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1. 发明申请

WO2006062962A3 MATERIALS AND METHODS FOR TREATING AND MANAGING PLAQUE DISEASE 审中-公开
标题翻译：材料和方法治疗和管理斑块病
公开(公告)号：WO2006062962A3
公开(公告)日：2006-10-12
申请号：PCT/US2005044090
申请日：2005-12-06
申请人： PERVASIS THERAPEUTICS INC , EDELMAN ELAZER , DALAL ANUPAM , NUGENT HELEN MARIE , BOLLINGER STEVE
发明人： EDELMAN ELAZER , DALAL ANUPAM , NUGENT HELEN MARIE , BOLLINGER STEVE
IPC分类号： A61F2/06 , A61L27/38 , A61L29/16 , A61P9/10
CPC分类号： A61L27/3808 , A61F2310/00365
摘要： Disclosed herein are materials and methods suitable for treating and managing plaque disease, including vulnerable plaque. An implantable material comprising cells, such as but not limited to endothelial cells, and a biocompatible matrix can reduce progression or deterioration of a plaque-associated lesion situated on the interior lumen of said blood vessel. The implantable material is implanted directly on an exterior surface of a blood vessel at or adjacent or in the vicinity of the site of a lesion on an interior lumen. Alternatively, the implantable material is deposited on an exterior surface at or adjacent or in the vicinity of the site of a lesion on an interior lumen by an intraluminal delivery device which traverses or penetrates the vessel wall or by a percutaneous delivery device which enters the perivascular space. Both modes of administration can be preceded by or coincident with an imaging step. The present invention can treat hemorrhage, erosion, fissure, plaque-associated thrombosis and occlusion, rupture, displacement and/or dislodgement of a plaque lesion.
摘要翻译：本文公开了适用于治疗和控制斑块疾病（包括易损斑块）的材料和方法。包含细胞（诸如但不限于内皮细胞）和生物相容性基质的可植入材料可以减少位于所述血管的内腔上的斑块相关病变的进展或恶化。可植入材料直接植入血管的外表面上，在血管的外表面上或在内腔的病变部位附近或其附近。或者，可植入材料通过横穿或穿透血管壁的腔内递送装置或通过进入血管周的经皮递送装置沉积在内腔上病变部位处或附近或其附近的外表面上空间。两种给药方式可以在成像步骤之前或与成像步骤重合。本发明可治疗斑块损伤的出血，侵蚀，裂隙，斑块相关血栓形成和闭塞，破裂，移位和/或脱出。

2. 发明申请

WO2007001744B1 METHODS AND COMPOSITIONS FOR ENHANCING VASCULAR ACCESS 审中-公开
公开(公告)号：WO2007001744B1
公开(公告)日：2007-12-21
申请号：PCT/US2006021755
申请日：2006-06-05
申请人： PERVASIS THERAPEUTICS INC , NUGENT HELEN MARIE , EDELMAN ELAZER , DALAL ANUPAM , BOLLINGER STEVE , EPPERLY SCOTT
发明人： NUGENT HELEN MARIE , EDELMAN ELAZER , DALAL ANUPAM , BOLLINGER STEVE , EPPERLY SCOTT
IPC分类号： A61F2/06 , A61K35/12 , A61K47/36 , A61K47/42 , A61L27/00 , A61L27/38 , A61L29/16 , C12N5/00 , C12N5/07 , C12N5/071
CPC分类号： C12N5/069 , A61L27/3808
摘要： Disclosed is an implantable material comprising a biocompatible matrix and cells which, when provided to a vascular access structure, can promote functionality generally. For example, implantable material of the present invention can enhance maturation of an arteriovenous native fistula as well as prolong the fistula in a mature, functional state suitable for dialysis. Additionally, the present invention can promote formation of a functional arteriovenous graft suitable for dialysis as well as promote formation of a functional peripheral bypass graft. Implantable material can be configured as a flexible planar form or a flowable composition with shape-retaining properties suitable for implantation at, adjacent or in the vicinity of an anastomoses or arteriovenous graft. According to the methods disclosed herein, the implantable material is provided to an exterior surface of a blood vessel. Certain embodiments of the flexible planar form define a slot. The materials and methods of the present invention comprise cells, preferably endothelial cells or cells having an endothelial-like phenotype.

