专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2010045241A1 BIODEGRADABLE PROLINE-BASED POLYMERS 审中-公开
标题翻译：生物可降解的基于聚合物的聚合物
公开(公告)号：WO2010045241A1
公开(公告)日：2010-04-22
申请号：PCT/US2009/060521
申请日：2009-10-13
申请人： MEDIVAS, LLC , TURNELL, William, G. , GOMURASHVILI, Zaza, D. , ANDERL, Jeffrey, Neil
发明人： TURNELL, William, G. , GOMURASHVILI, Zaza, D. , ANDERL, Jeffrey, Neil
IPC分类号： A61L15/16
CPC分类号： A61K9/5153 , A61K31/00 , C08G69/44 , C08L77/12
摘要： The invention provides sequential poly(ester amide)s derived from Proline and that are synthesized by a two-step method, involving a final thermal polyesterification reaction. Molecular weights of polymers prepared by this method are from 14,000 Da to about 77,000Da.l When invention proline-based PEAs were thermally characterized,, their glass transition temperatures were lower than other alpha-amino acid based poly(ester amides) due to lack of internal hydrogen bonding. These Proline-based PEAs assemble as nano-particles in aqueous solutions and form complexes with various cations and biologies, including hydrophobic small molecule drugs and biologies. Therefore the invention Proline- based PEAs are useful for drug delivery applications requiring a polymer with a molecular weight in the range from 14,000 Da to about 77,000Da and for fabrication of nanoparticles for delivery of hydrophobic drugs.
摘要翻译：本发明提供了源自脯氨酸的顺序聚（酯酰胺），并且通过两步法合成，涉及最终的热聚酯化反应。通过该方法制备的聚合物的分子量为14,000Da至约77,000Da。当本发明的脯氨酸基PEA被热表征时，由于缺乏，其玻璃化转变温度低于其它基于α-氨基酸的聚（酯酰胺）的内部氢键。这些基于脯氨酸的PEAs在水溶液中作为纳米颗粒组装，并与各种阳离子和生物制品形成复合物，包括疏水性小分子药物和生物制剂。因此，本发明的基于脯氨酸的PEAs可用于需要分子量范围为14,000Da至约77,000Da的聚合物并用于制备用于递送疏水性药物的纳米颗粒的药物递送应用。

2. 发明申请

WO2007067744A3 METHOD FOR ASSEMBLING A POLYMER-BIOLOGIC DELIVERY COMPOSITION 审中-公开
标题翻译：用于组装聚合物生物递送组合物的方法
公开(公告)号：WO2007067744A3
公开(公告)日：2009-09-24
申请号：PCT/US2006046896
申请日：2006-12-07
申请人： MEDIVAS LLC , TURNELL WILLIAM G , PARCHER BENJAMIN W , CHARLES CATHERINE H , PABBA CHITTARI NMN , VITIELLO MARIA A
发明人： TURNELL WILLIAM G , PARCHER BENJAMIN W , CHARLES CATHERINE H , PABBA CHITTARI NMN , VITIELLO MARIA A
IPC分类号： A61F2/00
CPC分类号： A61K39/0011 , A61K39/12 , A61K39/145 , A61K39/385 , A61K47/59 , A61K47/593 , A61K47/595 , A61K2039/543 , A61K2039/55505 , A61K2039/55555 , A61K2039/55561 , A61K2039/585 , C08G71/02 , C08G71/04 , C08G2230/00 , C12N2710/14043 , C12N2710/20022 , C12N2710/20034 , C12N2760/16134
摘要： A one-step method for assembly of delivery compositions for one or more antigens or therapeutic biologies is based on non-covalent affinity capture of molecules from solution using a biodegradable polymer having functional groups to which the affinity ligand binds. The polymer-bound affinity complex, which includes the molecule(s) of interest is then recovered from the reaction solution, for example, by size exclusion filtration, to yield the assembled delivery composition. The affinity ligand can be a monoclonal antibody or a metal affinity ligand with bound metal transition ion. The assembled delivery compositions can be formulated as polymer particles, which can then be lyophilized and reconstituted for in vivo delivery of the non-covalently complexed antigen(s) or therapeutic biologic(s) with substantial native activity.
摘要翻译：用于组装一种或多种抗原或治疗性生物制剂的递送组合物的一步法基于使用具有亲和配体结合的官能团的可生物降解的聚合物从溶液中分子的非共价亲和性捕获。然后，例如通过尺寸排阻过滤从反应溶液中回收包含目的分子的聚合物结合的亲和复合物，得到组装的输送组合物。亲和配体可以是具有结合金属过渡离子的单克隆抗体或金属亲和配体。组装的递送组合物可以配制成聚合物颗粒，然后可以将其冻干和重构用于体内递送非共价复合的抗原或具有实质天然活性的治疗性生物。

