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1. 发明申请

WO0168161A2 LOW DISTURBANCE PULSATILE FLOW SYSTEM 审中-公开
标题翻译：低干扰脉动流量系统
公开(公告)号：WO0168161A2
公开(公告)日：2001-09-20
申请号：PCT/US0107883
申请日：2001-03-13
申请人： MASSACHUSETTS INST TECHNOLOGY , EDELMAN ELAZER , KOLANDAIVELU KUMARAN
发明人： EDELMAN ELAZER , KOLANDAIVELU KUMARAN
IPC分类号： A61F2/06 , A61M1/00
CPC分类号： A61F2/06
摘要： A flow system device used for testing/creating fluid flow. The system comprises at least one fluid filled loop and a rotor stage for maintaining at least one rotor. The loop is positioned on the rotor. The device also includes a driving motor for rotating the rotor stage and a motion controller for controlling the speed and directional motion of the motor.
摘要翻译：用于测试/产生流体流动的流量系统装置。该系统包括至少一个流体填充回路和用于保持至少一个转子的转子级。回路定位在转子上。该装置还包括用于旋转转子级的驱动电机和用于控制电动机的速度和定向运动的运动控制器。

2. 发明申请

WO2006127907A3 LOCALIZED DELIVERY OF CARDIAC INOTROPIC AGENTS 审中-公开
标题翻译：本地化的心脏辅助药物
公开(公告)号：WO2006127907A3
公开(公告)日：2007-06-07
申请号：PCT/US2006020252
申请日：2006-05-25
申请人： MASSACHUSETTS INST TECHNOLOGY , EDELMAN ELAZER , LOVICH MARK
发明人： EDELMAN ELAZER , LOVICH MARK
IPC分类号： A61K31/00 , A61K31/137 , A61K31/4166 , A61K31/4168 , A61K31/4545 , A61K31/704 , A61K38/22 , A61P9/04 , A61P41/00
CPC分类号： A61K31/00 , A61K31/137 , A61K31/4166 , A61K31/4168 , A61K31/4545 , A61K31/704 , A61K38/2242
摘要： The present invention provides novel methods for the localized delivery of inotropic agents to the heart, including specific regions of the heart, such as the ventricles, for example in a subject undergoing cardiothoracic surgery, with the aim of supporting the myocardial contractile function of the heart.
摘要翻译：本发明提供了将肌力局部递送到心脏的新颖方法，包括心脏的特定区域，例如心室，例如经历心胸外科手术的受试者，目的是支持心脏的心肌收缩功能。

3. 发明申请

WO2006062962A3 MATERIALS AND METHODS FOR TREATING AND MANAGING PLAQUE DISEASE 审中-公开
标题翻译：材料和方法治疗和管理斑块病
公开(公告)号：WO2006062962A3
公开(公告)日：2006-10-12
申请号：PCT/US2005044090
申请日：2005-12-06
申请人： PERVASIS THERAPEUTICS INC , EDELMAN ELAZER , DALAL ANUPAM , NUGENT HELEN MARIE , BOLLINGER STEVE
发明人： EDELMAN ELAZER , DALAL ANUPAM , NUGENT HELEN MARIE , BOLLINGER STEVE
IPC分类号： A61F2/06 , A61L27/38 , A61L29/16 , A61P9/10
CPC分类号： A61L27/3808 , A61F2310/00365
摘要： Disclosed herein are materials and methods suitable for treating and managing plaque disease, including vulnerable plaque. An implantable material comprising cells, such as but not limited to endothelial cells, and a biocompatible matrix can reduce progression or deterioration of a plaque-associated lesion situated on the interior lumen of said blood vessel. The implantable material is implanted directly on an exterior surface of a blood vessel at or adjacent or in the vicinity of the site of a lesion on an interior lumen. Alternatively, the implantable material is deposited on an exterior surface at or adjacent or in the vicinity of the site of a lesion on an interior lumen by an intraluminal delivery device which traverses or penetrates the vessel wall or by a percutaneous delivery device which enters the perivascular space. Both modes of administration can be preceded by or coincident with an imaging step. The present invention can treat hemorrhage, erosion, fissure, plaque-associated thrombosis and occlusion, rupture, displacement and/or dislodgement of a plaque lesion.
摘要翻译：本文公开了适用于治疗和控制斑块疾病（包括易损斑块）的材料和方法。包含细胞（诸如但不限于内皮细胞）和生物相容性基质的可植入材料可以减少位于所述血管的内腔上的斑块相关病变的进展或恶化。可植入材料直接植入血管的外表面上，在血管的外表面上或在内腔的病变部位附近或其附近。或者，可植入材料通过横穿或穿透血管壁的腔内递送装置或通过进入血管周的经皮递送装置沉积在内腔上病变部位处或附近或其附近的外表面上空间。两种给药方式可以在成像步骤之前或与成像步骤重合。本发明可治疗斑块损伤的出血，侵蚀，裂隙，斑块相关血栓形成和闭塞，破裂，移位和/或脱出。

