专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2010132097A2 COMPOSITIONS AND METHODS FOR PEST CONTROL 审中-公开
标题翻译：用于病虫害防治的组合物和方法
公开(公告)号：WO2010132097A2
公开(公告)日：2010-11-18
申请号：PCT/US2010/001382
申请日：2010-05-11
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , NORTHEASTERN UNIVERSITY , BACHELET, Ido , SASISEKHARAN, Ram , BULMER, Mark , ROSENGAUS, Rebeca, B.
发明人： BACHELET, Ido , SASISEKHARAN, Ram , BULMER, Mark , ROSENGAUS, Rebeca, B.
IPC分类号： A01N43/16 , C08B37/00 , B32B1/02 , G01N33/53 , C12Q1/34 , A01P7/04
CPC分类号： C12Q1/34 , A01N43/16 , C08B37/0024 , G01N2333/43552 , G01N2333/43582 , G01N2333/924 , Y10T428/13 , A01N25/34
摘要： Provided herein are compositions and kits comprising carbohydrate-based inhibitors that bind GNBP and/or inhibit β(l,3)-glucanase activity. Also provided are methods of using such inhibitors to protect against or treat pest infestation, as are compositions and kits comprising subparts of the carbohydrate-based inhibitors.
摘要翻译：本文提供了包含结合GNBP和/或抑制β（1,3） - 葡聚糖酶活性的基于碳水化合物的抑制剂的组合物和试剂盒。还提供了使用这种抑制剂来防止或治疗害虫侵袭的方法，组合物和试剂盒包括基于碳水化合物的抑制剂的子部分。

2. 发明申请

WO2011130575A1 MODULAR GLYCAN ARRAYS 审中-公开
标题翻译：模块糖果阵列
公开(公告)号：WO2011130575A1
公开(公告)日：2011-10-20
申请号：PCT/US2011/032585
申请日：2011-04-14
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , SASISEKHARAN, Ram , VISWANATHAN, Karthik , AICH, Udayanath , RAMAN, Rahul , SHRIVER, Zachary , BACHELET, Ido
发明人： SASISEKHARAN, Ram , VISWANATHAN, Karthik , AICH, Udayanath , RAMAN, Rahul , SHRIVER, Zachary , BACHELET, Ido
IPC分类号： A61K31/70 , C40B40/12
CPC分类号： G01N33/56983 , C07B2200/11 , C40B40/12 , G01N2333/11 , G01N2400/12 , Y02A50/59
摘要： The present invention provides methods and systems for functionally analyzing glycans and their interaction partners. Among other things, the invention provides modular glycan arrays in which different glycan populations are associated with different discrete solid phase particles. Provided arrays offer many advantages over available systems for assessing glycan binding interactions.
摘要翻译：本发明提供用于功能分析聚糖及其相互作用配偶体的方法和系统。除此之外，本发明提供了模块化聚糖阵列，其中不同的聚糖群体与不同的离散固相颗粒相关联。提供的阵列比用于评估聚糖结合相互作用的可用系统提供了许多优点。

3. 发明申请

WO2009075774A2 GLYCOSAMINOGLYCAN-COATED PARTICLES AND USES THEREOF 审中-公开
标题翻译：谷氨酰胺糖包覆颗粒及其用途
公开(公告)号：WO2009075774A2
公开(公告)日：2009-06-18
申请号：PCT/US2008/013387
申请日：2008-12-05
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , BAN, Zhihui , BOSQUES, Carlos , SASISEKHARAN, Ram
发明人： BAN, Zhihui , BOSQUES, Carlos , SASISEKHARAN, Ram
IPC分类号： A61K33/24
CPC分类号： A61K33/24 , B82Y5/00 , C12Q1/34 , C12Q1/527 , G01N2400/40 , Y10T428/2991
摘要： The present invention is directed to metallic particles coated with glycosaminoglycans and methods for preparing them. Methods of using such glycosaminoglycan-coated metallic particles in biomedical and other applications are also disclosed. In certain embodiments, methods for assaying glycosaminoglycan-degrading activity in biological fluids, test samples, and/or therapeutic formulations using the glycosaminoglycan-coated particles are provided. Such methods may be used, for example, in diagnostic tests for diseases such as cancer, inflammatory diseases, or autoimmune diseases and to test activity of enzymes being developed as therapeutics.
摘要翻译：本发明涉及涂有糖胺聚糖的金属颗粒及其制备方法。还公开了在生物医学和其它应用中使用这种糖胺聚糖包被的金属颗粒的方法。在某些实施方案中，提供了使用糖胺聚糖包衣颗粒测定生物流体中的糖胺聚糖降解活性的方法，测试样品和/或治疗制剂。这样的方法可以用于例如癌症，炎性疾病或自身免疫性疾病等疾病的诊断试验，并测试作为治疗剂开发的酶的活性。