3. 发明申请

WO2009073814A2 OLIGO-ETHYLENE GLYCOL-BASED POLYMER COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：低聚乙二醇基聚合物组合物及其使用方法
公开(公告)号：WO2009073814A2
公开(公告)日：2009-06-11
申请号：PCT/US2008/085583
申请日：2008-12-04
申请人： MEDIVAS, LLC , CORNELL UNIVERSITY , CHU, Chih-Chang , KATSARAVA, Ramaz , GOMURASHVILI, Zaza, D. , TURNELL, William, G.
发明人： CHU, Chih-Chang , KATSARAVA, Ramaz , GOMURASHVILI, Zaza, D. , TURNELL, William, G.
IPC分类号： A61K9/14
CPC分类号： A61K47/34 , A61K9/0024 , C08G69/40 , C08G69/44 , C08G71/04 , C08G2230/00 , C08K5/0008 , C08L77/06 , C08L77/12
摘要： The invention provides biodegradable PEAs, PEURs and PEUs that are synthesized by solution polycondensation to include α-amino acids and oligo-ethylene ether segments in the polymer backbone. The polymers can be obtained by substituting oligo- ethylene glycol (OEG) for aliphatic di-acid and diols during their fabrication. Also provided are compositions in which bioactive agents are dispersed in the polymers. The compositions biodegrade by enzymatic action to release incorporated bioactive agents and oligo-ethylene glycol segments, which are fully biodegradable at a molecular weight less than 400 Da,. Due to their comparatively rapid surface enzymatic hydrolysis, the compositions can be used to deliver bioactive agents in a controlled manner within a relatively rapid delivery time, such as about 18 to 24 hours.
摘要翻译：本发明提供可生物降解的PEA，PEUR和PEU，其通过溶液缩聚合成以在聚合物骨架中包含α-氨基酸和低聚乙烯醚链段。聚合物可以通过在制造过程中用低聚乙二醇（OEG）取代脂肪族二酸和二醇来获得。还提供了生物活性剂分散在聚合物中的组合物。该组合物通过酶促作用生物降解以释放掺入的生物活性剂和低聚乙二醇片段，其在低于400Da的分子量下完全可生物降解。由于它们相对快速的表面酶水解，所述组合物可以用于在相对较快的传送时间内（例如约18至24小时）以受控方式传送生物活性剂。

4. 发明申请

WO2009026543A2 CATIONIC ALPHA-AMINO ACID-CONTAINING BIODEGRADABLE POLYMER GENE TRANSFER COMPOSITIONS 审中-公开
标题翻译：阳离子含α-氨基酸生物可降解聚合物基因转移组合物
公开(公告)号：WO2009026543A2
公开(公告)日：2009-02-26
申请号：PCT/US2008074069
申请日：2008-08-22
申请人： MEDIVAS LLC , TURNELL WILLIAM G , CRUZ-ARANDA GINA ANN , WU MARK MINZHI , CHANTUNG RONALD LEE , GOMURASHVILI ZAZA D , DEFIFE KRISTIN M
发明人： TURNELL WILLIAM G , CRUZ-ARANDA GINA ANN , WU MARK MINZHI , CHANTUNG RONALD LEE , GOMURASHVILI ZAZA D , DEFIFE KRISTIN M
IPC分类号： C08G63/48 , C12N15/11 , C12N15/87
CPC分类号： C12N15/111 , C08G69/44 , C12N15/87 , C12N2310/14 , C12N2320/32
摘要： The invention provides gene transfer compositions using as the gene carrier a biodegradable polymer that contains one or more cationic alpha amino acids, such as argininc or agmatine. The compositions form a tight soluble complex with a poly nucleic acid suitable for transfecting target cells to effect translation of the cargo poly nucleic acid by the target cell. Thus, such compounds are useful both in vitro and in vivo.
摘要翻译：本发明提供了使用含有一种或多种阳离子α氨基酸（例如精氨酸或胍丁胺）的生物可降解聚合物作为基因载体的基因转移组合物。该组合物与多核酸形成紧密可溶性复合物，所述多核酸适合于转染靶细胞以实现靶多孔性核酸的翻译。因此，这样的化合物在体外和体内都是有用的。

