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1. 发明申请

WO2006114738A2 RESPONSIVE MRI CONTRAST AGENTS 审中-公开
标题翻译：反应性MRI对比剂
公开(公告)号：WO2006114738A2
公开(公告)日：2006-11-02
申请号：PCT/IB2006/051235
申请日：2006-04-21
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , WILLARD, Nicolaas, P. , WEGH, Rene, T. , PIKKEMAAT, Jeroen, A. , GRUELL, Holger
发明人： WILLARD, Nicolaas, P. , WEGH, Rene, T. , PIKKEMAAT, Jeroen, A. , GRUELL, Holger
CPC分类号： A61K49/124 , A61K49/1812 , A61K49/1821
摘要： The invention provides MRI contrast agents which provide a high sensitivity and which have an optimised body retention time. These agents enable the mapping of the local pH, temperature, oxygen concentration or other metabolites in a patient's body by the use of Chemical Exchange Saturation Transfer (CEST). Particularly pH and temperature mapping are useful for the detection of small cancer lesions and localised inflammation respectively.
摘要翻译：本发明提供了提供高灵敏度并且具有优化的身体保留时间的MRI造影剂。这些试剂可以通过使用化学交换饱和转移（CEST）来测定患者体内的局部pH，温度，氧浓度或其他代谢物。特别是pH和温度映射可用于分别检测小癌病变和局部炎症。

2. 发明申请

WO2006114765A2 METHOD AND DEVICE FOR IMPROVED DETECTION OF MRI CONTRAST ENHANCEMENT 审中-公开
标题翻译：改善MRI对比增强检测的方法和装置
公开(公告)号：WO2006114765A2
公开(公告)日：2006-11-02
申请号：PCT/IB2006/051286
申请日：2006-04-25
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , WILLARD, Nicolaas, P. , WEGH, Rene, T. , PIKKEMAAT, Jeroen, A. , GRUELL, Holger , SCHAEFFTER, Tobias , LAMERICHS, Rudolf, M., J., N.
发明人： WILLARD, Nicolaas, P. , WEGH, Rene, T. , PIKKEMAAT, Jeroen, A. , GRUELL, Holger , SCHAEFFTER, Tobias , LAMERICHS, Rudolf, M., J., N.
CPC分类号： G01R33/5601 , A61K49/124 , G01R33/5605
摘要： The present invention provides a method MRI imaging. By applying a time modulation to the contrast enhancement of an MRI contrast agent, the method according to the invention leads to images with improved signal-to-noise ratio in the contrast-enhanced areas, strongly suppressed unwanted signal in the unenhanced areas, and reduced artefacts, such as motion artefacts.
摘要翻译：本发明提供一种MRI成像方法。通过对MRI造影剂的对比度增强应用时间调制，根据本发明的方法导致对比度增强区域中具有改善的信噪比的图像，强烈地抑制未增强区域中的不需要的信号，并且减少人造物，如运动文物。

3. 发明申请

WO2006114739A2 METHOD FOR USING CEST CONTRAST AGENTS IN MRI 审中-公开
标题翻译：在MRI中使用CEST对比剂的方法
公开(公告)号：WO2006114739A2
公开(公告)日：2006-11-02
申请号：PCT/IB2006/051237
申请日：2006-04-21
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , WEGH, Rene, T. , PIKKEMAAT, Jeroen, A. , WILLARD, Nicolaas, P.
发明人： WEGH, Rene, T. , PIKKEMAAT, Jeroen, A. , WILLARD, Nicolaas, P.
CPC分类号： G01R33/5601 , G01R33/4804
摘要： The invention relates to a method for mapping of a physico-chemical parameter using a chemical exchange saturation transfer contrast agent in Magnetic Resonance Imaging. This method may be used with agents having only one exchangeable entity pool, e.g. proton pool, by applying two different RF frequencies for pre-saturation of the contrast agent.
摘要翻译：本发明涉及使用化学交换饱和转移造影剂在磁共振成像中映射物理化学参数的方法。该方法可以与仅具有一个可交换实体池的代理一起使用。质子池，通过应用两种不同的RF频率来预处理造影剂。