4. 发明申请

WO02071975A9 METHOD AND APPARATUS FOR STENTING 审中-公开
标题翻译：方法和装置
公开(公告)号：WO02071975A9
公开(公告)日：2004-01-08
申请号：PCT/US0207529
申请日：2002-03-13
申请人： RICHTER YORAM , EDELMAN ELAZER
发明人： RICHTER YORAM , EDELMAN ELAZER
IPC分类号： A61F2/00 , A61F2/06 , A61F2/86
CPC分类号： A61F2/90 , A61F2/06 , A61F2/86 , A61F2/958 , A61F2002/068 , A61F2230/0006 , A61F2250/0039 , A61M25/1002
摘要： A method and an apparatus to create a more favorable flow regime in a lumen. An artificial shape in the lumen is created to at least one of eliminate flow disturbances and enhance aspects of fluid flow through a treatment site. First stent segment (12), second stent segment (14) and thrid stent segement (16) show a schematic view of the stent envelope or profile.
摘要翻译：一种在管腔中产生更有利的流动状态的方法和装置。产生管腔中的人造形状用于消除流动干扰中的至少一种并增强通过治疗部位的流体流动的方面。第一支架段（12），第二支架段（14）和支架支架（16）示出了支架包膜或轮廓的示意图。

5. 发明申请

WO2007001744B1 METHODS AND COMPOSITIONS FOR ENHANCING VASCULAR ACCESS 审中-公开
公开(公告)号：WO2007001744B1
公开(公告)日：2007-12-21
申请号：PCT/US2006021755
申请日：2006-06-05
申请人： PERVASIS THERAPEUTICS INC , NUGENT HELEN MARIE , EDELMAN ELAZER , DALAL ANUPAM , BOLLINGER STEVE , EPPERLY SCOTT
发明人： NUGENT HELEN MARIE , EDELMAN ELAZER , DALAL ANUPAM , BOLLINGER STEVE , EPPERLY SCOTT
IPC分类号： A61F2/06 , A61K35/12 , A61K47/36 , A61K47/42 , A61L27/00 , A61L27/38 , A61L29/16 , C12N5/00 , C12N5/07 , C12N5/071
CPC分类号： C12N5/069 , A61L27/3808
摘要： Disclosed is an implantable material comprising a biocompatible matrix and cells which, when provided to a vascular access structure, can promote functionality generally. For example, implantable material of the present invention can enhance maturation of an arteriovenous native fistula as well as prolong the fistula in a mature, functional state suitable for dialysis. Additionally, the present invention can promote formation of a functional arteriovenous graft suitable for dialysis as well as promote formation of a functional peripheral bypass graft. Implantable material can be configured as a flexible planar form or a flowable composition with shape-retaining properties suitable for implantation at, adjacent or in the vicinity of an anastomoses or arteriovenous graft. According to the methods disclosed herein, the implantable material is provided to an exterior surface of a blood vessel. Certain embodiments of the flexible planar form define a slot. The materials and methods of the present invention comprise cells, preferably endothelial cells or cells having an endothelial-like phenotype.

