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1. 发明申请

WO2010136942A2 A METHOD AND DEVICE FOR SIDE-EFFECT PROGNOSIS AND MONITORING 审中-公开
标题翻译：一种用于侧面预处理和监测的方法和装置
公开(公告)号：WO2010136942A2
公开(公告)日：2010-12-02
申请号：PCT/IB2010/052266
申请日：2010-05-21
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , RIBBING, Carolina , WEIBRECHT, Martin , BACHMANN, Peter, Klaus , PERKUHN, Michael , LIERFELD, Marco, Daniel, Pascal , PINKAWA, Michael
发明人： RIBBING, Carolina , WEIBRECHT, Martin , BACHMANN, Peter, Klaus , PERKUHN, Michael , LIERFELD, Marco, Daniel, Pascal , PINKAWA, Michael
IPC分类号： G06F19/00
CPC分类号： A61N5/103 , G06F19/3481 , G16H20/40
摘要： A method for radiotherapy monitoring is provided. The method comprises calculation of treatment-guiding indices of side-effects based on processing image derived descriptors and measurement values of selected disease specific biomarkers and optionally questionnaire data. A computer program product is also provided.
摘要翻译：提供放射治疗监测方法。该方法包括基于处理图像导出的描述符和所选疾病特异性生物标志物的测量值以及任选的问卷数据来计算副作用的治疗指导指数。还提供了计算机程序产品。

2. 发明申请

WO2011042829A1 METHOD OF EVALUATING TOXICITY LEVEL OF A PATIENT UNDERGOING A CANCER TREATMENT 审中-公开
标题翻译：评估治疗癌症患者的毒性水平的方法
公开(公告)号：WO2011042829A1
公开(公告)日：2011-04-14
申请号：PCT/IB2010/054332
申请日：2010-09-27
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , WEIBRECHT, Martin , RIBBING, Carolina , LIERFELD, Marco Daniel Pascal , WARTENA, Frank
发明人： WEIBRECHT, Martin , RIBBING, Carolina , LIERFELD, Marco Daniel Pascal , WARTENA, Frank
IPC分类号： G06F19/00
CPC分类号： G06F19/3481 , G06F19/00 , G06F19/3456
摘要： This invention relates to a method and a system of evaluating toxicity level of a patient undergoing a cancer treatment protocol. Patient's related data including biomarkers of toxicity level caused by said cancer treatment are received. These biomarkers of toxicity level are then compared with a range of reference biomarkers of toxicity level caused during a similar cancer treatment. Finally, an alert signal is issued in case the biomarkers of toxicity level fall outside said range of reference biomarkers of toxicity level.
摘要翻译：本发明涉及评估经历癌症治疗方案的患者的毒性水平的方法和系统。接受患者相关数据，包括由所述癌症治疗引起的毒性水平的生物标志物。然后将这些毒性水平的生物标志物与在类似的癌症治疗期间引起的毒性水平的参考生物标志物的范围进行比较。最后，如果毒性水平的生物标志物低于毒性水平的参考生物标志物的范围，则发出警报信号。

3. 发明申请

WO2010109357A1 MARKER ADAPTED NORMAL TISSUE COMPLICATION PROBABILITY 审中-公开
标题翻译：标记适应正常组织综合概率
公开(公告)号：WO2010109357A1
公开(公告)日：2010-09-30
申请号：PCT/IB2010/050732
申请日：2010-02-18
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , WEIBRECHT, Martin , GEORGI, Jens, Christoph , RIBBING, Carolina, M.
发明人： WEIBRECHT, Martin , GEORGI, Jens, Christoph , RIBBING, Carolina, M.
IPC分类号： A61N5/10
CPC分类号： A61N5/103 , A61N5/1038 , G06F19/00 , G06Q50/22
摘要： A therapy system includes a diagnostic image scanner (12) that acquires a diagnostic image of a target region to be treated. A planning processor (70) is configured to generate a patient specific adaptive radiation therapy plan based on patient specific biomarkers before and during therapy. A first set of patient specific biomarkers is determined then used for the determination of a first normal tissue complication probability (NTCP) model and a first tumor control probability (TCP) model. A radiation therapy device (40) administers a first dose of radiation to the target region with a protocol based on the first NTCP model and the first TCP model. A second set of patient specific biomarkers is determined. A relationship between the first set and second set of patient specific biomarkers is used to determine a second NTCP model and a second TCP model. The radiation therapy device (40) administers a second dose of radiation to the target region with a protocol based on the second NTCP model and second TCP model.
摘要翻译：治疗系统包括：诊断图像扫描器（12），其获取待治疗的对象区域的诊断图像。规划处理器（70）被配置为在治疗之前和期间基于患者特异性生物标志物产生患者特异性自适应放射治疗计划。确定第一组患者特异性生物标志物，然后用于确定第一正常组织并发症概率（NTCP）模型和第一肿瘤控制概率（TCP）模型。辐射治疗装置（40）使用基于第一NTCP模型和第一TCP模型的协议向目标区域施加第一剂量的辐射。确定第二组患者特异性生物标志物。使用第一组和第二组患者特异性生物标志物之间的关系来确定第二NTCP模型和第二TCP模型。辐射治疗装置（40）使用基于第二NTCP模型和第二TCP模型的协议向目标区域施加第二剂量的辐射。

