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1. 发明申请

WO2012116203A1 WATER SOLUBLE MEMBRANE PROTEINS AND METHODS FOR THE PREPARATION AND USE THEREOF 审中-公开
标题翻译：水溶性膜蛋白及其制备和使用方法
公开(公告)号：WO2012116203A1
公开(公告)日：2012-08-30
申请号：PCT/US2012/026353
申请日：2012-02-23
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , ZHANG, Shuguang , RICH, Alexander , CORIN, Karolina , TEGLER, Lotta, T.
发明人： ZHANG, Shuguang , RICH, Alexander , CORIN, Karolina , TEGLER, Lotta, T.
IPC分类号： A61K38/16 , C07K14/00
CPC分类号： C07K14/705 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1793 , C07K14/7158 , G01N33/6863
摘要： The present invention is directed to water-soluble membrane proteins, methods for the preparation thereof and methods of use thereof.
摘要翻译：本发明涉及水溶性膜蛋白，其制备方法及其使用方法。

2. 发明申请

WO2010014903A1 MULTIPLEXED OLFACTORY RECEPTOR-BASED MICROSURFACE PLASMON POLARITON DETECTOR 审中-公开
标题翻译：多功能基于受体的基于微波表面的PLASMON POLARITON检测器
公开(公告)号：WO2010014903A1
公开(公告)日：2010-02-04
申请号：PCT/US2009/052408
申请日：2009-07-31
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , MERSHIN, Andreas , COOK, Brian , KAISER, Liselotte , GRAVELAND-BIKKER, Joanke , MIURA, Yoshikatsu , NIWA, Daisuke , OHNISHI, Dai , TAZUKE, Atsushi , ZHANG, Shuguang
发明人： MERSHIN, Andreas , COOK, Brian , KAISER, Liselotte , GRAVELAND-BIKKER, Joanke , MIURA, Yoshikatsu , NIWA, Daisuke , OHNISHI, Dai , TAZUKE, Atsushi , ZHANG, Shuguang
IPC分类号： C12M1/34 , G01N21/75 , G01N21/55
CPC分类号： G01N21/553 , B82Y30/00 , C07K2/00 , G01N21/554 , G01N33/0031 , G01N2201/06113 , G01N2201/08
摘要： The invention provides a bio-sensing nanodevice comprising: a stabilized G- protein coupled receptor on a support, a real time receptor-ligand binding detection method, a test composition delivery system and a test composition recognition program. The G-protein coupled receptor can be stabilized using surfactant peptide. The nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a micro fluidic chip containing a stabilized G-protein coupled receptor immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor.
摘要翻译：本发明提供一种生物感测纳米装置，其包括：载体上的稳定的G-蛋白偶联受体，实时受体 - 配体结合检测方法，测试组合物递送系统和测试组合物识别程序。 G蛋白偶联受体可以使用表面活性肽稳定。纳米器件提供更大的表面积，以提高气味检测的精度和灵敏度。本发明进一步提供了一种含有稳定的G蛋白偶联受体的微流体芯片，其固定在载体上，并且被布置在至少二维微阵列系统中。本发明还提供了一种递送加臭剂的方法，其包括在复杂微流体网络中操作气泡的步骤，其中气泡在携带各种气体样品的微流体通道中移动到芯片上的精确位置。本发明还提供了制备hOR17-4嗅觉受体的方法。

3. 发明申请

WO2008136820A1 STABILIZATION OF MAMMALIAN MEMBRANE PROTEINS BY SHORT SURFACTANT PEPTIDES 审中-公开
标题翻译：短肌表皮生长因子抑制蛋白质膜蛋白的稳定
公开(公告)号：WO2008136820A1
公开(公告)日：2008-11-13
申请号：PCT/US2007/067845
申请日：2007-05-03
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , ZHANG, Shuguang
发明人： ZHANG, Shuguang
IPC分类号： A61K38/04
CPC分类号： A61K38/177 , A61K9/107 , A61K38/1793 , A61K38/1796 , A61K47/183 , A61K2300/00
摘要： The present invention provides for a method and kits for stabilizing mammalian membrane protein using short surfactant peptides. The mammalian membrane protein can be a G protein-coupled receptor.
摘要翻译：本发明提供了使用短表面活性剂肽稳定哺乳动物膜蛋白的方法和试剂盒。哺乳动物膜蛋白可以是G蛋白偶联受体。

