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1. 发明申请

WO1996026431A1 OPTICAL IMAGING USING TIME GATED SCATTERED LIGHT 审中-公开
标题翻译：使用时间分散散射光的光学成像
公开(公告)号：WO1996026431A1
公开(公告)日：1996-08-29
申请号：PCT/US1996002394
申请日：1996-02-21
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , PERELMAN, Lev, T. , WU, Jun , WANG, Yang , DASARI, Ramachandra, Rao , ITZKAN, Irving , FELD, Michael, S.
发明人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
IPC分类号： G01N21/47
CPC分类号： G01N21/4795 , A61B5/0073
摘要： The present invention relates to the use of time gated scattered light, for determining the location and composition of material within various organs of the human body. The systems and methods of the present invention provide for medical imaging in three dimensions of internal body structures for diagnostic purposes. Stationary and scanning fiber optic systems can be used to deliver laser radiation onto the object to be imaged and to collect the time gated information for image reconstruction.
摘要翻译：本发明涉及时间门控散射光的使用，用于确定人体各种器官内材料的位置和组成。本发明的系统和方法提供用于诊断目的的内部身体结构的三维的医学成像。固定和扫描光纤系统可用于将激光辐射传送到要成像的物体上，并收集用于图像重建的时间门控信息。

2. 发明申请

WO1996029925A3 APPARATUS AND METHODS OF RAMAN SPECTROSCOPY FOR ANALYSIS OF BLOOD GASES AND ANALYTES 审中-公开
公开(公告)号：WO1996029925A3
公开(公告)日：1996-10-03
申请号：PCT/US1996004136
申请日：1996-03-27
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , BERGER, Andrew, J. , BRENNAN, James, F., III , DASARI, Ramanchandra, R. , FELD, Michael, S. , ITZKAN, Irving , TANAKA, Kaz , WANG, Yang
发明人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
IPC分类号： A61B05/00

3. 发明申请

WO1990006718A1 A METHOD FOR LASER INDUCED FLUORESCENCE OF TISSUE 审中-公开
标题翻译：一种激光诱导组织荧光的方法
公开(公告)号：WO1990006718A1
公开(公告)日：1990-06-28
申请号：PCT/US1989005174
申请日：1989-11-17
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , KITTRELL, Carter , COTHREN, Robert, M. , FELD, Michael, S. , BARAGA, Joseph, J. , AN, Kyungwon , RICHARDS-KORTUM, Rebecca , RAVA, Richard, P. , PARK, Young, D. , MEHTA, Anand , TARONI, Paola , TONG, Lucene , DASARI, Ramachandra, Rao
发明人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
IPC分类号： A61B05/00
CPC分类号： A61B5/0084 , A61B5/0071 , A61B5/0075 , A61B5/1459 , A61B18/245 , A61B2562/0238
摘要： A method for laser induced fluorescence of tissue in which laser radiation is used to illuminate and induce fluorescence in the tissue under study to determine the chemical composition or pathologic condition of tissue. The laser radiation and the retrieved fluorescing radiation can be conveyed through a catheter using an array of optical fiber. The fluorescence spectrum of the tissue can be displayed and analyzed to obtain information regarding the chemical composition and medical condition of the tissue inside the human body.
摘要翻译：激光诱导荧光组织的方法，其中使用激光辐射来照射和诱导正在研究的组织中的荧光以确定组织的化学组成或病理状况。激光辐射和所检索的荧光辐射可以使用光纤阵列通过导管输送。可以显示和分析组织的荧光光谱，以获得关于人体内组织的化学成分和医疗状况的信息。

4. 发明申请

WO1992015008A1 SYSTEMS AND METHODS OF MOLECULAR SPECTROSCOPY TO PROVIDE FOR THE DIAGNOSIS OF TISSUE 审中-公开
标题翻译：分子谱分析系统和方法提供组织诊断
公开(公告)号：WO1992015008A1
公开(公告)日：1992-09-03
申请号：PCT/US1992000420
申请日：1992-01-17
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , RAVA, Richard, P. , BARAGA, Joseph, J. , FELD, Michael, S.
发明人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
IPC分类号： G01N21/65
CPC分类号： A61B5/0086 , A61B5/0071 , A61B5/0075 , A61B5/7203 , A61B5/7257 , A61B2562/0242 , G01N21/65 , G01N2021/656
摘要： Systems and methods for spectroscopic diagnosis and treatment are employed which utilize molecular spectroscopy to accurately diagnose the condition of tissue. Infrared Raman spectroscopy and infrared attenuated total reflectance measurements are performed utilizing a laser radiation source and a Fourier transform spectrometer. Information acquired and analyzed in accordance with the invention provides accurate details of biochemical composition and pathologic condition.
摘要翻译：使用光谱诊断和治疗的系统和方法，其利用分子光谱来准确地诊断组织的状况。使用激光辐射源和傅里叶变换光谱仪进行红外拉曼光谱和红外衰减全反射率测量。根据本发明获得和分析的信息提供了生物化学成分和病理状况的准确细节。