5. 发明申请

WO2006132950A3 THERAPEUTIC POLYMERS AND METHODS OF USE 审中-公开
标题翻译：治疗性聚合物及其使用方法
公开(公告)号：WO2006132950A3
公开(公告)日：2007-06-14
申请号：PCT/US2006021395
申请日：2006-06-02
申请人： MEDIVAS LLC , TURNELL WILLIAM G , GOMURASHVILI ZAZA D , KATSARAVA RAMAZ
发明人： TURNELL WILLIAM G , GOMURASHVILI ZAZA D , KATSARAVA RAMAZ
IPC分类号： A61K31/74 , A61K31/785 , C08F20/00
CPC分类号： A61K48/0041 , A61K31/785 , A61K47/58 , A61K47/59 , A61K47/593 , A61K47/595 , C08G71/04 , C08L77/12
摘要： The present invention provides biodegradable therapeutic polymer compositions based on poly(ester amide) (PEA), poly(ester urethane) (PEUR), and poly(ester urea) (PEU) polymers useful for in vivo delivery of at least one therapeutic diol or di-acid incorporated into the backbone of the biodegradable polymer. The therapeutic polymer compositions biodegrade in vivo by enzymatic action to release therapeutic diols or di-acids from the polymer backbone in a controlled manner over time. The invention compositions are stable, can be lyophilized for transportation and storage, and can be redispersed for administration. Due to structural properties of the PEA and PEUR polymers used, the invention therapeutic polymer compositions provide for high loading of the therapeutic diol or di-acid, as well as optional bioactive agents.
摘要翻译：本发明提供了可用于体内递送至少一种治疗性二醇的聚（酯酰胺）（PEA），聚（酯聚氨酯）（PEUR）和聚（酯尿素）（PEU）聚合物的可生物降解的治疗性聚合物组合物，二酸掺入可生物降解聚合物的骨架中。治疗性聚合物组合物通过酶作用在体内生物降解，以随时间的控制方式从聚合物主链释放治疗性二醇或二酸。本发明组合物是稳定的，可以冻干运输和储存，并且可以再分散用于给药。由于所使用的PEA和PEUR聚合物的结构性质，本发明的治疗性聚合物组合物提供治疗性二醇或二酸的高负载量以及任选的生物活性剂。

6. 发明申请

WO2009137711A1 BIODEGRADABLE METAL-CHELATING POLYMERS AND VACCINES 审中-公开
标题翻译：生物可降解金属螯合聚合物和疫苗
公开(公告)号：WO2009137711A1
公开(公告)日：2009-11-12
申请号：PCT/US2009/043192
申请日：2009-05-07
申请人： MEDIVAS, LLC , TURNELL, William, G. , GOMURASHVILI, Zaza, D. , PARCHER, Benjamin, W. , HUGHES, Jonathan , ANDERL, Jeffrey, N.
发明人： TURNELL, William, G. , GOMURASHVILI, Zaza, D. , PARCHER, Benjamin, W. , HUGHES, Jonathan , ANDERL, Jeffrey, N.
IPC分类号： A61M37/00 , C08F283/04
CPC分类号： C08F283/04 , A61K47/593 , A61K47/595 , A61K47/60 , A61K47/6935 , A61K49/0047 , A61K49/0093 , A61K49/128 , C08G69/44 , C08G73/028 , C08L77/12 , C08L79/02
摘要： The invention provides metal-chelating poly (ether amide) polymers useful in preparation of polymer compositions for delivering a variety of cargo molecules, such as bioactive agents. In solution metal ions and cargo molecules, such as vaccine epitopes, that include metal avid amino acids can be loaded into the polymer compositions and held in a non-covalent complex. Nanoparticles of such polymer compositions can also be prepared directly from the solution.
摘要翻译：本发明提供了可用于制备用于递送各种货物分子的生物活性剂的聚合物组合物的金属螯合聚（醚酰胺）聚合物。在溶液中，金属离子和货物分子，如疫苗表位，包括金属氨基酸，可加载到聚合物组合物中并保持在非共价复合物中。这种聚合物组合物的纳米颗粒也可以直接从溶液制备。