4. 发明申请

WO2007070645A3 BIO-SENSITIZED SOLAR CELLS (BSSC) 审中-公开
公开(公告)号：WO2007070645A3
公开(公告)日：2007-06-21
申请号：PCT/US2006/047768
申请日：2006-12-14
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , MERSHIN, Andreas , COOK, Brian , ZHANG, Shuguang
发明人： MERSHIN, Andreas , COOK, Brian , ZHANG, Shuguang
IPC分类号： H01L31/00
摘要： The present invention provides a wet or dry bio-sensitized photoelectric conversion device (photodetector or photovoltaic) comprising: a stabilized biologically-derived sensitizer, such as a stablilized photosystem I (PS-I), deposited on nanowires, semiconductor material, electrodes and a support. The nanowires provide a greater surface area of the light absorption layer for better energy conversion efficiency and are chosen such as to complement the absorption spectrum of the sensitizer and protect the sensitizer from photobleaching.

5. 发明申请

WO2002062969A2 CELLULAR REPROGRAMMING IN PEPTIDE HYDROGEL AND USES THEREOF 审中-公开
标题翻译：肽水解中的细胞重编码及其用途
公开(公告)号：WO2002062969A2
公开(公告)日：2002-08-15
申请号：PCT/US2002/003607
申请日：2002-02-06
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , SEMINO, Carlos, E. , SHERLEY, James , ZHANG, Shuguang
发明人： SEMINO, Carlos, E. , SHERLEY, James , ZHANG, Shuguang
IPC分类号： C12N5/00
CPC分类号： C12N5/0655 , A61K35/12 , C12N5/0012 , C12N5/0618 , C12N5/0672 , C12N2500/25 , C12N2501/11 , C12N2501/13 , C12N2502/1317 , C12N2533/30 , C12N2533/50
摘要： The present invention provides compositions featuring cells, e.g., progenitor cells, stem cells, and their progeny encapsulated within self-assembling three-dimensional peptide hydrogel structures (scaffolds). The scaffolds provide a nanoscale environment. Thus the invention provides a nanoscale environment scaffold encapsulating cells. According to certain embodiments of the invention the progenitor cells and/or their progeny are able to differentiate or transdifferentiate within the structures. According to certain embodiments of the invention the cells are liver lineage cells or neural lineage cells. The peptide hydrogel environment renders the cells permissive for instruction by differentiation-enhancing agents such as growth factors. The invention provides an in vitro culture system for growing stem and progenitor cells, for inducing their differentiation and transdifferentiation, and for studying their properties; an in vitro culture system for growing hepatocyte-like cells and/or mature hepatocytes, which may be used, for example, to propagate hepatotropic viruses; a system for controlling and manipulating cell differentiation and transdifferentiation in vitro, from which cells can be extracted and then either maintained in vitro or administered to a subject, e.g., for treating a tissue defect or other condition; a system for controlling and manipulating cell differentiation and transdifferentiation in vitro within a structure that is to be implanted within a subject, e.g., for treating a tissue defect or other condition, and assay systems for testing compounds.
摘要翻译：本发明提供了组合物，其特征在于，细胞，例如祖细胞，干细胞及其后代，其包封在自组装的三维肽水凝胶结构（支架）内。支架提供了纳米尺度的环境。因此，本发明提供了一种封装细胞的纳米级环境支架。根据本发明的某些实施方案，祖细胞和/或其后代能够在结构内分化或转分化。根据本发明的某些实施方案，细胞是肝谱系细胞或神经谱系细胞。肽水凝胶环境使细胞允许通过分化增强剂如生长因子的指导。本发明提供了用于培养干细胞和祖细胞，用于诱导其分化和转分化并用于研究其性质的体外培养系统。用于生长肝细胞样细胞和/或成熟肝细胞的体外培养系统，其可以用于例如增殖嗜肝病毒; 用于控制和操纵体外细胞分化和转分化的系统，从中可以提取细胞，然后在体外保持或施用于受试者，例如用于治疗组织缺陷或其他病症; 用于在待植入受试者的结构内（例如用于治疗组织缺陷或其他病症）和用于测试化合物的测定系统的体外控制和操纵细胞分化和转分化的系统。