3. 发明申请

WO2007001744A3 METHODS AND COMPOSITIONS FOR ENHANCING VASCULAR ACCESS 审中-公开
标题翻译：用于增强血管通路的方法和组合物
公开(公告)号：WO2007001744A3
公开(公告)日：2007-10-04
申请号：PCT/US2006021755
申请日：2006-06-05
申请人： PERVASIS THERAPEUTICS INC , NUGENT HELEN MARIE , EDELMAN ELAZER , DALAL ANUPAM , BOLLINGER STEVE , EPPERLY SCOTT
发明人： NUGENT HELEN MARIE , EDELMAN ELAZER , DALAL ANUPAM , BOLLINGER STEVE , EPPERLY SCOTT
IPC分类号： A61F2/06 , A61K35/12 , A61K47/36 , A61K47/42 , A61L27/00 , A61L27/38 , A61L29/16 , C12N5/00 , C12N5/07 , C12N5/071
CPC分类号： C12N5/069 , A61L27/3808
摘要： Disclosed is an implantable material comprising a biocompatible matrix and cells which, when provided to a vascular access structure, can promote functionality generally. For example, implantable material of the present invention can enhance maturation of an arteriovenous native fistula as well as prolong the fistula in a mature, functional state suitable for dialysis. Additionally, the present invention can promote formation of a functional arteriovenous graft suitable for dialysis as well as promote formation of a functional peripheral bypass graft. Implantable material can be configured as a flexible planar form or a flowable composition with shape-retaining properties suitable for implantation at, adjacent or in the vicinity of an anastomoses or arteriovenous graft. According to the methods disclosed herein, the implantable material is provided to an exterior surface of a blood vessel. Certain embodiments of the flexible planar form define a slot. The materials and methods of the present invention comprise cells, preferably endothelial cells or cells having an endothelial-like phenotype.
摘要翻译：公开了一种包含生物相容性基质和细胞的可植入材料，所述细胞当被提供给血管通路结构时通常可以促进功能。例如，本发明的可植入材料可以增强动静脉天然瘘的成熟以及延长适于透析的成熟功能状态的瘘。此外，本发明可以促进适合于透析的功能性动静脉移植物的形成，并促进功能性外周分流移植物的形成。可植入材料可以被配置为柔性平面形式或具有适于在吻合或动静脉移植物附近或其附近植入的形状保持特性的可流动组合物。根据本文公开的方法，将可植入材料提供至血管的外表面。柔性平面形式的某些实施例限定槽。本发明的材料和方法包含细胞，优选内皮细胞或具有内皮样表型的细胞。

4. 发明申请

WO2006062909A3 METHODS AND COMPOSITIONS FOR ENHANCING VASCULAR ACCESS 审中-公开
标题翻译：用于增强血管通路的方法和组合物
公开(公告)号：WO2006062909A3
公开(公告)日：2006-08-31
申请号：PCT/US2005043967
申请日：2005-12-06
申请人： PERVASIS THERAPEUTICS INC , NUGENT HELEN MARIE , EDELMAN ELAZER , DALAL ANUPAM , BOLLINGER STEVE , EPPERLY SCOTT
发明人： NUGENT HELEN MARIE , EDELMAN ELAZER , DALAL ANUPAM , BOLLINGER STEVE , EPPERLY SCOTT
IPC分类号： A61L27/38 , A61F2/06 , A61L29/16
CPC分类号： A61L27/3808 , A61L27/3839
摘要： Disclosed is an implantable material comprising a biocompatible matrix and cells which, when provided to a vascular access structure, can promote functionality generally. For example, implantable material of the present invention can enhance maturation of an arteriovenous native fistula as well as prolong the fistula in a mature, functional state suitable for dialysis. Additionally, the present invention can promote formation of a functional arteriovenous graft suitable for dialysis as well as promote formation of a functional peripheral bypass graft. Implantable material can be configured as a flexible planar form or a flowable composition with shaperetaining properties suitable for implantation at, adjacent or in the vicinity of an anastomoses or arteriovenous graft. According to the methods disclosed herein, the implantable material is provided to an exterior surface of a blood vessel. Certain embodiments of the flexible planar form define a slot. The materials and methods of the present invention comprise cells, preferably endothelial cells or cells having an endothelial-like phenotype.
摘要翻译：公开了一种包含生物相容性基质和细胞的可植入材料，所述细胞当被提供给血管通路结构时通常可以促进功能。例如，本发明的可植入材料可以增强动静脉天然瘘的成熟以及延长适于透析的成熟功能状态的瘘。此外，本发明可以促进适合于透析的功能性动静脉移植物的形成，并促进功能性外周分流移植物的形成。可植入材料可以配置成柔性平面形式或具有适合于在吻合或动静脉移植物附近或其附近植入的形状保持特性的可流动组合物。根据本文公开的方法，将可植入材料提供至血管的外表面。柔性平面形式的某些实施例限定槽。本发明的材料和方法包含细胞，优选内皮细胞或具有内皮样表型的细胞。

