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1. 发明申请

WO2008068701A2 METHOD AND APPARATUS FOR APPLYING A SHEET TO A SUBSTRATE 审中-公开
标题翻译：将片材施用于基材的方法和设备
公开(公告)号：WO2008068701A2
公开(公告)日：2008-06-12
申请号：PCT/IB2007/054888
申请日：2007-12-03
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VERSCHUUREN, Marcus, A. , MEGENS, Mischa
发明人： VERSCHUUREN, Marcus, A. , MEGENS, Mischa
IPC分类号： B05D1/28
CPC分类号： B05D1/28 , B05C1/027 , B82Y10/00 , B82Y40/00 , G03F7/0002
摘要： The invention provides a method and apparatus for laminating a sheet to a substrate in a stress free and distortion-less manner. The method comprises providing the sheet and substrate such that an attractive force between them exists that is capable of bringing the sheet and surface together at least when their distance is shorter than a critical distance. The method creates these conditions by locally making an initial contact between the sheet and substrate such that at a contact front, being the boundary between areas where the substrate and sheet are in contact and those where they are not in contact, these conditions exist. In a further step the sheet and substrate are allowed to gradually make contact such that the contact front advances along either of the substrate or sheet surface therewith increasing the contacting area between the substrate and the sheet. The method is advantages when used during imprint lithography or embossing processes or other processes where feature patterns need to be transferred from the substrate to the surface or vice versa.
摘要翻译：本发明提供了一种以无应力和无变形的方式将薄片层压到衬底上的方法和设备。该方法包括提供片材和基材，使得它们之间存在吸引力，其至少在它们的距离短于临界距离时能够将片材和表面结合在一起。该方法通过在片材和基材之间局部地进行初始接触而产生这些条件，使得在接触前方，作为基材和片材接触的区域与它们不接触的区域之间的边界，存在这些条件。在进一步的步骤中，允许片材和基材逐渐接触，使得接触前沿沿着基材或片材表面中的任一个前进，由此增加基材和片材之间的接触面积。该方法在压印平版印刷或压印过程或其他特征图案需要从基片转印到表面或反过来的过程中使用时是有利的。

2. 发明申请

WO2008087573A2 METHOD AND SYSTEM FOR CONTACTING OF A FLEXIBLE SHEET AND A SUBSTRATE 审中-公开
标题翻译：用于接触柔性片和基片的方法和系统
公开(公告)号：WO2008087573A2
公开(公告)日：2008-07-24
申请号：PCT/IB2008/050093
申请日：2008-01-11
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VERSCHUUREN, Marcus, A. , MEGENS, Mischa
发明人： VERSCHUUREN, Marcus, A. , MEGENS, Mischa
CPC分类号： G03F7/0002 , B05D1/28 , B82Y10/00 , B82Y40/00 , Y10S438/973 , Y10S438/976
摘要： The invention relates to a method for contacting a flexible sheet to a first element with improved lateral alignment. The method includes a step of measuring a first lateral misalignment after establishing a first contact between the flexible sheet and either of the first element and a sheet parking surface called anchor in the first stage. If the 5 misalignment exceeds a predetermined threshold the flexible sheet is parked at the anchor such that it is not in contact with the first element, and the relative position of the first element and the anchor is altered during the second stage for correcting the mismatch during a contact between the flexible sheet and the first element to be established within the next step of the method. During the steps of shifting the contact point to obtain the second stage 10 the contacting process is more accurate and reproducible than the process for establishing the init ial contact. The invention also relates to an apparatus for executing the method, and the use of the method and apparatus for the manufacture of devices.
摘要翻译：本发明涉及一种使柔性片与第一元件接触的方法，该方法具有改进的横向对准。该方法包括在第一阶段中建立柔性片与第一元件中的任一个和称为锚的片材停车面之间的第一接触之后，测量第一侧向偏移的步骤。如果5个未对准超过预定阈值，则柔性片材停放在锚固件处，使得其不与第一元件接触，并且在第二阶段期间改变第一元件和锚的相对位置以纠正不匹配在该方法的下一步骤中在柔性片和要建立的第一元件之间的接触。在移动接触点以获得第二阶段10的步骤期间，接触过程比建立初始接触的过程更准确和可重现。本发明还涉及一种用于执行该方法的装置，以及用于制造装置的方法和装置的使用。

