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1. 发明申请

WO2009032509A1 NUCLEIC ACID SEQUENCING BY SELECTIVE EXCITATION OF MICROPARTICLES 审中-公开
标题翻译：通过选择性激活微阵列进行核酸序列测序
公开(公告)号：WO2009032509A1
公开(公告)日：2009-03-12
申请号：PCT/US2008/073349
申请日：2008-08-15
申请人： LIGHTSPEED GENOMICS, INC. , HONG, Stanley, S. , RYU, Jekwan , PARK, Jong, Buhm
发明人： HONG, Stanley, S. , RYU, Jekwan , PARK, Jong, Buhm
IPC分类号： C12Q1/68 , G01N21/45
CPC分类号： G06K9/00 , C12Q1/6869 , G01N21/6428 , G06K2209/07 , Y10T436/143333 , C12Q2563/107 , C12Q2563/149
摘要： Nucleic acid microparticles are sequenced by performing a sequencing reaction on the microparticles using one or more reagents, selectively exciting the microparticles in an excitation pattern, optically imaging the microparticles at a resolution insufficient to resolve individual microparticles, and processing the optical images of the microparticles using information on the excitation pattern to determine the presence or absence of the optical signature, which indicates the sequence information of the nucleic acid. An apparatus for optical excitation of the microparticles comprises an optical fiber delivering a first laser beam, and an interference pattern generation module coupled to the optical fiber. The interference pattern generation module splits the first laser beam into second and third laser beams and generates the excitation pattern for selectively exciting the microparticles by interference between the second and third laser beams.
摘要翻译：通过使用一种或多种试剂对微粒进行测序反应来对核酸微粒进行测序，选择性地以激发图案激发微粒，以不足以分辨各个微粒的分辨率光学成像微粒，并使用以下方式处理微粒的光学图像关于激发模式的信息以确定光学特征的存在或不存在，其指示核酸的序列信息。用于微粒的光激发的装置包括传送第一激光束的光纤和耦合到光纤的干涉图案生成模块。干涉图案生成模块将第一激光束分割成第二和第三激光束，并产生用于通过第二和第三激光束之间的干涉选择性地激发微粒的激励图案。

2. 发明申请

WO2009032510A1 APPARATUS FOR SELECTIVE EXCITATION OF MICROPARTICLES 审中-公开
标题翻译：选择性激活微生物的装置
公开(公告)号：WO2009032510A1
公开(公告)日：2009-03-12
申请号：PCT/US2008/073353
申请日：2008-08-15
申请人： LIGHTSPEED GENOMICS, INC. , HONG, Stanley, S. , RYU, Jekwan , PARK, Jong, Buhm
发明人： HONG, Stanley, S. , RYU, Jekwan , PARK, Jong, Buhm
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , B01J19/0046 , B01L7/52 , G01N21/6452 , G01N33/54366 , G01N33/54373
摘要： Nucleic acid microparticles are sequenced by performing a sequencing reaction on the microparticles using one or more reagents, selectively exciting the microparticles in an excitation pattern, optically imaging the microparticles at a resolution insufficient to resolve individual microparticles, and processing the optical images of the microparticles using information on the excitation pattern to determine the presence or absence of the optical signature, which indicates the sequence information of the nucleic acid. An apparatus for optical excitation of the microparticles comprises an optical fiber delivering a first laser beam, and an interference pattern generation module coupled to the optical fiber. The interference pattern generation module splits the first laser beam into second and third laser beams and generates the excitation pattern for selectively exciting the microparticles by interference between the second and third laser beams.
摘要翻译：通过使用一种或多种试剂对微粒进行测序反应来对核酸微粒进行测序，选择性地以激发图案激发微粒，以不足以分辨各个微粒的分辨率光学成像微粒，并使用以下方式处理微粒的光学图像关于激发模式的信息以确定光学特征的存在或不存在，其指示核酸的序列信息。用于微粒的光激发的装置包括传送第一激光束的光纤和耦合到光纤的干涉图案生成模块。干涉图案生成模块将第一激光束分割成第二和第三激光束，并产生用于通过第二和第三激光束之间的干涉选择性地激发微粒的激励图案。

