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1. 发明申请

WO2017102349A1 PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS 审中-公开
标题翻译：使用硫代吡啶酮化合物来制备角蛋白材料的方法
公开(公告)号：WO2017102349A1
公开(公告)日：2017-06-22
申请号：PCT/EP2016/079394
申请日：2016-12-01
申请人： L'OREAL
发明人： MARAT, Xavier , GUEGUINIAT, Amélie , GREGOIRE, Sébastien , XU, Jinzhu , GUERREIRO, Patricio
IPC分类号： C07D213/82 , A61Q19/02 , A61K8/49
CPC分类号： A61Q19/02 , A61K8/4933 , C07D213/82
摘要： The invention relates to a cosmetic process for depigmenting, lightening and/or bleaching keratin materials, in particular the skin, comprising the application of a cosmetic composition comprising a compound of formula (I): compound of formula (I): (I) The invention also relates to the novel compounds of formula (I), to the compositions containing same and also to the cosmetic use of a compound (I) as an agent for bleaching, lightening and/or depigmenting keratin materials.
摘要翻译：本发明涉及用于使角蛋白材料特别是皮肤脱色素，亮白和/或漂白的美容方法，其包括施用包含式（I）化合物的化妆品组合物：式（I）的化合物：（I）本发明还涉及式（I）的新化合物，含有它的组合物以及化合物（I）作为漂白，增亮和/或脱色角蛋白材料

2. 发明申请

WO2012080075A1 PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS 审中-公开
标题翻译：使用噻吗啉酮化合物制备克拉霉素材料的方法
公开(公告)号：WO2012080075A1
公开(公告)日：2012-06-21
申请号：PCT/EP2011/072180
申请日：2011-12-08
申请人： L'OREAL , MARAT, Xavier
发明人： MARAT, Xavier
IPC分类号： C07D213/82 , A61K8/49 , A61Q19/02
CPC分类号： A61K8/4926 , A61K8/4933 , A61Q19/02 , C07D213/82
摘要： The invention relates to a cosmetic process for depigmenting, lightening and/or whitening keratin materials, in particular the skin, which comprises the application of a cosmetic composition comprising a compound of formula (I): or its tautomer form of formula (I) in which: R 1 and R 2 , which may be identical or different, denote a radical chosen from: a) a hydrogen atom; b) a C 1 -C 20 alkyl group optionally interrupted with N, S or O, optionally substituted with one or more group(s) chosen from -OR 3 , -SR 3 , -NR 3 R 4 , -CONHR3; -COOR 3 ; and an aryl group optionally substituted with one or more hydroxyls and/or with one or more C 1 -C 8 alkoxy radicals;c) a C 1 -C 8 alkyl group substituted with a C 5 -C 12 aryl radical optionally substituted with one or more hydroxyls and/or with one or more C 1 -C 8 alkoxy radicals; d) a phenyl group optionally substituted with one or more hydroxyls and/or with one or more C1-C8 alkoxy radicals; R3 denoting H or a C 1 -C 5 alkyl group, R 4 denoting H, a C 1 -C 5 hydrocarbon-based group or an acetyl group; it being possible for R 1 and R 2 to form, with the nitrogen atom which bears them, a ring chosen from pyrrolidine, pyrroline, piperidine, piperazine, morpholine, thiomorpholine and azepine. The invention also relates to the cosmetic use of a compound (I) or (I) as a whitening, lightening and/or depigmenting agent for keratin materials.
摘要翻译：本发明涉及一种用于脱色，减轻和/或增白角蛋白材料，特别是皮肤的美容方法，其包括将包含式（I）化合物或其式（I）的互变异构体形式的化妆品组合物应用于其中R1和R2可以相同或不同，表示选自以下的基团：a）氢原子; b）任选地被N，S或O中断的任选被一个或多个选自-OR 3，-SR 3，-NR 3 R 4，-CONHR 3的基团取代的C 1 -C 20烷基; -COOR 3; 任选被一个或多个羟基和/或一个或多个C 1 -C 8烷氧基取代的芳基; c）被任选被一个或多个羟基和/或任选取代的C 5 -C 12芳基取代的C 1 -C 8烷基与一个或多个C 1 -C 8烷氧基; d）任选被一个或多个羟基和/或与一个或多个C 1 -C 8烷氧基取代的苯基; R3表示H或C1-C5烷基，R4表示H，C1-C5烃基或乙酰基; R 1和R 2可以与带有它们的氮原子一起形成选自吡咯烷，吡咯啉，哌啶，哌嗪，吗啉，硫代吗啉和氮杂的环。本发明还涉及化合物（I）或（I）作为角蛋白材料的增白剂，增白剂和/或脱色剂的化妆用途。

