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1. 发明申请

WO2009130469A1 DNA-PK INHIBITORS 审中-公开
标题翻译： DNA-PK抑制剂
公开(公告)号：WO2009130469A1
公开(公告)日：2009-10-29
申请号：PCT/GB2009001041
申请日：2009-04-24
申请人： KUDOS PHARM LTD , CANCER RESEARCH TECHNOLOGY LIM , FRIGERIO MARK , DUGGAN HEATHER MARY ELLEN , HUMMERSONE MARC GEOFFREY , MENEAR KEITH ALLAN , MARTIN NIALL MORRISON BARR , CANO CELINE , GRIFFIN ROGER JOHN , GOLDING BERNARD THOMAS , HARDCASTLE IAN ROBERT
发明人： CANCER RESEARCH TECHNOLOGY LIM , FRIGERIO MARK , DUGGAN HEATHER MARY ELLEN , HUMMERSONE MARC GEOFFREY , MENEAR KEITH ALLAN , MARTIN NIALL MORRISON BARR , CANO CELINE , GRIFFIN ROGER JOHN , GOLDING BERNARD THOMAS , HARDCASTLE IAN ROBERT
IPC分类号： C07D413/14 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/551 , A61P35/00 , C07D471/14
CPC分类号： C07D413/14 , C07D417/14
摘要： A compound of formula (I) wherein: R1 and R2 are independently selected from hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; and RN1 and RN2 are selected from hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms.
摘要翻译：式（I）的化合物，其中：R 1和R 2独立地选自氢，任选取代的C 1-7烷基，C 3-20杂环基或C 5-20芳基，或者可以与氮原子一起形成与它们相连的任选取代的具有4至8个环原子的杂环; 并且RN1和RN2选自氢，任选取代的C 1-7烷基，C 3-20杂环基或C 5-20芳基，或者可以与它们所连接的氮原子一起形成任选取代的具有4至8个环原子的杂环。

2. 发明申请

WO2008114023A3 PHTHALAZINONE DERIVATIVES 审中-公开
标题翻译：酞嗪酮衍生物
公开(公告)号：WO2008114023A3
公开(公告)日：2008-11-13
申请号：PCT/GB2008000990
申请日：2008-03-20
申请人： KUDOS PHARM LTD , MAYBRIDGE LTD , MENEAR KEITH ALLAN , HUMMERSONE MARC GEOFFREY , GOMEZ SYLVIE , JAVAID MUHAMMAD HASHIM , MARTIN NIALL MORRISON BARR , KERRIGAN FRANK
发明人： MENEAR KEITH ALLAN , HUMMERSONE MARC GEOFFREY , GOMEZ SYLVIE , JAVAID MUHAMMAD HASHIM , MARTIN NIALL MORRISON BARR , KERRIGAN FRANK
IPC分类号： C07D237/32 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/10 , C07D405/10 , C07D405/14 , C07D409/06 , C07D409/10 , C07D409/14 , C07D411/10 , C07D413/10 , C07D417/06 , C07D417/10 , C07D417/14
CPC分类号： C07D237/32 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/10 , C07D405/10 , C07D405/14 , C07D409/06 , C07D409/10 , C07D409/14 , C07D411/10 , C07D413/10 , C07D417/06 , C07D417/10 , C07D417/14
摘要： A compound of the formula (I) wherein: A and B together represent an optionally substituted, fused aromatic ring or an optionally substituted, fused cyclohexene ring; D is selected from: (i), where Y 1 is selected from CH and N, Y 2 is selected from CH and N, Y 3 is selected from CH, CF and N and Y 4 is selected from CH and N; (ii) where Y 1 is selected from CH and N and Y 2 is selected from CH and N; (iii) and where Q is O or S; and (iv), where Q is O or S; and R D is an optionally substituted C 5-20 aryl group, bound to D by a carbon-carbon bond.
摘要翻译：式（I）化合物，其中：A和B一起表示任选取代的稠合芳环或任选取代的稠合环己烯环; D选自：（i），其中Y 1选自CH和N，Y 2选自CH和N，Y 3 SUP >选自CH，CF和N且Y 4选自CH和N; （ii）其中Y 1选自CH和N并且Y 2选自CH和N; （iii）并且其中Q是O或S; 和（iv），其中Q是O或S; 并且R D是通过碳 - 碳键与D结合的任选取代的C 5至C 20芳基。