4. 发明申请

WO2007141767A3 ELIMINATION OF CONTRAST AGENT CONCENTRATION DEPENDENCY IN MRI 审中-公开
公开(公告)号：WO2007141767A3
公开(公告)日：2007-12-13
申请号：PCT/IB2007/052179
申请日：2007-06-08
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , LAMERICHS, Rudolf, M., J., N. , WEGH, Rene, T. , PIKKEMAAT, Jeroen, A. , GRUELL, Holger
发明人： LAMERICHS, Rudolf, M., J., N. , WEGH, Rene, T. , PIKKEMAAT, Jeroen, A. , GRUELL, Holger
IPC分类号： A61K49/06
摘要： The present invention relates to a method for MRI imaging to obtain information about a local physiochemical parameter after administration to a patient of a contrast agent comprising at least one non-responsive contrast enhancing entity that does not occur naturally in a human body and at least one responsive contrast enhancing entity attached to or mixed with the non-responsive contrast enhancing entity. By using such non- responsive contrast enhancing entities, a value for the physicochemical parameter can be obtained by acquiring only three images through which the method according to the present invention will be easier to apply in clinical routine since it will be faster and less sensitive to motion or flow artefacts.

5. 发明申请

WO2007063454A1 DISTINGUISHING BOUND AND UNBOUND CONTRAST AGENTS USING MAGNETIC RESONANCE 审中-公开
标题翻译：使用磁共振的辨别边界和不对称对比剂
公开(公告)号：WO2007063454A1
公开(公告)日：2007-06-07
申请号：PCT/IB2006/054383
申请日：2006-11-22
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , LAMERICHS, Rudolf, M., J., N. , WEGH, Rene, T. , PIKKEMAAT, Jeroen, A. , GRUELL, Holger
发明人： LAMERICHS, Rudolf, M., J., N. , WEGH, Rene, T. , PIKKEMAAT, Jeroen, A. , GRUELL, Holger
IPC分类号： G01R33/28 , G01R33/563
CPC分类号： G01R33/281 , G01R33/5601 , G01R33/56341
摘要： Magnetic resonance monitoring of a target (30) uses the detected magnetic resonance to determine movement such as diffusion of contrast agent relative to the object, and uses the movement to discriminate (50, 60) a part of the contrast agent which is bound to the target, from the rest of the contrast agent. The need for clearing agents can be avoided or reduced, and hence imaging is instantaneous. A "stationary spin map" of the object can be formed by comparing the movements in the different directions, and determining if the differences between them are less than a given threshold. Determining isotropic movement in this way for a number of locations on the object allows the map to be generated.
摘要翻译：目标（30）的磁共振监测使用检测到的磁共振来确定造影剂相对于物体的扩散的运动，并且使用该运动来区分（50,60）一部分与目标，从其余的造影剂。可以避免或减少对清除剂的需要，因此成像是瞬时的。可以通过比较不同方向上的运动并确定它们之间的差异是否小于给定阈值来形成对象的“固定自旋图”。以这种方式确定对象上多个位置的各向同性运动允许生成地图。

6. 发明申请

WO2010086766A1 ILLUMINATION SYSTEM WITH REMOTE PHOSPHOR LAYER AND/OR SCATTERING LAYER 审中-公开
标题翻译：具有远离磷光体层和/或散射层的照明系统
公开(公告)号：WO2010086766A1
公开(公告)日：2010-08-05
申请号：PCT/IB2010/050264
申请日：2010-01-21
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN DIJK, Gerardus, A., R. , VAN DER PUTTEN, Andreas, M., T., P. , WEGH, Rene, T. , PEETERS, Martinus, P., J. , HENDRIKS, René, J.
发明人： VAN DIJK, Gerardus, A., R. , VAN DER PUTTEN, Andreas, M., T., P. , WEGH, Rene, T. , PEETERS, Martinus, P., J. , HENDRIKS, René, J.
IPC分类号： F21K2/00 , F21V13/00 , F21V9/10 , F21Y113/00 , F21Y101/02 , G02F1/13357
CPC分类号： G02F1/133603 , G02F1/133606 , G02F1/133611
摘要： The invention relates to an illumination system (10,12), to a remote phosphor layer (30; 32, 34), to a scattering layer (32), to a luminaire (100), to a display device (300) and to a method of at least partially correcting a light emission characteristic of at least one light source (22) in the illumination system. The illumination system comprises an array of light sources (20) and a remote phosphor layer and/or a scattering layer arranged between the array of light sources and a light output window (40) for emitting the light from the light sources. At least one light source of the array of light sources comprises a light emission characteristic different from the other light sources of the array of light sources. The luminescent material (52, 54) is distributed across the remote phosphor layer and/or the scattering structures (52) and/or scattering material (52) are distributed across the scattering layer for compensating at least partially the difference in light emission characteristic of the at least one light source. The effect of the illumination system according to the invention is that the deviation of the at least one light source can be compensated, and as such, binning of light sources may be omitted.
摘要翻译：本发明涉及一种照明系统（10,12），一个远程荧光体层（30; 32,34），一个散射层（32），一个照明器（100），一个显示设备（300）和至少部分地校正照明系统中的至少一个光源（22）的发光特性的方法。所述照明系统包括光源阵列（20）和远离荧光体层和/或布置在所述光源阵列之间的散射层和用于发射来自所述光源的光的光输出窗口（40）。光源阵列的至少一个光源包括与光源阵列的其它光源不同的发光特性。发光材料（52,54）分布在远离荧光体层和/或散射结构（52）和/或散射材料（52）之间分布在散射层上，以至少部分地补偿发光特性所述至少一个光源。根据本发明的照明系统的效果是可以补偿至少一个光源的偏差，因此可以省略光源的合并。

