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1. 发明申请

WO2005040194A3 METHODS AND COMPOSITIONS FOR PDGF-C ACTIVATION AND INHIBITION 审中-公开
标题翻译： PDGF-C激活和抑制的方法和组合
公开(公告)号：WO2005040194A3
公开(公告)日：2007-06-28
申请号：PCT/US2004035248
申请日：2004-10-25
申请人： LUDWIG INST CANCER RES , FREDRIKSSON LINDA , LI HONG , FIEBER CHRISTINA , LI XURI , ERIKSSON ULF
发明人： FREDRIKSSON LINDA , LI HONG , FIEBER CHRISTINA , LI XURI , ERIKSSON ULF
IPC分类号： A61K39/395 , A61K38/16 , A61K38/43 , C07K20060101 , C07K14/49 , C07K16/22 , C07K16/40 , C12N9/72 , C12N9/99
CPC分类号： C07K16/22 , A61K2039/505 , C07K14/49 , C07K14/8132 , C07K16/40 , C12N9/6459 , C12N9/99 , C12Y304/21069
摘要： Methods for inhibiting angiogenesis comprising administering tissue-plasminogen activator (tPA) inhibitors, and pharmaceutical compositions suitable for the methods comprising the tPA inhibitors. Also provided are methods for stimulating angiogenesis comprising administering tPA to a patient in need thereof, and pharmaceutical compositions comprising an effective amount of tPA for the methods of stimulation. The present invention discloses that tPA is a specific PDGF-C activating protease, and that the CUB-domains in PDGF-CC directly interact with the protease, are required for efficient proteolysis, and released CUB-domains are tPA inhibitors. Preferably, the method and compositions of the present invention are used for simultaneously stimulating, or simultaneously inhibiting, thrombolysis and angiogenesis.
摘要翻译：抑制血管发生的方法包括施用组织纤溶酶原激活剂（tPA）抑制剂和适用于包含tPA抑制剂的方法的药物组合物。还提供了用于刺激血管生成的方法，其包括向有需要的患者施用tPA，以及包含用于刺激方法的有效量的tPA的药物组合物。本发明公开了tPA是特异性PDGF-C活化蛋白酶，PDGF-CC中的CUB结构域与蛋白酶直接相互作用，是有效的蛋白水解所必需的，而释放的CUB结构域是tPA抑制剂。优选地，本发明的方法和组合物用于同时刺激或同时抑制溶栓和血管发生。

2. 发明申请

WO2013036736A3 GLASS COMPOSITIONS AND FIBERS MADE THEREFROM 审中-公开
标题翻译：玻璃组合物和纤维制成
公开(公告)号：WO2013036736A3
公开(公告)日：2013-05-16
申请号：PCT/US2012054113
申请日：2012-09-07
申请人： PPG IND OHIO INC , LI HONG
发明人： LI HONG
IPC分类号： C03C3/112 , C03C3/087 , C03C13/00
CPC分类号： C03C3/095 , C03C3/087 , C03C3/112 , C03C3/118 , C03C13/00 , C03C13/001 , C03C13/06 , C03C2213/00
摘要： Embodiments of the present invention relate to glass compositions, glass fibers formed from such compositions, and related products. In one embodiment, a glass composition comprises 58-62 weight percent SiO2, 14-17 weight percent Al2O3, 14-17.5 weight percent CaO, and 6-9 weight percent MgO, wherein the amount of Na2O is 0.09 weight percent or less.
摘要翻译：本发明的实施方案涉及玻璃组合物，由这些组合物形成的玻璃纤维及相关产品。在一个实施方案中，玻璃组合物包含58-62重量％的SiO 2，14-17重量％的Al 2 O 3，14-17.5重量％的CaO和6-9重量％的MgO，其中Na 2 O的量为0.09重量％或更少。

