专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2016138503A1 METHODS AND SYSTEMS FOR CONTINUOUS HETEROGENEOUS CRYSTALLIZATION 审中-公开
标题翻译：连续异质结晶的方法与系统
公开(公告)号：WO2016138503A1
公开(公告)日：2016-09-01
申请号：PCT/US2016/019976
申请日：2016-02-26
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： MYERSON, Allan, Stuart , TROUT, Bernhardt, Levy , JENSEN, Keith, Dale , PERALA, Siva, Rama Krishna , TESTA, Christopher, James
IPC分类号： B01D9/00
CPC分类号： A61K47/26 , A61K31/167 , B01D9/0036 , B01D9/0059
摘要： Methods of heterogeneous crystallization and related systems are provided. In some embodiments, a method comprises crystallizing an agent in a suspension comprising a heteronucleant and the dissolved agent. Crystallization may occur on the surface of the heteronucleant with little or no bulk crystallization and/or secondary nucleation. In some embodiments, a crystallizer may be configured to inhibit secondary nucleation and/or bulk crystallization, for example, by reducing the formation of free crystals that may serve as nucleation surfaces while allowing for adequate mass and heat transfer. In some such embodiments, the crystallizer may be designed to flow (e.g., continuously) a suspension comprising a heteronucleant and an agent in a fluidized state. The methods and systems of the present invention may be used in a wide variety of applications, including the crystallization of pharmaceutically active agents.
摘要翻译：提供了异相结晶和相关系统的方法。在一些实施方案中，一种方法包括使包含异源核苷酸和溶解试剂的悬浮液中的试剂结晶。结晶可能发生在异源核的表面上，很少或没有本体结晶和/或二次成核。在一些实施方案中，结晶器可以被配置为抑制二次成核和/或体积结晶，例如通过减少可用作成核表面的自由晶体的形成，同时允许足够的质量和热传递。在一些这样的实施方案中，结晶器可以被设计成流动（例如，连续地）流态化的包含异源核苷酸和试剂的悬浮液。本发明的方法和系统可以用于各种应用，包括药物活性剂的结晶。

IPRDB

热门服务

关于我们

友情链接

联系方式