3. 发明申请

WO2011101778A1 ABLATION CATHETER AND A METHOD OF PERFORMING ABLATION 审中-公开
标题翻译：吸引管和一种执行排除的方法
公开(公告)号：WO2011101778A1
公开(公告)日：2011-08-25
申请号：PCT/IB2011/050599
申请日：2011-02-14
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , MEGENS, Mischa , SUIJVER, Jan Frederik , HARKS, Godefridus Antonius , VAN DUSSCHOTEN, Anna Hendrika
发明人： MEGENS, Mischa , SUIJVER, Jan Frederik , HARKS, Godefridus Antonius , VAN DUSSCHOTEN, Anna Hendrika
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B8/12 , A61B2018/00011 , A61B2018/00029 , A61B2018/1472 , A61B2090/3784 , A61B2218/002
摘要： The invention relates to an ablation catheter, for performing ablation of a target tissue in a patient, where the ablation catheter comprises an elongate body part with a distal end, and an ablation electrode with a distal part. A tissue abutment part extends to a location distal of the ablation electrode distal part in order to separate the distal part of the ablation electrode spatially from the target tissue. This allows of more efficient irrigation and cooling of the target tissue site and of the ablation electrode, and further allows direct monitoring of the target tissue, e.g. by an ultrasound transducer.
摘要翻译：本发明涉及消融导管，用于对患者的靶组织进行消融，其中消融导管包括具有远端的细长主体部分和具有远端部分的消融电极。组织抵靠部分延伸到消融电极远端部分的远侧位置，以便将消融电极的远端部分与靶组织分开。这允许目标组织部位和消融电极更有效的灌注和冷却，并且还允许直接监测目标组织，例如，通过超声波换能器。

4. 发明申请

WO2008018001A2 LIGHT-EMITTING APPARATUS, PARTICULARLY FOR FLOW MEASUREMENTS 审中-公开
标题翻译：发光装置，特别用于流量测量
公开(公告)号：WO2008018001A2
公开(公告)日：2008-02-14
申请号：PCT/IB2007/053082
申请日：2007-08-06
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , SUIJVER, Jan Frederik , MEGENS, Mischa , BABIC, Drazenko
发明人： SUIJVER, Jan Frederik , MEGENS, Mischa , BABIC, Drazenko
IPC分类号： A61B5/027 , G01S17/58 , G02B6/34
CPC分类号： G01S17/58 , A61B5/027 , G01S7/4811 , G02B6/2726 , G02B6/2773
摘要： The invention relates to a light-emitting apparatus (100) comprising an optical waveguide, particularly an optical fiber (1), for guiding a primary light beam (B prim ) into a light-splitting unit (101) which splits it into two or more partial light beams (Bl, B3, B4) which are emitted in different directions and have different optical qualities, e.g. different spectral compositions or polarizations. The apparatus may optionally comprise a detector (4) for determining a Doppler shift (Δλ i ) in reflected light reentering the light-splitting unit (101). This renders it possible to measure simultaneously two or more spatially independent vector components of the flow velocity of a fluid, particularly of blood, surrounding the light-splitting unit (101).
摘要翻译：本发明涉及一种发光装置（100），其包括光波导，特别是光纤（1），用于将初级光束（B SUB）引导到光分离单元（101）中）将其分成两个或更多个沿不同方向发射并具有不同光学质量的部分光束（B1，B3，B4），例如不同的光谱组成或极化。该装置可以可选地包括用于确定重新进入光分离单元（101）的反射光中的多普勒频移（ΔθN i）的检测器（4）。这使得可以同时测量围绕光分离单元（101）的流体（特别是血液）的流速的两个或更多个空间上独立的矢量分量。