3. 发明申请

WO2007038246A2 SOLID POLYMER DELIVERY COMPOSITIONS AND METHODS FOR USE THEREOF 审中-公开
标题翻译：固体聚合物递送组合物及其使用方法
公开(公告)号：WO2007038246A2
公开(公告)日：2007-04-05
申请号：PCT/US2006036935
申请日：2006-09-21
申请人： MEDIVAS LLC , LI HONG , TURNELL WILLIAM G , YUAN YUMIN , LANDIS GEOFFREY C , KNOY RYAN L
发明人： LI HONG , TURNELL WILLIAM G , YUAN YUMIN , LANDIS GEOFFREY C , KNOY RYAN L
IPC分类号： A61K48/00 , A61F2/02 , A61K39/395 , C08F20/00
CPC分类号： C08G69/44 , A61K9/0024 , A61K47/34 , A61L27/34 , A61L31/10 , C08L77/12 , C08L2666/02
摘要： The present invention provides an implantable solid polymer delivery composition that can be formulated to release a bioactive agent to an interior body site at a controlled rate over an extended period of time by adjusting the various components of the composition. The controlled delivery of the composition avoids an initial drug spike, resulting in a smooth delivery profile over time. Polymer layers in the composition can be porous and are both biodegradable in water and body enzymes and biocompatible. Methods of making the implantable solid polymer compositions and methods of delivering a bioactive agent at a controlled rate to an interior body site are also provided.
摘要翻译：本发明提供了一种可植入固体聚合物递送组合物，其可以通过调节组合物的各种组分而配制为在延长的时间段内以受控速率将生物活性剂释放到体内部位。组合物的受控递送避免了最初的药物峰值，导致随着时间流逝递送顺畅。组合物中的聚合物层可以是多孔的并且在水和身体酶中都是可生物降解的并且是生物相容的。还提供了制备可植入固体聚合物组合物的方法以及以受控速率将生物活性剂递送至体内部位的方法。

4. 发明申请

WO2004053676A3 METHODS AND APPARATUS FOR IMPROVING TEH BREATHING OF DISK SCHEDULING ALOGORITHMS 审中-公开
标题翻译：改进盘调度算法的呼吸的方法和装置
公开(公告)号：WO2004053676A3
公开(公告)日：2005-06-16
申请号：PCT/IB0305758
申请日：2003-12-08
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS CORP , KORST JOHANNES HENRICUS MARIA , LI HONG , JOCHEMSEN ROBERT , LAMBERT NICOLAAS , VAN DER HEIJDEN GERARDUS WILHE
发明人： KORST JOHANNES HENRICUS MARIA , LI HONG , JOCHEMSEN ROBERT , LAMBERT NICOLAAS , VAN DER HEIJDEN GERARDUS WILHE
IPC分类号： G06F3/06 , H04N5/00 , H04N7/24
CPC分类号： H04N21/2393 , G06F3/0613 , G06F3/0656 , G06F3/0659 , G06F3/0676 , H04N21/2326 , H04N21/23406 , H04N21/44004 , H04N21/47202
摘要： A method for breathing of scheduling algorithms for a storage device (110). The method including: (a) computing a worst-case duration of a breathing cycle (P) for the storage device (110); (b) starting a breathing cycle; (c) determining if one of the following becomes true before the end of P: (i) a number of real-time requests is at least a predetermined threshold based on a number of data streams and performance parameters of the storage device; and (ii) a number of pending requests for any single stream becomes more than one; (d) if at least one of (i) and (ii) remain true during the duration of P, starting a subsequent breathing cycle after completion of the breathing cycle; and (e) if both of (i) and (ii) are not true during the duration of P, waiting P time units from the start of the breathing cycle before starting the subsequent breathing cycle.
摘要翻译：一种用于呼叫用于存储设备（110）的调度算法的方法。该方法包括：（a）计算存储装置（110）的呼吸周期（P）的最差情况持续时间; （b）开始呼吸循环; （c）在P结束之前确定以下之一是否成立：（i）基于数据流的数量和存储设备的性能参数，多个实时请求至少为预定阈值; 和（ii）任何单个流的一些未决请求变得不止一个; （d）如果（i）和（ii）中的至少一个在P期间保持为真，则在呼吸循环完成之后开始随后的呼吸周期; 和（e）如果在P持续时间内（i）和（ii）两者都不为真，则在开始随后的呼吸循环之前从呼吸循环开始等待P时间单位。

