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1. 发明申请

WO2013188433A1 APPARATUS AND METHODS FOR ANCHORING ELECTRODE LEADS ADJACENT TO NERVOUS TISSUE 审中-公开
标题翻译：用于锚固与神经组织相邻的电极引线的装置和方法
公开(公告)号：WO2013188433A1
公开(公告)日：2013-12-19
申请号：PCT/US2013/045223
申请日：2013-06-11
申请人： MAINSTAY MEDICAL LIMITED , SHIROFF, Jason Alan , DEMORETT, Henry Thomas , RAWAT, Prashant Brijmohansingh , HEEMELS, Johannes Petrus , CROSBY, Peter Andrew
发明人： SHIROFF, Jason Alan , DEMORETT, Henry Thomas , RAWAT, Prashant Brijmohansingh , HEEMELS, Johannes Petrus , CROSBY, Peter Andrew
IPC分类号： A61N1/05
CPC分类号： A61N1/0558 , A61N1/36057 , A61N1/36071
摘要： Apparatus for neuromuscular electrical stimulation and methods for anchoring the same are provided. The apparatus may include an elongated member having one or more electrodes disposed at the distal region of the elongated member and at least one fixation element disposed at the distal region of the elongated member. The fixation element may be shaped and sized to be deployed between tissue layers, such as muscle layers, without damaging the tissue layers so as to secure the one or more electrodes in or adjacent to a desired anatomical site within a patient. An additional fixation element may be disposed at the distal region of the elongated member so that tissue, such as a muscle, may be sandwiched between the fixation elements without damaging the tissue.
摘要翻译：提供了用于神经肌肉电刺激的装置和用于锚定其的方法。该装置可以包括细长构件，其具有设置在细长构件的远侧区域处的一个或多个电极和设置在细长构件的远侧区域处的至少一个固定元件。固定元件可以被成形和定尺寸成在诸如肌肉层的组织层之间展开，而不损坏组织层，以便将一个或多个电极固定在患者内的期望的解剖部位内或邻近于患者内的期望的解剖部位。可以在细长构件的远侧区域处设置另外的固定元件，使得诸如肌肉的组织可以夹在固定元件之间而不损坏组织。

2. 发明申请

WO2011112773A2 MODULAR STIMULATOR FOR TREATMENT OF BACK PAIN, IMPLANTABLE RF ABLATION SYSTEM AND METHODS OF USE 审中-公开
标题翻译：用于治疗背部疼痛的模块化刺激器，可植入式射频消融系统和使用方法
公开(公告)号：WO2011112773A2
公开(公告)日：2011-09-15
申请号：PCT/US2011/027834
申请日：2011-03-10
申请人： MAINSTAY MEDICAL, INC. , CROSBY, Peter, Andrew , SACHS, Dan , RAWAT, Prashant Brijmohansingh , SHIROFF, Jason, Alan , HEEMELS, Johannes, Petrus
发明人： CROSBY, Peter, Andrew , SACHS, Dan , RAWAT, Prashant Brijmohansingh , SHIROFF, Jason, Alan , HEEMELS, Johannes, Petrus
IPC分类号： A61N1/05 , A61N1/06 , A61N1/34
CPC分类号： A61N1/0551 , A61B18/1492 , A61B2017/00221 , A61B2018/00339 , A61B2018/00577 , A61B2018/124 , A61B2018/1467 , A61B2034/2048 , A61N1/06 , A61N1/36042 , A61N1/36071 , A61N1/37211
摘要： Apparatus and methods for treating back pain are provided, in which an implantable stimulator is configured to communicate with an external control system, the implantable stimulator providing a neuromuscular electrical stimulation therapy designed to cause muscle contraction to rehabilitate the muscle, restore neural drive and restore spinal stability; the implantable stimulator further including one or more of a number of additional therapeutic modalities, including a module that provides analgesic stimulation; a module that monitors muscle performance and adjusts the muscle stimulation regime; and/or a module that provides longer term pain relief by selectively and repeatedly ablating nerve fibers. In an alternative embodiment, a standalone implantable RF ablation system is described.
摘要翻译：提供了用于治疗背痛的装置和方法，其中可植入刺激器被配置成与外部控制系统通信，所述可植入刺激器提供神经肌肉电刺激疗法，所述神经肌肉电刺激疗法被设计为引起肌肉收缩以恢复肌肉，恢复神经驱动和恢复脊柱稳定性; 所述植入式刺激器进一步包括多种其他治疗形式中的一种或多种，包括提供止痛刺激的模块; 监测肌肉性能并调整肌肉刺激状态的模块; 和/或通过选择性地和反复地消融神经纤维来提供长期疼痛缓解的模块。在替代实施例中，描述了独立的可植入RF消融系统。

