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1. 发明申请

WO2011042829A1 METHOD OF EVALUATING TOXICITY LEVEL OF A PATIENT UNDERGOING A CANCER TREATMENT 审中-公开
标题翻译：评估治疗癌症患者的毒性水平的方法
公开(公告)号：WO2011042829A1
公开(公告)日：2011-04-14
申请号：PCT/IB2010/054332
申请日：2010-09-27
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , WEIBRECHT, Martin , RIBBING, Carolina , LIERFELD, Marco Daniel Pascal , WARTENA, Frank
发明人： WEIBRECHT, Martin , RIBBING, Carolina , LIERFELD, Marco Daniel Pascal , WARTENA, Frank
IPC分类号： G06F19/00
CPC分类号： G06F19/3481 , G06F19/00 , G06F19/3456
摘要： This invention relates to a method and a system of evaluating toxicity level of a patient undergoing a cancer treatment protocol. Patient's related data including biomarkers of toxicity level caused by said cancer treatment are received. These biomarkers of toxicity level are then compared with a range of reference biomarkers of toxicity level caused during a similar cancer treatment. Finally, an alert signal is issued in case the biomarkers of toxicity level fall outside said range of reference biomarkers of toxicity level.
摘要翻译：本发明涉及评估经历癌症治疗方案的患者的毒性水平的方法和系统。接受患者相关数据，包括由所述癌症治疗引起的毒性水平的生物标志物。然后将这些毒性水平的生物标志物与在类似的癌症治疗期间引起的毒性水平的参考生物标志物的范围进行比较。最后，如果毒性水平的生物标志物低于毒性水平的参考生物标志物的范围，则发出警报信号。

2. 发明申请

WO2010136942A3 A METHOD AND DEVICE FOR SIDE-EFFECT PROGNOSIS AND MONITORING 审中-公开
标题翻译：一种用于侧面预处理和监测的方法和装置
公开(公告)号：WO2010136942A3
公开(公告)日：2011-04-07
申请号：PCT/IB2010052266
申请日：2010-05-21
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS INTELLECTUAL PROPERTY , RIBBING CAROLINA , WEIBRECHT MARTIN , BACHMANN PETER KLAUS , PERKUHN MICHAEL , LIERFELD MARCO DANIEL PASCAL , PINKAWA MICHAEL
发明人： RIBBING CAROLINA , WEIBRECHT MARTIN , BACHMANN PETER KLAUS , PERKUHN MICHAEL , LIERFELD MARCO DANIEL PASCAL , PINKAWA MICHAEL
IPC分类号： G06F19/00 , A61N5/10
CPC分类号： A61N5/103 , G06F19/3481
摘要： A method for radiotherapy monitoring is provided. The method comprises calculation of treatment-guiding indices of side-effects based on processing image derived descriptors and measurement values of selected disease specific biomarkers and optionally questionnaire data. A computer program product is also provided.
摘要翻译：提供放射治疗监测方法。该方法包括基于处理图像导出的描述符和所选疾病特异性生物标志物的测量值以及任选的问卷数据来计算副作用的治疗指导指数。还提供了计算机程序产品。

3. 发明申请

WO2010106449A3 FUNCTIONAL IMAGING 审中-公开
标题翻译：功能成像
公开(公告)号：WO2010106449A3
公开(公告)日：2010-12-29
申请号：PCT/IB2010050579
申请日：2010-02-09
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS INTELLECTUAL PROPERTY , SOLF TORSTEN , SCHWEIZER BERND , WEIBRECHT MARTIN , RIBBING CAROLINA
发明人： SOLF TORSTEN , SCHWEIZER BERND , WEIBRECHT MARTIN , RIBBING CAROLINA
IPC分类号： A61B6/00 , G06F19/00 , G06T11/00
CPC分类号： A61B6/00 , A61B5/055 , A61B5/743 , A61B6/037 , A61B6/463 , A61B6/545 , A61B8/463 , A61B8/481 , A61B8/585 , G06F19/321 , G16H15/00
摘要： A method includes obtaining an image of a region of interest of a subject, wherein the image is generated with image data produced by an imaging system used to scan the subject, obtaining a signal indicative of a physiological state of the subject before the scan, and displaying both the image and data indicative of the physiological state. In another aspect, a method includes correcting, via a processor, a tracer uptake value for a target region of interest based on a tracer uptake correction factor.
摘要翻译：一种方法包括获得对象感兴趣区域的图像，其中使用由用于扫描对象的成像系统产生的图像数据来生成图像，获得指示扫描之前对象的生理状态的信号，以及显示指示生理状态的图像和数据。在另一方面，一种方法包括：通过处理器，基于示踪剂摄取校正因子来校正目标感兴趣区域的示踪剂吸收值。