5. 发明申请

WO2005092068A3 NOVEL METHOD OF NEUROPROTECTION BY PHARMACOLOGICAL INHIBITION OF AMP-ACTIVATED PROTEIN KINASE 审中-公开
标题翻译：通过药代动力学抑制AMP活化蛋白激酶进行神经保护的新方法
公开(公告)号：WO2005092068A3
公开(公告)日：2007-09-20
申请号：PCT/US2005009797
申请日：2005-03-23
申请人： FASGEN LLC , UNIV JOHNS HOPKINS , MCCULLOUGH LOUISE D , LI HONG , MCFADDEN JILL , RONNETT GABRIELE V
发明人： MCCULLOUGH LOUISE D , LI HONG , MCFADDEN JILL , RONNETT GABRIELE V
IPC分类号： A61K35/00 , A61K38/00 , C07K14/00
CPC分类号： A61K31/00
摘要： A method of neuroprotection which comprises administration of an AMPK inhibitor to a patient who is experiencing or has experienced a stroke, the compound being an AMPK inhibitor. Treatments with these agents significantly reduce the size of infarcts, and therefore minimize the loss of brain tissue and neurons. Thus, function can be preserved after stroke or ischemic injury in the brain. Similarly, neuronal loss can be minimized in degenerative diseases that cause neuronal compromise by perturbing energy utilization and availability in neurons.
摘要翻译：一种神经保护方法，其包括将AMPK抑制剂施用于正在经历或已经发生中风的患者，所述化合物是AMPK抑制剂。与这些药物的治疗显着减少梗塞的大小，从而使脑组织和神经元的损失最小化。因此，大脑中风或缺血性损伤后功能可以保留。类似地，在通过扰乱能量利用和神经元可用性导致神经元损害的退行性疾病中，神经元损失可以最小化。

6. 发明申请

WO2006083874A2 VACCINE DELIVERY COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：疫苗输送组合物及其使用方法
公开(公告)号：WO2006083874A2
公开(公告)日：2006-08-10
申请号：PCT/US2006003412
申请日：2006-01-31
申请人： MEDIVAS LLC , TUNELL WILLIAM G , VASSILEV VASSIL P , DEFIFE KRISTIN M , LI HONG , GOMURASHVILI ZAZA D , KATSARAVA RAMAZ
发明人： TUNELL WILLIAM G , VASSILEV VASSIL P , DEFIFE KRISTIN M , LI HONG , GOMURASHVILI ZAZA D , KATSARAVA RAMAZ
IPC分类号： A61K39/00
CPC分类号： A61K39/39 , A61K9/0019 , A61K47/593 , A61K47/595 , A61K2039/55511 , A61K2039/57
摘要： The present invention provides synthetic vaccine delivery compositions based on polyester amide (PEA), polyester urethane (PEUR), and polyester urea (PEU) polymers for stimulating an immune response to a variety of pathogenic organisms and tumor cells in humans and other mammals. The vaccine delivery compositions are formulated as a liquid dispersion of polymer particles or molecules including class I or class II antigen peptides derived from organism or tumor cell proteins, which are taken up by antigen presenting cells of the mammal to induce an immune response in the mammal. Methods of inducing an immune response to the pathogenic organism or tumor cells in the invention compositions are also included.
摘要翻译：本发明提供了基于聚酯酰胺（PEA），聚酯聚氨酯（PEUR）和聚酯尿素（PEU）聚合物的合成疫苗递送组合物，用于刺激人和其它哺乳动物中各种致病生物体和肿瘤细胞的免疫应答。疫苗递送组合物被配制为聚合物颗粒或分子的液体分散体，包括衍生自生物或肿瘤细胞蛋白的I类或II类抗原肽，其被哺乳动物的抗原呈递细胞吸收以在哺乳动物中诱导免疫应答。还包括诱导本发明组合物中致病生物或肿瘤细胞的免疫应答的方法。