3. 发明申请

WO2015187426A1 SYSTEMS AND METHODS FOR IMPLANTING ELECTRODE LEADS FOR USE WITH IMPLANTABLE NEUROMUSCULAR ELECTRICAL STIMULATOR 审中-公开
标题翻译：用于植入电极引线的系统和方法，用于可植入神经电刺激器
公开(公告)号：WO2015187426A1
公开(公告)日：2015-12-10
申请号：PCT/US2015/032732
申请日：2015-05-27
申请人： MAINSTAY MEDICAL LIMITED , RAWAT, Prashant Brijmohansingh , DEMORETT, Henry Thomas , SHIROFF, Jason Alan
发明人： RAWAT, Prashant Brijmohansingh , DEMORETT, Henry Thomas , SHIROFF, Jason Alan
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36071 , A61N1/0551 , A61N1/36003 , A61N1/36042 , A61N1/36142
摘要： A system of implanting electrode leads for restoring muscle function to the lumbar spine to treat low back pain is provided. The system provides efficient implantation of the leads, including the ability to verify deployment of anchoring mechanisms on the lead using an impedance assessment, such that the implanted lead may be secured within the patient and used to restore muscle function of local segmental muscles associated with the lumbar spine stabilization system.
摘要翻译：提供了一种植入用于将肌肉功能恢复到腰椎以治疗腰痛的电极引线的系统。该系统提供线的有效植入，包括使用阻抗评估来验证在引线上部署锚定机构的能力，使得植入的引线可以固定在患者体内，并用于恢复与患者相关联的局部节段性肌肉的肌肉功能腰椎稳定系统。

4. 发明申请

WO2015059570A1 SYSTEMS AND METHODS FOR RESTORING MUSCLE FUNCTION TO THE LUMBAR SPINE 审中-公开
标题翻译：将肌肉功能恢复到腰椎的系统和方法
公开(公告)号：WO2015059570A1
公开(公告)日：2015-04-30
申请号：PCT/IB2014/002920
申请日：2014-10-16
申请人： MAINSTAY MEDICAL LIMITED
发明人： SACHS, Dan , RAWAT, Prashant Brijmohansingh , SHIROFF, Jason Alan , CROSBY, Peter, Andrew
IPC分类号： A61N1/36 , A61N1/04 , A61N1/05 , A61N1/378 , A61B5/0488 , A61B5/11 , A61N1/372
CPC分类号： A61N1/36071 , A61B5/0488 , A61B5/1104 , A61B5/1107 , A61B5/1121 , A61B5/4809 , A61B5/4821 , A61B2562/0219 , A61B2562/0247 , A61B2562/0261 , A61N1/0551 , A61N1/0558 , A61N1/36003 , A61N1/36021 , A61N1/36042 , A61N1/36139 , A61N1/36157 , A61N1/36171 , A61N1/36175 , A61N1/37235 , A61N1/3787
摘要： A system for restoring muscle function to the lumbar spine to treat low back pain is provided. The system may include electrodes coupled to an implantable pulse generator (IPG), a handheld activator configured to transfer a stimulation command to the IPG, and an external programmer configured to transfer programming data to the IPG. The stimulation command directs the programmable controller to stimulate the tissue in accordance with the programming data. The system may include a software-based programming system run on a computer such that the treating physician may program and adjust stimulation parameters.
摘要翻译：提供了一种用于恢复腰椎肌肉功能以治疗腰痛的系统。该系统可以包括耦合到可植入脉冲发生器（IPG）的电极，被配置为将刺激命令传送到IPG的手持激活器以及被配置为将编程数据传送到IPG的外部编程器。刺激指令指示可编程控制器根据编程数据刺激组织。系统可以包括在计算机上运行的基于软件的编程系统，使得治疗医师可编程和调整刺激参数。

5. 发明申请

WO2016020846A1 ELECTRODE LEADS FOR USE WITH IMPLANTABLE NEUROMUSCULAR ELECTRICAL STIMULATOR 审中-公开
标题翻译：电极导线与可植入神经电刺激仪一起使用
公开(公告)号：WO2016020846A1
公开(公告)日：2016-02-11
申请号：PCT/IB2015/055926
申请日：2015-08-05
申请人： MAINSTAY MEDICAL LIMITED
发明人： SHIROFF, Jason Alan , SKUBITZ, Jason John , RAWAT, Prashant Brijmohansingh
IPC分类号： A61N1/05 , A61N1/18 , A61N1/36
CPC分类号： A61N1/05 , A61N1/0504 , A61N1/0558 , A61N1/18 , A61N1/3605
摘要： An apparatus for neuromuscular electrical stimulation is provided. The apparatus may be a stimulation lead having an elongated member made up of at least one conductor and an insulative sheath surrounding at least a portion of the conductor. A distal portion of the elongated member may include one or more electrodes and at least one fixation element to secure the one or more electrodes in or adjacent to a desired anatomical site for providing stimulation thereto. The stimulation lead has a strain relief portion on the proximal side of the one or more electrodes, configured to reduce axial forces on the distal region of the elongated member, and the effects thereof, to reduce the risk of, or even prevent, displacement of the one or more electrodes and to accommodate localized flexural motion. The apparatus also may include at least one fixation element sized and configured to be deployed between muscle layers to maintain the electrode position at the stimulation site.
摘要翻译：提供神经肌肉电刺激装置。该装置可以是具有由至少一个导体构成的细长构件和围绕导体的至少一部分的绝缘护套的刺激引线。细长构件的远侧部分可以包括一个或多个电极和至少一个固定元件，以将一个或多个电极固定在期望的解剖部位中或附近，以便向其提供刺激。刺激引线在一个或多个电极的近侧具有应变消除部分，其被构造成减小细长构件的远侧区域上的轴向力及其影响，以减少或甚至防止位移的风险一个或多个电极并且适应局部弯曲运动。该装置还可以包括至少一个固定元件，其尺寸和构造为被布置在肌肉层之间以将电极位置维持在刺激部位。

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