6. 发明申请

WO2004007683A2 CELLULAR REPROGRAMMING IN PEPTIDE HYDROGEL AND USES THEREOF 审中-公开
标题翻译：肽水解中的细胞重编码及其用途
公开(公告)号：WO2004007683A2
公开(公告)日：2004-01-22
申请号：PCT/US2003/021981
申请日：2003-07-15
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , SEMINO, Carlos , SHEN, Collette , SHERLEY, James , ZHANG, Shuguang
发明人： SEMINO, Carlos , SHEN, Collette , SHERLEY, James , ZHANG, Shuguang
IPC分类号： C12N
CPC分类号： C12N5/0671 , A61K2035/126 , C12N5/0677 , C12N2501/01 , C12N2501/06 , C12N2501/11 , C12N2501/115 , C12N2501/998 , C12N2506/14 , C12N2533/50
摘要： The present invention provides compositions featuring cells, e.g., progenitor cells, stem cells, and their progeny encapsulated within self-assembling threedimensional peptide hydrogel structures (scaffolds). The scaffolds provide a nanoscale environment. Thus the invention provides a nanoscale environment scaffold encapsulating cells. According to certain embodiments of the invention the progenitor cells and/or their progeny are able to differentiate or transdifferentiate within the structures. According to certain embodiments of the invention the cells are or differentiate into liver lineage cells, neural lineage cells, or pancreatic lineage cells. The peptide hydrogel environment renders the cells permissive for instruction by differentiation-enhancing agents such as growth factors or extracellular matrix components. The invention provides an in vitro culture system for growing stem and progenitor cells, for inducing their differentiation and transdifferentiation, and for studying their properties; an in vitro culture system for growing hepatocyte-like cells and/or mature hepatocytes, which may be used, for example, to propagate hepatotropic viruses; a system for generating insulin secreting cells; a system for controlling and manipulating cell differentiation and transdifferentiation in vitro, from which cells can be extracted and then either maintained in vitro or administered to a subject; a system for controlling and manipulating cell differentiation and transdifferentiation in vitro, and assay systems for testing compounds. The invention provides methods of treating disease by implanting peptide hydrogel structures containing cells or cells extracted following culture in peptide hydrogels into the body.
摘要翻译：本发明提供了组合物，其特征在于细胞，例如祖细胞，干细胞及其后代，其封装在自组装三维肽水凝胶结构（支架）内。支架提供了纳米尺度的环境。因此，本发明提供了一种封装细胞的纳米级环境支架。根据本发明的某些实施方案，祖细胞和/或其后代能够在结构内分化或转分化。根据本发明的某些实施方案，细胞是或分化成肝谱系细胞，神经谱系细胞或胰腺谱系细胞。肽水凝胶环境使细胞允许通过分化增强剂如生长因子或细胞外基质组分的指导。本发明提供了用于培养干细胞和祖细胞，用于诱导其分化和转分化并用于研究其性质的体外培养系统。用于生长肝细胞样细胞和/或成熟肝细胞的体外培养系统，其可以用于例如增殖嗜肝病毒; 用于产生胰岛素分泌细胞的系统; 用于控制和操纵体外细胞分化和转分化的系统，从中可以提取细胞，然后在体外维持或施用于受试者; 用于在体外控制和操纵细胞分化和转分化的系统以及用于测试化合物的测定系统。本发明提供了通过在肽水凝胶中将含有细胞或细胞提取的细胞或细胞的肽水凝胶结构植入体内来治疗疾病的方法。