5. 发明申请

WO2006062871A9 MATERIALS AND METHODS FOR MINIMALLY-INVASIVE ADMINISTRATION OF A CELL-CONTAINING FLOWABLE COMPOSITION 审中-公开
标题翻译：含细胞流动性组合物的微量入侵管理的材料与方法
公开(公告)号：WO2006062871A9
公开(公告)日：2009-01-22
申请号：PCT/US2005043844
申请日：2005-12-06
申请人： PERVASIS THERAPEUTICS INC , NUGENT HELEN MARIE , EDELMAN ELAZER , BOLLINGER STEVE
发明人： NUGENT HELEN MARIE , EDELMAN ELAZER , BOLLINGER STEVE
IPC分类号： A61L24/10
CPC分类号： A61L27/3886 , A61L27/3804 , A61L27/3808 , A61L27/3839 , A61L2400/06
摘要： The disclosed invention is based on the discovery that a cell-based therapy can be used to treat, ameliorate, manage and/or reduce the progression of clinical sequelae associated with vascular interventions or cardiovascular diseases, particularly occlusive thrombosis, restenosis, intimal hyperplasia, inflammation and vasodilation. The invention further benefits from the additional discovery that a heretofore undescribed implantable flowable composition is capable of sustaining a confluent population of sufficiently viable cells which can be effectively administered via a minimally-invasive surgical procedure without diminishing the clinical effectiveness or the viability of the cells. The disclosed invention can be used to treat vasculature as well as non-vascular tubular structures such as a fallopian tube.
摘要翻译：所公开的发明基于以下发现：基于细胞的治疗可用于治疗，改善，管理和/或减少与血管干预或心血管疾病特别是闭塞血栓形成，再狭窄，内膜增生，炎症相关的临床后遗症的进展和血管舒张。本发明进一步受益于另外的发现，即迄今为止未描述的可植入可流动组合物能够维持足够活细胞的汇合群体，其可以通过微创外科手术有效地施用，而不降低细胞的临床有效性或活力。所公开的发明可用于治疗脉管系统以及诸如输卵管的非血管管状结构。

6. 发明申请

WO2006062871A3 MATERIALS AND METHODS FOR MINIMALLY-INVASIVE ADMINISTRATION OF A CELL-CONTAINING FLOWABLE COMPOSITION 审中-公开
标题翻译：微细管理含细胞可流动组合物的材料和方法
公开(公告)号：WO2006062871A3
公开(公告)日：2006-09-28
申请号：PCT/US2005043844
申请日：2005-12-06
申请人： PERVASIS THERAPEUTICS INC , NUGENT HELEN MARIE , EDELMAN ELAZER , BOLLINGER STEVE
发明人： NUGENT HELEN MARIE , EDELMAN ELAZER , BOLLINGER STEVE
IPC分类号： A61L24/10
CPC分类号： A61L27/3886 , A61L27/3804 , A61L27/3808 , A61L27/3839 , A61L2400/06
摘要： The disclosed invention is based on the discovery that a cell-based therapy can be used to treat, ameliorate, manage and/or reduce the progression of clinical sequelae associated with vascular interventions or cardiovascular diseases, particularly occlusive thrombosis, restenosis, intimal hyperplasia, inflammation and vasodilation. The invention further benefits from the additional discovery that a heretofore undescribed implantable flowable composition is capable of sustaining a confluent population of sufficiently viable cells which can be effectively administered via a minimally-invasive surgical procedure without diminishing the clinical effectiveness or the viability of the cells. The disclosed invention can be used to treat vasculature as well as non-vascular tubular structures such as a fallopian tube.
摘要翻译：所公开的发明基于以下发现：基于细胞的疗法可用于治疗，改善，管理和/或减少与血管介入或心血管疾病相关的临床后遗症的进展，特别是闭塞性血栓形成，再狭窄，内膜增生，炎症和血管舒张。本发明进一步得益于另外的发现，即迄今未描述的可植入流动性组合物能够维持足够活细胞的汇合群，其可以通过微创外科手术有效地施用而不降低细胞的临床有效性或存活力。所公开的发明可用于治疗脉管系统以及非脉管式管状结构如输卵管。