3. 发明申请

WO2007144652A3 PARP INHIBITORS 审中-公开
标题翻译： PARP抑制剂
公开(公告)号：WO2007144652A3
公开(公告)日：2008-04-10
申请号：PCT/GB2007002247
申请日：2007-06-15
申请人： KUDOS PHARM LTD , JAVAID MUHAMMAD HASHIM , GOMEZ SYLVIE , COCKCROFT XIAO-LING FAN , MENEAR KEITH ALLAN , MARTIN NIALL MORRISON BARR
发明人： JAVAID MUHAMMAD HASHIM , GOMEZ SYLVIE , COCKCROFT XIAO-LING FAN , MENEAR KEITH ALLAN , MARTIN NIALL MORRISON BARR
IPC分类号： C07D211/08 , A61K31/166 , A61K31/4015 , A61K31/435 , A61K31/45 , A61K31/497 , A61K31/55 , C07C235/60 , C07D211/34 , C07D211/70 , C07D217/02 , C07D225/02 , C07D241/04 , C07D243/08 , C07D405/02
CPC分类号： C07D211/34 , C07C235/60 , C07D211/08 , C07D211/70 , C07D217/02 , C07D225/02 , C07D241/04 , C07D243/08 , C07D405/02
摘要： A compound of the formula (I), and pharmaceutically acceptable salts thereof, wherein: R 2 , R 3 , R 4 and R 5 are independently selected from the group consisting of H, C 1-7 alkoxy, amino, halo or hydroxy; Y is -CR C1 R C2 -(CH 2 ) m -, where m is 0 or 1, R ci is selected from CH 3
摘要翻译：式（I）化合物及其药学上可接受的盐，其中：R 2，R 3，R 4和R 3 > 5 独立地选自H，C 1-7烷氧基，氨基，卤素或羟基; Y是-CR C 1 -C 2 - （CH 2）m - ，其中m是0或1， R 3选自CH 3 3

4. 发明申请

WO2006090167A3 HYDRAZINOMETHYL, HYDR ZONOMETHYL AND 5-MEMBERED HETEROCYLIC COMPOUNDS WHICH ACT AS MTOR INHIBITORS AND THEIR USE AS ANTI CANCER AGENTS 审中-公开
标题翻译：氢化二甲基丙烯酸，氢化二甲基乙烯基醚和作为MT抑制剂的5组分的杂环化合物及其用作抗癌剂
公开(公告)号：WO2006090167A3
公开(公告)日：2007-05-10
申请号：PCT/GB2006000668
申请日：2006-02-24
申请人： KUDOS PHARM LTD , HUMMERSONE MARC GEOFFREY , GOMEZ SYLVIE , MENEAR KEITH ALLAN , COCKCROFT XIAO-LING FAN , SMITH GRAEME CAMERON MURRAY
发明人： HUMMERSONE MARC GEOFFREY , GOMEZ SYLVIE , MENEAR KEITH ALLAN , COCKCROFT XIAO-LING FAN , SMITH GRAEME CAMERON MURRAY
IPC分类号： C07D251/70 , A61K31/506 , A61K31/517 , A61K31/53 , C07D403/04
CPC分类号： C07D251/70 , C07D239/48 , C07D239/50 , C07D239/94 , C07D295/135 , C07D403/04 , C07D403/12 , C07D405/04 , C07D413/12 , C07D417/04 , C07D471/04
摘要： Compounds of formula (I): A-B-C and isomers, salts, solvates, chemically protected forms, and prodrugs thereof wherein: B is selected from the group consisting of formula (i) where R N is H or Me; or B is a divalent C 5 heterocyclic residue containing one or two ring heteroatoms; A is formula (ii) R A3 and R A5 are independently selected from halo, OR O and R AC , where R O is H or Me, and R AC is H or C 1-4 alkyl; X A is selected from N and CR A4 , where R A4 is selected from H, OR O , CH 2 OH, CO 2 H, NHSO 2 Me and NHCOMe; R A2 and R A6 are independently selected from H, halo and OR O ; or R A3 and R A4 together with the carbon atoms to which they are attached, or RA2 and R A3 together with the carbon atoms to which they are attached, may form a C 5-6 heterocylic or heteroaromatic ring, containing at least one nitrogen ring atom; where if X is not N, 1 , 2, or 3 of R A2 to R A6 are not H; C is formula (iii) where X is selected from N and CH, Y is selected from N and CH, and Z is selected from N and CR C6 ; R C3 is selected from H, halo and an optionally substituted N-containing C 5-7 heterocyclic group; R C5 is a group selected from formula (iv) which group may be selected by one or two C 1-4 alkyl groups or a carboxy group; R C6 is H; or, when X and Y are N, R C5 and R C6 (when Z is CR C6 ) together with the carbon atoms to which they are attached may form a fused C 6 aromatic ring selected from the group consisting of formula (v).
摘要翻译：式（I）化合物：ABC及其异构体，盐，溶剂化物，化学保护形式及其前体药物，其中：B选自式（ⅰ），其中R N为H或Me ; 或B是含有一个或两个环杂原子的二价C 5 - 5杂环残基; A是式（ⅱ），R A3和R A5各自独立地选自卤素，O或O，其中R O是H或Me，且R AC是H或C 1-4烷基; 从其中R A4选自H，OR，O，CH，N， 2 OH，CO 2 H，NHSO 2 Me和NHCOMe; R A2和R A6各自独立地选自H，卤素和ORO; 或R A3与它们所连接的碳原子一起形成，或者与其连接的碳原子一起，或者R A2和R A3与其中的碳原子一起它们可以形成含有至少一个氮环原子的C 5〜6 - 杂环或杂芳环; 其中如果X不是N，则R A2与R A6之间的1,2或3不是H; C是式（ⅲ）其中X选自N和CH，Y选自N和CH，Z选自N和CR 6 C 6。 R 3选自H，卤素和任选取代的含N C的5-7杂环基; R 5是选自式（ⅳ）的基团，该基团可以被一个或两个C 1-4烷基或羧基选择; C 6 H 6是H; 或者当X和Y为N时，R 5和R 6 C（当Z为CR 6 C 6）时，与它们的碳原子一起可以形成选自由式（v）组成的组的稠合C 6芳香环。

