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1. 发明申请

WO2008093263A3 BREATH ANALYSIS DEVICE 审中-公开
公开(公告)号：WO2008093263A3
公开(公告)日：2008-08-07
申请号：PCT/IB2008/050253
申请日：2008-01-24
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VINK, Teunis, J. , VAN KESTEREN, Hans, W. , WILLARD, Nicolaas, P.
发明人： VINK, Teunis, J. , VAN KESTEREN, Hans, W. , WILLARD, Nicolaas, P.
IPC分类号： A61B5/08
摘要： A breath analysis device (10) comprising an inlet (11) for receiving a breath of a user, an analyzer (12) for determining a concentration of at least one element in the breath and output (15) for indicating the health zone corresponding to the concentration. The device also comprises a database for comprising previously determined concentrations and corresponding times at which the previously determined concentrations have been stored in the database and a processor (14) for storing in the concentrations in the database, comparing a measured concentration to at least one threshold for determining a health zone and recalculating the at least one threshold, based on the concentration and at least one of the previously determined concentrations.

2. 发明申请

WO2006114738A2 RESPONSIVE MRI CONTRAST AGENTS 审中-公开
标题翻译：反应性MRI对比剂
公开(公告)号：WO2006114738A2
公开(公告)日：2006-11-02
申请号：PCT/IB2006/051235
申请日：2006-04-21
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , WILLARD, Nicolaas, P. , WEGH, Rene, T. , PIKKEMAAT, Jeroen, A. , GRUELL, Holger
发明人： WILLARD, Nicolaas, P. , WEGH, Rene, T. , PIKKEMAAT, Jeroen, A. , GRUELL, Holger
CPC分类号： A61K49/124 , A61K49/1812 , A61K49/1821
摘要： The invention provides MRI contrast agents which provide a high sensitivity and which have an optimised body retention time. These agents enable the mapping of the local pH, temperature, oxygen concentration or other metabolites in a patient's body by the use of Chemical Exchange Saturation Transfer (CEST). Particularly pH and temperature mapping are useful for the detection of small cancer lesions and localised inflammation respectively.
摘要翻译：本发明提供了提供高灵敏度并且具有优化的身体保留时间的MRI造影剂。这些试剂可以通过使用化学交换饱和转移（CEST）来测定患者体内的局部pH，温度，氧浓度或其他代谢物。特别是pH和温度映射可用于分别检测小癌病变和局部炎症。

3. 发明申请

WO2004018144A1 METHOD OF BREAKING A BRITTLE SUBSTRATE 审中-公开
标题翻译：破碎基片的方法
公开(公告)号：WO2004018144A1
公开(公告)日：2004-03-04
申请号：PCT/IB2003/003271
申请日：2003-07-18
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BRZESOWSKY, Rudolf, H. , BALKENENDE, Abraham, R. , VAN AGTHOVEN, Raymond, G., A. , TIMMERMANS, Petrus, H., M. , WILLARD, Nicolaas, P.
发明人： BRZESOWSKY, Rudolf, H. , BALKENENDE, Abraham, R. , VAN AGTHOVEN, Raymond, G., A. , TIMMERMANS, Petrus, H., M. , WILLARD, Nicolaas, P.
IPC分类号： B23K26/14
CPC分类号： B23K26/073 , B23K26/146 , B23K26/40 , B23K2201/40 , B23K2203/50 , B23K2203/52 , B28D5/0011 , C03B33/091 , Y10T225/12 , Y10T225/304
摘要： The invention relates to a method of breaking a substrate of a brittle material, the method comprising the steps of providing a substrate (1) of a brittle material, heating the substrate with a laser beam (3) to create a heated spot on the substrate, moving the laser beam and the substrate with respect to each other to create a line of heated spots on the substrate (2), cooling the heated spots on the substrate by locally applying a cooling medium (4) behind the heated spots such that a micro-crack is propagated in the line of heated spots, and breaking the substrate along the line of the propagated micro-cracks by applying a mechanical force on the substrate wherein, the cooling medium comprises an aqueous surfactant solution. The surfactants will connect to the broken siloxane bonds inside the surface cracks. Then recombination and healing of the broken siloxane bonds will not occur and the required breaking load will remain constant over time.
摘要翻译：本发明涉及一种破碎脆性材料的基材的方法，所述方法包括以下步骤：提供脆性材料的基材（1），用激光束（3）加热基材以在基材上产生加热点相对于彼此移动激光束和衬底以在衬底（2）上产生一线加热点，通过在加热点之后局部施加冷却介质（4）来冷却衬底上的加热点，使得微裂纹在加热点线上传播，并且通过在衬底上施加机械力来破坏基底，沿着传播微裂纹的线，其中冷却介质包含表面活性剂水溶液。表面活性剂将连接到表面裂纹内的破裂的硅氧烷键。然后，破裂的硅氧烷键的复合和愈合将不会发生，并且所需的断裂载荷随时间保持恒定。