7. 发明申请

WO2004034489A3 NOVEL ELECTRODES FOR LI-BASED ELECTROCHEMICAL ENERGY STORAGE DEVICES AND A LI-BASED ELECTROCHEMICAL STORAGE DEVICE 审中-公开
标题翻译：用于基于锂的电化学能量储存装置和基于锂的电化学存储装置的新型电极
公开(公告)号：WO2004034489A3
公开(公告)日：2005-03-03
申请号：PCT/EP0310138
申请日：2003-09-11
申请人： MAX PLANCK GES ZUR , BALAYA PALANI , LI HONG , MAIER JOACHIM
发明人： BALAYA PALANI , LI HONG , MAIER JOACHIM
IPC分类号： H01M4/00 , H01M4/36 , H01M4/48 , H01M4/485 , H01M4/58 , H01M4/62 , H01M10/052 , H01M10/36 , H01M4/02 , H01M10/40
CPC分类号： H01M4/485 , H01M4/622 , H01M4/624 , H01M10/052 , H01M2004/021 , H01M2300/0082 , H01M2300/0085
摘要： The description relates to the use of at least one transition metal halide with a binder, e.g. at least one of PVDF, PTFE, PAN and ETDM and optionally with at least one conductive additive such as carbon black, graphite, metal powder and metal fibres as an electrode in an Li-based electrochemical energy storage device. Further electrode materials are also described based on ruthenium oxide, molybdenum oxide, a nano-composite composed of transition metal and lithium fluoride or lithium oxide clusters with a typical grain size of 1-10 nm.
摘要翻译：该描述涉及至少一种过渡金属卤化物与粘合剂的使用，例如， PVDF，PTFE，PAN和ETDM中的至少一种，并且任选地具有至少一种导电添加剂，例如在基于Li的电化学能量存储装置中作为电极的炭黑，石墨，金属粉末和金属纤维。还描述了另外的电极材料，其基于氧化钌，氧化钼，由过渡金属和具有1-10nm的典型晶粒尺寸的氟化锂或氧化锂簇组成的纳米复合物。

8. 发明申请

WO2008048298A2 POLYMER PARTICLES FOR DELIVERY OF MACROMOLECULES AND METHODS OF USE 审中-公开
标题翻译：用于输送大分子的聚合物颗粒和使用方法
公开(公告)号：WO2008048298A2
公开(公告)日：2008-04-24
申请号：PCT/US2006045268
申请日：2006-11-21
申请人： MEDIVAS LLC , GOMURASHVILI ZAZA D , LANDIS GEOFFREY C , LI HONG , TURNELL WILLIAM D , DEFIFE KRISTIN , VASSILEV VASSIL P , YUAN YUMIN NMN
发明人： GOMURASHVILI ZAZA D , LANDIS GEOFFREY C , LI HONG , TURNELL WILLIAM D , DEFIFE KRISTIN , VASSILEV VASSIL P , YUAN YUMIN NMN
IPC分类号： A61K48/00 , A61K9/14 , A61K38/28 , C08F20/00
CPC分类号： A61K9/167 , A61K9/1075 , A61K9/5146 , A61K38/28 , A61K47/59 , A61K47/593 , A61K47/595 , C08L77/12
摘要： The present invention provides biodegradable polymer particle delivery compositions for delivery of macromolecular biologies, for example in crystal form, based on polymers, such as polyester amide (PEA), polyester urethane (PEUR), and polyester urea (PEU) polymers, which contain amino acids in the polymer. The polymer particle delivery compositions can be formulated either as a liquid dispersion or a lyophilized powder of polymer particles containing bound water molecules with the macromolecular biologies, for example insulin, dispersed in the particles. Bioactive agents, such as drugs, polypeptides, and polynucleotides can also be delivered by using particles sized for local, oral, mucosal or circulatory delivery. Methods of delivering a macromolecular biologic with substantial native activity to a subject, for example orally, are also included.
摘要翻译：本发明提供了生物可降解聚合物颗粒递送组合物，其用于递送基于聚合物例如聚酯酰胺（PEA），聚酯氨基甲酸酯（PEUR）和聚酯脲（PEU）聚合物的大分子生物学，例如晶体形式，其含有氨基酸在聚合物中。聚合物颗粒递送组合物可以配制成液体分散体或含有结合水分子的聚合物颗粒与分散在颗粒中的大分子生物制剂（例如胰岛素）的冻干粉末。生物活性剂如药物，多肽和多核苷酸也可以通过使用大小适合局部，口服，粘膜或循环递送的颗粒来递送。也包括向受试者递送具有大量天然活性的大分子生物制剂的方法，例如口服。

