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1. 发明申请

WO2009018467A2 BIO-SENSING NANODEVICE 审中-公开
标题翻译：生物感应纳米器件
公开(公告)号：WO2009018467A2
公开(公告)日：2009-02-05
申请号：PCT/US2008/071804
申请日：2008-07-31
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , ZHANG, Shuguang , MERSHIN, Andreas , KAISER, Liselotte , COOK, Brian , GRAVELAND-BIKKER, Johanna , PRAKASH, Manu , KONG, David , MAGUIRE, Yael
发明人： ZHANG, Shuguang , MERSHIN, Andreas , KAISER, Liselotte , COOK, Brian , GRAVELAND-BIKKER, Johanna , PRAKASH, Manu , KONG, David , MAGUIRE, Yael
IPC分类号： G01N33/53
CPC分类号： G01N33/54366 , G01N2333/726
摘要： The invention provides a bio-sensing nanodevice comprising: a stabilized biologically-derived G-protein coupled receptor -the olfactory receptor- on a support, a real time receptor-ligand binding detection method, an odorant delivery system and an odorant recognition program. The biologically-derived G-protein coupled receptor can be stabilized on nanotechnology using surfactant peptide. The said nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a micro fluidic chip containing a stabilized biologically-derived G-protein coupled receptor -the olfactory receptor- immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor.
摘要翻译：本发明提供了一种生物感测纳米装置，其包含：稳定的生物衍生的G蛋白偶联受体 - 载体上的嗅觉受体，实时受体 - 配体结合检测方法，加味剂递送系统和气味识别程序。生物衍生的G蛋白偶联受体可以使用表面活性剂肽在纳米技术上稳定。所述纳米器件提供更大的表面积，以提高气味检测的精度和灵敏度。本发明还提供了含有稳定的生物衍生的G蛋白偶联受体 - 嗅觉受体 - 固定在载体上并且布置在至少二维微阵列系统中的微流体芯片。本发明还提供了一种递送加臭剂的方法，其包括在复杂微流体网络中操作气泡的步骤，其中气泡在携带各种气体样品的微流体通道中移动到芯片上的精确位置。本发明还提供了制备hOR17-4嗅觉受体的方法。

2. 发明申请

WO2010014903A1 MULTIPLEXED OLFACTORY RECEPTOR-BASED MICROSURFACE PLASMON POLARITON DETECTOR 审中-公开
标题翻译：多功能基于受体的基于微波表面的PLASMON POLARITON检测器
公开(公告)号：WO2010014903A1
公开(公告)日：2010-02-04
申请号：PCT/US2009/052408
申请日：2009-07-31
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , MERSHIN, Andreas , COOK, Brian , KAISER, Liselotte , GRAVELAND-BIKKER, Joanke , MIURA, Yoshikatsu , NIWA, Daisuke , OHNISHI, Dai , TAZUKE, Atsushi , ZHANG, Shuguang
发明人： MERSHIN, Andreas , COOK, Brian , KAISER, Liselotte , GRAVELAND-BIKKER, Joanke , MIURA, Yoshikatsu , NIWA, Daisuke , OHNISHI, Dai , TAZUKE, Atsushi , ZHANG, Shuguang
IPC分类号： C12M1/34 , G01N21/75 , G01N21/55
CPC分类号： G01N21/553 , B82Y30/00 , C07K2/00 , G01N21/554 , G01N33/0031 , G01N2201/06113 , G01N2201/08
摘要： The invention provides a bio-sensing nanodevice comprising: a stabilized G- protein coupled receptor on a support, a real time receptor-ligand binding detection method, a test composition delivery system and a test composition recognition program. The G-protein coupled receptor can be stabilized using surfactant peptide. The nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a micro fluidic chip containing a stabilized G-protein coupled receptor immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor.
摘要翻译：本发明提供一种生物感测纳米装置，其包括：载体上的稳定的G-蛋白偶联受体，实时受体 - 配体结合检测方法，测试组合物递送系统和测试组合物识别程序。 G蛋白偶联受体可以使用表面活性肽稳定。纳米器件提供更大的表面积，以提高气味检测的精度和灵敏度。本发明进一步提供了一种含有稳定的G蛋白偶联受体的微流体芯片，其固定在载体上，并且被布置在至少二维微阵列系统中。本发明还提供了一种递送加臭剂的方法，其包括在复杂微流体网络中操作气泡的步骤，其中气泡在携带各种气体样品的微流体通道中移动到芯片上的精确位置。本发明还提供了制备hOR17-4嗅觉受体的方法。