7. 发明申请

WO2008057580A3 MATERIALS AND METHODS FOR TREATING AND MANAGING ANGIOGENESIS-MEDIATED DISEASES 审中-公开
标题翻译：用于治疗和管理血管生成介质性疾病的材料和方法
公开(公告)号：WO2008057580A3
公开(公告)日：2008-07-31
申请号：PCT/US2007023535
申请日：2007-11-07
申请人： PERVASIS THERAPEUTICS INC , NUGENT HELEN MARIE , EDELMAN ELAZER R , TJIN THAM SJIN ROBERT M , NG YIN SHAN
发明人： NUGENT HELEN MARIE , EDELMAN ELAZER R , TJIN THAM SJIN ROBERT M , NG YIN SHAN
IPC分类号： A61K35/12 , A61F2/06 , A61L27/38 , A61L29/16 , A61P19/02 , A61P37/00 , A61P43/00
CPC分类号： A61K35/36 , A61K35/44 , A61L31/005
摘要： Disclosed herein are materials and methods suitable for treating sites of pathological angiogenesis and abnormal neovascularization. Sites of pathological angiogenesis or abnormal neovascularization can be treated by contacting a surface at or adjacent or in the vicinity of an area of pathological angiogenesis or abnormal neovascularization with an implantable material. The implantable material comprises a biocompatible matrix and cells and is in an amount effective to treat the affected site. The composition can be a flexible planar material or a flowable composition. Diseases susceptible to treatment with the present invention include, for example, macular degeneration, rheumatoid arthritis, psoriasis, psoriatic arthritis, systemic inflammatory diseases, and treatment of tumors by surgical resection, radiation therapy or chemotherapy.
摘要翻译：本文公开了适用于治疗病理性血管生成和异常新血管形成的部位的材料和方法。病理性血管生成或异常新血管形成的部位可以通过将病理性血管发生或异常新生血管形成区域附近的表面与可植入材料接触来处理。可植入材料包括生物相容性基质和细胞，并且具有有效治疗受影响部位的量。组合物可以是柔性平面材料或可流动组合物。用本发明治疗的疾病包括例如黄斑变性，类风湿性关节炎，牛皮癣，银屑病关节炎，全身性炎症性疾病，以及通过手术切除，放射治疗或化疗治疗肿瘤。

8. 发明申请

WO2009020650A3 MATERIALS AND METHODS FOR TREATING AND MANAGING WOUNDS AND THE EFFECTS OF TRAUMA 审中-公开
标题翻译：治疗和管理伤口的材料和方法以及TRAUMA的作用
公开(公告)号：WO2009020650A3
公开(公告)日：2009-04-02
申请号：PCT/US2008009540
申请日：2008-08-08
申请人： PERVASIS THERAPEUTICS INC , NUGENT HELEN MARIE , BOLLINGER STEPHEN A , EDELMAN ELAZER R , SCHUBERT SHAI , NG YIN SHAN , TJIN THAM SJIN ROBERT
发明人： NUGENT HELEN MARIE , BOLLINGER STEPHEN A , EDELMAN ELAZER R , SCHUBERT SHAI , NG YIN SHAN , TJIN THAM SJIN ROBERT
IPC分类号： A61K35/12 , A61F2/06 , A61L27/38 , A61L29/16 , A61P17/02
CPC分类号： A61K35/44 , A61K35/36 , A61L24/0005 , A61L24/0015 , A61L27/3808 , A61L27/3813 , A61L27/3886 , A61L27/54 , A61L2300/25 , A61L2300/404 , A61L2300/41 , A61L2300/45 , A61L2400/06
摘要： Disclosed herein are materials and methods suitable for treating traumatic injury sites resulting from wounds, surgery or other tissue disruption. Traumatic injury sites can be treated by contacting a surface of a traumatic injury at or adjacent or in the vicinity of an area of injury or damage with an implantable material. The implantable material comprises a biocompatible matrix and cells and is in an amount effective to treat the traumatic injury site. A composition comprising a biocompatible matrix and cells engrafted therein or thereon can be used to treat the traumatic injury site. The composition can be a flexible planar material or a flowable composition.
摘要翻译：本文公开了适用于治疗由伤口，手术或其他组织破裂引起的创伤性损伤部位的材料和方法。创伤性损伤部位可以通过在损伤或损伤区域附近或附近与可植入材料接触创伤性损伤的表面进行治疗。可植入材料包括生物相容性基质和细胞，并且是有效治疗创伤性损伤部位的量。包含生物相容性基质和植入其中或其上的细胞的组合物可用于治疗创伤性损伤部位。组合物可以是柔性平面材料或可流动组合物。