5. 发明申请

WO2007072243A1 MAGNETOCHEMICAL SENSOR 审中-公开
标题翻译：磁化学传感器
公开(公告)号：WO2007072243A1
公开(公告)日：2007-06-28
申请号：PCT/IB2006/054415
申请日：2006-11-24
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BRUGGEN, Michel Paul Barbara , MEGENS, Mischa , VAN ZON, Hans , KURT, Ralph , PENTERMAN, Roel , BROER, Dirk Jan , PEETERS, Emiel
发明人： BRUGGEN, Michel Paul Barbara , MEGENS, Mischa , VAN ZON, Hans , KURT, Ralph , PENTERMAN, Roel , BROER, Dirk Jan , PEETERS, Emiel
IPC分类号： G01N27/72 , G01R33/09 , H01F1/00
CPC分类号： H01F1/0045 , B82Y25/00 , G01N35/0098 , H01F10/3268
摘要： The application is directed to a sensor element for use in a magnetochemical sensor, which comprises a first gel-like material (10), especially a swellable hydrogel such as polyacrylamide, and a magnetic second material (20) in the form of particles, especially magnetite (Fe304) nanoparticles, embedded in the first material along with a receptor for an alalyte, eg glucose. Changes in magnetic field due to interaction with the analyte are detected with GMR element (50). Applications include biosensors, DNA testing devices, and high throughput screening.
摘要翻译：该应用涉及用于磁化学传感器的传感器元件，该传感器元件包括第一凝胶状材料（10），特别是诸如聚丙烯酰胺的可溶胀水凝胶和颗粒形式的磁性第二材料（20），特别是磁铁矿（Fe304）纳米颗粒，与一种alalyte（例如葡萄糖）的受体一起嵌入第一种材料中。用GMR元件（50）检测与分析物相互作用导致的磁场变化。应用包括生物传感器，DNA测试设备和高通量筛选。

6. 发明申请

WO2011033454A1 MEDICAL ULTRASOUND DEVICE WITH TEMPERATURE DETECTION AT DISTAL END 审中-公开
标题翻译：具有温度检测功能的医用超声波装置
公开(公告)号：WO2011033454A1
公开(公告)日：2011-03-24
申请号：PCT/IB2010/054153
申请日：2010-09-15
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , MEGENS, Mischa , SUIJVER, Jan Frederik
发明人： MEGENS, Mischa , SUIJVER, Jan Frederik
IPC分类号： A61B8/08
CPC分类号： A61B8/08 , A61B8/0883 , A61B8/12 , A61B8/445 , A61B8/4483 , A61B8/546 , A61B18/1206 , A61B18/1492 , A61B2018/00702 , A61B2018/00791 , A61B2090/3782 , A61N2007/0078 , G01K11/24 , G01K13/002 , G01K2217/00
摘要： A medical ultrasound device is disclosed. The device comprises an elongated body having a proximal end, a distal end (10) and a distal end region (1). One or more ultrasound transducers (4) for generating acoustic radiation are positioned in the distal end region, inside the elongated body. A transmission element (5) which is substantially transparent to acoustic radiation is positioned in the radiation path of the acoustic radiation, and a controller unit is operatively connected to the ultrasound transducer. The controller unit detects the acoustic path length through the transmission element and determines the temperature at the distal end from the detected acoustic path length. In an embodiment, the medical device is an ultrasound RF ablation catheter.
摘要翻译：公开了一种医用超声波装置。该装置包括具有近端，远端（10）和远端区域（1）的细长主体。用于产生声辐射的一个或多个超声换能器（4）位于细长体内的远端区域。对声辐射基本透明的传输元件（5）位于声辐射的辐射路径中，并且控制器单元可操作地连接到超声换能器。控制器单元通过传输元件检测声路长度，并根据检测到的声道长度确定远端处的温度。在一个实施例中，医疗装置是超声RF消融导管。

