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1. 发明申请

WO2007008016A1 A COMPOUND COMPRISING PRODIGIOSIN ISOLATED FROM SERRATIA MARCESCENCE B-1231 KCTC 0386BP FOR PROVENTION AND TREATMENT OF ACUTE GRAFT-VERSUS-HOST DISEASE 审中-公开
标题翻译：包含从SERRATIA MARCESCENCE B-1231 KCTC 0386BP分离的原核生物的化合物用于急性冠状动脉病毒的预防和治疗
公开(公告)号：WO2007008016A1
公开(公告)日：2007-01-18
申请号：PCT/KR2006/002700
申请日：2006-07-10
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , KIM, Hwan Mook , HAN, Sang Bae , LEE, Chang Woo , LEE, Ki Hoon , PARK, Sung Kyu , LEE, Ki Ho , KANG, Jong Soon , YOON, Won Kee , KIM, Young Kook
发明人： KIM, Hwan Mook , HAN, Sang Bae , LEE, Chang Woo , LEE, Ki Hoon , PARK, Sung Kyu , LEE, Ki Ho , KANG, Jong Soon , YOON, Won Kee , KIM, Young Kook
IPC分类号： A61K31/4025 , A61P37/06
CPC分类号： C12P17/10
摘要： This invention relates to a composition for the prevention and treatment of acute graft-versus-host disease comprising prodigiosin isolated from Serratia marcescence B- 1231 KCTC 0386BP, as an effective ingredient. The prodigiosin is immunosuppressive by selectively suppressing the proliferation of T-cells through the suppression of the expression of IL-2 receptors, which is needed for the activation of T-cells. Prodigiosin can be used either alone or in conjunction with cyclosporin A for greater effect, since the two substances have different mode of actions. These make prodigiosin effective for the prevention and treatment of acute graft-versus-host disease.
摘要翻译：本发明涉及一种用于预防和治疗急性移植物抗宿主病的组合物，其包含从沙雷氏菌属（Serratia marcescence）B1231KCTC 0386BP分离的生殖细胞因子作为有效成分。通过抑制T细胞活化所需的IL-2受体的表达，通过选择性抑制T细胞的增殖，产前抑素是免疫抑制的。由于两种物质具有不同的作用模式，因此可以单独使用或与环孢菌素A联合使用。这些使癌细胞生成素有效预防和治疗急性移植物抗宿主病。

2. 发明申请

WO2007037627A1 PHARMACEUTICAL COMPOSITION COMPRISING POLYSACCHARIDES FROM ANGELICA GIGAS NAKAI FOR PREVENTION AND TREATMENT OF CANCER DISEASE 审中-公开
标题翻译：包括来自安哥拉GIGAS NAKAI的多糖的药物组合物用于预防和治疗癌症疾病
公开(公告)号：WO2007037627A1
公开(公告)日：2007-04-05
申请号：PCT/KR2006/003880
申请日：2006-09-28
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , KIM, Hwan Mook , HAN, Sang Bae , LEE, Chang Woo , LEE, Ki Hoon , PARK, Sung Kyu , LEE, Ki Ho , KANG, Jong Soon , YOON, Won Kee
发明人： KIM, Hwan Mook , HAN, Sang Bae , LEE, Chang Woo , LEE, Ki Hoon , PARK, Sung Kyu , LEE, Ki Ho , KANG, Jong Soon , YOON, Won Kee
IPC分类号： A61K31/715 , A61P35/00
CPC分类号： A61K36/232 , A61K2300/00
摘要： Disclosed is a pharmaceutical composition for prevention and treatment of cancers, comprising Angelan, a polysaccharide isolated from Angelica gigas Nakai, as an active ingredient, and a pharmaceutically acceptable carrier, excipient or diluents. In detail, Angelan is excellent in the inhibition of cancer cell growth and the suppression of attachment and invasion of cancer cells to extracellular matrix, thereby inhibiting metastasis of cancer cells. In addition, when Angelan is taken in combination with an existing anticancer drug such as doxorubicin, synergic anticancer effects can be obtained.
摘要翻译：公开了一种用于预防和治疗癌症的药物组合物，其包含作为活性成分从Angelica gigas Nakai分离的多糖的Angelan和药学上可接受的载体，赋形剂或稀释剂。详细地说，安琪儿在抑制癌细胞生长和抑制癌细胞附着和侵入细胞外基质方面是极好的，从而抑制癌细胞的转移。此外，当将Angelan与现有的抗癌药物如多柔比星联合使用时，可以获得协同的抗癌作用。