7. 发明申请

WO2005112587A3 WOUND HEALING POLYMER COMPOSITIONS AND METHODS FOR USE THEREOF 审中-公开
标题翻译：创伤治疗聚合物组合物及其使用方法
公开(公告)号：WO2005112587A3
公开(公告)日：2009-04-09
申请号：PCT/US2005016678
申请日：2005-05-12
申请人： MEDIVAS LLC , CARPENTER KENNETH W , ZHANG HUASHI , MCCARTHY BRENDAN J , SZINAI ISTVAN , TURNELL WILLIAM G , GOPALAN SINDHU M , KATSARAVA RAMAZ
发明人： CARPENTER KENNETH W , ZHANG HUASHI , MCCARTHY BRENDAN J , SZINAI ISTVAN , TURNELL WILLIAM G , GOPALAN SINDHU M , KATSARAVA RAMAZ
IPC分类号： A61K47/00
CPC分类号： A61K35/44 , A61K9/0024 , A61K38/00 , A61K47/34 , A61K47/59 , A61K47/593 , A61K47/595 , A61L15/26 , A61L15/44 , A61L15/60 , A61L15/64 , A61L26/0019 , A61L26/0066 , A61L31/10 , A61L31/148 , A61L2300/252 , A61L2300/412 , A61L2300/414 , A61L2300/416 , A61L2300/604 , A61L2300/64 , C08L77/12 , C08L79/02
摘要： The present invention provides bioactive polymer compositions that can be formulated to release a wound healing agent at a controlled rate by adjusting the various components of the composition. The composition can be used in an external wound dressing, as a polymer implant for delivery of the wound healing agent to an internal body site, or as a coating on the surface of an implantable surgical device to deliver wound healing agents that are covalently attached to a biocompatible, biodegradable polymer and/or embedded within a hydrogel. Methods of using the invention bioactive polymer compositions to promote natural healing of wounds, especially chronic wounds, are also provided. Examples of biodegradable copolymer polyesters useful in forming the blood-compatible, hydrophilic layer or coating include copolyester amides, copolyester urethanes, glycolide-lactide copolymers, glycolide-caprolactone copolymers, poly-3-hydroxy butyratevalerate copolymers, and copolymers of the cyclic diester monomer, 3(S)[(alkyloxycarbonyl)methyl]-1,4-dioxane-2,5-dione, with L-lactide. The glycolide-lactide copolymers include poly(glycolide-L-lactide) copolymers formed utilizing a monomer mole ratio of glycolic acid to L-lactic acid ranging from 5:95 to 95:5 and preferably a monomer mole ratio of glycolic acid to L-lactic acid ranging from 45:65 to 95:5. The glycolide-caprolactone copolymers include glycolide and e-caprolactone block copolymer, e.g., Monocryl or Poliglecaprone.
摘要翻译：本发明提供生物活性聚合物组合物，其可配制成通过调节组合物的各种组分以受控的速率释放伤口愈合剂。组合物可以用作外部伤口敷料，作为用于将伤口愈合剂递送到内部身体部位的聚合物植入物，或者作为可植入手术装置的表面上的涂层，以递送共价连接到生物相容的，可生物降解的聚合物和/或嵌入在水凝胶内。还提供了使用本发明生物活性聚合物组合物促进伤口，特别是慢性伤口的自然愈合的方法。可用于形成血液相容的亲水层或涂层的可生物降解的共聚物聚酯的实例包括共聚酯酰胺，共聚酯氨基甲酸酯，乙交酯 - 丙交酯共聚物，乙交酯 - 己内酯共聚物，聚-3-羟基丁酸戊酯共聚物，以及环状二酯单体的共聚物， 3（S）[（烷氧基羰基）甲基] -1,4-二恶烷-2,5-二酮与L-丙交酯。乙交酯 - 丙交酯共聚物包括使用乙醇酸与L-乳酸的单体摩尔比为5:95至95:5的聚（乙交酯-L-丙交酯）共聚物，优选乙醇酸与L-乳酸的单体摩尔比，乳酸范围为45:65至95:5。乙交酯 - 己内酯共聚物包括乙交酯和ε-己内酯嵌段共聚物，例如Monocryl或Poliglecaprone。

8. 发明申请

WO2009026543A3 CATIONIC ALPHA-AMINO ACID-CONTAINING BIODEGRADABLE POLYMER GENE TRANSFER COMPOSITIONS 审中-公开
公开(公告)号：WO2009026543A3
公开(公告)日：2009-02-26
申请号：PCT/US2008/074069
申请日：2008-08-22
申请人： MEDIVAS, LLC , TURNELL, William, G. , CRUZ-ARANDA, Gina, Ann , WU, Mark, Minzhi , CHANTUNG, Ronald, Lee , GOMURASHVILI, Zaza, D. , DEFIFE, Kristin, M.
发明人： TURNELL, William, G. , CRUZ-ARANDA, Gina, Ann , WU, Mark, Minzhi , CHANTUNG, Ronald, Lee , GOMURASHVILI, Zaza, D. , DEFIFE, Kristin, M.
IPC分类号： C08G63/48
摘要： The invention provides gene transfer compositions using as the gene carrier a biodegradable polymer that contains one or more cationic alpha amino acids, such as argininc or agmatine. The compositions form a tight soluble complex with a poly nucleic acid suitable for transfecting target cells to effect translation of the cargo poly nucleic acid by the target cell. Thus, such compounds are useful both in vitro and in vivo.

