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1. 发明申请

WO2013029021A1 COMPOSITIONS AND METHODS FOR DETECTION OF MULTIPLE MICROORGANISMS 审中-公开
标题翻译：用于检测多种微生物的组合物和方法
公开(公告)号：WO2013029021A1
公开(公告)日：2013-02-28
申请号：PCT/US2012/052383
申请日：2012-08-24
申请人： LIFE TECHNOLOGIES CORPORATION , TEBBS, Robert , CUMMINGS, Craig , BRZOSKA, Pius , MATHENY, Sharon , O'CONNELL, Catherine , FURTADO, Manohar , FANG, Rixun , PETRAUSKENE, Olga , LIEW, Sueh-Ning , SCHUMAKER, Michael
发明人： TEBBS, Robert , CUMMINGS, Craig , BRZOSKA, Pius , MATHENY, Sharon , O'CONNELL, Catherine , FURTADO, Manohar , FANG, Rixun , PETRAUSKENE, Olga , LIEW, Sueh-Ning , SCHUMAKER, Michael
IPC分类号： C12Q1/68
CPC分类号： C12Q1/686 , C12Q1/689 , C12Q2600/16
摘要： The present teachings describe compositions, methods and kits for detection of one or multiple microorganism contaminants in samples. Some embodiments relate to detecting one or more microorganisms producing virulence factors such as a shiga toxin ( stx ) or an eae . In some embodiments, compositions, methods and kits can detect and identify individual strains and serotypes of shiga toxin producing microorganisms. Some embodiments describe compositions, methods and kits for detecting STEC microbes. Workflows for multiple microbe detection and identification are also described.
摘要翻译：本教导描述了用于检测样品中一种或多种微生物污染物的组合物，方法和试剂盒。一些实施方案涉及检测产生毒力因子（例如志贺毒素（stx）或eae）的一种或多种微生物。在一些实施方案中，组合物，方法和试剂盒可以检测和鉴定产生志贺毒素的微生物的个体菌株和血清型。一些实施方案描述了用于检测STEC微生物的组合物，方法和试剂盒。还描述了用于多个微生物检测和鉴定的工作流程。

2. 发明申请

WO2011053871A2 MULTI-PRIMER ASSAY FOR MYCOPLASMA DETECTION 审中-公开
标题翻译：多发性骨髓瘤检测
公开(公告)号：WO2011053871A2
公开(公告)日：2011-05-05
申请号：PCT/US2010/054867
申请日：2010-10-29
申请人： LIFE TECHNOLOGIES CORPORATION , PETRAUSKENE, Olga , BRZOSKA, Pius , BIT, Somaya , LIU, Jen-Kuei , TEBBS, Robert , FURTADO, Manohar
发明人： PETRAUSKENE, Olga , BRZOSKA, Pius , BIT, Somaya , LIU, Jen-Kuei , TEBBS, Robert , FURTADO, Manohar
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/689 , C12Q2600/16
摘要： Disclosed is a multi-primer amplification assay, method and kits for detecting Mycoplasma species and closely related species utilizing a plurality of oligonucleotide primers in contact with a sample in a single vessel and detecting the amplification product, wherein the presence of an amplification product indicates Mycoplasma in the sample.
摘要翻译：公开了利用与单个容器中的样品接触的多个寡核苷酸引物并检测扩增产物的用于检测支原体物种和紧密相关物种的多引物扩增测定法，方法和试剂盒，其中扩增产物的存在表明样品中的支原体。