3. 发明申请

WO2007142392A1 PHARMACEUTICAL COMPOSITION COMPRISING POLYSACCHARIDES FROM ANGELICA GIGAS NAKAI FOR ACTIVATION OF DENDRITIC CELLS 审中-公开
标题翻译：药物组合物，包括来自天然GIGAS NAKAI的多糖，用于激活细胞
公开(公告)号：WO2007142392A1
公开(公告)日：2007-12-13
申请号：PCT/KR2006/003926
申请日：2006-09-29
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , KIM, Hwan Mook , HAN, Sang Bae , PARK, Song Kyu , LEE, Ki Ho , KANG, Jong Soon , LEE, Ki Hoon , KIM, Jee Youn , LEE, Chang Woo
发明人： KIM, Hwan Mook , HAN, Sang Bae , PARK, Song Kyu , LEE, Ki Ho , KANG, Jong Soon , LEE, Ki Hoon , KIM, Jee Youn , LEE, Chang Woo
IPC分类号： A61K31/715 , A61P37/02
CPC分类号： A61K31/715
摘要： The present invention relates to a pharmaceutical composition for activating dendritic cells having polysaccharides from Angelica gigas Nakai as valid component. The angelan, polysaccharides separated from Angelica gigas Nakai, can improve the revelation of surface molecule of dendritic cells, the secret of cytokine of dendritic cells, the proliferation capability of T cells of dendritic cells, and the generation of cytokine such as IL-2.
摘要翻译：本发明涉及一种用于激活具有来自当归奈加的多糖的树突状细胞作为有效成分的药物组合物。从当归纳西分离的天竺鼠多糖可以改善树突状细胞表面分子的揭示，树突状细胞的细胞因子的分泌，树突状细胞的T细胞的增殖能力和细胞因子如IL-2的产生。

4. 发明申请

WO2008018778A1 NEW HETEROCYCLIC COMPOUNDS CONTAINING NITROGEN ATOMS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME FOR TREATMENT OF CANCER 审中-公开
标题翻译：含有氮原子或其药学上可接受的盐的新的杂环化合物，其制备方法和包含其的治疗癌症的药物组合物
公开(公告)号：WO2008018778A1
公开(公告)日：2008-02-14
申请号：PCT/KR2007/003861
申请日：2007-08-10
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , SEOUL PHARMA. CO., LTD. , HAN, Gyoon Hee , CHOI, Eun Hyun , YANG, Jee Sun , HONG, Sung Hee , KIM, Myung Sook , WON, Mi Sun , CHUNG, Kyung Sook , KIM, Dong Myung , YOO, Hyang Sook , KIM, Hwan Mook , PARK, Song Kyu , LEE, Ki Ho , LEE, Chang Woo , CHOI, Youn Woong , JEONG, Yong Mi , MIN, Byung Gu
发明人： HAN, Gyoon Hee , CHOI, Eun Hyun , YANG, Jee Sun , HONG, Sung Hee , KIM, Myung Sook , WON, Mi Sun , CHUNG, Kyung Sook , KIM, Dong Myung , YOO, Hyang Sook , KIM, Hwan Mook , PARK, Song Kyu , LEE, Ki Ho , LEE, Chang Woo , CHOI, Youn Woong , JEONG, Yong Mi , MIN, Byung Gu
IPC分类号： C07D295/185 , C07D241/04 , C07D243/08 , A61P35/00
CPC分类号： C07D295/185 , C07D243/08 , C07D295/26
摘要： The present invention relates to new heterocyclic compounds containing nitrogen atoms or pharmaceutically acceptable salts thereof, a process for the preparation thereof, and a phar¬ maceutical composition comprising the same for treatment of cancer. The compounds according to the present invention induce DNA damage due to reactive oxygen species to activate c-abl and p53, induce RhoB to generate apoptosis, and induce cell death by down-regulating Bcl2 involved in cell survival, which is generated by dysregulated signals via the mitochondria pathway, thereby inhibiting tumor cell growth and inducing apoptosis. Accordingly, the composition according to the present invention can be used to treat cancer.
摘要翻译：本发明涉及含有氮原子的新型杂环化合物或其药学上可接受的盐，其制备方法和包含其的用于治疗癌症的药物组合物。根据本发明的化合物诱导由于活性氧物质引起的DNA损伤以激活c-abl和p53，诱导RhoB产生细胞凋亡，并通过下调参与细胞存活的Bcl2诱导细胞死亡，其由失调信号通过线粒体途径，从而抑制肿瘤细胞生长并诱导细胞凋亡。因此，本发明的组合物可以用于治疗癌症。

