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1. 发明申请

WO2018036912A1 DETECTION OF TREATMENT FAILURE FOR MILD HYPERTHERMIA 审中-公开
标题翻译：轻度高热患者治疗失败的检测
公开(公告)号：WO2018036912A1
公开(公告)日：2018-03-01
申请号：PCT/EP2017/070887
申请日：2017-08-17
申请人： KONINKLIJKE PHILIPS N.V.
发明人： STARUCH, Robert, Michael , BHARAT, Shyam , SETHURAMAN, Shriram , PARTHASARATHY, Vijay , ANAND, Ajay , DEHGHAN MARVAST, Ehsan
IPC分类号： A61N7/02 , A61B8/08 , A61B5/01 , A61B5/00 , A61B90/00 , A61B5/055 , A61B18/00 , A61B17/00 , A61N7/00
CPC分类号： A61N7/02 , A61B5/0036 , A61B5/015 , A61B5/055 , A61B5/4836 , A61B5/4848 , A61B8/483 , A61B8/485 , A61B8/5261 , A61B90/04 , A61B2017/00084 , A61B2017/00106 , A61B2017/00123 , A61B2017/00128 , A61B2018/00791 , A61B2018/00898 , A61B2034/101 , A61B2090/0472 , A61B2090/374 , A61B2090/378 , A61B2560/0276 , A61N2007/0039 , A61N2007/0052 , G01R33/4804 , G01R33/4814 , G01S7/52036 , G01S7/52042 , G01S15/8993
摘要： A system (100) includes an imaging system (130), and a therapy control device (122). The imaging system (130) generates temperature maps (140) and strain maps (142) of localized tissues of a patient. The therapy control device (122) includes one or more computer processors configured to detect at least one failure mode (300, 302, 304, 400) of generated mild hyperthermia in the localized tissues of the patient according to at least one of the temperature maps, the strain maps, or a signal indicative of detected inertial cavitation. In some embodiments, the therapy control device either halts therapy or issues a warning.
摘要翻译：系统（100）包括成像系统（130）和治疗控制装置（122）。成像系统（130）生成患者的局部组织的温度图（140）和应变图（142）。治疗控制装置（122）包括一个或多个计算机处理器，该一个或多个计算机处理器被配置成根据温度图中的至少一个来检测在患者的局部组织中产生的温和高热的至少一个故障模式（300,302,304,400），应变图或指示检测到的惯性空化的信号。在一些实施例中，治疗控制装置或者停止治疗或者发出警告。

2. 发明申请

WO2019042856A1 POWER ADJUSTMENT IN MAGNETIC RESONANCE GUIDED HIGH INTENSITY FOCUSED ULTRASOUND 审中-公开
公开(公告)号：WO2019042856A1
公开(公告)日：2019-03-07
申请号：PCT/EP2018/072746
申请日：2018-08-23
申请人： KONINKLIJKE PHILIPS N.V.
发明人： HEIJMAN, Edwin , SEBEKE, Lucas, Christian , STARUCH, Robert, Michael
IPC分类号： A61N7/02 , G01R33/48 , A61B90/00 , A61N7/00 , A61B5/00 , A61B5/01
摘要： The invention provides for a medical instrument (100) comprising: a magnetic resonance imaging system (102) and a high intensity focused ultrasound system (122) comprising an ultrasonic transducer (126). The ultrasonic transducer being configured for simultaneously heating multiple sonication volumes (138, 138', 138''). Execution of machine executable instructions (180) cause a processor (174) to: receive (300) sonication commands (188) configured for controlling the ultrasonic transducer to sonicate the multiple sonication volumes, receive (302) an acoustic power setting (190) for scaling the acoustic power, wherein the relative power of the electrical voltage supplied to each of the multiple ultrasonic transducer elements is scaled using the acoustic power setting, and control (304) the high intensity focused ultrasound system to sonicate the multiple sonication volumes. During the sonication, the processor repeatedly: acquires (306), and reconstructs (308), and displays 310) a thermal map (194) of the multiple sonication volumes. During the sonication, the processor further repeatedly: receives (312) a pause command (196) which causes the processor to pause the sonication of the multiple sonication volumes; receives (314) a resume command (196) which causes the processor to resume the sonication of the multiple sonication volumes; and receives (316) a change power command which causes the processor to change (320) the relative power of the electrical voltage supplied to each of the multiple ultrasonic transducer elements proportionally by a value specified in the change power command, wherein an increase of the relative power of the electrical voltage supplied to the ultrasonic transducer above a predetermined value (198) is only performed if (318) the sonication of the multiple sonication volumes is paused.

3. 发明申请

WO2017071965A1 ADAPTIVE TREATMENT PLANNING FOR HYPERTHERMIA-ENHANCED RADIATION THERAPY 审中-公开
标题翻译：高温放射治疗的适应性治疗计划
公开(公告)号：WO2017071965A1
公开(公告)日：2017-05-04
申请号：PCT/EP2016/074609
申请日：2016-10-13
申请人： KONINKLIJKE PHILIPS N.V.
发明人： BHARAT, Shyam , ANAND, Ajay , STARUCH, Robert, Michael , SETHURAMAN, Shriram , PARTHASARATHY, Vijay , DEHGHAN MARVAST, Ehsan
IPC分类号： A61N5/10 , A61N7/02
CPC分类号： A61N5/1048 , A61N5/1037 , A61N5/1038 , A61N5/1039 , A61N7/02 , A61N2005/1087
摘要： A method includes generating a hyperthermia heat plan for tissue of interest, generating a hyperthermia adapted radiation therapy plan for the tissue of interest, controlling a heat source (126) to deliver heat to the tissue of interest according to the hyperthermia heat plan, and controlling a radiation source of a radiation therapy system (100) to deliver radiation to the tissue of interest according to the hyperthermia adapted radiation therapy plan. A system includes a radiation treatment planner (124) configured to generate a hyperthermia adapted radiation therapy plan for the tissue of interest, a radiation therapy system (100) configured to deliver radiation in accordance with the hyperthermia adapted radiation therapy plan, and a hyperthermia heat delivery system (126) configured to deliver heat in accordance with a hyperthermia plan.
摘要翻译：一种方法包括生成感兴趣组织的高热加热计划，生成针对感兴趣组织的高热适应放射疗法计划，控制热源（126）以将热量传递至感兴趣组织并且控制放射疗法系统（100）的辐射源以根据适合高热的放射疗法计划向所关注的组织递送辐射。一种系统包括：辐射治疗计划器（124），被配置为生成针对感兴趣组织的高热适应放射疗法计划;辐射治疗系统（100），被配置为根据高热适应放射疗法计划递送辐射;以及高温热量输送系统（126），其被配置为根据高热计划输送热量。

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