7. 发明申请

WO2009093163A2 ILLUMINATION DEVICE WITH LED AND A TRANSMISSIVE SUPPORT COMPRISING A LUMINESCENT MATERIAL 审中-公开
标题翻译：带LED的发光装置和包含发光材料的传输支持
公开(公告)号：WO2009093163A2
公开(公告)日：2009-07-30
申请号：PCT/IB2009/050177
申请日：2009-01-19
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HOELEN, Christoph, G., A. , WEGH, Rene, T. , WAUMANS, Lars, R., C. , ANSEMS, Johannes, P., M.
发明人： HOELEN, Christoph, G., A. , WEGH, Rene, T. , WAUMANS, Lars, R., C. , ANSEMS, Johannes, P., M.
IPC分类号： F21K7/00 , H01L33/00
CPC分类号： F21V14/08 , F21K9/232 , F21K9/62 , F21K9/64 , F21K9/65 , F21V3/08 , F21V9/30 , F21Y2115/10 , H01L33/507 , H01L33/58
摘要： The invention provides an illumination device 10 with a light emitting diode 20, a transmissive support 50 comprising a luminescent material 51, and a translucent exit window 60. The luminescent material 51 LED 20 distance dLL is larger than 0 mm, and the luminescent material 51 exit window 60 distance dLW is also larger than 0 mm. With the proposed illumination device 10 the lamp may especially look white when it is in the off- state and illuminated with white light. Other advantages are that an intrinsically efficient system may be provided and that a warm white option may be provided.
摘要翻译：本发明提供具有发光二极管20的照明装置10，包括发光材料51的透射支撑件50和半透明出射窗60.发光材料51的LED20距离dLL大于0mm，发光材料51 出口窗口60距离dLW也大于0 mm。利用所提出的照明装置10，当灯处于关闭状态并用白光照明时，灯可能特别看起来是白色的。其他优点是可以提供本质上有效的系统，并且可以提供温暖的白色选项。

8. 发明申请

WO2008142638A1 COLOR-TUNABLE ILLUMINATION SYSTEM 审中-公开
标题翻译：彩色照明系统
公开(公告)号：WO2008142638A1
公开(公告)日：2008-11-27
申请号：PCT/IB2008/051972
申请日：2008-05-20
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , WEGH, Rene, T. , HOELEN, Christoph, G., A. , SWEEGERS, Chantal , HENDRIKS, René, J. , LANKHORST, Martijn, H., R.
发明人： WEGH, Rene, T. , HOELEN, Christoph, G., A. , SWEEGERS, Chantal , HENDRIKS, René, J. , LANKHORST, Martijn, H., R.
IPC分类号： F21K7/00
CPC分类号： F21S10/02 , F21K9/62 , F21K9/64 , F21V7/0008 , F21Y2113/13 , F21Y2115/10
摘要： The invention relates to a color-tunable illumination system (10; 12; 14) and a luminaire. The color-tunable illumination system comprises a first light source comprising a first set of light emitting diodes (21, 24), and a second light source comprising a second set of light emitting diodes (31, 37, 34). Both the first and second light source emit light of substantially a first predefined color into a light mixing chamber (60). The light mixing chamber further comprises a first luminescent material (50) converting light of the first predefined color into light of a second predefined color. The first light source is positioned with respect to the first luminescent material for illuminating the first luminescent material with a first flux of light being part of the light emitted by the first light source into the light mixing chamber. The second light source is positioned with respect to the first luminescent material for illuminating the first luminescent material with a second flux of light being part of the light emitted by the second light source into the light mixing chamber. The first flux is different from the second flux. The effect of the measures according to the invention is that a change in the intensity of the light emitted by the first light source relative to the intensity of the light emitted by the second light source results in a change of the color emitted by the color- tunable illumination system.
摘要翻译：本发明涉及一种可调色照明系统（10; 12; 14）和照明装置。颜色可调照明系统包括包括第一组发光二极管（21,24）的第一光源和包括第二组发光二极管（31,37,34）的第二光源。第一和第二光源都将基本上第一预定颜色的光发射到光混合室（60）中。光混合室还包括将第一预定颜色的光转换成第二预定颜色的光的第一发光材料（50）。第一光源相对于第一发光材料定位，用于照射第一发光材料，第一光束是由第一光源发射到光混合室中的光的一部分。第二光源相对于第一发光材料定位，用于用作为由第二光源发射到光混合室中的光的一部分的第二光束照射第一发光材料。第一通量与第二通量不同。根据本发明的措施的效果是，由第一光源发射的光的强度相对于由第二光源发射的光的强度的变化导致颜色发射的颜色的变化，可调照明系统。