7. 发明申请

WO2006079998A1 RAPID AND SENSITIVE BIOSENSING 审中-公开
标题翻译：快速敏感的生物传感
公开(公告)号：WO2006079998A1
公开(公告)日：2006-08-03
申请号：PCT/IB2006/050322
申请日：2006-01-30
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KAHLMAN, Josephus, A., H., M. , THILWIND, Rachel, E. , PRINS, Menno, W., J. , MEGENS, Mischa , WIMBERGER-FRIEDL, Reinhold
发明人： KAHLMAN, Josephus, A., H., M. , THILWIND, Rachel, E. , PRINS, Menno, W., J. , MEGENS, Mischa , WIMBERGER-FRIEDL, Reinhold
IPC分类号： G01N33/553 , G01N33/543
CPC分类号： G01N27/745 , G01N33/54333 , G01N33/553
摘要： A sensor device (15) for detecting magnetic particles (13) has a binding surface (40) with binding sites thereon and comprises: at least one sensor element (23) for detecting the presence of magnetic particles (13), means for attracting magnetic structures comprising at least one magnetic particle (13) toward and onto the binding surface (40) of the sensor device (15), and means for re-arranging and randomizing the position of individual magnetic particles (13) with respect to the binding sites on the binding surface (40) to give binding sites on all individual particles (13) a substantial probability to have a contact time with binding sites on the binding surface (40). With such sensor device (15), the speed of detection of target molecules in a fluid is enhanced.
摘要翻译：用于检测磁性颗粒（13）的传感器装置（15）具有在其上具有结合位置的结合表面（40），并包括：用于检测磁性颗粒（13）的存在的至少一个传感器元件（23），用于吸引磁性颗粒包括朝向和传递到传感器装置（15）的结合表面（40）上的至少一个磁性颗粒（13）的结构，以及用于重新排列和随机化各个磁性颗粒（13）相对于结合位点在结合表面（40）上以在所有单独的颗粒（13）上产生与结合表面（40）上的结合位点具有接触时间的可能性。利用这种传感器装置（15），提高了流体中目标分子的检测速度。

8. 发明申请

WO2010140069A1 VISUALIZATION APPARATUS 审中-公开
标题翻译：可视化装置
公开(公告)号：WO2010140069A1
公开(公告)日：2010-12-09
申请号：PCT/IB2010/051919
申请日：2010-05-03
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BARLEY, Maya, E. , DELADI, Szabolcs , HARKS, Godefridus, A. , SUIJVER, Jan, F. , MEGENS, Mischa
发明人： BARLEY, Maya, E. , DELADI, Szabolcs , HARKS, Godefridus, A. , SUIJVER, Jan, F. , MEGENS, Mischa
IPC分类号： A61B19/00 , A61B18/14
CPC分类号： A61B90/36 , A61B18/1492 , A61B34/20 , A61B2017/00106 , A61B2090/062 , A61B2090/065 , A61B2090/376 , G06F19/00
摘要： The invention relates to a visualization apparatus for visualizing aquality of applying energy to an object. The quality of applying energy at a location on the object (3) is visualized based on a) a provided image of the object and b) a provided quality value representing the quality of applying energy to the object at the location on the object (3), wherein a visual property assigning unit (9) assigns a visual property to the location depending on the quality value and a display(10) displays the provided image and the assigned visual property at the location on the object shown in the image.In general a person who applies energy to the object is focused on the location at which energy is applied. Since quality information is shown at the location on which the person is already focused, the quality dependent information can easily be absorbed by the person.
摘要翻译：本发明涉及一种可视化装置，用于将能量施加到物体上的可视化。基于a）所提供的对象图像和b）提供的质量值，表示在物体上的位置处对物体施加能量的质量（3），可视化对象（3）上的位置处的能量的质量），其中视觉特性分配单元（9）根据所述质量值向所述位置分配视觉特性，并且显示器（10）在所述图像中所示的对象上的位置处显示所提供的图像和所分配的视觉特性。将能量施加到物体的人一般集中在施加能量的位置上。由于质量信息显示在人已经聚焦的位置，所以质量依赖信息可以容易地被人吸收。