4. 发明申请

WO2007044471A2 METHODS AND PRODUCTS RELATED TO THE IMPROVED ANALYSIS OF CARBOHYDRATES 审中-公开
标题翻译：与改进的碳水化合物分析相关的方法和产品
公开(公告)号：WO2007044471A2
公开(公告)日：2007-04-19
申请号：PCT/US2006/038988
申请日：2006-10-05
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , PARIVID LLC , BOSQUES, Carlos , KEISER, Nishla , SRINIVASAN, Aravind , RAMAN, Rahul , VISWANATHAN, Karthik , SASISEKHARAN, Ram , GANDHE, Pankaj , RAGURAM, Sasi
发明人： BOSQUES, Carlos , KEISER, Nishla , SRINIVASAN, Aravind , RAMAN, Rahul , VISWANATHAN, Karthik , SASISEKHARAN, Ram , GANDHE, Pankaj , RAGURAM, Sasi
IPC分类号： G06F19/00
CPC分类号： G01N33/6851 , G01N33/66 , G01N33/68 , G01N33/6842 , G01N33/6848 , G01N2400/10 , G06F19/703
摘要： The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O- glycans found on proteins and saccharides attached to lipids. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information from the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation. Such methods are also provided. Methods are further provided to assess production processes, to assess the purity of samples containing glycoconjugates, and to select glycocoηjugates with the desired glycosylation.
摘要翻译：本发明部分涉及碳水化合物的改进分析。特别地，本发明涉及对附着于脂质的蛋白质和糖类上发现的碳水化合物如N-聚糖和O-聚糖的分析。因此，还提供了改进的方法，用于研究细胞，组织和体液上的糖基化模式。来自聚糖分析的信息，例如细胞，组织和体液中的糖基化模式，可用于诊断和治疗方法以及促进糖基化/改变糖基化作用的研究。还提供了这样的方法。进一步提供方法以评估生产过程，以评估含有糖缀合物的样品的纯度，并选择具有所需糖基化的糖多糖。