3. 发明申请

WO2010040603A1 DITHIOLANE COMPOUNDS; COMPOSITIONS CONTAINING THEM; USES FOR PHOTOPROTECTING THE SKIN 审中-公开
标题翻译：二氢化合物包含它们的组合物; 用于光滑保护皮肤
公开(公告)号：WO2010040603A1
公开(公告)日：2010-04-15
申请号：PCT/EP2009/061277
申请日：2009-09-01
申请人： L'OREAL , MARAT, Xavier
发明人： MARAT, Xavier
IPC分类号： C07D339/04 , A61K31/385 , A61P17/18 , A61P39/06 , A61Q17/04 , A61Q19/08
CPC分类号： C07D339/04 , A61K8/4986 , A61K2800/522 , A61Q19/004 , A61Q19/007 , A61Q19/08
摘要： The present invention relates to novel dithiolane compounds of formula (I) below: formula (I), in which Y denotes 0, NR 1 or S; R 1 denotes a hydrogen atom; a saturated linear C 1 -C 20 or branched C 3 -C 20 or unsaturated C 2 -C 20 alkyl hydrocarbon- based group; an aryl group optionally substituted with one or more hydroxyls and/or with one or more C 1 -C 8 alkoxy radicals; R denotes a hydrogen atom; a saturated linear C 1 -C 20 or branched C 3 -C 20 or unsaturated C 2 -C 20 alkyl hydrocarbon- based group; a radical having the following formula (Ia), in which n = 0, 1, 2, 3 or 4; x = 0, 1, 2 or 3 and R 3 , which may be identical or different, denote a hydrogen atom or a linear or branched C 1 -C 4 alkyl such as methyl, ethyl or isopropyl; the radical 4-methyl dithiolane when Y denotes NH; when Y denotes NHR 1 and R 1 is other than hydrogen, R and Ri may form a ring. The invention also relates to the uses of these compounds for reinforcing the natural antioxidant protection of the skin against oxidative stress caused especially by UV radiation.
摘要翻译：本发明涉及式（I）的新型二硫戊环化合物：式（I），其中Y表示0，NR1或S; R1表示氢原子; 饱和直链C 1 -C 20或支链C 3 -C 20或不饱和C 2 -C 20烷基烃基; 任选被一个或多个羟基和/或与一个或多个C 1 -C 8烷氧基取代的芳基; R表示氢原子; 饱和直链C 1 -C 20或支链C 3 -C 20或不饱和C 2 -C 20烷基烃基; 具有下式（Ia）的基团，其中n = 0,1,2,3或4; x = 0,1,2或3，R 3可以相同或不同，表示氢原子或直链或支链C 1 -C 4烷基如甲基，乙基或异丙基; 当Y表示NH时，基团4-甲基二硫戊环; 当Y表示NHR1且R 1不是氢时，R和R 1可以形成环。本发明还涉及这些化合物用于增强皮肤的抗氧化保护对抗UV辐射特别引起的氧化应激的用途。

4. 发明申请

WO2018220020A3 RESORCINOL DERIVATIVES FOR THEIR COSMETIC USE 审中-公开
公开(公告)号：WO2018220020A3
公开(公告)日：2018-12-06
申请号：PCT/EP2018/064199
申请日：2018-05-30
申请人： L'OREAL
发明人： MARAT, Xavier , MA, Chunyu
IPC分类号： C07D319/06 , A61K8/37 , A61K8/42 , A61Q19/02 , C07C69/732 , C07C235/34 , C07C235/36 , C07D295/185
摘要： The invention relates to resorcinol-derived compounds of formula (I) and also the salts thereof, the solvates thereof and the optical and/or geometrical isomers thereof, including enantiomers and diastereoisomers, the racemic mixtures thereof, alone or as a mixture. The invention also relates to a cosmetic process for depigmenting, lightening and/or bleaching keratin materials, in particular the skin, using these compounds (I).