6. 发明申请

WO2007001744A3 METHODS AND COMPOSITIONS FOR ENHANCING VASCULAR ACCESS 审中-公开
标题翻译：用于增强血管通路的方法和组合物
公开(公告)号：WO2007001744A3
公开(公告)日：2007-10-04
申请号：PCT/US2006021755
申请日：2006-06-05
申请人： PERVASIS THERAPEUTICS INC , NUGENT HELEN MARIE , EDELMAN ELAZER , DALAL ANUPAM , BOLLINGER STEVE , EPPERLY SCOTT
发明人： NUGENT HELEN MARIE , EDELMAN ELAZER , DALAL ANUPAM , BOLLINGER STEVE , EPPERLY SCOTT
IPC分类号： A61F2/06 , A61K35/12 , A61K47/36 , A61K47/42 , A61L27/00 , A61L27/38 , A61L29/16 , C12N5/00 , C12N5/07 , C12N5/071
CPC分类号： C12N5/069 , A61L27/3808
摘要： Disclosed is an implantable material comprising a biocompatible matrix and cells which, when provided to a vascular access structure, can promote functionality generally. For example, implantable material of the present invention can enhance maturation of an arteriovenous native fistula as well as prolong the fistula in a mature, functional state suitable for dialysis. Additionally, the present invention can promote formation of a functional arteriovenous graft suitable for dialysis as well as promote formation of a functional peripheral bypass graft. Implantable material can be configured as a flexible planar form or a flowable composition with shape-retaining properties suitable for implantation at, adjacent or in the vicinity of an anastomoses or arteriovenous graft. According to the methods disclosed herein, the implantable material is provided to an exterior surface of a blood vessel. Certain embodiments of the flexible planar form define a slot. The materials and methods of the present invention comprise cells, preferably endothelial cells or cells having an endothelial-like phenotype.
摘要翻译：公开了一种包含生物相容性基质和细胞的可植入材料，所述细胞当被提供给血管通路结构时通常可以促进功能。例如，本发明的可植入材料可以增强动静脉天然瘘的成熟以及延长适于透析的成熟功能状态的瘘。此外，本发明可以促进适合于透析的功能性动静脉移植物的形成，并促进功能性外周分流移植物的形成。可植入材料可以被配置为柔性平面形式或具有适于在吻合或动静脉移植物附近或其附近植入的形状保持特性的可流动组合物。根据本文公开的方法，将可植入材料提供至血管的外表面。柔性平面形式的某些实施例限定槽。本发明的材料和方法包含细胞，优选内皮细胞或具有内皮样表型的细胞。

7. 发明申请

WO2006062909A3 METHODS AND COMPOSITIONS FOR ENHANCING VASCULAR ACCESS 审中-公开
标题翻译：用于增强血管通路的方法和组合物
公开(公告)号：WO2006062909A3
公开(公告)日：2006-08-31
申请号：PCT/US2005043967
申请日：2005-12-06
申请人： PERVASIS THERAPEUTICS INC , NUGENT HELEN MARIE , EDELMAN ELAZER , DALAL ANUPAM , BOLLINGER STEVE , EPPERLY SCOTT
发明人： NUGENT HELEN MARIE , EDELMAN ELAZER , DALAL ANUPAM , BOLLINGER STEVE , EPPERLY SCOTT
IPC分类号： A61L27/38 , A61F2/06 , A61L29/16
CPC分类号： A61L27/3808 , A61L27/3839
摘要： Disclosed is an implantable material comprising a biocompatible matrix and cells which, when provided to a vascular access structure, can promote functionality generally. For example, implantable material of the present invention can enhance maturation of an arteriovenous native fistula as well as prolong the fistula in a mature, functional state suitable for dialysis. Additionally, the present invention can promote formation of a functional arteriovenous graft suitable for dialysis as well as promote formation of a functional peripheral bypass graft. Implantable material can be configured as a flexible planar form or a flowable composition with shaperetaining properties suitable for implantation at, adjacent or in the vicinity of an anastomoses or arteriovenous graft. According to the methods disclosed herein, the implantable material is provided to an exterior surface of a blood vessel. Certain embodiments of the flexible planar form define a slot. The materials and methods of the present invention comprise cells, preferably endothelial cells or cells having an endothelial-like phenotype.
摘要翻译：公开了一种包含生物相容性基质和细胞的可植入材料，所述细胞当被提供给血管通路结构时通常可以促进功能。例如，本发明的可植入材料可以增强动静脉天然瘘的成熟以及延长适于透析的成熟功能状态的瘘。此外，本发明可以促进适合于透析的功能性动静脉移植物的形成，并促进功能性外周分流移植物的形成。可植入材料可以配置成柔性平面形式或具有适合于在吻合或动静脉移植物附近或其附近植入的形状保持特性的可流动组合物。根据本文公开的方法，将可植入材料提供至血管的外表面。柔性平面形式的某些实施例限定槽。本发明的材料和方法包含细胞，优选内皮细胞或具有内皮样表型的细胞。