9. 发明申请

WO2008057590A3 METHODS AND COMPOSITIONS FOR MODULATING TISSUE MODELING 审中-公开
标题翻译：用于调制组织建模的方法和组合
公开(公告)号：WO2008057590A3
公开(公告)日：2008-07-17
申请号：PCT/US2007023566
申请日：2007-11-07
申请人： PERVASIS THERAPEUTICS INC , NUGENT HELEN MARIE , EDELMAN ELAZER R , TJIN THAM SJIN ROBERT M
发明人： NUGENT HELEN MARIE , EDELMAN ELAZER R , TJIN THAM SJIN ROBERT M
IPC分类号： A61K35/12 , A61F2/06 , A61L27/38 , A61L29/16 , A61P7/00 , A61P41/00
CPC分类号： A61K35/44 , A61L31/005
摘要： Disclosed is an implantable material comprising a biocompatible matrix and cells which, when provided to a tubular or non-tubular tissue, structure or organ, can promote functionality and positive tissue modeling generally. For example, implantable material of the present invention can reduce fibrosis, fibroblast proliferation and migration, tissue thickening and/or MMP expression and/or activation. According to the methods disclosed herein, the implantable material is provided adjacent to a surface of a tubular or non-tubular tissue, structure or organ. The materials and methods of the present invention comprise cells, preferably endothelial cells or cells having an endothelial-like phenotype.
摘要翻译：公开了一种可植入材料，其包含生物相容性基质和当提供给管状或非管状组织结构或器官时可以通常促进功能和阳性组织建模的细胞。例如，本发明的可植入材料可以减少纤维化，成纤维细胞增殖和迁移，组织增厚和/或MMP表达和/或活化。根据本文公开的方法，可植入材料邻近管状或非管状组织，结构或器官的表面设置。本发明的材料和方法包括细胞，优选内皮细胞或具有内皮样表型的细胞。

10. 发明申请

WO2009020651A2 MATERIALS AND METHODS FOR TREATING SKELETAL SYSTEM DAMAGE AND PROMOTING SKELETAL SYSTEM REPAIR AND REGENERATION 审中-公开
标题翻译：治疗骨骼系统损伤和促进骨骼系统修复和再生的材料和方法
公开(公告)号：WO2009020651A2
公开(公告)日：2009-02-12
申请号：PCT/US2008009543
申请日：2008-08-08
申请人： PERVASIS THERAPEUTICS INC , NUGENT HELEN MARIE , NG YIN SHAN , TJIN THAM SJIN ROBERT , SCHUBERT SHAI , BIRKHEAD JAMES RICHARD
发明人： NUGENT HELEN MARIE , NG YIN SHAN , TJIN THAM SJIN ROBERT , SCHUBERT SHAI , BIRKHEAD JAMES RICHARD
IPC分类号： A61L27/38
CPC分类号： A61L27/3843 , A61L27/54 , A61L27/58 , A61L2300/25 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/45
摘要： Disclosed herein are materials and methods suitable for treating injured, damaged or diseased mineralized and non-mineralized skeletal tissues, including bones, joints, tendons, ligaments, cartilage and/or other non-mineralized skeletal tissues. The affected structure can be treated by contacting a surface of the skeletal element at or adjacent to or in the vicinity of an area of injury, damage or disease with an implantable material. The implantable material comprises a biocompatible matrix and cells and is in an amount effective to treat the affected structure. A composition comprising a biocompatible matrix and cells engrafted therein or thereon can be used to treat the affected structure. The composition can be a flexible planar material or a flowable composition.
摘要翻译：本文公开了适用于治疗损伤，损伤或患病的矿化和非矿化骨骼组织（包括骨骼，关节，腱，韧带，软骨和/或其他非矿化骨骼组织）的材料和方法。受影响的结构可以通过在损伤，损伤或疾病区域附近或附近与可植入材料接触骨骼元件的表面来处理。可植入材料包括生物相容性基质和细胞，并且是有效治疗受影响结构的量。可以使用包含生物相容性基质和植入其中或其上的细胞的组合物来治疗受影响的结构。组合物可以是柔性平面材料或可流动组合物。

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