7. 发明申请

WO2003096972A2 ANGIOGENESIS AND CARDIAC TISSUE ENGINEERING WITH PEPTIDE HYDROGELS AND RELATED COMPOSITIONS AND METHODS OF USE THEREOF 审中-公开
标题翻译：肽类水凝胶的生物发生和心脏组织工程及相关组合物及其使用方法
公开(公告)号：WO2003096972A2
公开(公告)日：2003-11-27
申请号：PCT/US2003/014092
申请日：2003-05-07
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , NARMONEVA, Daria , ZHANG, Shuguang , KAMM, Roger, D. , LEE, Richard, T.
发明人： NARMONEVA, Daria , ZHANG, Shuguang , KAMM, Roger, D. , LEE, Richard, T.
IPC分类号： A61K
CPC分类号： C12N5/0657 , A61K35/12 , A61K38/10 , A61K2035/126 , A61L27/227 , A61L27/3808 , A61L27/3886 , A61L2400/16 , A61L2430/20 , C12N5/069 , C12N2502/28 , C12N2533/50
摘要： The invention provides compositions comprising self-assembling peptide hydrogels and cardiovascular system cells, particularly endothelial cells, cultured in or on the gels. According to certain embodiments of the invention the endothelial cells form capillary-like structures. The endothelial cell-gel matrix serves as a prevascularized scaffold that may be used to culture additional cell types. Formation of mature blood vessels in or on the scaffold involves addition of smooth muscle cells and/or fibroblasts. Compositions of the invention may be used for cell culture and for administration to a subject to treat a variety of conditions including, but not limited to, myocardial dysfunction or damage.
摘要翻译：本发明提供了包含自组装肽水凝胶和在凝胶中或凝胶上培养的心血管系统细胞，特别是内皮细胞的组合物。根据本发明的某些实施方案，内皮细胞形成毛细管样结构。内皮细胞凝胶基质用作可以用于培养另外的细胞类型的血管前支架。在支架中或其上的成熟血管的形成包括加入平滑肌细胞和/或成纤维细胞。本发明的组合物可用于细胞培养和用于给予受试者以治疗多种病症，包括但不限于心肌功能障碍或损伤。

8. 发明申请

WO2009018467A2 BIO-SENSING NANODEVICE 审中-公开
标题翻译：生物感应纳米器件
公开(公告)号：WO2009018467A2
公开(公告)日：2009-02-05
申请号：PCT/US2008/071804
申请日：2008-07-31
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , ZHANG, Shuguang , MERSHIN, Andreas , KAISER, Liselotte , COOK, Brian , GRAVELAND-BIKKER, Johanna , PRAKASH, Manu , KONG, David , MAGUIRE, Yael
发明人： ZHANG, Shuguang , MERSHIN, Andreas , KAISER, Liselotte , COOK, Brian , GRAVELAND-BIKKER, Johanna , PRAKASH, Manu , KONG, David , MAGUIRE, Yael
IPC分类号： G01N33/53
CPC分类号： G01N33/54366 , G01N2333/726
摘要： The invention provides a bio-sensing nanodevice comprising: a stabilized biologically-derived G-protein coupled receptor -the olfactory receptor- on a support, a real time receptor-ligand binding detection method, an odorant delivery system and an odorant recognition program. The biologically-derived G-protein coupled receptor can be stabilized on nanotechnology using surfactant peptide. The said nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a micro fluidic chip containing a stabilized biologically-derived G-protein coupled receptor -the olfactory receptor- immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor.
摘要翻译：本发明提供了一种生物感测纳米装置，其包含：稳定的生物衍生的G蛋白偶联受体 - 载体上的嗅觉受体，实时受体 - 配体结合检测方法，加味剂递送系统和气味识别程序。生物衍生的G蛋白偶联受体可以使用表面活性剂肽在纳米技术上稳定。所述纳米器件提供更大的表面积，以提高气味检测的精度和灵敏度。本发明还提供了含有稳定的生物衍生的G蛋白偶联受体 - 嗅觉受体 - 固定在载体上并且布置在至少二维微阵列系统中的微流体芯片。本发明还提供了一种递送加臭剂的方法，其包括在复杂微流体网络中操作气泡的步骤，其中气泡在携带各种气体样品的微流体通道中移动到芯片上的精确位置。本发明还提供了制备hOR17-4嗅觉受体的方法。