5. 发明申请

WO1990012536A1 SPECTRAL DIAGNOSIS OF DISEASED TISSUE 审中-公开
标题翻译：疾病组织的光谱诊断
公开(公告)号：WO1990012536A1
公开(公告)日：1990-11-01
申请号：PCT/US1990001914
申请日：1990-04-09
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , RICHARDS-KORTUM, Rebecca , TONG, Lucene , FELD, Michael, S.
发明人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
IPC分类号： A61B05/00
CPC分类号： A61B5/42 , A61B5/0071 , A61B5/0075 , A61B5/0084
摘要： The present invention relates to a method of diagnosing the condition of gastrointestinal tissue, and in particular, to a method employing the laser induced fluorescence of tissue to detect the presence of abnormal tissue within the human body.
摘要翻译：本发明涉及一种诊断胃肠道组织病情的方法，特别是涉及使用激光诱导组织荧光检测人体内异常组织的存在的方法。

6. 发明申请

WO1998018494A1 METHODS FOR THE SYNTHESIS OF FUNCTIONALIZABLE POLY(ETHYLENE OXIDE) STAR MACROMOLECULES 审中-公开
标题翻译：功能性聚（乙氧基）星形分子的合成方法
公开(公告)号：WO1998018494A1
公开(公告)日：1998-05-07
申请号：PCT/US1997019257
申请日：1997-10-27
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , MERRILL, Edward, W. , YEN, Diane, Rintzler , SAGAR, Ambuj
IPC分类号： A61K47/48
CPC分类号： B82Y5/00 , A61K47/6949 , C08G65/329 , C08G81/025 , C08G83/003
摘要： Methods are provided for the synthesis of poly(ethylene oxide) ("PEO") star macromolecules including functionalizable groups. In one embodiment, a core molecule including a plurality of dendritic branches or having a comb structure, and including a plurality of accessible reactive groups is reacted with functionalizable poly(ethylene oxide) ("PEO") molecules. The functionalizable poly(ethylene oxide) molecules include a reactive group capable of reacting with the reactive group on the core molecule, and a functionalizable group capable of being chemically modified, which optionally is protected. In the reaction, the PEO molecules are covalently attached to the core molecule, to form a PEO star macromolecule with terminal functionalizable groups. Preferably, the functionalizable PEO is a heterofunctional linear PEO which includes the reactive group at one terminus and the functionalizable group at the other terminus. The functionalizable groups on the PEO molecules then may be deprotected if necessary, and the further derivatized, for example, by the attachment of a biologically active molecule or polymer thereof.
摘要翻译：提供了用于合成包含可官能化基团的聚（环氧乙烷）（“PEO”）星型大分子的方法。在一个实施方案中，包含多个树枝状枝或具有梳结构并且包括多个可接触的反应性基团的核心分子与可官能化的聚（环氧乙烷）（“PEO”）分子反应。可官能化的聚（环氧乙烷）分子包括能够与芯分子上的反应性基团反应的反应性基团和能够被化学改性的可官能化基团，其任选被保护。在反应中，PEO分子共价连接到核心分子上，形成具有末端官能团的PEO星型大分子。优选地，可官能化PEO是异功能线性PEO，其包括一个末端的反应性基团和另一个末端的可官能化基团。如果需要，PEO分子上的可官能化基团可以被去保护，并且例如通过附着生物活性分子或其聚合物进一步衍生化。

7. 发明申请

WO1998015515A1 SYNTHESIS OF ARYL ETHERS, METHODS AND REAGENTS RELATED THERETO 审中-公开
标题翻译： ARYL ETHERS，与其相关的方法和试剂的合成
公开(公告)号：WO1998015515A1
公开(公告)日：1998-04-16
申请号：PCT/US1997018719
申请日：1997-10-10
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , BUCHWALD, Stephen, L. , WOLFE, John, P. , PALUCKI, Michael
发明人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
IPC分类号： C07C43/20
CPC分类号： C07D307/79 , C07C41/16 , C07C253/30 , C07C2601/08 , C07C2601/16 , C07C2603/24 , C07D309/12 , C07D311/58 , C07D311/82 , C07D311/94 , C07D313/08 , C07C255/54 , C07C43/225 , C07C43/205 , C07C43/235
摘要： A method for preparing an aryl ether compound is provided in which an alcohol is reacted with an aromatic compound in the presence of a base, and a transition metal catalyst to form an aryl ether.
摘要翻译：提供了一种芳基醚化合物的制备方法，其中醇与芳族化合物在碱的存在下和过渡金属催化剂反应形成芳基醚。