4. 发明申请

WO2004017134A1 FULL-COLOR ELECTROCHROMIC DISPLAY WITH STACKED IN CELL MONOCHROMIC ELECTROCHROMES 审中-公开
标题翻译：全彩色电致发光显示器，用于单色单色电解质
公开(公告)号：WO2004017134A1
公开(公告)日：2004-02-26
申请号：PCT/IB2003/003030
申请日：2003-07-01
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , JAGT, Hendrik, J., B. , WILLARD, Nicolaas, P. , JOHNSON, Mark, T.
发明人： JAGT, Hendrik, J., B. , WILLARD, Nicolaas, P. , JOHNSON, Mark, T.
IPC分类号： G02F1/15
CPC分类号： G09G3/38 , G02F1/15 , G02F1/155 , G02F2001/1515 , G09G2300/0809 , G09G2340/16
摘要： A display device comprising a plurality of independently addressable pixels (1) comprising: a first substrate (2); a counter-electrode (3); a second substrate (4); a stack of electrochromic layers (5a, 5b, 5c) associated with said second substrate (4); an electrolyte (6) disposed between said counter-electrode (3) and said stack of electrochromic layers (5a, 5b, 5c). Said electrochromic layers (5a, 5b, 5c) are each independently addressable for switching operation; and separated from each other by layers of an electrolyte (7). A driving method for operating said pixel (1) comprises the steps of: providing at least one power line (8) which is selectively connectable to an electrochromic layer (5) or a working electrode (10) associated with said electrochromic layer (5); selectively applying to said power line (8) a bleaching or coloring voltage; addressing the electrochromic layer (5) which is to be bleached or colored; connecting said power line (8) to said addressed electrochromic layer (5); retaining the connection of said power line (8) during a hold period; and disconnecting said power line (8).
摘要翻译：一种显示装置，包括多个可独立寻址的像素（1），包括：第一基板（2）; 反电极（3）; 第二基板（4）; 与所述第二基板（4）相关联的一叠电致变色层（5a，5b，5c）; 设置在所述对电极（3）和所述电致变色层（5a，5b，5c）的叠层之间的电解质（6）。所述电致变色层（5a，5b，5c）各自独立地可寻址用于切换操作; 并通过电解质层（7）彼此分离。用于操作所述像素（1）的驱动方法包括以下步骤：提供可选择性地连接到与所述电致变色层（5）相关联的电致变色层（5）或工作电极（10）的至少一个电力线（8） ; 选择性地向所述电力线（8）施加漂白或着色电压; 寻址待漂白或着色的电致变色层（5）; 将所述电力线（8）连接到所述寻址的电致变色层（5）; 在保持期间保持所述电力线（8）的连接; 以及断开所述电力线（8）。

5. 发明申请

WO2003100810A1 A PHOSPHOR SCREEN OF A CATHODE RAY TUBE AND A METHOD OF MANUFACTURING SAME 审中-公开
标题翻译：阴极射线管的荧光屏及其制造方法
公开(公告)号：WO2003100810A1
公开(公告)日：2003-12-04
申请号：PCT/IB2003/001763
申请日：2003-04-29
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN BOMMEL, Ties , WILLARD, Nicolaas, P. , OFFERMANS, Paulus, H., G.
发明人： VAN BOMMEL, Ties , WILLARD, Nicolaas, P. , OFFERMANS, Paulus, H., G.
IPC分类号： H01J29/28
CPC分类号： H01J29/28
摘要： The invention relates to a phosphor screen of a cathode ray tube (CRT) which comprises on an inner surface of a CRT panel (11), in addition to a reflective metal back layer (15), an additional reflective metal layer (13), which covers a structured black matrix layer (12) providing a one-sided reflective film. Light generated by phosphor (14) located above the black matrix (12) will be reflected by the reflective layer (13) instead of being absorbed by the black matrix (12) as would occur for a conventional CRT without this reflective layer (13). Thus, the absorption of emitted light is decreased leading to an increase in the total amount of emitted light and improved luminance and contrast performance (LCP). The invention also relates to an inexpensive method of manufacturing a said phosphor screen. In addition, the invention relates to a CRT comprising said phosphor screen.
摘要翻译：本发明涉及一种阴极射线管（CRT）的荧光屏，该荧光屏除了反射金属背层（15），附加反射金属层（13）之外，还包括在CRT面板（11）的内表面上，其覆盖提供单面反射膜的结构化黑色矩阵层（12）。由位于黑矩阵（12）上方的荧光体（14）产生的光将被反射层（13）反射，而不是由黑色矩阵（12）吸收，如常规CRT（没有该反射层）。因此，发射光的吸收减少，导致发光总量的增加和亮度和对比度性能（LCP）的提高。本发明还涉及制造所述荧光屏的廉价方法。此外，本发明涉及包括所述荧光屏的CRT。