4. 发明申请

WO2011070461A2 DIAGNOSTIC TECHNIQUES FOR CONTINUOUS STORAGE AND JOINT ANALYSIS OF BOTH IMAGE AND NON-IMAGE MEDICAL DATA 审中-公开
标题翻译：连续存储和图像和非图像医学数据联合分析的诊断技术
公开(公告)号：WO2011070461A2
公开(公告)日：2011-06-16
申请号：PCT/IB2010/055237
申请日：2010-11-17
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , RIBBING, Carolina , WEIBRECHT, Martin , BACHMANN, Peter, K.
发明人： RIBBING, Carolina , WEIBRECHT, Martin , BACHMANN, Peter, K.
IPC分类号： G06F19/00
CPC分类号： G06F19/321 , G06F19/00 , G16H50/20
摘要： An apparatus comprises: a database (30) storing medical data including image medical data and non-image medical data for a plurality of patients; a digital processor (40) configured to (i) generate a features vector (56) comprising features indicative of a patient derived from patient medical data stored in the database including both patient image medical data and patient non-image medical data and (ii) perform multivariate analysis (64) on a features vector generated for a patient of interest to determine a proposed diagnosis for the patient of interest; and a user interface (42) configured to output a human perceptible representation of the proposed diagnosis for the patient of interest.
摘要翻译：一种设备，包括：数据库（30），其存储包括用于多个患者的图像医学数据和非图像医学数据的医学数据; （i）生成特征向量（56），所述特征向量包括表示从存储在所述数据库中的患者医学数据导出的患者的特征，所述患者医学数据包括患者图像医学数据和患者非图像医学数据，以及（ii）针对感兴趣的患者生成的特征向量执行多变量分析（64）以确定针对感兴趣的患者的建议诊断; 和用户界面（42），其被配置为输出针对感兴趣的患者的所提出的诊断的人类可感知表示。

5. 发明申请

WO2010106449A2 FUNCTIONAL IMAGING 审中-公开
标题翻译：功能成像
公开(公告)号：WO2010106449A2
公开(公告)日：2010-09-23
申请号：PCT/IB2010/050579
申请日：2010-02-09
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , SOLF, Torsten , SCHWEIZER, Bernd , WEIBRECHT, Martin , RIBBING, Carolina
发明人： SOLF, Torsten , SCHWEIZER, Bernd , WEIBRECHT, Martin , RIBBING, Carolina
IPC分类号： A61B6/00
CPC分类号： A61B6/00 , A61B5/055 , A61B5/743 , A61B6/037 , A61B6/463 , A61B6/545 , A61B8/463 , A61B8/481 , A61B8/585 , G06F19/00 , G06F19/321 , G16H15/00
摘要： A method includes obtaining an image of a region of interest of a subject, wherein the image is generated with image data produced by an imaging system used to scan the subject, obtaining a signal indicative of a physiological state of the subject before the scan, and displaying both the image and data indicative of the physiological state. In another aspect, a method includes correcting, via a processor, a tracer uptake value for a target region of interest based on a tracer uptake correction factor.
摘要翻译：一种方法包括获得对象的感兴趣区域的图像，其中该图像是利用由用于扫描该对象的成像系统产生的图像数据生成的，获得指示生理状态的信号在扫描之前，显示图像和指示生理状态的数据。在另一方面，一种方法包括经由处理器基于示踪剂吸收校正因子校正目标感兴趣区域的示踪剂吸收值。