5. 发明申请

WO2007081091A1 RHODANDSE DERIVARIVES, A PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME 审中-公开
标题翻译： RHODANDSE DERIVARIVES，其制备方法和含有该化合物的药物组合物
公开(公告)号：WO2007081091A1
公开(公告)日：2007-07-19
申请号：PCT/KR2006/005343
申请日：2006-12-08
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY , RYU, Seong Eon , KIM, Seung Jun , JEONG, Dae Gwin , LEE, Sang Hyeup , JUNG, Suk Kyeong , KIM, Hwan Mook , PARK, Song Kyu , LEE, Ki Ho , LEE, Chang Woo , CHOI, Joong-Kwon , AHN, Jin Hee
发明人： RYU, Seong Eon , KIM, Seung Jun , JEONG, Dae Gwin , LEE, Sang Hyeup , JUNG, Suk Kyeong , KIM, Hwan Mook , PARK, Song Kyu , LEE, Ki Ho , LEE, Chang Woo , CHOI, Joong-Kwon , AHN, Jin Hee
IPC分类号： C07D277/06 , A61K31/426 , A61P3/04 , A61P3/10 , A61P35/00
CPC分类号： C07D277/20 , C07D417/12
摘要： Disclosed herein are rhodanine derivatives, a method for the preparation thereof, and a pharmaceutical composition containing the same. The rhodanine derivatives have inhibitory activity against protein phosphatases (PPase) such as PTPlB, Prl-3, LAR, CD45, Cdc25A, Cdc25B, Cdc25C, Yop, PPl and VHR, and can be applied for the prevention and treatment of PPase-caused diseases, including autoimmune diseases, diabetes, impaired glucose intolerance, insulin resistance, obesity, cancers, etc. when the inhibitory activity fliereof is modulated.
摘要翻译：本文公开了罗丹宁衍生物，其制备方法以及包含其的药物组合物。绕丹宁衍生物对PTP1B，Prl-3，LAR，CD45，Cdc25A，Cdc25B，Cdc25C，Yop，PP1和VHR等蛋白质磷酸酶（PPase）具有抑制活性，可用于预防和治疗由PPase引起的疾病，包括自身免疫性疾病，糖尿病，葡萄糖耐受不良，胰岛素抵抗，肥胖症，癌症等，当抑制活性受到调节时。