9. 发明申请

WO2007072354A3 RECORDING OF PROTECTED BROADCAST CONTENT WITH SELECTABLE USER RIGHTS 审中-公开
标题翻译：用可选用户权限记录受保护的广播内容
公开(公告)号：WO2007072354A3
公开(公告)日：2007-11-01
申请号：PCT/IB2006054852
申请日：2006-12-14
申请人： KONINKL PHILIPS ELECTRONICS NV , LI HONG , RIJCKAERT ALBERT M A , PETKOVIC MILAN
发明人： LI HONG , RIJCKAERT ALBERT M A , PETKOVIC MILAN
IPC分类号： G06F21/10 , G06F21/72 , H04N7/16 , H04N7/167
CPC分类号： H04N5/913 , G06F21/10 , G06F21/72 , G06F2221/0797 , H04N5/781 , H04N5/85 , H04N5/907 , H04N21/4143 , H04N21/4182 , H04N21/4325 , H04N21/4334 , H04N21/4408 , H04N21/4627 , H04N21/4751 , H04N2005/91364
摘要： An apparatus for recording a signal having a signal content, where the apparatus comprises a receiver for receiving the signal, a processor configured to determine rights to the signal content received with the received signal, and a recorder for recording the received signal and a signal representing the determined rights to the signal content, wherein the processor is configured to give, to right holders, individual rights to the content respecting the determined rights to the content. A user who receives the signal can give individual rights to right holders respecting the rights to the content. The given rights comprise full rights and restricted rights such as owner rights corresponding to the rights to the content received with the received signal, and user rights that allow the right holder to use, such as view, the signal content. Use of the individual rights requires a corresponding individual key.
摘要翻译：一种用于记录具有信号内容的信号的装置，其中该装置包括用于接收信号的接收器，被配置为确定对利用接收到的信号接收的信号内容的权限的处理器，以及用于记录接收到的信号的记录器和用于表示所确定的对信号内容的权利，其中处理器被配置成向权利持有者提供关于所确定的对内容的权利的个人权利。接收到信号的用户可以赋予权利持有者关于内容权利的个人权利。给定的权利包括全部权利和受限制的权利，例如与接收到的信号一起接收的内容的权利相对应的所有权，以及允许权利持有者使用（例如查看）信号内容的用户权利。个人权利的使用需要相应的个人密钥。

10. 发明申请

WO2007015184A2 APPARATUS AND METHOD FOR AUTOMATICALLY DETERMINING PRIVACY SETTINGS FOR CONTENT 审中-公开
标题翻译：用于自动确定内容隐私设置的装置和方法
公开(公告)号：WO2007015184A2
公开(公告)日：2007-02-08
申请号：PCT/IB2006052482
申请日：2006-07-20
申请人： KONINKL PHILIPS ELECTRONICS NV , BARBIERI MAURO , WEDA JOHANNES , LI HONG
发明人： BARBIERI MAURO , WEDA JOHANNES , LI HONG
IPC分类号： G06F21/62
CPC分类号： G06F21/6218 , G06F21/6209 , G06F2221/2101
摘要： An apparatus and method are provided for automatically determining privacy settings for content, such as audio-video content, photographs and other documents. The apparatus (1) comprises an audio-video content source (2), an intrinsic content analyser (3) that is communicatively connected to an audio-visual source (2), such as a picture or film source (9). The content is analysed for intrinsic information (10). Further, the system comprises a privacy engine (4) communicatively connected to the intrinsic content analyser. A recommended privacy setting (8) is determined based upon privacy setting rules from a privacy rules base (5) and the intrinsic information (10). The privacy setting rules are updated, by a privacy rules update unit (6), taking into account the recommended privacy setting (8) and the intrinsic information (10). The audio-video content is then stored, in a storage unit (7), according to the recommended privacy setting (8).
摘要翻译：提供了一种用于自动确定诸如音频 - 视频内容，照片和其他文档的内容的隐私设置的装置和方法。该装置（1）包括音频 - 视频内容源（2），通信地连接到诸如图片或电影源（9）的视听源（2）的本征内容分析器（3）。内容分析内在信息（10）。此外，该系统包括通信地连接到本征内容分析器的隐私引擎（4）。基于来自隐私规则库（5）和内在信息（10）的隐私设置规则确定推荐的隐私设置（8）。通过隐私规则更新单元（6）更新隐私设置规则，同时考虑到推荐的隐私设置（8）和内在信息（10）。然后，根据推荐的隐私设置（8）将音频 - 视频内容存储在存储单元（7）中。

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