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1. 发明申请

WO2016088075A1 SHAPE BASED INITIALIZATION AND QA OF PROGRESSIVE AUTO-PLANNING 审中-公开
标题翻译：基于形状的初始化和进步自动计划的质量
公开(公告)号：WO2016088075A1
公开(公告)日：2016-06-09
申请号：PCT/IB2015/059327
申请日：2015-12-03
申请人： KONINKLIJKE PHILIPS N.V. , THE JOHNS HOPKINS UNIVERSITY
发明人： BZDUSEK, Karl Antonin , KUMAR, Prashant , MCNUTT, Todd
IPC分类号： G06F19/00 , A61N5/10
CPC分类号： A61N5/103 , A61N2005/1041 , G06F19/00 , G06F19/321 , G06F19/3481 , G16H50/20
摘要： A system and method for automatically generating radiation therapy treatment plans including one or more processors configured to capture geometries of organs at risk and a target volume specific to a subject, and use a shape-based algorithm to mine (152) a knowledgbase (38) of previously constructed treatment plans for similar geometries to the subject. The system and method interfaces (154) dosimetric information from a plan with a similar geometry as a patient specific starting point for a progressive tuning optimization algorithm resulting in fewer iterations. The progressive tuning algorithm (156, 158, 162) generates an optimized treatment plan. The optimized plan is evaluated against treatment goals. Trade-off plans are generated (164) to create alternative plans according to unmet treatment goals.
摘要翻译：一种用于自动产生放射治疗治疗计划的系统和方法，包括一个或多个处理器，其配置成捕获处于危险中的器官的几何形状，以及特定于受试者的目标体积，并且使用基于形状的算法来挖掘（152）知识库（38）的以前构建的治疗计划与类似的几何对象。系统和方法接口（154）来自具有类似几何形状的计划的剂量测量信息，作为逐渐调谐优化算法的患者特定起点，导致较少的迭代。逐行调整算法（156,158,162）产生优化的处理计划。针对治疗目标评估优化计划。产生权衡计划（164）根据未满足的治疗目标制定替代计划。

2. 发明申请

WO2014147511A1 AUDIO-VISUAL SUMMARIZATION SYSTEM FOR RT PLAN EVALUATION 审中-公开
标题翻译：用于RT计划评估的视听概述系统
公开(公告)号：WO2014147511A1
公开(公告)日：2014-09-25
申请号：PCT/IB2014/059607
申请日：2014-03-11
申请人： KONINKLIJKE PHILIPS N.V.
发明人： KUMAR, Prashant , RANGANATHAN, Vaitheeswaran , BZDUSEK, Karl Antonin
IPC分类号： A61N5/10
CPC分类号： A61N5/1031 , A61N5/103 , A61N5/1071 , A61N2005/1074
摘要： A method for reviewing a treatment plan (24) for delivering radiation therapy to a patient. The treatment plan(24)includes geometric analysis data, dose distribution analysis data, dose volume histogram data, parametric analysis data or deliverability analysis data of a patient. First, for the treatment plan (24), a plurality of clinical and delivery goals are identified (20, 22).Next, goal data points are extracted (26)from the treatment plan (24). Then, data points are correlated (28) to identify deficiencies in the treatment plan (24). A report is generated (30) to display on a display (10) the correlated data points using visual markings (84) to highlight identified deficiencies. Text and audio notations can be attached to the report to explain the correlations and warn a user of plan deficiencies.
摘要翻译：一种用于检查将辐射治疗递送给患者的治疗计划（24）的方法。治疗计划（24）包括患者的几何分析数据，剂量分布分析数据，剂量体积直方图数据，参数分析数据或递送能力分析数据。首先，对于治疗计划（24），确定多个临床和递送目标（20,22）。接下来，从治疗计划（24）中提取目标数据点（26）。然后，数据点是相关的（28）来识别治疗计划中的缺陷（24）。生成报告（30），使用视觉标记（84）在显示器（10）上显示相关数据点，以突出识别缺陷。文本和音频符号可以附加到报告中，以解释相关性，并向用户警告计划缺陷。