9. 发明申请

WO2009144635A2 A HIGHER ORDER DISPERSION COMPENSATION DEVICE 审中-公开
标题翻译：更高排序补偿装置
公开(公告)号：WO2009144635A2
公开(公告)日：2009-12-03
申请号：PCT/IB2009/052114
申请日：2009-05-20
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HET HOOFT, Gert , HENDRIKS, Bernardus, H., W. , MEGENS, Mischa
发明人： HET HOOFT, Gert , HENDRIKS, Bernardus, H., W. , MEGENS, Mischa
CPC分类号： G02B5/00 , G02B5/04 , G02B27/095 , G02B2207/117 , H01S3/0057
摘要： The present invention relates to a higher-order dispersion compensation device (210), the device being adapted to cooperate with a pair of optical components (Pl, P2), e.g. a pair of prisms, being arranged to compensate first-order dispersion by separating different wavelengths spatially. The compensation device (210) has the form of a phase plate, wherein the phase change for each wavelength is adjusted by designing the height (h) at the corresponding position (x) of the plate so as to substantially compensate for higher-order dispersion. The invention is advantageous for obtaining a higher-order dispersion compensation device which is relatively simple to construct and use making it a quite cost- effective device. The invention also relates to a corresponding optical system and method for compensating dispersion where this is important, e.g. in a multiple-photon imaging system.
摘要翻译：本发明涉及一种高阶色散补偿装置（210），该装置适于与一对光学部件（P1，P2）配合，例如，一对棱镜被布置成通过在空间上分离不同波长来补偿一阶色散。补偿装置（210）具有相位板的形式，其中通过设计板的对应位置（x）处的高度（h）来调整每个波长的相位变化，以便基本上补偿高阶色散。本发明有利于获得构造和使用相对简单的高阶色散补偿装置，使其成为一种非常具有成本效益的装置。本发明还涉及一种相应的光学系统和方法，用于补偿这一点很重要的色散。在多光子成像系统中。

10. 发明申请

WO2005111596A1 MAGNETIC ROTATION TO IMPROVE SIGNAL-OVER-BACKGROUND IN BIOSENSING 审中-公开
标题翻译：磁性旋转以提高生物传感中的信号
公开(公告)号：WO2005111596A1
公开(公告)日：2005-11-24
申请号：PCT/IB2005/051574
申请日：2005-05-13
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PRINS, Menno, W., J. , VAN DER MARK, Martinus, B. , DUINEVELD, Paulus, C. , MEGENS, Mischa , KAHLMAN, Josephus, A., H., M.
发明人： PRINS, Menno, W., J. , VAN DER MARK, Martinus, B. , DUINEVELD, Paulus, C. , MEGENS, Mischa , KAHLMAN, Josephus, A., H., M.
IPC分类号： G01N27/72
CPC分类号： G01N33/54373 , B82Y5/00 , B82Y25/00 , G01N27/745
摘要： The invention provides a method and a device (10) for distinguishing a specific binding from a less specific binding between at least one magnetic nanoparticle (11) and a surface of another entity by applying a magnetic field and detecting a physical parameter relating to magnetic nanoparticle rotational or motional freedom while the magnetic nanoparticle (11) is attached to the surface. The method and device (10) may be applied to in-vivo and in-vitro biomolecular diagnostics. The sensor (10) according to the present invention combines in one sensor (10) the detection of magnetic particles or labels (11) and determination of the binding quality and the properties of magnetic particles or labels (11) which are bound to the surface of another entity.
摘要翻译：本发明提供了一种方法和装置（10），用于通过施加磁场和检测与磁性纳米颗粒相关的物理参数来区分特定结合与至少一个磁性纳米颗粒（11）和另一个实体的表面之间的较小特异性结合旋转或运动自由而磁性纳米颗粒（11）附着于表面。方法和装置（10）可以应用于体内和体外生物分子诊断。根据本发明的传感器（10）在一个传感器（10）中结合了磁性颗粒或标签（11）的检测以及结合质量的测定以及与表面结合的磁性颗粒或标签（11）的性质的另一个实体。

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