5. 发明申请

WO2018053706A1 COMPOSITION COMPRISING PAEONIFLORIN OR ALBIFLORIN ANALOGUE, METHOD OF PREPARATION THEREOF 审中-公开
标题翻译：含有芍药苷或阿拉伯林类似物的组合物，其制备方法
公开(公告)号：WO2018053706A1
公开(公告)日：2018-03-29
申请号：PCT/CN2016/099572
申请日：2016-09-21
申请人： L'OREAL , MA, Chunyu , JEULIN, Severine , MARAT, Xavier , DALKO-CSIBA, Maria , YU, Biao
发明人： MA, Chunyu , JEULIN, Severine , MARAT, Xavier , DALKO-CSIBA, Maria , YU, Biao
IPC分类号： C07H17/04 , C07H1/00 , A61K8/97 , A61Q19/02 , A61Q17/04
CPC分类号： C07H1/00 , A61K8/60 , A61K8/9789 , A61Q17/04 , A61Q19/02 , C07H17/04
摘要： A composition comprises a compound of formula (I) and at least one cosmetically acceptable carrier. It can be used for preventing or decreasing skin pigmentation and /or lightening skin tone.
摘要翻译：组合物包含式（I）的化合物和至少一种化妆品可接受的载体。它可以用于预防或减少皮肤色素沉着和/或美白肤色。

6. 发明申请

WO2017102802A1 RESORCINOL DERIVATIVES FOR THEIR COSMETIC USE 审中-公开
标题翻译：间苯二酚衍生物的美容用途
公开(公告)号：WO2017102802A1
公开(公告)日：2017-06-22
申请号：PCT/EP2016/080911
申请日：2016-12-14
申请人： L'OREAL
发明人： MARAT, Xavier , MA, Chunyu
IPC分类号： C07C235/34 , C07C235/36 , C07D295/185 , C07C231/02 , A61K8/42 , A61K8/49 , A61K8/60 , A61Q19/02
CPC分类号： C07C235/34 , A61K8/42 , A61K8/49 , A61K8/60 , A61Q19/02 , C07C231/02 , C07C235/36 , C07C2601/14 , C07D295/185
摘要： The present invention relates to a compound of formula (I) for its depigmenting, lightening and/or bleaching the skin in which R 1 and R 2 independently denote H, an alkyl radical, a radical S* denoting a monosaccharide sugar radical or a polysaccharide sugar radical, a radical COR6; R3 denotes a C 1 -C 20 alkyl radical; R4 and R5 independently denote H, a saturated C 1 -C 20 or unsaturated C 2 -C 20 or branched C 3 -C 20 , or cyclic C 3 -C 8 alkyl radical, which is optionally interrupted and/or optionally substituted; R7 and R8, which may be identical or different, being chosen from H, an unsaturated linear C 1 -C 10 alkyl group, an unsaturated linear C 2 -C 10 alkyl group, a saturated or unsaturated branched C 3 -C 10 alkyl group, and a C 3 -C 8 cycloalkyl group; a (C 1 -C 4 )alkyl(hetero)(C 6 )aryl group optionally containing a nitrogen atom, especially a benzyl group; an acetyl radical, and also the salts thereof, the solvates thereof and the optical and/or geometrical isomers thereof, and the racemic mixtures thereof, alone or as a mixture. The present invention also relates to novel compounds (II), and also to the process for preparing them and to a cosmetic process for depigmenting the skin using such compounds (I) or (II).
摘要翻译：本发明涉及式（I）的化合物，其用于使其皮肤脱色，增亮和/或漂白，其中R 1和R 2彼此不同，独立地表示H，烷基，表示单糖糖基或多糖糖基的基S *，基COR6; R3表示C 1 -C 20烷基; R 3表示C 1 -C 20烷基。 R4和R5独立地表示H，饱和的C 1 -C 20或不饱和的C 2 -C 20或支链C 3 -C 20或环C 3 -C 8烷基，其任选中断和 /或任选取代的; R 7和R 8可以相同或不同，选自H，不饱和的直链C 1 -C 10烷基，不饱和的直链C 2 -C 10烷基， C 10 -C 10烷基，饱和或不饱和的支链C 3 -C 10烷基和C≡C3 -C 10烷基 -C 8 - 环烷基; 任选含有氮原子，特别是苄基的（C 1 -C 4）烷基（杂）（C≡6）芳基; 乙酰基及其盐，其溶剂化物和其光学和/或几何异构体，及其外消旋混合物，其单独或作为混合物。本发明还涉及新型化合物（II），还涉及制备它们的方法以及使用这样的化合物（I）或（II）使皮肤脱色的美容方法。