6. 发明申请

WO2007057855A2 METHOD FOR DISPLAYING HIGH RESOLUTION IMAGE DATA TOGETHER WITH TIME-VARYING LOW RESOLUTION IMAGE DATA 审中-公开
标题翻译：将高分辨率图像数据与时变低分辨率图像数据一起显示的方法
公开(公告)号：WO2007057855A2
公开(公告)日：2007-05-24
申请号：PCT/IB2006/054297
申请日：2006-11-16
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GmBH , KONINKLIJKE PHILIPS ELECTRONICS N.V. , WEIBRECHT, Martin , ECABERT, Olivier , WEESE, Juergen , KIEFER, Gundolf
发明人： WEIBRECHT, Martin , ECABERT, Olivier , WEESE, Juergen , KIEFER, Gundolf
IPC分类号： G06T15/10
CPC分类号： G06T15/10
摘要： A method allowing display of time-varying merged high resolution and low resolution image data with a smooth frame rate. In one embodiment the high resolution data is structural image data and the low resolution image data is functional image data. The functional image data is gathered (20) into groups and each group is rendered and merged (24) together. The merged images produced are then stored (28) in a First In First Out (FIFO) buffer for display. While the merged images are displayed the next set of functional image data is merged and rendered and supplied to the FIFO buffer, allowing a smooth frame rate to be achieved. A computer program and a medical imaging apparatus using the method are also disclosed.
摘要翻译：
一种允许以平滑帧速率显示时变合并的高分辨率和低分辨率图像数据的方法。在一个实施例中，高分辨率数据是结构图像数据，低分辨率图像数据是功能图像数据。功能图像数据被收集（20）成组，并且每个组被渲染和合并（24）在一起。然后将生成的合并图像存储（28）在先进先出（FIFO）缓冲器中以供显示。在显示合并的图像时，下一组功能图像数据被合并并渲染并提供给FIFO缓冲器，从而实现平滑的帧速率。还公开了使用该方法的计算机程序和医学成像设备。

7. 发明申请

WO2011070484A3 A METHOD AND A CORRECTION SYSTEM FOR CORRECTING TRACER-UPTAKE MEASUREMENTS 审中-公开
公开(公告)号：WO2011070484A3
公开(公告)日：2011-06-16
申请号：PCT/IB2010/055530
申请日：2010-12-01
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , WEIBRECHT, Martin
发明人： WEIBRECHT, Martin
IPC分类号： A61B6/00 , G01T1/161 , G06T7/00 , G06F19/00
摘要： This invention relates to a method and a correction system for correcting tracer-uptake measurements for patient specific variations in the tracer-uptake. Input data are received about the patient and subsequently it is determining whether the received input data include tracer-impact data that impact the tracer-uptake measurements for the patient. In case the tracer-impact data are included in the input data a comparing is performed where the tracer-impact data are compared with pre-stored reference data that have associated thereto a correction indicator indicating an amount of deviation of the tracer-uptake measurement due to the tracer-uptake dependent data. The correction indicator of the pre-stored reference data that match with the tracer-impact data is then used to correct the tracer-uptake measurements for the patient.

8. 发明申请

WO2005110230A1 SYSTEM AND METHOD FOR DIAGNOSING BREAST CANCER 审中-公开
标题翻译：用于诊断乳腺癌的系统和方法
公开(公告)号：WO2005110230A1
公开(公告)日：2005-11-24
申请号：PCT/IB2005/051409
申请日：2005-04-29
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N. V. , WEIBRECHT, Martin , BREDNO, Joerg
发明人： WEIBRECHT, Martin , BREDNO, Joerg
IPC分类号： A61B6/02
CPC分类号： A61B6/502 , A61B6/025
摘要： The invention relates to a system and a method for the investigation of a body volume (3), particularly for the diagnosis of breast cancer. According to the method, a sequence of X-ray projections (P, P') from different directions is produced by a rotatable X-ray source (1) and a stationary digital X-ray detector (5). From these projections (P, P'), a set of sectional images (a, b, c, d) is calculated by tomosynthesis. A physician may indicate a suspicious structure on a reference image (R) that is derived from one of the projections (P, P') or sectional images (a, b, c, d) and displayed on a monitor (6). The computer (7) may then locate the structure on all sectional images (a, b, c, d) and calculate the similarity of a corresponding image feature. The sectional 10 image at which the similarity is strongest then indicates the depth (zo) at which the structure (4) is positioned in the body volume (3). Based on this information, a biopsy device (9) with a needle (10) can be advanced into the body volume (3) until it reaches the suspicious structure (4).
摘要翻译：本发明涉及一种用于体检（3）的研究的系统和方法，特别是用于乳腺癌的诊断。根据该方法，通过可旋转X射线源（1）和固定数字X射线检测器（5）产生来自不同方向的X射线投影（P，P'）的序列。通过这些投影（P，P'），通过断层合成计算出一组截面图像（a，b，c，d）。医生可以在从投影（P，P'）中的一个或截面图像（a，b，c，d）导出并显示在监视器（6）上的参考图像（R）上指示可疑结构。然后，计算机（7）可以在所有截面图像（a，b，c，d）上定位结构，并计算相应图像特征的相似度。相似度最强的截面10图像表示结构（4）位于体积（3）中的深度（zo）。基于该信息，具有针（10）的活检装置（9）可以前进到体积（3）中，直到达到可疑结构（4）。