5. 发明申请

WO2006099445A2 NANOCELLS FOR DIAGNOSIS AND TREATMENT OF DISEASES AND DISORDERS 审中-公开
标题翻译：用于诊断和治疗疾病和疾病的纳米技术
公开(公告)号：WO2006099445A2
公开(公告)日：2006-09-21
申请号：PCT/US2006/009213
申请日：2006-03-14
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , SENGUPTA, Shiladitya , SASISEKHARAN, Ram , BOSQUES, Carlos, J.
发明人： SENGUPTA, Shiladitya , SASISEKHARAN, Ram , BOSQUES, Carlos, J.
CPC分类号： A61K51/1241 , A61K9/1271 , A61K9/14 , A61K45/06 , A61K47/6923 , A61K47/6929 , A61K51/1244 , B82Y5/00 , B82Y10/00
摘要： The present invention relates to novel nanocell compositions and their use in imaging, diagnostic and treatment methods. In one embodiment, nanocells tailored for imaging methods comprise a nanocore surrounded by a lipid matrix, and are modified to contain a radionuclide core or a nanocore with an emission spectra. The nanocells may be size restricted such as being greater than about 60 nm so that they selectively extravasate at sites of angiogenesis (e.g. tumor) and do not pass through normal vasculature or enter non-tumor bearing tissue. In this way, angiogenic sites can be both detected and treated. In another embodiment, nanocells are tailored for various treatment methods, including the treatment of brain cancer, asthma, Grave's Disease, Cystic Fibrosis, and Pulmonary Fibrosis.
摘要翻译：本发明涉及新型纳米细胞组合物及其在成像，诊断和治疗方法中的用途。在一个实施方案中，针对成像方法定制的纳细胞包括被脂质基质包围的纳米孔，并且被修饰成包含具有发射光谱的放射性核素核心或纳米核心。纳米细胞的尺寸可能受限于大于约60nm，使得它们在血管生成位点（例如肿瘤）选择性地外渗，并且不通过正常脉管系统或进入非肿瘤携带组织。以这种方式，可以检测和处理血管生成位点。在另一个实施方案中，针对各种治疗方法，包括治疗脑癌，哮喘，格雷夫斯病，囊性纤维化和肺纤维化，为纳米细胞定制。

6. 发明申请

WO2006076627A2 METHODS AND COMPOSITIONS RELATED TO MODULATING THE EXTRACELLULAR STEM CELL ENVIRONMENT 审中-公开
标题翻译：与调节细胞间干细胞环境相关的方法和组合
公开(公告)号：WO2006076627A2
公开(公告)日：2006-07-20
申请号：PCT/US2006/001321
申请日：2006-01-12
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , SASISEKHARAN, Ram
发明人： SASISEKHARAN, Ram
IPC分类号： C12N5/071 , C12N5/0735
CPC分类号： A61K31/726 , A61K31/727 , A61K38/47 , C12N5/0606 , C12N5/0691 , C12N2501/70 , C12N2506/02
摘要： This invention relates, in part, to methods and compositions that modulate the stem cell environment. More specifically, the invention relates, in part, to methods and compositions for modulating stem cell differentiation. Such modulation, in some aspects of the invention, is accomplished by agents that modulate glycosaminoglycans in the stem cell microenvironment (i.e., at or on the cell surface and/or in the extracellular matrix). Therefore, methods and compositions are provide for modulating glycosaminoglycan moieties, e.g., heparan sulfate glycosaminoglycan (HSGAG) moieties, in the microenvironment of stem cells. Methods and compositions for promoting or inhibiting embryonic stem cell differentiation (e.g., differentiation into endothelial cells) are also provided. This invention also relates, therefore, in part, to cell populations (e.g., endothelial cell populations or impoverished endothelial cell populations) that can be produced with the methods and compositions provided. Furthermore, the invention relates, in part, to tissues, and uses thereof, formed by the methods and compositions provided. Moreover, the invention also relates, in part, to methods of treatment using the methods and compositions provided.
摘要翻译：本发明部分涉及调节干细胞环境的方法和组合物。更具体地，本发明部分地涉及用于调节干细胞分化的方法和组合物。在本发明的某些方面，这种调节是通过调节干细胞微环境中的糖胺聚糖（即在细胞表面上和/或细胞外基质中）上的调节剂来完成的。因此，提供了在干细胞的微环境中调节糖胺聚糖部分，例如硫酸乙酰肝素糖胺聚糖（HSGAG）部分的方法和组合物。还提供了用于促进或抑制胚胎干细胞分化（例如分化成内皮细胞）的方法和组合物。因此，本发明还部分地涉及可以用所提供的方法和组合物产生的细胞群体（例如内皮细胞群体或贫瘠的内皮细胞群体）。此外，本发明部分地涉及通过所提供的方法和组合物形成的组织及其用途。此外，本发明还部分地涉及使用提供的方法和组合物的治疗方法。