9. 发明申请

WO2008082721A2 POLYMER-STABILIZED LIPOSOMAL COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：聚合物稳定的脂肪组合物和使用方法
公开(公告)号：WO2008082721A2
公开(公告)日：2008-07-10
申请号：PCT/US2007/077561
申请日：2007-09-04
申请人： MEDIVAS, LLC , TURNELL, William, G. , LANDIS, Geoffrey, C. , PARCHER, Benjamin, W. , DOMINGUEZ, Alan
发明人： TURNELL, William, G. , LANDIS, Geoffrey, C. , PARCHER, Benjamin, W. , DOMINGUEZ, Alan
IPC分类号： A61K48/00 , A61K38/28 , C08F20/00 , A61K9/14
CPC分类号： C12N15/88 , A61K9/1075 , A61K9/1271 , A61K9/1272 , A61K9/1277 , A61K9/19 , A61K9/4891 , A61K38/28 , C08F20/00
摘要： The invention provides liposomal particle compositions, which incorporate a lipophilic biodegradable polymer, such as amino acid-containing polyester amide (PEA), polyester urethane (PEUR), and polyester urea (PEU), throughout the particles to stabilize (he composition for in vivo delivery in of an incorporated biologic agent For oral delivery, a biologic, such as insulin, is conjugated directly to the polymer Lipids in the particle are selected to further stabilize the composition during fabrication and digestion, providing sustained delivery of the biologic with native activity Methods of making and using the invention compositions to administer the biologic agent in vivo are also included.
摘要翻译：本发明提供脂质体颗粒组合物，其在整个颗粒中掺入亲脂性生物可降解聚合物，例如含氨基酸的聚酯酰胺（PEA），聚酯聚氨酯（PEUR）和聚酯尿素（PEU））以稳定（组合物用于体内输入的并入的生物制剂对于口服递送，生物制剂如胰岛素直接与聚合物结合选择颗粒中的脂质以在制备和消化期间进一步稳定组合物，从而提供具有天然活性的生物制剂的持续递送方法也包括制造和使用本发明组合物以体内施用生物制剂。

10. 发明申请

WO2006132950A2 THERAPEUTIC POLYMERS AND METHODS OF USE 审中-公开
标题翻译：治疗性聚合物及其使用方法
公开(公告)号：WO2006132950A2
公开(公告)日：2006-12-14
申请号：PCT/US2006/021395
申请日：2006-06-02
申请人： MEDIVAS, LLC , TURNELL, William, G. , GOMURASHVILI, Zaza, D. , KATSARAVA, Ramaz
发明人： TURNELL, William, G. , GOMURASHVILI, Zaza, D. , KATSARAVA, Ramaz
IPC分类号： A61K48/00 , A61K31/785
CPC分类号： A61K48/0041 , A61K31/785 , A61K47/58 , A61K47/59 , A61K47/593 , A61K47/595 , C08G71/04 , C08L77/12
摘要： The present invention provides biodegradable therapeutic polymer compositions based on poly(ester amide) (PEA), poly(ester urethane) (PEUR), and poly(ester urea) (PEU) polymers useful for in vivo delivery of at least one therapeutic diol or di-acid incorporated into the backbone of the biodegradable polymer. The therapeutic polymer compositions biodegrade in vivo by enzymatic action to release therapeutic diols or di-acids from the polymer backbone in a controlled manner over time. The invention compositions are stable, can be lyophilized for transportation and storage, and can be redispersed for administration. Due to structural properties of the PEA and PEUR polymers used, the invention therapeutic polymer compositions provide for high loading of the therapeutic diol or di-acid, as well as optional bioactive agents.
摘要翻译：本发明提供了可用于体内递送至少一种治疗性二醇的聚（酯酰胺）（PEA），聚（酯聚氨酯）（PEUR）和聚（酯尿素）（PEU）聚合物的可生物降解的治疗性聚合物组合物，二酸掺入可生物降解聚合物的骨架中。治疗性聚合物组合物通过酶作用在体内生物降解，以随时间的控制方式从聚合物主链释放治疗性二醇或二酸。本发明组合物是稳定的，可以冻干运输和储存，并且可以再分散用于给药。由于所使用的PEA和PEUR聚合物的结构性质，本发明的治疗性聚合物组合物提供治疗性二醇或二酸的高负载量以及任选的生物活性剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式