5. 发明申请

WO2008047082A3 POLYMORPHIC FORM OF 4-[3-(4-CYCLOPROPANECARBONYL-PIPERAZINE-1-CARBONYL)-4-FLUORO-BENZYL]-2H-PHTHALAZIN-1-ONE 审中-公开
标题翻译： 4- [3-（4-环丙基羰基苯基 - 哌嗪-1-羰基）-4-氟 - 苄基] -2H-苯并咪唑-1-酮的多晶型
公开(公告)号：WO2008047082A3
公开(公告)日：2008-09-25
申请号：PCT/GB2007003888
申请日：2007-10-15
申请人： KUDOS PHARM LTD , MENEAR KEITH ALLAN , OTTRIDGE ANTHONY PETER , LONDESBROUGH DEREK JOHN , HALLETT MICHAEL RAYMOND , MULLHOLLAND KEITH RAYMOND , PITTAM JOHN DAVID , LAFFAN DAVID DERMOT PATRICK , ASHWORTH IAN WOODWARD , JONES MARTIN FRANCIS , CHERRYMAN JANETTE HELEN
发明人： MENEAR KEITH ALLAN , OTTRIDGE ANTHONY PETER , LONDESBROUGH DEREK JOHN , HALLETT MICHAEL RAYMOND , MULLHOLLAND KEITH RAYMOND , PITTAM JOHN DAVID , LAFFAN DAVID DERMOT PATRICK , ASHWORTH IAN WOODWARD , JONES MARTIN FRANCIS , CHERRYMAN JANETTE HELEN
IPC分类号： C07D237/32 , A61K31/502 , A61P35/00
CPC分类号： C07D237/32
摘要： 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one as crystalline Form A.
摘要翻译： 4- [3-（4-环丙烷羰基 - 哌嗪-1-羰基）-4-氟 - 苄基] -2H-酞嗪-1-酮，为晶型A.

6. 发明申请

WO2004080976A8 PHTHALAZINONE DERIVATIVES 审中-公开
标题翻译：苯乙烯酮衍生物
公开(公告)号：WO2004080976A8
公开(公告)日：2006-01-05
申请号：PCT/GB2004001059
申请日：2004-03-12
申请人： KUDOS PHARM LTD , MAYBRIDGE LTD
发明人： MARTIN NIALL MORRISON BARR , SMITH GRAEME CAMERON MURRAY , JACKSON STEPHEN PHILIP , LOH VINCENT JUNIOR M , COCKCROFT XIAO-LING FAN , MATTHEWS IAN TIMOTHY WILLIAMS , MENEAR KEITH ALLAN , KERRIGAN FRANK , ASHWORTH ALAN
IPC分类号： A61K31/00 , A61P31/20 , C07D237/32 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/20 , C07D491/04 , C07D495/04 , A61K31/502 , C07D407/12
CPC分类号： C07D403/10 , A61K31/00 , C07D237/32 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D491/04 , C07D495/04
摘要： Compounds of the formula (I): wherein A and B together represent an optionally substituted, fused aromatic ring; X can be NR
摘要翻译：式（I）的化合物：其中A和B一起表示任选取代的稠合芳环; X可以是NR

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