4. 发明申请

WO2010136942A2 A METHOD AND DEVICE FOR SIDE-EFFECT PROGNOSIS AND MONITORING 审中-公开
标题翻译：一种用于侧面预处理和监测的方法和装置
公开(公告)号：WO2010136942A2
公开(公告)日：2010-12-02
申请号：PCT/IB2010/052266
申请日：2010-05-21
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , RIBBING, Carolina , WEIBRECHT, Martin , BACHMANN, Peter, Klaus , PERKUHN, Michael , LIERFELD, Marco, Daniel, Pascal , PINKAWA, Michael
发明人： RIBBING, Carolina , WEIBRECHT, Martin , BACHMANN, Peter, Klaus , PERKUHN, Michael , LIERFELD, Marco, Daniel, Pascal , PINKAWA, Michael
IPC分类号： G06F19/00
CPC分类号： A61N5/103 , G06F19/3481 , G16H20/40
摘要： A method for radiotherapy monitoring is provided. The method comprises calculation of treatment-guiding indices of side-effects based on processing image derived descriptors and measurement values of selected disease specific biomarkers and optionally questionnaire data. A computer program product is also provided.
摘要翻译：提供放射治疗监测方法。该方法包括基于处理图像导出的描述符和所选疾病特异性生物标志物的测量值以及任选的问卷数据来计算副作用的治疗指导指数。还提供了计算机程序产品。

5. 发明申请

WO2005110230A1 SYSTEM AND METHOD FOR DIAGNOSING BREAST CANCER 审中-公开
标题翻译：用于诊断乳腺癌的系统和方法
公开(公告)号：WO2005110230A1
公开(公告)日：2005-11-24
申请号：PCT/IB2005/051409
申请日：2005-04-29
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N. V. , WEIBRECHT, Martin , BREDNO, Joerg
发明人： WEIBRECHT, Martin , BREDNO, Joerg
IPC分类号： A61B6/02
CPC分类号： A61B6/502 , A61B6/025
摘要： The invention relates to a system and a method for the investigation of a body volume (3), particularly for the diagnosis of breast cancer. According to the method, a sequence of X-ray projections (P, P') from different directions is produced by a rotatable X-ray source (1) and a stationary digital X-ray detector (5). From these projections (P, P'), a set of sectional images (a, b, c, d) is calculated by tomosynthesis. A physician may indicate a suspicious structure on a reference image (R) that is derived from one of the projections (P, P') or sectional images (a, b, c, d) and displayed on a monitor (6). The computer (7) may then locate the structure on all sectional images (a, b, c, d) and calculate the similarity of a corresponding image feature. The sectional 10 image at which the similarity is strongest then indicates the depth (zo) at which the structure (4) is positioned in the body volume (3). Based on this information, a biopsy device (9) with a needle (10) can be advanced into the body volume (3) until it reaches the suspicious structure (4).
摘要翻译：本发明涉及一种用于体检（3）的研究的系统和方法，特别是用于乳腺癌的诊断。根据该方法，通过可旋转X射线源（1）和固定数字X射线检测器（5）产生来自不同方向的X射线投影（P，P'）的序列。通过这些投影（P，P'），通过断层合成计算出一组截面图像（a，b，c，d）。医生可以在从投影（P，P'）中的一个或截面图像（a，b，c，d）导出并显示在监视器（6）上的参考图像（R）上指示可疑结构。然后，计算机（7）可以在所有截面图像（a，b，c，d）上定位结构，并计算相应图像特征的相似度。相似度最强的截面10图像表示结构（4）位于体积（3）中的深度（zo）。基于该信息，具有针（10）的活检装置（9）可以前进到体积（3）中，直到达到可疑结构（4）。