8. 发明申请

WO1998009334A1 CHARGE MODULATION DEVICE 审中-公开
标题翻译：充电调制装置
公开(公告)号：WO1998009334A1
公开(公告)日：1998-03-05
申请号：PCT/US1997014638
申请日：1997-08-20
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , REICH, Robert, K. , SAVOYE, Eugene, D. , KOSICKI, Bernard, B.
IPC分类号： H01L27/148
CPC分类号： H01L29/76833 , H01L27/1464 , H01L31/1126
摘要： A charge modulation device having a semiconductor region of a first conductivity type. An epitaxial layer of second conductivity type is provided on a portion of the semiconductor region so as to define an FET channel region. A first epitaxial region of the second conductivity type is provided adjacent to and in contact with the epitaxial layer so as to define an FET drain region, the first epitaxial region being electrically isolated from the semiconductor region. A second epitaxial region of the second conductivity type is provided adjacent to and in contact with the epitaxial layer so as to define an FET source region, the second epitaxial region being electrically isolated from the semiconductor region. A third epitaxial region of the first conductivity type or a metal oxide semiconductor is provided to the channel region between the source and drain regions.
摘要翻译：一种具有第一导电类型的半导体区域的电荷调制装置。在半导体区域的一部分上设置第二导电类型的外延层，以限定FET沟道区。第二导电类型的第一外延区域设置成与外延层相邻并与外延层接触，以便限定FET漏区，该第一外延区域与半导体区域电绝缘。第二导电类型的第二外延区域被设置为与外延层相邻并与外延层接触，以限定FET源极区域，第二外延区域与半导体区域电隔离。第一导电类型的第三外延区域或金属氧化物半导体被提供给源区和漏区之间的沟道区。

9. 发明申请

WO1998000698A1 METHOD AND APPARATUS FOR THE EVALUATION OF A DEPTH PROFILE OF THERMO-MECHANICAL PROPERTIES OF LAYERED AND GRADED MATERIALS AND COATINGS 审中-公开
标题翻译：评估层状和分级材料和涂层的热机械性能深度剖面的方法和装置
公开(公告)号：WO1998000698A1
公开(公告)日：1998-01-08
申请号：PCT/US1997011689
申请日：1997-06-30
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , FINOT, Marc , KESLER, Olivera , SURESH, Subra
IPC分类号： G01N03/20
CPC分类号： G01N3/20 , B33Y80/00
摘要： A technique for determining properties such as Young's modulus, coefficient of thermal expansion, and residual stress of individual layers within a multi-layered sample is presented. The technique involves preparation of a series of samples, each including one additional layer relative to the preceding sample. By comparison of each sample to a preceding sample, properties of the topmost layer can be determined, and residual stress at any depth in each sample, resulting from deposition of the top layer, can be determined.
摘要翻译：提出了一种用于确定多层样品中各层的性能如杨氏模量，热膨胀系数和残余应力的技术。该技术包括制备一系列样品，每个样品相对于前述样品包括一个附加层。通过比较每个样品与前一个样品，可以确定最上层的性质，并且可以确定由顶层沉积产生的每个样品中任何深度的残余应力。

10. 发明申请

WO1997046998A1 FEATURE-BASED SPEECH RECOGNIZER HAVING PROBABILISTIC LINGUISTIC PROCESSOR PROVIDING WORD MATCHING BASED ON THE ENTIRE SPACE OF FEATURE VECTORS 审中-公开
标题翻译：基于特征的语音识别器，具有基于特征向量的整体空间的概念语音处理器提供字符匹配
公开(公告)号：WO1997046998A1
公开(公告)日：1997-12-11
申请号：PCT/US1997009267
申请日：1997-06-02
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , GLASS, James, Robert
IPC分类号： G10L03/00
CPC分类号： G10L15/04 , G10L15/10 , G10L2015/022
摘要： A feature-based speech recognizer having a probabilistic linguistic processor provides word matching based on the entire space of feature vectors. In this manner, the errors and inaccuracies associated with the heretofore known feature-based speech recognizers, which provided word matching on less than the entire space of feature vectors, are overcome, thereby resulting in improved-accuracy speech recognition. The word matching may be on feature vectors computed either from segments or from landmarks or from both segments and landmarks. For word matching on segment-based feature vectors, acoustic likelihoods may be normalized by extra-acoustic likelihoods defined by at least one extra-acoustic ("not" or "anti") model. Context-dependent and context-independent acoustic models may be employed.
摘要翻译：具有概率语言处理器的基于特征的语音识别器基于特征向量的整个空间提供词匹配。以这种方式，克服了与以前已知的基于特征的语音识别器相关联的误差和不准确性，其提供小于特征向量的整个空间的字匹配，由此导致改进的精度语音识别。词匹配可以是从段或从地标或从段和地标计算的特征向量。对于基于段的特征向量的字匹配，声学似然性可以通过由至少一个超声（“非”或“反”）模型限定的超声可能性进行归一化。可以使用与上下文有关的和与上下文无关的声学模型。

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