6. 发明申请

WO2008140198A1 NOVEL CARBAMOYLOXY ARYLALKANOYL ARYLPIPERAZINE COMPOUND, PHARMACEUTICAL COMPOSITIONS COMPRISING THE COMPOUND AND METHOD FOR TREATING PAIN, ANXIETY AND DEPRESSION BY ADMINISTERING THE COMPOUND 审中-公开
标题翻译：新型卡巴酰氧基亚氨基亚氨基哌啶化合物，包含该化合物的药物组合物和通过施用化合物治疗疼痛，不适和呕吐的方法
公开(公告)号：WO2008140198A1
公开(公告)日：2008-11-20
申请号：PCT/KR2008/002470
申请日：2008-04-30
申请人： SK HOLDINGS CO., LTD. , KWAK, Byong Sung , MOON, Hong Sik , YI, Han-Ju , KANG, Young Soon , IM, Dae Joong , CHAE, Eun Hee , CHAE, Sang Mi , LEE, Ki Ho
发明人： KWAK, Byong Sung , MOON, Hong Sik , YI, Han-Ju , KANG, Young Soon , IM, Dae Joong , CHAE, Eun Hee , CHAE, Sang Mi , LEE, Ki Ho
IPC分类号： C07D413/06 , C07D211/58 , C07D471/02 , C07D401/12 , A61P25/24
CPC分类号： C07D239/42 , C07D213/74 , C07D241/04 , C07D241/44 , C07D265/18 , C07D265/36 , C07D295/033 , C07D307/54 , C07D317/58 , C07D317/66 , C07D319/18
摘要： There is provided a novel carbamoyloxy arylalkanoyl arylpiperazine derivative compound having abundant racemic or enantiomeric characteristics, represented by the Formula 1, and pharmaceutically available salts or hydrates thereof. Also, there are provided a pharmaceutical composition for treating pain, anxiety or depression including an effective amount of the compound, and a method for treating pain, anxiety or depression in mammals by administering an effective amount of the compound to the mammals in need of treatment thereof.
摘要翻译：提供了具有由式1表示的大量外消旋或对映体特征的新型氨基甲酰氧基芳基烷酰基芳基哌嗪衍生物化合物及其药学上可用的盐或水合物。此外，提供了一种用于治疗疼痛，焦虑或抑郁的药物组合物，包括有效量的化合物，以及通过向需要治疗的哺乳动物施用有效量的化合物来治疗哺乳动物的疼痛，焦虑或抑郁的方法它们。

7. 发明申请

WO2009025425A1 RFID READER SUPPORTING DENSE MODE 审中-公开
标题翻译： RFID读写器支持DENSE模式
公开(公告)号：WO2009025425A1
公开(公告)日：2009-02-26
申请号：PCT/KR2008/000035
申请日：2008-01-03
申请人： VICTEK CO., LTD. , JO, Won Sang , KIM, Sang Hun , LEE, Kyung Il , SONG, Ji Heon , JUN, Chul Min , CHUN, Young Hee , LEE, Ki Ho
发明人： JO, Won Sang , KIM, Sang Hun , LEE, Kyung Il , SONG, Ji Heon , JUN, Chul Min , CHUN, Young Hee , LEE, Ki Ho
IPC分类号： H04B5/02
CPC分类号： H04B1/1027
摘要： Disclosed herein is a passive Radio Frequency Identification (RFID) reader supporting a dense mode. The RFID reader includes a modulator, a Radio Frequency (RF) transmitter, an RF receiver, a demodulator, a coupler, a scan receiver, and a microcontroller. The modulator encodes and modulates interrogation signals, and converts resulting signals into analog signals. The RF transmitter performs frequency up-conversion and power amplification on the analog signals, and radiates resulting signals. The RF receiver receives response signals from tags, and performs frequency down-conversion and then power amplification on the response signals. The demodulator converts the response signals into digital signals, and demodulates and decodes the digital signals. The coupler samples interrogation signals from other readers. The scan receiver scans the frequency channels of all sampled interrogation signals. The microcontroller receives the results of the scanning, detects a currently unoccupied frequency channel, and communicates with a tag using the detected frequency channel.
摘要翻译：本文公开了一种支持密集模式的无源射频识别（RFID）阅读器。 RFID读取器包括调制器，射频（RF）发射器，RF接收器，解调器，耦合器，扫描接收器和微控制器。调制器对询问信号进行编码和调制，并将结果信号转换为模拟信号。 RF发射机对模拟信号进行上变频和功率放大，并辐射出结果信号。 RF接收机从标签接收响应信号，并对响应信号进行频率下变频，然后进行功率放大。解调器将响应信号转换为数字信号，并对数字信号进行解调和解码。耦合器对来自其他读取器的询问信号进行采样。扫描接收机扫描所有采样询问信号的频道。微控制器接收扫描结果，检测当前未被占用的频道，并使用检测到的频道与标签进行通信。

