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    • 4. 发明申请
    • 1-(3,4-DISUBSTITUTED)PHENYL-2-(3,4-DISUBSTITUTED)PHENYLETHANE COMPOUNDS AND USE THEREOF
    • 1-(3,4-取代的)苯基-2-(3,4-取代的)苯乙烯化合物及其用途
    • WO2016102472A1
    • 2016-06-30
    • PCT/EP2015/080801
    • 2015-12-21
    • L'OREAL
    • HITCE, JulienDALKO, MariaFRANTZ, Marie-Céline
    • C07C39/12C07C69/017C07C39/15C07C43/205C07C43/23C07C49/83C07C49/84A61K8/33A61Q19/00
    • C07C43/23A61K8/33A61K8/347A61K2800/522A61Q17/04A61Q19/08
    • The present invention relates to the cosmetic use, in a composition containing a physiologically acceptable medium, of at least one compound of formula (1): in which: - R 1 means a hydrogen atom, a linear or branched C 1 -C 6 alkyl radical; a benzyl radical; a linear or branched C 1 -C 6 alkylcarbonyl radical not conjugated with the carbonyl; or a linear or branched C 1 -C 6 alkoxycarbonyl, - R 2 means a hydrogen atom, a hydroxy! radical, a linear or branched C 1 -C 6 alkoxy radical; a benzyloxy radical; a linear or branched C 1 -C 6 alkylcarbonyloxy radical not conjugated with the carbonyl, or a linear or branched C 1 -C 6 alkoxycarbonyloxy radical, - R 3 means a hydrogen atom or a hydroxy! radical, on the understanding that R 3 means a hydrogen atom only in the cases where R 2 also means a hydrogen atom, and/or of an isomer and/or of a salt and/or of a solvate of the compound of formula (I), for protecting the skin and/or skin appendages against oxidative stress caused by exposure to UV radiation.
    • 本发明涉及至少一种式(1)化合物的含有生理学上可接受的介质的组合物的化妆品用途:其中:-R 1表示氢原子,直链或支链C 1 -C 6烷基; 苄基; 不与羰基缀合的直链或支链C 1 -C 6烷基羰基; 或直链或支链C 1 -C 6烷氧基羰基,-R 2表示氢原子,羟基, 自由基,直链或支链C 1 -C 6烷氧基; 苄氧基; 不与羰基共轭的直链或支链C 1 -C 6烷基羰基氧基,或直链或支链C 1 -C 6烷氧基羰氧基,-R 3表示氢原子或羟基。 基于这样的理解,只有在R2还表示氢原子的情况下,和/或式(I)的化合物的异构体和/或盐和/或溶剂化物的情况下,R 3表示氢原子, 用于保护皮肤和/或皮肤附件免受由于暴露于紫外线辐射引起的氧化应激。