3. 发明申请

WO2010132832A1 E. COLI O157:H7 SPECIFIC ASSAY 审中-公开
标题翻译：大肠杆菌O157：H7特异性测定
公开(公告)号：WO2010132832A1
公开(公告)日：2010-11-18
申请号：PCT/US2010/034998
申请日：2010-05-14
申请人： LIFE TECHNOLOGIES CORPORATION , VATTA, Paolo , PETRAUSKENE, Olga , FURTADO, Manohar , BRZOSKA, Pius , WONG, Lily , BARKER, Melissa , CUMMINGS, Craig, A.
发明人： VATTA, Paolo , PETRAUSKENE, Olga , FURTADO, Manohar , BRZOSKA, Pius , WONG, Lily , BARKER, Melissa , CUMMINGS, Craig, A.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12Q2600/142
摘要： Disclosed are assays, methods and kits for the specific detection of E. coli 0157:H7 and not E. coli O55:H7 from complex food matrices, water, a beverage sample, a fermentation broth, a forensic sample, an environmental sample ( e.g. , soil, dirt, garbage, sewage, air, or water), including food processing and manufacturing surfaces, or a biological sample.
摘要翻译：公开了用于特异性检测大肠杆菌0157：H7而不是大肠杆菌O55：H7的测定，方法和试剂盒，来自复合食物基质，水，饮料样品，发酵液，法医样品，环境样品（例如，土壤，污垢，垃圾，污水，空气或水），包括食品加工和制造表面，或生物样品。

4. 发明申请

WO2012174119A2 COMPOSITIONS AND METHODS FOR DETECTION OF CRONOBACTER SPP. AND CRONOBACTER SPECIES AND STRAINS 审中-公开
标题翻译：用于检测CRONOBACTER SPP的组合物和方法。和克隆物种和菌株
公开(公告)号：WO2012174119A2
公开(公告)日：2012-12-20
申请号：PCT/US2012/042263
申请日：2012-06-13
申请人： LIFE TECHNOLOGIES CORPORATION , JI, Yongmei , SHIH, Sheung-Mei ("Rita") , DEGORICIJA, Lovorka , ZHOU, Zhaohui , CUMMINGS, Craig , FURTADO, Manohar , BRZOSKA, Pius , BURRELL, Angela , LEONG, Harrison , FANG, Xingwang , BOUNPHENG, Mangkey , SHAH, Rohan
发明人： JI, Yongmei , SHIH, Sheung-Mei ("Rita") , DEGORICIJA, Lovorka , ZHOU, Zhaohui , CUMMINGS, Craig , FURTADO, Manohar , BRZOSKA, Pius , BURRELL, Angela , LEONG, Harrison , FANG, Xingwang , BOUNPHENG, Mangkey , SHAH, Rohan
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12R1/01
摘要： Disclosed are genomic sequences for nine strains of C ronobacter spp . (C. sakazakii - 696, 701, 680; C. malonaticus - 507, 681; C. turicensis - 564; C. muytjensii - 530; C. dublinensis - 582; C. genomospl - 581) and compositions, methods, and kits for detecting, identifying and distinguishing C ronobacter spp . strains from each other and from non-C ronobacter spp . strains. Some embodiments describe isolated nucleic acid compositions unique to certain C ronobacter strains as well as compositions that are specific to all C ronobacter spp . Primer and probe compositions and methods of use of primers and probes are also provided. Kits for identification of C ronobacter spp . are also described. Some embodiments relate to computer software methods for setting a control based threshold for analysis of PCR
摘要翻译：公开了九个克罗杆菌属菌株的基因组序列。（C. sakazakii-696,701,680; C. malonaticus-507,681; C. turicensis-564; C. muytjensii-530; C.dublinensis-582; C.基因组蛋白-58）和组合物，方法和试剂盒用于检测，识别和鉴别克罗杆菌属。菌株彼此和非克罗杆菌属。株。一些实施方案描述了某些克罗杆菌菌株特有的分离的核酸组合物以及对所有克罗杆菌属特异性的组合物。还提供引物和探针组合物以及引物和探针的使用方法。克隆杆菌属鉴定试剂盒也被描述。一些实施例涉及用于设置用于PCR分析的基于控制的阈值的计算机软件方法