8. 发明申请

WO2006062871A9 MATERIALS AND METHODS FOR MINIMALLY-INVASIVE ADMINISTRATION OF A CELL-CONTAINING FLOWABLE COMPOSITION 审中-公开
标题翻译：含细胞流动性组合物的微量入侵管理的材料与方法
公开(公告)号：WO2006062871A9
公开(公告)日：2009-01-22
申请号：PCT/US2005043844
申请日：2005-12-06
申请人： PERVASIS THERAPEUTICS INC , NUGENT HELEN MARIE , EDELMAN ELAZER , BOLLINGER STEVE
发明人： NUGENT HELEN MARIE , EDELMAN ELAZER , BOLLINGER STEVE
IPC分类号： A61L24/10
CPC分类号： A61L27/3886 , A61L27/3804 , A61L27/3808 , A61L27/3839 , A61L2400/06
摘要： The disclosed invention is based on the discovery that a cell-based therapy can be used to treat, ameliorate, manage and/or reduce the progression of clinical sequelae associated with vascular interventions or cardiovascular diseases, particularly occlusive thrombosis, restenosis, intimal hyperplasia, inflammation and vasodilation. The invention further benefits from the additional discovery that a heretofore undescribed implantable flowable composition is capable of sustaining a confluent population of sufficiently viable cells which can be effectively administered via a minimally-invasive surgical procedure without diminishing the clinical effectiveness or the viability of the cells. The disclosed invention can be used to treat vasculature as well as non-vascular tubular structures such as a fallopian tube.
摘要翻译：所公开的发明基于以下发现：基于细胞的治疗可用于治疗，改善，管理和/或减少与血管干预或心血管疾病特别是闭塞血栓形成，再狭窄，内膜增生，炎症相关的临床后遗症的进展和血管舒张。本发明进一步受益于另外的发现，即迄今为止未描述的可植入可流动组合物能够维持足够活细胞的汇合群体，其可以通过微创外科手术有效地施用，而不降低细胞的临床有效性或活力。所公开的发明可用于治疗脉管系统以及诸如输卵管的非血管管状结构。

9. 发明申请

WO2006062871A3 MATERIALS AND METHODS FOR MINIMALLY-INVASIVE ADMINISTRATION OF A CELL-CONTAINING FLOWABLE COMPOSITION 审中-公开
标题翻译：微细管理含细胞可流动组合物的材料和方法
公开(公告)号：WO2006062871A3
公开(公告)日：2006-09-28
申请号：PCT/US2005043844
申请日：2005-12-06
申请人： PERVASIS THERAPEUTICS INC , NUGENT HELEN MARIE , EDELMAN ELAZER , BOLLINGER STEVE
发明人： NUGENT HELEN MARIE , EDELMAN ELAZER , BOLLINGER STEVE
IPC分类号： A61L24/10
CPC分类号： A61L27/3886 , A61L27/3804 , A61L27/3808 , A61L27/3839 , A61L2400/06
摘要： The disclosed invention is based on the discovery that a cell-based therapy can be used to treat, ameliorate, manage and/or reduce the progression of clinical sequelae associated with vascular interventions or cardiovascular diseases, particularly occlusive thrombosis, restenosis, intimal hyperplasia, inflammation and vasodilation. The invention further benefits from the additional discovery that a heretofore undescribed implantable flowable composition is capable of sustaining a confluent population of sufficiently viable cells which can be effectively administered via a minimally-invasive surgical procedure without diminishing the clinical effectiveness or the viability of the cells. The disclosed invention can be used to treat vasculature as well as non-vascular tubular structures such as a fallopian tube.
摘要翻译：所公开的发明基于以下发现：基于细胞的疗法可用于治疗，改善，管理和/或减少与血管介入或心血管疾病相关的临床后遗症的进展，特别是闭塞性血栓形成，再狭窄，内膜增生，炎症和血管舒张。本发明进一步得益于另外的发现，即迄今未描述的可植入流动性组合物能够维持足够活细胞的汇合群，其可以通过微创外科手术有效地施用而不降低细胞的临床有效性或存活力。所公开的发明可用于治疗脉管系统以及非脉管式管状结构如输卵管。

10. 发明申请

WO9301286A3 LOCALIZED OLIGONUCLEOTIDE THERAPY 审中-公开
标题翻译：本地化寡核苷酸治疗
公开(公告)号：WO9301286A3
公开(公告)日：1993-04-01
申请号：PCT/US9205305
申请日：1992-06-23
申请人： MASSACHUSETTS INST TECHNOLOGY
发明人： ROSENBERG ROBERT D , SIMONS MICHAEL , EDELMAN ELAZER , LANGER ROBERT S , DEKEYSER JEAN-LUC
IPC分类号： A61K31/70 , A61K9/00 , A61K31/7088 , A61K38/00 , A61K48/00 , A61P43/00 , C07H21/04 , C12N15/00 , C12N15/113 , C12Q1/68 , C12N15/11
CPC分类号： A61K9/0024 , A61K38/00 , A61K48/00 , C12N15/113 , C12N15/1135 , C12N2310/315
摘要： Disclosed is a method for localized application of antisense oligonucleotides, which has been found to be effective in inhibiting expression and translation of a variety of genes. The method utilizes antisense oligonucleotides which are specific for the mRNA transcribed from the gene of interest. The antisense oligonucleotides are applied directly to the desired locus of the cells to be treated, where they hybridize with the mRNA and inhibit expression of the gene. Devices for localized antisense application and methods for making them also are described.

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