7. 发明申请

WO2013189930A1 PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING NOVEL RESORCINOL-BASED COMPOUNDS 审中-公开
标题翻译：使用新型基于烯烃的化合物来制备克拉霉素材料的方法
公开(公告)号：WO2013189930A1
公开(公告)日：2013-12-27
申请号：PCT/EP2013/062623
申请日：2013-06-18
申请人： L'OREAL
发明人： MARAT, Xavier
IPC分类号： C07C69/732 , C07C235/34 , A61Q19/02 , C07D209/40 , C07D211/68 , C07D265/30
CPC分类号： A61Q19/02 , A61K8/42 , A61K8/44 , A61K8/492 , A61K8/4926 , C07C69/732 , C07C235/34 , C07C323/59 , C07C2601/14 , C07D265/30 , C07D307/33 , C07D313/08
摘要： Process for depigmenting keratin materials using novel resorcinol-based compounds The invention relates to compounds of formula (I): in which: · R denotes a hydrogen atom or an acetyl group; · Y denotes a radical chosen from OR' and NAR''; The invention also relates to a cosmetic process for depigmenting, lightening and/or bleaching keratin materials, especially the skin, using these compounds (I).
摘要翻译：使用新型间苯二酚类化合物脱色角蛋白材料的方法本发明涉及式（I）化合物：其中：R表示氢原子或乙酰基; ·Y表示选自OR'和NAR“的基团; 本发明还涉及使用这些化合物（I）脱色，减轻和/或漂白角蛋白材料，特别是皮肤的美容方法。

8. 发明申请

WO2022079122A1 USE OF THIOPYRIDINONE COMPOUNDS FOR PREVENTING THE FORMATION OF CUTANEOUS BLACKHEADS 审中-公开
公开(公告)号：WO2022079122A1
公开(公告)日：2022-04-21
申请号：PCT/EP2021/078360
申请日：2021-10-13
申请人： L'OREAL
发明人： PREVOT-GUEGUINIAT, Amélie , MARAT, Xavier , BILLONI, Nelly
IPC分类号： A61K8/49 , A61P17/10 , A61Q19/00
摘要： The present invention relates to the cosmetic use of at least one compound corresponding to the following formula (I) or (I') and also their salts, their solvates, their optical isomers and their racemates, as inhibitor of the black or brown colouration of comedones. It also relates to a cosmetic method for preventing the black or brown colouration of the comedones, comprising the topical application, to the skin, of a cosmetic composition comprising at least one compound corresponding to the formula (I) or (I').

9. 发明申请

WO2018210933A1 RESORCINOL DERIVATIVES FOR THEIR COSMETIC USE 审中-公开
公开(公告)号：WO2018210933A1
公开(公告)日：2018-11-22
申请号：PCT/EP2018/062742
申请日：2018-05-16
申请人： L'OREAL
发明人： MARAT, Xavier , MA, Chunyu
IPC分类号： C07F9/6571 , A61K8/55 , C07F9/38 , C07F9/40
摘要： The invention relates to resorcinol derivatives of formula (I) and also the salts thereof, the solvates thereof and the optical and/or geometrical isomers thereof, including enantiomers and diastereoisomers, and the racemic mixtures thereof, alone or as a mixture. The invention also relates to a cosmetic process for depigmenting, lightening and/or bleaching keratin materials, especially the skin, using these compounds (I).

10. 发明申请

WO2016146588A1 PROCEDE DE SYNTHESE DE NOUVEAUX COMPOSES DERIVES D'ACIDE 3-HYDROXY-CYCLOPENTYL ACETIQUE 审中-公开
标题翻译：合成来自3-羟基 - 环戊酸乙酸的新型化合物的方法
公开(公告)号：WO2016146588A1
公开(公告)日：2016-09-22
申请号：PCT/EP2016/055459
申请日：2016-03-14
申请人： L'OREAL
发明人： DALKO, Maria , MARAT, Xavier , HITCE, Julien , LI, Chao-Jun
IPC分类号： C07C45/69 , C07C47/222 , C07C49/597 , C07C45/61 , C07C51/38 , C07C62/02
CPC分类号： C07C59/11 , A61K8/365 , A61Q17/00 , A61Q19/00 , C07C45/54 , C07C45/69 , C07C51/09 , C07C51/38 , C07C59/54 , C07C59/56 , C07C59/72 , C07C67/347 , C07C69/675 , C07C69/732 , C07C69/734 , C07C69/757 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C59/48 , C07C47/27 , C07C47/273 , C07C49/747 , C07C69/716 , C07C69/738
摘要： La présente invention concerne des composés de formule (I) : dans laquelle R1 représente un atome d'hydrogène, un radical phényle ou un radical hydrocarboné, linéaire ou ramifié, saturé ou insaturé ayant 1 à 8 atomes de carbone.
摘要翻译：本发明涉及式（I）化合物：其中R 1为氢原子，苯基或具有1至8个碳原子的直链或支链，饱和或不饱和烃基。

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