5. 发明申请

WO2008103770A3 MULTIPLEX COMPOSITIONS AND METHODS FOR QUANTIFICATION OF HUMAN NUCLEAR DNA AND HUMAN MALE DNA AND DETECTION OF PCR INHIBITORS 审中-公开
公开(公告)号：WO2008103770A3
公开(公告)日：2008-08-28
申请号：PCT/US2008/054477
申请日：2008-02-20
申请人： APPLERA CORPORATION , SHEWALE, Jaiprakash , FURTADO, Manohar , BRZOSKA, Pius , BARBISIN, Maura , FANG, Rixun , MALICDEM, Michael , O'SHEA, Cristin
发明人： SHEWALE, Jaiprakash , FURTADO, Manohar , BRZOSKA, Pius , BARBISIN, Maura , FANG, Rixun , MALICDEM, Michael , O'SHEA, Cristin
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04
摘要： The invention relates to a method for simultaneous quantification of human nuclear DNA and human male DNA in a biological sample while also detecting the presence of PCR inhibitors in a single reaction. The multiplex quantification method also provides a ratio of human nuclear and male DNA present in a biological sample. Such sample characterization is useful for achieving efficient and accurate results in downstream molecular techniques such as genotyping.

6. 发明申请

WO2012083189A2 METHODS, COMPOSITIONS, SYSTEMS, APPARATUSES AND KITS FOR NUCLEIC ACID AMPLIFICATION 审中-公开
标题翻译：用于核酸扩增的方法，组合物，系统，装置和试剂盒
公开(公告)号：WO2012083189A2
公开(公告)日：2012-06-21
申请号：PCT/US2011/065535
申请日：2011-12-16
申请人： LIFE TECHNOLOGIES CORPORATION , LI, Bin , LAO, Kai Qin , O'NEIL, Jennifer , KUNKEL, Jennifer , HALEY, Kellie , KASINSKAS, Rachel , MA, Zhaochun , BRZOSKA, Pius
发明人： LI, Bin , LAO, Kai Qin , O'NEIL, Jennifer , KUNKEL, Jennifer , HALEY, Kellie , KASINSKAS, Rachel , MA, Zhaochun , BRZOSKA, Pius
IPC分类号： C12Q1/68
CPC分类号： C12Q1/46 , C12P19/34 , C12Q1/6834 , C12Q1/6846 , C12Q1/6853 , C12Q1/6869 , C12Q1/6874 , C12Q2531/119 , C12Q2565/537
摘要： Novel methods of generating a localized population of immobilized clonal amplicons on a support are provided.
摘要翻译：提供了在支持物上产生固定化克隆扩增子的局部群体的新方法。

7. 发明申请

WO2013151648A1 COMPOSITIONS AND METHODS FOR DETECTION OF MICROORGANISMS OF THE MYCOBACTERIUM AVIUM COMPLEX EXCLUDING MYCOBACTERIUM AVIUM PARATUBERCULOSIS 审中-公开
标题翻译：用于检测MYCOBACTERIUM AVIUM复合物微生物的组合物和方法，不包括MYCOBACTERIUM AVIUM PARATUBERCULOSIS
公开(公告)号：WO2013151648A1
公开(公告)日：2013-10-10
申请号：PCT/US2013/029093
申请日：2013-03-05
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： CUMMINGS, Craig , BRZOSKA, Pius , BURRELL, Angela , O'CONNELL, Catherine
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12Q2600/112
摘要： Disclosed are compositions, assays, methods, diagnostic methods, kits and diagnostic kits for the specific and differential detection of a non-Mycobacterium avium subsp. paratuberculosis (non-MAP) organism, wherein a non-MAP organism is a Mycobacterium avium complex (MAC) organism that does not belong to the Mycobacterium avium subsp. paratuberculosis (MAP) organism, from samples including veterinary samples, clinical samples, food samples, forensic sample, an environmental sample (e.g., soil, dirt, garbage, sewage, air, or water), including food processing and manufacturing surfaces, or a biological sample. Exemplary non-MAP organisms including M. avium subsp. avium (MAA), M. avium subsp. hominissuis (MAH), and M. avium subsp. silvaticum (MAS) can be detected by the present compositions, kits and methods.
摘要翻译：公开了用于特异性和差异性检测非分枝杆菌鸟属亚种的组合物，测定，方法，诊断方法，试剂盒和诊断试剂盒。副结核病（非MAP）生物体，其中非MAP生物体是不属于鸟分枝杆菌亚种的鸟分枝杆菌复合体（MAC）生物体。来自包括兽医样品，临床样品，食品样品，法医样品，环境样品（如土壤，污垢，垃圾，污水，空气或水）在内的样品的副结核病（MAP）生物，包括食品加工和制造表面，或生物样品。示例性非MAP生物体，包括鸟分枝杆菌鸟类（MAA），鸟分枝杆菌山楂（MAH）和鸟分枝杆菌可以通过本发明的组合物，试剂盒和方法检测silvaticum（MAS）。