3. 发明申请

WO2015015343A1 AUTOMATION OF THERAPY PLANNING 审中-公开
标题翻译：治疗计划自动化
公开(公告)号：WO2015015343A1
公开(公告)日：2015-02-05
申请号：PCT/IB2014/063020
申请日：2014-07-11
申请人： KONINKLIJKE PHILIPS N.V.
发明人： KUMAR, Prashant , BZDUSEK, Karl Antonin
IPC分类号： A61N5/10
CPC分类号： A61N5/1039 , A61N5/1038
摘要： An automated treatment planning system having a planning image memory (14) which stores a volume diagnostic image; a user interface device (32) configured for a user to input data defining a plurality of regions of interest within the volume diagnostic image; and one or more processors. The processors are configured to receive the volume diagnostic image and plurality of user-defined regions of interest indicated within the volume diagnostic image;map the plurality of regions of interest to the body atlas (35) to determine anatomical locations within the plurality of regions of interest; map each region of interest of the plurality of regions of interest to the body atlas to select correct corresponding anatomical structures;receive a treatment plan template based upon the anatomical structures from a knowledge base (36). A planning module (38) is configured to generate a treatment plan using the treatment plan template.
摘要翻译：一种具有计划图像存储器（14）的自动治疗计划系统，其存储体积诊断图像; 用户界面设备（32），其被配置用于用户输入定义所述体积诊断图像内的多个感兴趣区域的数据; 和一个或多个处理器。处理器被配置为接收体积诊断图像和在体积诊断图像内指示的多个用户定义的感兴趣区域;将感兴趣的多个区域映射到身体图集（35），以确定多个区域内的解剖位置利益; 将感兴趣的多个感兴趣区域的感兴趣区域映射到身体图集以选择正确的对应解剖结构;基于来自知识库（36）的解剖结构接收治疗计划模板。计划模块（38）被配置为使用治疗计划模板生成治疗计划。

4. 发明申请

WO2016198979A1 RADIATION THERAPY OPTIMIZATION UNIT WITH GLOBAL CONSIDERATIONS 审中-公开
标题翻译：具有全球考虑的辐射治疗优化单位
公开(公告)号：WO2016198979A1
公开(公告)日：2016-12-15
申请号：PCT/IB2016/053000
申请日：2016-05-23
申请人： KONINKLIJKE PHILIPS N.V.
发明人： BZDUSEK, Karl Antonin , KUMAR, Prashant
IPC分类号： A61N5/10
CPC分类号： A61N5/1031 , A61N5/1039 , A61N5/1047 , A61N5/1077
摘要： A radiation therapy planning system (100) includes a radiation therapy optimization unit (124), which receives at least one target structure and at least one organ-at- risk (OAR) structure segmented from a volumetric image, and generates an optimized plan (126) based on at least one modified objective function. The optimized plan (126) includes a planned radiation dose for each voxel.
摘要翻译：辐射治疗计划系统（100）包括辐射治疗优化单元（124），其接收从体积图像分割的至少一个目标结构和至少一个风险组织（OAR）结构，并且生成优化的计划（ 126）基于至少一个修改的目标函数。优化计划（126）包括每个体素的计划辐射剂量。