7. 发明申请

WO2008014478A2 NANOCELL DRUG DELIVERY SYSTEM 审中-公开
标题翻译： NANOCELL药物递送系统
公开(公告)号：WO2008014478A2
公开(公告)日：2008-01-31
申请号：PCT/US2007/074634
申请日：2007-07-27
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , CAPILA, Ishan , SENGUPTA, Shiladitya , ZHAO, Ganlin , EAVARONE, David , SASISEKHARAN, Ram
发明人： CAPILA, Ishan , SENGUPTA, Shiladitya , ZHAO, Ganlin , EAVARONE, David , SASISEKHARAN, Ram
IPC分类号： A61K9/14 , A61L9/04
CPC分类号： A61K9/5153 , A61K9/0073 , A61K9/127 , A61K9/1271 , A61K9/167 , A61K9/19 , A61K9/5031 , A61K9/5073 , A61K9/51 , A61K9/5123 , A61K31/09 , A61K31/7012 , A61K31/704 , A61K31/737 , A61K45/06 , A61K47/593 , A61K49/0043 , A61K49/0047 , A61K49/0093 , B82Y5/00 , B82Y10/00 , Y10T428/2982
摘要： Nanocells allow the sequential delivery of two different therapeutic agents with different modes of action or different pharmacokinetics. A nanocell is formed by encapsulating a nanocore with a first agent inside a lipid vesicle containing a second agent. The agent in the outer lipid compartment is released first and may exert its effect before the agent in the nanocore is released. The nanocell delivery system may be formulated in pharmaceutical composition for delivery to patients suffering from diseases such as cancer, inflammatory diseases such as asthma, autoimmune diseases such as rheumatoid arthritis, infectious diseases, and neurological diseases such as epilepsy. In treating cancer, a traditional antineoplastic agent is contained in the outer lipid vesicle of the nanocell, and an antiangiogenic agent is loaded into the nanocore. This arrangement allows the antineoplastic agent to be released first and delivered to the tumor before the tumor's blood supply is cut off by the antianiogenic agent.
摘要翻译：纳米细胞允许以不同的作用方式或不同的药代动力学顺序递送两种不同的治疗剂。通过在含有第二药剂的脂质囊泡内将第一药剂包封纳米孔而形成纳米细胞。首先释放外部脂质隔室中的药剂，并在释放纳米孔内的药剂之前发挥其作用。纳米细胞递送系统可以配制成药物组合物，用于递送患有疾病如癌症，炎性疾病如哮喘，自身免疫性疾病如类风湿性关节炎，感染性疾病和神经疾病如癫痫的患者。在治疗癌症中，传统的抗肿瘤剂包含在纳米细胞的外脂质囊泡中，抗血管生成剂被加载到纳米孔中。这种布置允许抗肿瘤药物首先释放并在肿瘤的血液供应被抗生血药剂切断之前被递送到肿瘤。

8. 发明申请

WO2006105315A3 COMPOSITIONS AND METHODS FOR REGULATING INFLAMMATORY RESPONSES 审中-公开
公开(公告)号：WO2006105315A3
公开(公告)日：2006-10-05
申请号：PCT/US2006/011680
申请日：2006-03-29
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , BERRY, David , KWAN, Chi-Pong , LANGER, Robert , SASISEKHARAN, Ram
发明人： BERRY, David , KWAN, Chi-Pong , LANGER, Robert , SASISEKHARAN, Ram
IPC分类号： C07K14/50 , A61K38/18
摘要： This invention relates, in part, to compositions and methods for the regulation of inflammatory responses. Specifically, the invention relates, in part, to compositions of and methods for using fibroblast growth factor (FGF) proteins, proteoglycans (e.g., syndecans), agents that modulate proteoglycans and agents that affect Wnt signaling. The invention also provides compositions and methods for treating subjects with undesired inflammatory activity and/or diseases associated therewith. The invention further provides, in part, compositions and methods for disrupting intercellular junctions with FGFs, such as for the enhanced delivery of therapeutic agents.