9. 发明申请

WO2009107052A1 ILLUMINATION DEVICE WITH LED AND ONE OR MORE TRANSMISSIVE WINDOWS 审中-公开
标题翻译： LED和一个或多个传输窗口的照明设备
公开(公告)号：WO2009107052A1
公开(公告)日：2009-09-03
申请号：PCT/IB2009/050718
申请日：2009-02-23
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HOELEN, Christoph, G., A. , DEEBEN, Josephus, P., A. , BOREL, George, H. , LAMMENS, Vicky, B. , KEUPER, Matthijs, H. , WEGH, Rene, T. , WAUMANS, Lars, R., C.
发明人： HOELEN, Christoph, G., A. , DEEBEN, Josephus, P., A. , BOREL, George, H. , LAMMENS, Vicky, B. , KEUPER, Matthijs, H. , WEGH, Rene, T. , WAUMANS, Lars, R., C.
IPC分类号： H05B33/14
CPC分类号： C09K11/778 , C09K11/7774 , F21K9/64 , F21V3/12 , F21V23/0457 , F21Y2115/10 , G02F2001/133614
摘要： The invention provides an illumination device (100) comprising a translucent exit window (200), one or more transmissive windows (300), arranged upstreamfrom LED(s) and downstream from the translucent exit window (200), and one or more luminescent material layers (400), which may particularlybe coated to the downstream and upstream faces of the transmissive windows (300).
摘要翻译：本发明提供了一种包括半透明出射窗（200），一个或多个透射窗（300）的照明装置（100），其布置在LED的上游并且位于半透明出射窗（200）的下游，以及一个或多个发光材料层（400），其可以特别地涂覆到透射窗（300）的下游和上游面。

10. 发明申请

WO2008132666A1 T1 REDUCTION IN 19F MAGNETIC RESONANCE IMAGING (MRI) 审中-公开
标题翻译： 19F磁共振成像中的T1减少（MRI）
公开(公告)号：WO2008132666A1
公开(公告)日：2008-11-06
申请号：PCT/IB2008/051560
申请日：2008-04-23
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , LAMERICHS, Rudolf, M., J., N. , BURDINSKI, Dirk , LANGEREIS, Sander , WEGH, Rene, T. , GRUELL, Holger
发明人： LAMERICHS, Rudolf, M., J., N. , BURDINSKI, Dirk , LANGEREIS, Sander , WEGH, Rene, T. , GRUELL, Holger
IPC分类号： A61K49/08 , A61K49/10 , A61K49/18 , C07C49/167 , C07C49/24 , C07C49/92 , C07F5/00 , A61B5/055
CPC分类号： C07C49/92 , A61K49/106 , A61K49/1818 , B82Y5/00 , G01R33/5601
摘要： Nanoparticles comprising paramagnetic complexes and use thereof are provided which are designed for the purpose of shortening the Tl relaxation time of fluorinated contrast agents in 19 F Magnetic Resonance Imaging. Preferably, the complexes are included in perfluorinated nanoparticle 19 F MRI contrast agents.
摘要翻译：提供包含顺磁性复合物的纳米颗粒及其用途，其被设计用于缩短氟化造影剂在19 F磁共振成像中的T1弛豫时间。优选地，所述复合物包括在全氟化纳米颗粒中的MRI造影剂。

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