6. 发明申请

WO2009147576A2 BREATH COLLECTION DEVICE AND METHOD 审中-公开
标题翻译：肠道收集装置和方法
公开(公告)号：WO2009147576A2
公开(公告)日：2009-12-10
申请号：PCT/IB2009/052219
申请日：2009-05-27
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , VINK, Teunis, J. , COENE, Willem, M., J., M. , WILLARD, Nicolaas, P.
发明人： VINK, Teunis, J. , COENE, Willem, M., J., M. , WILLARD, Nicolaas, P.
IPC分类号： A61B5/097
CPC分类号： A61B5/097
摘要： The present invention relates to a simple, efficient and accurate breath collection device and a corresponding method for collecting the breath of a patient for analysis. The device comprises a gas mixture container (1) containing a gas mixture for inhalation by the patient, and a breathing unit (2) containing an inlet (21) connected to said gas mixture container (1) for letting in gas from the gas mixture container (1), an outlet (22) for letting out gas exhaled by the patientand a breathing element (23) for inhaling gas from the inlet (21) and exhaling gas to the outlet (22). The gas mixture container (1) contains a gas mixture containing a predetermined set of volatile organic compounds (VOC) markers.
摘要翻译：本发明涉及一种简单，有效和准确的呼吸收集装置和用于收集患者呼吸以进行分析的相应方法。所述装置包括含有用于由患者吸入的气体混合物的气体混合物容器（1）和包含连接到所述气体混合物容器（1）的入口（21）的呼吸单元（2），用于从气体混合物容器（1），用于排出患者呼出的气体的出口（22）和用于从入口（21）吸入气体的呼吸元件（23）并将气体排出到出口（22）。气体混合容器（1）含有含有预定的挥发性有机化合物（VOC）标记物的气体混合物。

7. 发明申请

WO2008084354A1 METHOD, DETECTOR AND SYSTEM FOR MEASURING A SAMPLE CONCENTRATION 审中-公开
标题翻译：方法，用于测量样品浓度的检测器和系统
公开(公告)号：WO2008084354A1
公开(公告)日：2008-07-17
申请号：PCT/IB2007/055242
申请日：2007-12-20
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , WILLARD, Nicolaas, P. , HELWEGEN, Ivon, F. , SAALMINK, Milan , VINK, Teunis, J.
发明人： WILLARD, Nicolaas, P. , HELWEGEN, Ivon, F. , SAALMINK, Milan , VINK, Teunis, J.
IPC分类号： G01N27/414
CPC分类号： G01N27/414
摘要： A method for measuring a concentration of a sample in a sample mixture, the method comprising bringing the sample mixture in contact with an organic semiconductor transistor, applying measurement signals to electrodes of the transistor for enabling measuring a drain current through the transistor, applying a refreshment signal to the gate electrode for counteracting effects imposed on the transistor during the measurement signal, measuring the drain current, applying an adaptation to at least one of said signals for stabilizing the drain current, and determining the concentration based on the adaptation.
摘要翻译：一种用于测量样品混合物中样品浓度的方法，所述方法包括使样品混合物与有机半导体晶体管接触，将测量信号施加到晶体管的电极，以测量通过晶体管的漏极电流，施加刷新信号到栅电极，用于在测量信号期间施加在晶体管上的抵消效应，测量漏极电流，对至少一个所述信号施加适应以稳定漏极电流，以及基于适应性确定浓度。

8. 发明申请

WO2006114739A3 METHOD FOR USING CEST CONTRAST AGENTS IN MRI 审中-公开
标题翻译：在MRI中使用CEST对比剂的方法
公开(公告)号：WO2006114739A3
公开(公告)日：2007-07-12
申请号：PCT/IB2006051237
申请日：2006-04-21
申请人： KONINKL PHILIPS ELECTRONICS NV , WEGH RENE T , PIKKEMAAT JEROEN A , WILLARD NICOLAAS P
发明人： WEGH RENE T , PIKKEMAAT JEROEN A , WILLARD NICOLAAS P
IPC分类号： G01R33/28 , G01R33/48
CPC分类号： G01R33/5601 , G01R33/4804
摘要： The invention relates to a method for mapping of a physico-chemical parameter such as pH, temperature, pO 2 or metabolite concentration using a chemical exchange saturation transfer contrast agent in Magnetic Resonance Imaging. This method is a modification of the known ratiometric method and may be used with agents having only one exchangeable entity pool, e.g. proton pool, by applying two different RF frequencies for pre-saturation of the contrast agent.
摘要翻译：本发明涉及一种使用化学交换饱和转移造影剂在磁共振成像中映射物理化学参数如pH，温度，pO 2或代谢物浓度的方法。该方法是已知比例法的修改，并且可以与仅具有一个可交换实体池的代理一起使用。质子池，通过应用两种不同的RF频率来预处理造影剂。