5. 发明申请

WO2015083035A1 EFFICIENT TREATMENT PLAN TRADE-OFF ANALYSIS 审中-公开
标题翻译：有效的处理计划贸易分析
公开(公告)号：WO2015083035A1
公开(公告)日：2015-06-11
申请号：PCT/IB2014/066293
申请日：2014-11-24
申请人： KONINKLIJKE PHILIPS N.V.
发明人： BZDUSEK, Karl Antonin , GOPALAKRISHNAN, Sankara Hari , KUMAR, Prashant
IPC分类号： G06F19/00 , A61N5/10
CPC分类号： A61N5/103 , A61N2005/1041 , G06F19/00 , G06F19/321 , G06F19/3481 , G06N99/005 , G16H50/30
摘要： A planning image memory (14) stores a volume diagnostic image. A user inputs data defining clinical objectives including organs-at-risk with a user interface device (32). An auto-planning module (36) generates a candidate treatment plan. A trade- off module (38) having a processor evaluates the treatment plan against the clinical objectives. When one or more objectives is not met, the trade-off module (38) performs a trade-off analysis to determine an effect on other clinical objectives and generates at least one trade-off treatment plan which more closely meets the not met objectives. The candidate and at least one trade-off plan are displayed on a display device (30) and/or analyzed by the processor and a final treatment plan is selected from the at least one trade-off or candidate treatment plan.
摘要翻译：规划图像存储器（14）存储卷诊断图像。用户输入定义临床目标的数据，包括与用户界面设备（32）有风险的器官。自动计划模块（36）产生候选治疗计划。具有处理器的权衡模块（38）根据临床目标评估治疗计划。当不满足一个或多个目标时，权衡模块（38）执行权衡分析以确定对其他临床目标的影响，并产生更接近满足未达到目标的至少一个权衡处理计划。候选人和至少一个权衡计划显示在显示装置（30）上和/或由处理器分析，并且从至少一个权衡或候选治疗计划中选择最终治疗计划。

6. 发明申请

WO2014068435A3 AUTOMATIC OPTIMAL IMRT/VMAT TREATMENT PLAN GENERATION. 审中-公开
公开(公告)号：WO2014068435A3
公开(公告)日：2014-05-08
申请号：PCT/IB2013/059440
申请日：2013-10-18
申请人： KONINKLIJKE PHILIPS N.V.
发明人： KUMAR, Prashant , BZDUSEK, Karl Antonin , PALMER, Matthew , KANTOR, Michael
IPC分类号： G06F19/00
摘要： A therapy planning system (18) and method generate an optimal treatment plan. A plurality of objectives are automatically formulated (154) based on a plurality of clinical goals including dose profiles and priorities. The dose profiles and the priorities correspond to a plurality of structures including a plurality of target and/or critical structures identified within a planning image. Further, a plurality of treatment plan parameters are optimized (156) based on the plurality of objectives to generate a treatment plan. The plurality of objectives are reformulated (162) and the plurality of treatment plan parameters are reoptimized (156) based on the reformulated plurality of objectives to generate a reoptimized treatment plan. The optimizing (156) is repeated based on the reformulated plurality of objectives to generate a reformulated treatment plan.

7. 发明申请

WO2014016720A2 DOSE DEFORMATION ERROR CALCULATION METHOD AND SYSTEM 审中-公开
标题翻译：剂量变形误差计算方法与系统
公开(公告)号：WO2014016720A2
公开(公告)日：2014-01-30
申请号：PCT/IB2013/055632
申请日：2013-07-09
申请人： KONINKLIJKE PHILIPS N.V.
发明人： BZDUSEK, Karl Antonin , WIESMEYER, Mark David
IPC分类号： G06T7/20 , A61N5/10
CPC分类号： A61N5/1037 , A61B6/035 , A61B6/469 , A61N5/1031 , A61N5/1071 , A61N2005/1072 , G06T7/248 , G06T7/337 , G06T2207/10081
摘要： A method and system for determining a radiation dose transformation error are provided, wherein there is a deformation in one or more imaged structures as recorded by at least one fixed image data set and at least one moving image data set. Corresponding landmark points in the fixed image and in the moving image are automatically or semi- automatically identified.
摘要翻译：提供了用于确定辐射剂量变换误差的方法和系统，其中在由至少一个固定图像数据集和至少一个运动图像数据记录的一个或多个成像结构中存在变形组。自动或半自动识别固定图像和运动图像中的相应界标点。

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