9. 发明申请

WO2006088491A2 METHODS AND COMPOSITIONS RELATED TO THE MODULATION OF INTERCELLULAR JUNCTIONS 审中-公开
标题翻译：与细胞间结合调节相关的方法和组成
公开(公告)号：WO2006088491A2
公开(公告)日：2006-08-24
申请号：PCT/US2005/023266
申请日：2005-06-29
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , CHANDRASEKARAN, Aarthi , SENGUPTA, Shiladitya , BERRY, David, A. , HOLLEY, Kristine , ZHAO, Ganlin , SASISEKHARAN, Ram
发明人： CHANDRASEKARAN, Aarthi , SENGUPTA, Shiladitya , BERRY, David, A. , HOLLEY, Kristine , ZHAO, Ganlin , SASISEKHARAN, Ram
IPC分类号： A61K38/00 , A61K38/51 , A61K31/00
CPC分类号： A61K38/51 , A61K31/00 , A61K31/726 , A61K31/727 , A61K31/737 , A61K38/45 , A61K45/06 , A61K47/36 , A61K2300/00
摘要： The invention relates to compositions and methods for the modulation of the permeability of the epithelial cell barrier complex. In particular, the invention provides compositions and methods for using polysaccharides, preferably glycosaminoglycans, and agents that modify cell surface glycosaminoglycans, preferably glycosaminoglycan-degrading enzymes to modulate intercellular junctions. The compositions and methods provided can be used to facilitate the delivery of biologically active molecules.
摘要翻译：本发明涉及调节上皮细胞屏障复合物渗透性的组合物和方法。特别地，本发明提供使用多糖，优选糖胺聚糖的组合物和方法，以及修饰细胞表面糖胺聚糖（优选为糖胺聚糖降解酶）以调节细胞间连接的试剂。所提供的组合物和方法可用于促进生物活性分子的递送。

10. 发明申请

WO2004062592A2 2-O SULFATASE COMPOSITIONS AND RELATED METHODS 审中-公开
标题翻译： 2-O硫酸盐组合物及相关方法
公开(公告)号：WO2004062592A2
公开(公告)日：2004-07-29
申请号：PCT/US2004/000332
申请日：2004-01-07
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , SASISEKHARAN, Ram , MYETTE, James, R. , SHRIVER, Zachary , VENKATARAMAN, Ganesh
发明人： SASISEKHARAN, Ram , MYETTE, James, R. , SHRIVER, Zachary , VENKATARAMAN, Ganesh
IPC分类号： A61K
CPC分类号： C12N9/16 , A61K38/00 , C12P19/04 , G01N33/5041 , G01N2400/40
摘要： The invention relates to 2-O sulfatase and uses thereof. In particular, the invention relates to recombinantly produced 2-O sulfatase, functional variants and nucleic acid molecules that encode these molecules. The invention also provides methods of using 2-O sulfatase for a variety of purposes, including degrading and analyzing glycosaminoglycans (GAGS) present in a sample. For instance, 2-O sulfatase may be used for determining the purity, identity, composition and sequence of glycosaminoglycans present in a sample. The invention also relates to methods of inhibiting angiogenesis and cellular proliferation as well as methods for treating cancer, neurodegenerative disease, atherosclerosis and microbial infection using 2-O sulfatase and/or GAG fragments produced by degradation with 2-O sulfatase.
摘要翻译：本发明涉及2-O硫酸酯酶及其用途。特别地，本发明涉及编码这些分子的重组产生的2-O硫酸酯酶，功能变体和核酸分子。本发明还提供了用于各种目的的2-O硫酸酯酶的方法，包括降解和分析样品中存在的糖胺聚糖（GAGS）。例如，2-O硫酸酯酶可用于测定样品中存在的糖胺聚糖的纯度，同一性，组成和顺序。本发明还涉及抑制血管生成和细胞增殖的方法以及使用2-O硫酸酯酶降解产生的2- O硫酸酯酶和/或GAG片段来治疗癌症，神经变性疾病，动脉粥样硬化和微生物感染的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式