9. 发明申请

WO2006114765A2 METHOD AND DEVICE FOR IMPROVED DETECTION OF MRI CONTRAST ENHANCEMENT 审中-公开
标题翻译：改善MRI对比增强检测的方法和装置
公开(公告)号：WO2006114765A2
公开(公告)日：2006-11-02
申请号：PCT/IB2006/051286
申请日：2006-04-25
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , WILLARD, Nicolaas, P. , WEGH, Rene, T. , PIKKEMAAT, Jeroen, A. , GRUELL, Holger , SCHAEFFTER, Tobias , LAMERICHS, Rudolf, M., J., N.
发明人： WILLARD, Nicolaas, P. , WEGH, Rene, T. , PIKKEMAAT, Jeroen, A. , GRUELL, Holger , SCHAEFFTER, Tobias , LAMERICHS, Rudolf, M., J., N.
CPC分类号： G01R33/5601 , A61K49/124 , G01R33/5605
摘要： The present invention provides a method MRI imaging. By applying a time modulation to the contrast enhancement of an MRI contrast agent, the method according to the invention leads to images with improved signal-to-noise ratio in the contrast-enhanced areas, strongly suppressed unwanted signal in the unenhanced areas, and reduced artefacts, such as motion artefacts.
摘要翻译：本发明提供一种MRI成像方法。通过对MRI造影剂的对比度增强应用时间调制，根据本发明的方法导致对比度增强区域中具有改善的信噪比的图像，强烈地抑制未增强区域中的不需要的信号，并且减少人造物，如运动文物。

10. 发明申请

WO2006085256A1 DISPLAY DEVICE WITH SOLID REDOX CENTRES 审中-公开
标题翻译：具有固体氧化还原中心的显示装置
公开(公告)号：WO2006085256A1
公开(公告)日：2006-08-17
申请号：PCT/IB2006/050378
申请日：2006-02-06
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , WILLARD, Nicolaas, P. , JAGT, Henri
发明人： WILLARD, Nicolaas, P. , JAGT, Henri
IPC分类号： G02F1/153 , G02F1/155
CPC分类号： G02F1/1533 , G02F1/155 , G02F2001/1557 , G02F2202/022
摘要： A display device (1) comprises a base layer (2) and a top layer (4). A conduction layer (5) is applied to the base layer in a pattern, to form electrodes 6 and 8. These can be made of ITO coated with conductive PEDOT. An insulating isolation layer (14) is then applied in a pattern on top of the conduction layer (5) and fills in the spaces between the electrodes (6, 8) of the conduction layer (5). Gaps in the isolation layer (14) extend over a part of the electrodes. A conductive electrochromic material is deposited and fills in these gaps, to form redox centres 16 and 18 each in electrical contact with one of the electrodes 6 and 8. Sealing (20) defines a cavity, which is filled with a water- based electrolyte (22). The isolation layer (14) and the redox centres (16, 18) protect the electrodes (6, 8) from the electrolyte. Providing a light source and using transparent materials for all of the base layer (2), the top layer (4), the electrodes 6 and 8, and the isolation layer (14) allows the device (1) to be used for the transmission of light. Alternatively, one of the top and base layers (2, 4) can be reflective and the other transparent, in which case the device (1) can be used for light reflection. By selecting suitable materials, a washable and flexible display device can be constructed.
摘要翻译：显示装置（1）包括基层（2）和顶层（4）。将导电层（5）以图案施加到基底层，以形成电极6和8.这些可以由涂覆有导电PEDOT的ITO制成。然后将绝缘隔离层（14）以图案涂覆在导电层（5）的顶部上，并填充在导电层（5）的电极（6,8）之间的空间中。隔离层（14）中的间隙在电极的一部分上延伸。导电电致变色材料被沉积并填充在这些间隙中，以形成各自与电极6和8中的一个电接触的氧化还原中心16和18.密封（20）限定一个空腔，其填充有水基电解质 22）。隔离层（14）和氧化还原中心（16,18）保护电极（6,8）免受电解质的影响。为所有基层（2）提供光源并使用透明材料，顶层（4），电极6和8以及隔离层（14）允许装置（1）用于传输的光。或者，顶层和底层（2,4）中的一个可以是反射的，另一个是透明的，在这种情况下，装置（1）可以用于光反射。通过选择合适的材料，可以构建可洗涤和柔性的显示装置。

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