9. 发明申请

WO2005014615A2 SELF-ASSEMBLING PEPTIDES INCORPORATING MODIFICATIONS AND METHODS OF USE THEREOF 审中-公开
标题翻译：自组装肽及其使用方法
公开(公告)号：WO2005014615A2
公开(公告)日：2005-02-17
申请号：PCT/US2004/020549
申请日：2004-06-25
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , GENOVE, Elsa , SEMINO, Carlos , ZHANG, Shuguang
发明人： GENOVE, Elsa , SEMINO, Carlos , ZHANG, Shuguang
IPC分类号： C07K
CPC分类号： C07K7/08 , A61K38/00 , A61K47/62 , A61K47/6903 , A61L27/227 , A61L27/38 , C07K7/06 , C07K14/39 , C07K14/78 , C07K2319/00 , C12N5/0068 , C12N5/069
摘要： The invention provides a self-assembling peptide comprising (a) a first amino acid domain that mediates self-assembly, wherein the domain comprises alternating hydrophobic and hydrophilic amino acids that are complementary and structurally compatible and self-assemble into a macroscopic structure when present in unmodified form; and (b) a second amino acid domain that does not self-assemble in isolated form. In certain embodiments of the invention the second amino acid domain comprises a biologically active peptide motif, e.g., a peptide motif found in a naturally occurring protein, or a target site for an interaction with a biomolecule. In certain embodiments of the invention the naturally occurring protein is a component of the extracellular matrix, e.g., a component of the basement membrane. The invention further provides scaffolds comprising the self-assembling peptides and methods of using the scaffolds including for cell culture, tissue engineering, and tissue repair.
摘要翻译：本发明提供了一种自组装肽，其包含（a）介导自组装的第一氨基酸结构域，其中所述结构域包含互补和结构相容的交替的疏水性和亲水性氨基酸，并且如果存在于，将其自组装成宏观结构未经修改的形式; 和（b）不以分离形式自组装的第二个氨基酸结构域。在本发明的某些实施方案中，第二氨基酸结构域包含生物活性肽基序，例如在天然存在的蛋白质中发现的肽基序，或与生物分子相互作用的靶位点。在本发明的某些实施方案中，天然存在的蛋白质是细胞外基质的组分，例如基底膜的组分。本发明还提供了包含自组装肽的支架和使用支架的方法，包括用于细胞培养，组织工程和组织修复。

10. 发明申请

WO2008039483A3 MODIFIED SELF-ASSEMBLING PEPTIDES 审中-公开
公开(公告)号：WO2008039483A3
公开(公告)日：2008-04-03
申请号：PCT/US2007/020754
申请日：2007-09-26
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , HORII, Akihiro , ZHANG, Shuguang , WANG, Xiumei , GELAIN, Fabrizio
发明人： HORII, Akihiro , ZHANG, Shuguang , WANG, Xiumei , GELAIN, Fabrizio
IPC分类号： C07K19/00 , C07K17/02 , C07K14/00 , A61L15/00 , C12N11/06
摘要： The present invention provides a self-assembling peptide comprising: (a) a first amino acid domain that mediates self-assembly, wherein the domain comprises alternating hydrophobic and hydrophilic amino acids that are complementary and structurally compatible and self-assemble into a macroscopic structure when present in unmodified form; and (b) a second amino acid domain that does not mediate self- assembly in isolated form, wherein the second amino acid domain comprises at least one minimal biologically active sequence. Such self-assembling peptides are described herein as "modified self-assembling peptides." The present invention also provides pharmaceutical compositions, kits and maxtrices comprising a modified self-assembling peptide, and methods of using and making such compositions, kits and matrices.

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