00 , A61J3/06 , A61K9/2072 , A61K9/2086 , A61K9/2095 , A61K31/137 , A61K31/167 , A61K31/4545 , A61K2300/00
摘要： In one aspect, the present invention features a method of manufacturing a solid dosage form, the method including the steps of: (a) measuring an amount of a first powder blend within a dosing nozzle, wherein the first powder blend includes a pharmaceutically active agent; (b) discharging the measured amount of a first powder blend from the dosing nozzle into a forming cavity within a die block, the forming cavity having an inner wall, a first opening at the surface of one side of the die block, and a second opening at the surface on the opposite side of the die block; (c) moving a first forming tool into the forming cavity through the first opening of the forming cavity such that the first powder blend is formed into the shape of the dosage form within the forming cavity between the inner wall, the first forming tool and a second forming tool within or adjacent to the cavity; (d) applying RF energy between a first electrode and a second electrode such that the energy heats the first powder blend within the forming cavity to form the dosage form; and (e) removing the dosage form from the forming cavity.
摘要翻译：一方面，本发明的特征在于制备固体剂型的方法，所述方法包括以下步骤：（a）测量剂量喷嘴内的第一粉末混合物的量，其中第一粉末混合物包含药物活性剂 ; （b）将测量量的第一粉末混合物从计量喷嘴排出到模具块内的成形腔中，所述成型腔具有内壁，在模块的一侧的表面处的第一开口，以及第二在模块的相对侧的表面开口; （c）通过成形腔的第一开口将第一成形工具移动到成形腔中，使得第一粉末混合物在内壁，第一成形工具和第一成形工具之间的成形腔内形成为剂型的形状第二成形工具在腔体内或邻近腔体; （d）在第一电极和第二电极之间施加RF能量，使得所述能量加热所述成形腔内的第一粉末混合物以形成所述剂型; 和（e）从形成腔去除剂型。

5. 发明申请

WO2013166138A1 MACHINE FOR PRODUCTION OF SOLID DOSAGE FORMS 审中-公开
标题翻译：生产固体剂型的机器
公开(公告)号：WO2013166138A1
公开(公告)日：2013-11-07
申请号：PCT/US2013/039047
申请日：2013-05-01
申请人： MCNEIL-PPC, INC.
发明人： STUHL, William J. , SOWDEN, Harry S. , MCNALLY, Gerard P. , ANDERSON, Oliver
IPC分类号： B30B15/30 , B30B11/02
CPC分类号： B29C43/58 , B30B11/027 , B30B11/10 , B30B15/306
摘要： In one aspect, the present invention features a machine for the production of a solid dosage form, the machine including: (a) a die block having one or more forming cavities each having an inner wall, a first opening at the surface of one side of the die block, and a second opening at the surface on the opposite side of the die block; (b) one or more first dosing nozzle adapted to both measure an amount of a first powder blend and discharge the measured amount of the first powder blend within one of the one or more forming cavity; (d) one or more first forming tools each adapted to move into one of the cavities through the first opening of the forming cavity; (e) one or more second forming tools each adapted to move adjacent to one of the second openings or into one of the cavities through the second opening of the forming cavity; (f) at least one first RF electrode operably associated with the one or more first forming tools, the one or more second forming tools, or the inner wall of the one or more forming cavities; and (g) at least one second RF electrode operably associated with the one or more first forming tools, the one or more second forming tools, or the inner wall of the one or more forming cavities; wherein the machine is adapted to form a dosage form between a first forming tool and a second forming tool within a forming cavity and wherein the first RF electrode and the second RF electrode are arranged within the machine such that when RF energy is applied between the first RF electrode and the second RF electrode, the RF energy passes through the portion of the forming cavity adapted to form the dosage form.
摘要翻译：一方面，本发明的特征在于一种用于生产固体剂型的机器，该机器包括：（a）具有一个或多个成形腔的模具块，每个模腔具有内壁，在一侧的表面上具有第一开口和在模块的相对侧的表面处的第二开口; （b）一个或多个第一计量喷嘴，其适于测量第一粉末共混物的量并将所测量的第一粉末混合物的量在所述一个或多个成形腔内的一个中排出; （d）一个或多个第一成形工具，每个适于通过成形腔的第一开口移动到一个空腔中; （e）一个或多个第二成形工具，每个第二成形工具适于通过成形腔的第二开口移动到第二开口中的一个或通过成形腔的第二开口移动到一个空腔中; （f）至少一个第一RF电极，其与所述一个或多个第一成形工具，所述一个或多个第二成形工具或所述一个或多个成形腔的内壁可操作地相关联; 和（g）至少一个第二RF电极，其可操作地与所述一个或多个第一成形工具，所述一个或多个第二成形工具或所述一个或多个成形腔的内壁相关联; 其中所述机器适于在成形腔内的第一成形工具和第二成形工具之间形成剂型，并且其中所述第一RF电极和所述第二RF电极被布置在所述机器内，使得当RF能量施加在所述第一 RF电极和第二RF电极，RF能量通过适于形成剂型的成形腔的部分。

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