8. 发明申请

WO2021231827A2 SIRNA SEQUENCES TARGETING CORONAVIRUS-2 审中-公开
公开(公告)号：WO2021231827A2
公开(公告)日：2021-11-18
申请号：PCT/US2021/032391
申请日：2021-05-14
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： WICKHAM, Jonathan , BASKIN, Louise , PAGANI, Ioanna , BRZOSKA, Pius
IPC分类号： C12N15/113 , A61K31/713 , C12N15/1131 , C12N2310/14
摘要： Provided herein are compositions and methods useful for silencing RNA encoded by SARS-CoV-2. The compositions and methods can be used either in vitro (e.g., for research purposes), or in vitro (e.g., for therapeutic purposes). When administered to subjects who are afflicted with COVID-19, the compositions provided herein may facilitate recovery and/or ameliorate symptoms cause by SARS-CoV-2.

9. 发明申请

WO2017218938A1 NOVEL COMPOSITIONS, METHODS AND KITS FOR MICROORGANISM DETECTION 审中-公开
标题翻译：用于微生物检测的新型组合物，方法和试剂盒
公开(公告)号：WO2017218938A1
公开(公告)日：2017-12-21
申请号：PCT/US2017/037947
申请日：2017-06-16
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： PAGANI, Ioanna , BRZOSKA, Pius , LI, Kelly , PATEL, Sunali , HUANG, Boli , VARMA, Kamini , PURI, Nitin , DIAMOND, Evan
IPC分类号： C12Q1/68
摘要： Methods, compositions and kits for detecting microorganisms and/or profiling microbiota such as for example through use of nucleic acid amplification and detection.
摘要翻译：用于检测微生物和/或分析微生物群的方法，组合物和试剂盒，例如通过使用核酸扩增和检测。

10. 发明申请

WO2015143385A1 MULTI-COPY REFERENCE ASSAY 审中-公开
标题翻译：多重参考测量
公开(公告)号：WO2015143385A1
公开(公告)日：2015-09-24
申请号：PCT/US2015/021853
申请日：2015-03-20
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： MERRILL, David , BRZOSKA, Pius , LI, Zheng , LIN, Wendy , LEE, Wing , WONG, Mandi
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6851 , C12Q1/6858 , C12Q2600/156 , C12Q2600/158 , C12Q2600/166 , C12Q2537/16 , C12Q2543/10 , C12Q2545/101 , C12Q2547/107 , C12Q2561/101
摘要： A method, comprising amplifying a nucleic acid sequence of interest in a sample comprising genomic DNA of a subject; amplifying a reference nucleic acid sequence in the sample; quantifying the amplified sequence of interest relative to the amplified reference sequence; and determining a copy number of the sequence of interest from the relative quantified amplified sequence of interest. The reference sequence may have at least 80% sequence identity to at least one of SEQ ID NO:1-38, such as SEQ ID NO:1-13. Also disclosed are kits and compositions, each comprising a first probe which specifically hybridizes to at least a portion of at least one reference sequence. Also disclosed is a system configured to perform the above method.
摘要翻译：一种方法，包括在包含受试者的基因组DNA的样品中扩增目的核酸序列; 扩增样品中的参考核酸序列; 相对于扩增的参考序列量化扩增的感兴趣的序列; 以及从所述相关量化的放大感兴趣序列确定感兴趣序列的拷贝数。参考序列可以与SEQ ID NO：1-38中的至少一个具有至少80％的序列同一性，例如SEQ ID NO：1-13。还公开了试剂盒和组合物，每种试剂盒和组合物包含与至少一个参考序列的至少一部分特异性杂交的第一探针。还公开了配置为执行上述方法的系统。

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