3. 发明申请

WO2011116175A1 SYNTHETIC APERTURE OPTICS IMAGING METHOD USING MINIMUM SELECTIVE EXCITATION PATTERNS 审中-公开
标题翻译：使用最小选择性激励模式的合成孔径光学成像方法
公开(公告)号：WO2011116175A1
公开(公告)日：2011-09-22
申请号：PCT/US2011/028792
申请日：2011-03-17
申请人： LIGHTSPEED GENOMICS, INC. , PARK, Jong, Buhm
发明人： PARK, Jong, Buhm
IPC分类号： G03H1/04
CPC分类号： G01N21/6458 , G01N15/1434 , G01N2015/145 , G01N2201/0635
摘要： A synthetic aperture optics (SAO) imaging method minimizes the number of selective excitation patterns used to illuminate the imaging target, based on the objects' physical characteristics corresponding to spatial frequency content from the illuminated target and/or one or more parameters of the optical imaging system used for SAO. With the minimized number of selective excitation patterns, the time required to perform SAO is reduced dramatically, thereby allowing SAO to be used with DNA sequencing applications that require massive parallelization for cost reduction and high throughput. In addition, an SAO apparatus optimized to perform the SAO method is provided. The SAO apparatus includes a plurality of interference pattern generation modules that can be arranged in a half- ring shape.
摘要翻译：基于对象对应于来自被照射的目标的空间频率内容的物理特性和/或光学成像的一个或多个参数，合成孔径光学（SAO）成像方法最小化用于照射成像目标的选择性激发图案的数量系统用于SAO。使用最小数量的选择性激发模式，执行SAO所需的时间显着降低，从而允许SAO与需要大规模并行化以降低成本和高吞吐量的DNA测序应用一起使用。另外，提供了优化以执行SAO方法的SAO装置。 SAO装置包括可以布置成半环形状的多个干涉图案生成模块。

4. 发明申请

WO2011116178A1 ILLUMINATION APPARATUS OPTIMIZED FOR SYNTHETIC APERTURE OPTICS IMAGING USING MINIMUM SELECTIVE EXCITATION PATTERNS 审中-公开
标题翻译：使用最小选择性激励模式优化合成孔径光学成像的照明设备
公开(公告)号：WO2011116178A1
公开(公告)日：2011-09-22
申请号：PCT/US2011/028796
申请日：2011-03-17
申请人： LIGHTSPEED GENOMICS, INC. , LEE, Chun-Sheu , PARK, Jong, Buhm
发明人： LEE, Chun-Sheu , PARK, Jong, Buhm
IPC分类号： H04N9/47
CPC分类号： G02B27/58 , G02B21/06 , G02B21/18 , G02B21/367 , G06K9/00134 , G06K9/0014 , G06T5/001 , G06T5/50 , G06T7/0012 , G06T2207/10056 , G06T2207/30072
摘要： A synthetic aperture optics (SAO) imaging method minimizes the number of selective excitation patterns used to illuminate the imaging target, based on the objects' physical characteristics corresponding to spatial frequency content from the illuminated target and/or one or more parameters of the optical imaging system used for SAO. With the minimized number of selective excitation patterns, the time required to perform SAO is reduced dramatically, thereby allowing SAO to be used with DNA sequencing applications that require massive parallelization for cost reduction and high throughput. In addition, an SAO apparatus optimized to perform the SAO method is provided. The SAO apparatus includes a plurality of interference pattern generation modules that can be arranged in a half- ring shape.
摘要翻译：基于对象对应于来自被照射的目标的空间频率内容的物理特性和/或光学成像的一个或多个参数，合成孔径光学（SAO）成像方法最小化用于照射成像目标的选择性激发图案的数量系统用于SAO。使用最小数量的选择性激发模式，执行SAO所需的时间显着降低，从而允许SAO与需要大规模并行化以降低成本和高吞吐量的DNA测序应用一起使用。另外，提供了优化以执行SAO方法的SAO装置。 SAO装置包括可以布置成半环形状的多个干涉图案生成模块。

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