8. 发明申请

WO2005124093A1 AN AUTO LUBRICATION DEVICE FOR HYDRAULIC BREAKER 审中-公开
标题翻译：液压断路器自动润滑装置
公开(公告)号：WO2005124093A1
公开(公告)日：2005-12-29
申请号：PCT/KR2005/000673
申请日：2005-03-10
申请人： LEE, Ki Ho
发明人： LEE, Ki Ho
IPC分类号： E21B10/24
CPC分类号： B25D17/26 , B25D2216/0015 , F16N13/06
摘要： Disclosed herein is an automatic lubrication device for automatically supplying grease to a hydraulic breaker. The device is designed to supply a predetermined amount of grease to requisite components in a constant striking period by use of a pressure difference in a space above a piston within the breaker where a high pressure and a low pressure are alternately generated according to strike of the piston. The device comprises an input mechanism re¬ ciprocating whenever the breaker strikes for transmitting strike and force thereof to a compressing mechanism, the compressing mechanism for converting reciprocation of the input mechanism into rotation and compressing a spring of a pumping mechanism, the pumping mechanism compressed by amplified force of the compressing mechanism and pumping the grease in the constant striking period, and a filling mechanism for supplying the grease to the pumping mechanism while containing the grease.
摘要翻译：这里公开了一种用于自动向液压破碎机供给润滑脂的自动润滑装置。该装置被设计成通过使用断路器内的活塞上方的压力差在恒定的打击时间内向所需的部件提供预定量的润滑脂，其中根据冲击时的交替产生交替产生高压和低压活塞。该装置包括一个输入机构，每当断路器撞击以将其撞击力传递到压缩机构时，该压缩机构用于将输入机构的往复运动转换成压缩机构的弹簧，泵送机构由压缩机构的放大力并在恒定的打击期间泵送润滑脂;以及填充机构，用于在容纳润滑脂的同时将润滑脂供给泵送机构。

9. 发明申请

WO2008140197A1 NOVEL CARBAMOYLOXY ARYL ALKAN ARYLPIPERAZINE COMPOUND, PHARMACEUTICAL COMPOSITIONS COMPRISING THE COMPOUND AND METHOD FOR TREATING PAIN, ANXIETY AND DEPRESSION BY ADMINISTERING THE COMPOUND 审中-公开
标题翻译：新型卡巴酰氧基亚氨基阿拉伯哌啶化合物，包含该化合物的药物组合物和通过施用化合物治疗疼痛，不适和呕吐的方法
公开(公告)号：WO2008140197A1
公开(公告)日：2008-11-20
申请号：PCT/KR2008/002466
申请日：2008-04-30
申请人： SK HOLDINGS CO., LTD. , LEE, Ki Ho , YI, Han Ju , CHO, Hyeon , IM, Dae Joong , CHAE, Eun Hee , CHOI, Yeon Jung
发明人： LEE, Ki Ho , YI, Han Ju , CHO, Hyeon , IM, Dae Joong , CHAE, Eun Hee , CHOI, Yeon Jung
IPC分类号： C07D413/06 , C07D403/04 , C07D241/04
CPC分类号： C07D239/42 , C07D213/74 , C07D241/04 , C07D241/44 , C07D265/18 , C07D265/36 , C07D295/033 , C07D307/54 , C07D317/58 , C07D317/66 , C07D319/18
摘要： There is provided a novel carbamoyloxy arylalkan arylpiperazine derivative compound having abundant racemic or enantiomeric characteristics, represented by the Ibrmula 1, and pharmaceutically available salts or hydrates thereof. Also, there are provided a pharmaceutical composition for treating pain (i.e., acute or chronic pain, neuropathic pain, inflammatory pain, diabetic pain, postherpetic neuralgia, etc.), anxiety or depression including an effective amount of the compound, and a method for treating pain, anxiety or depression in mammals by administering an effective amount of the compound to the mammals in need of treatment thereof.
摘要翻译：提供了具有由Ibrmula 1表示的大量外消旋或对映体特征的新型氨基甲酰氧基芳基烷基芳基哌嗪衍生物化合物及其药学上可用的盐或水合物。此外，提供了用于治疗疼痛（即急性或慢性疼痛，神经性疼痛，炎性疼痛，糖尿病性疼痛，带状疱疹后神经痛等），焦虑或抑郁的药物组合物，包括有效量的化合物，以及用于通过向需要治疗的哺乳动物施用有效量的化合物来治疗哺乳动物的疼痛，焦虑或抑郁。

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