3. 发明申请

WO2007070645A3 BIO-SENSITIZED SOLAR CELLS (BSSC) 审中-公开
公开(公告)号：WO2007070645A3
公开(公告)日：2007-06-21
申请号：PCT/US2006/047768
申请日：2006-12-14
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , MERSHIN, Andreas , COOK, Brian , ZHANG, Shuguang
发明人： MERSHIN, Andreas , COOK, Brian , ZHANG, Shuguang
IPC分类号： H01L31/00
摘要： The present invention provides a wet or dry bio-sensitized photoelectric conversion device (photodetector or photovoltaic) comprising: a stabilized biologically-derived sensitizer, such as a stablilized photosystem I (PS-I), deposited on nanowires, semiconductor material, electrodes and a support. The nanowires provide a greater surface area of the light absorption layer for better energy conversion efficiency and are chosen such as to complement the absorption spectrum of the sensitizer and protect the sensitizer from photobleaching.

4. 发明申请

WO2022155516A1 METHOD FOR MYCOTECTURE 审中-公开
公开(公告)号：WO2022155516A1
公开(公告)日：2022-07-21
申请号：PCT/US2022/012594
申请日：2022-01-14
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , STANDARD BANK GROUP LIMITED
发明人： MERSHIN, Andreas , MAURER, Christopher , STATHATOU, Patritsia, Maria , CAMERON-KIRKSMITH, Carolyn, Margaret
IPC分类号： A01G18/20 , A01G18/00 , A01G18/60 , A01G18/80 , C12N1/14
摘要： A method of making a food source or medicinal composition and a mycotecture construction unit includes (a) cultivating a mycelium/substrate composite and edible mushrooms, and (b) manufacturing the mycotecture construction unit. A mycelium inoculum is formed of a preselected fungus and used to inoculate a substrate. Mycelium are grown in the inoculated substrate in a growing column and edible mushrooms are harvested from the mycelium, leaving a mycelium-substrate composite. The manufacture of the mycotecture construction unit includes placing the mycelium-substrate composite into a modular, reconfigurable press having a cavity with a predetermined shape; pressing the mycelium-substrate composite at a predetermined pressure; and heating the mycelium-substrate composite in a heating chamber. The construction unit is packaging, an insulation panel, a building construction material, or a household fitting with excellent compression strength, compressive modulus, flexural strength, flexural modulus, insulative properties, and fire retardant properties.

5. 发明申请

WO2015017733A1 METHODS AND APPARATUS FOR TRANSPLANTATION OF NUCLEIC ACID MOLECULES 审中-公开
标题翻译：用于转运核酸分子的方法和装置
公开(公告)号：WO2015017733A1
公开(公告)日：2015-02-05
申请号：PCT/US2014/049305
申请日：2014-07-31
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , J. CRAIG VENTER INSTITUTE, INC. , GOVERNMENT OF U.S.A AS REP. BY THE SEC. OF COMMERCE, THE NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY
发明人： MERSHIN, Andreas , PELLETIER, James , GERSHENFELD, Neil , GLASS, John , STRYCHALSKI, Elizabeth
IPC分类号： C12N5/02
CPC分类号： C12M35/08 , C12N15/87
摘要： In exemplary implementations, transplantation of nucleic acids into cells occurs in microfluidic chambers. The nucleic acids may be large nucleic acid molecules with more than 100 kbp. In some cases, the microfluidic chambers have only one orifice that opens to a flow channel. In some cases, flow through a microfluidic chamber temporarily ceases due to closing one or more valves. Transplantation occurs during a period in which the contents of the chambers are shielded from shear forces. Diffusion, centrifugation, suction from a vacuum channel, or dead-end loading may be used to move cells or buffers into the chambers.
摘要翻译：在示例性实施方案中，将核酸移植到细胞中发生在微流体室中。核酸可以是大于100kbp的大核酸分子。在一些情况下，微流体室仅具有一个通向流动通道的孔口。在一些情况下，由于关闭一个或多个阀门，流过微流体室的流动暂时停止。移植发生在室内容物被剪切力屏蔽的期间。可以使用扩散，离心，真空通道抽吸或死端装载将细胞或缓冲液移动到腔室中。

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