9. 发明申请

WO2005020205A2 METHOD AND ARRANGEMENT FOR CALIBRATING AN ARRANGEMENT FOR DRIVING IMAGE-REPRODUCING MEANS SUBJECT TO INERTIA 审中-公开
标题翻译：用于校准驱动图像再现方法的装置的方法和装置
公开(公告)号：WO2005020205A2
公开(公告)日：2005-03-03
申请号：PCT/IB2004/051464
申请日：2004-08-16
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N. V. , SOLF, Torsten , WEIBRECHT, Martin
发明人： SOLF, Torsten , WEIBRECHT, Martin
IPC分类号： G09G3/36
CPC分类号： G09G3/3611 , G09G2320/0252 , G09G2320/0261 , G09G2320/0285 , G09G2340/16
摘要： In a method and arrangement for correcting an arrangement for driving imagereproducing means subject to inertia, and particularly liquid crystal displays, wherein a stored correcting variable is added to infed video signals to compensate for the effects of inertia, which correcting variable depends on changes in the video signals from frame to frame, and wherein the corrected video signals are conveyed to the image-reproducing means, provision is made for a test pattern that contains signal jumps that occur from frame to frame to be generated, for the signal jumps to vary in respect of their sign, their size and their position in the amplitude range of the video signals, for the test video signals to be shown on the imagereproducing means at least in a part that is covered by at least one opto-electrical sensor, and for correcting parameters to be derived from the signals generated by the at least one optoelectrical sensor while taking account of the totality of the signals generated by the at least one opto-electrical sensor.
摘要翻译：在用于校正用于驱动经受惯性的图像再现装置的布置的装置的方法和装置中，特别是液晶显示器，其中将存储的校正变量添加到infed视频信号以补偿惯性的影响，该校正变量取决于视频信号从帧到帧，并且其中校正的视频信号被传送到图像再现装置，提供包含发生在要生成的帧之间的信号跳跃的测试模式，以使信号跳变在在视频信号的幅度范围内对它们的符号，它们的大小和位置的影响，至少在由至少一个光电传感器覆盖的部分中，在图像再现装置上显示测试视频信号，并且修正由所述至少一个光电传感器产生的信号导出的参数，同时考虑到所述信号的总和由至少一个光电传感器驱动。

10. 发明申请

WO2005020204A1 SYSTEM FOR DRIVING INERTIA-PRONE PICTURE-REPRODUCING DEVICES 审中-公开
标题翻译：用于驱动图像传播设备的系统
公开(公告)号：WO2005020204A1
公开(公告)日：2005-03-03
申请号：PCT/IB2004/051463
申请日：2004-08-16
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N. V. , SOLF, Torsten , ECK, Kai , WEIBRECHT, Martin
发明人： SOLF, Torsten , ECK, Kai , WEIBRECHT, Martin
IPC分类号： G09G3/36
CPC分类号： G09G3/3648 , G09G2320/0252 , G09G2320/0261 , G09G2320/0285 , G09G2340/16
摘要： In a system for driving inertia-prone picture-reproducing devices, in particular liquid-crystal displays, in which a correcting value that depends on changes in the video signals from frame to frame is added to incoming video signals to compensate for the inertial effects and in which the corrected video signals are passed to the picture-reproducing device to form the correcting value, a model of the picture-reproducing device is provided that has a state variable as an output variable, the video signals as a first input variable and the state variable from a preceding frame as a second input variable. Furthermore, to derive the correcting value, a function having the incoming video signals and the state variable of the preceding variable as input variables and the corrected video signals as an output variable.
摘要翻译：在用于驱动惯性倾向的图像再现装置的系统中，特别是液晶显示器，其中将依赖于帧间视频信号的变化的校正值加到输入视频信号上以补偿惯性效应，其中校正的视频信号被传送到图像再现装置以形成校正值，提供了具有状态变量作为输出变量的图像再现装置的模型，视频信号作为第一输入变量，并且状态变量作为第二个输入变量。此外，为了导出校正值，具有输入视频信号和前一变量的状态变量作为输入变量的函数和校正后的视频信号作为输出变量。

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