6. 发明申请

WO2010109357A1 MARKER ADAPTED NORMAL TISSUE COMPLICATION PROBABILITY 审中-公开
标题翻译：标记适应正常组织综合概率
公开(公告)号：WO2010109357A1
公开(公告)日：2010-09-30
申请号：PCT/IB2010/050732
申请日：2010-02-18
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , WEIBRECHT, Martin , GEORGI, Jens, Christoph , RIBBING, Carolina, M.
发明人： WEIBRECHT, Martin , GEORGI, Jens, Christoph , RIBBING, Carolina, M.
IPC分类号： A61N5/10
CPC分类号： A61N5/103 , A61N5/1038 , G06F19/00 , G06Q50/22
摘要： A therapy system includes a diagnostic image scanner (12) that acquires a diagnostic image of a target region to be treated. A planning processor (70) is configured to generate a patient specific adaptive radiation therapy plan based on patient specific biomarkers before and during therapy. A first set of patient specific biomarkers is determined then used for the determination of a first normal tissue complication probability (NTCP) model and a first tumor control probability (TCP) model. A radiation therapy device (40) administers a first dose of radiation to the target region with a protocol based on the first NTCP model and the first TCP model. A second set of patient specific biomarkers is determined. A relationship between the first set and second set of patient specific biomarkers is used to determine a second NTCP model and a second TCP model. The radiation therapy device (40) administers a second dose of radiation to the target region with a protocol based on the second NTCP model and second TCP model.
摘要翻译：治疗系统包括：诊断图像扫描器（12），其获取待治疗的对象区域的诊断图像。规划处理器（70）被配置为在治疗之前和期间基于患者特异性生物标志物产生患者特异性自适应放射治疗计划。确定第一组患者特异性生物标志物，然后用于确定第一正常组织并发症概率（NTCP）模型和第一肿瘤控制概率（TCP）模型。辐射治疗装置（40）使用基于第一NTCP模型和第一TCP模型的协议向目标区域施加第一剂量的辐射。确定第二组患者特异性生物标志物。使用第一组和第二组患者特异性生物标志物之间的关系来确定第二NTCP模型和第二TCP模型。辐射治疗装置（40）使用基于第二NTCP模型和第二TCP模型的协议向目标区域施加第二剂量的辐射。

7. 发明申请

WO2007057855A2 METHOD FOR DISPLAYING HIGH RESOLUTION IMAGE DATA TOGETHER WITH TIME-VARYING LOW RESOLUTION IMAGE DATA 审中-公开
标题翻译：将高分辨率图像数据与时变低分辨率图像数据一起显示的方法
公开(公告)号：WO2007057855A2
公开(公告)日：2007-05-24
申请号：PCT/IB2006/054297
申请日：2006-11-16
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GmBH , KONINKLIJKE PHILIPS ELECTRONICS N.V. , WEIBRECHT, Martin , ECABERT, Olivier , WEESE, Juergen , KIEFER, Gundolf
发明人： WEIBRECHT, Martin , ECABERT, Olivier , WEESE, Juergen , KIEFER, Gundolf
IPC分类号： G06T15/10
CPC分类号： G06T15/10
摘要： A method allowing display of time-varying merged high resolution and low resolution image data with a smooth frame rate. In one embodiment the high resolution data is structural image data and the low resolution image data is functional image data. The functional image data is gathered (20) into groups and each group is rendered and merged (24) together. The merged images produced are then stored (28) in a First In First Out (FIFO) buffer for display. While the merged images are displayed the next set of functional image data is merged and rendered and supplied to the FIFO buffer, allowing a smooth frame rate to be achieved. A computer program and a medical imaging apparatus using the method are also disclosed.
摘要翻译：
一种允许以平滑帧速率显示时变合并的高分辨率和低分辨率图像数据的方法。在一个实施例中，高分辨率数据是结构图像数据，低分辨率图像数据是功能图像数据。功能图像数据被收集（20）成组，并且每个组被渲染和合并（24）在一起。然后将生成的合并图像存储（28）在先进先出（FIFO）缓冲器中以供显示。在显示合并的图像时，下一组功能图像数据被合并并渲染并提供给FIFO缓冲器，从而实现平滑的帧速率。还公开了使用该方法的计算机程序和医学成像设备。

8. 发明申请

WO2005020204A8 SYSTEM FOR DRIVING INERTIA-PRONE PICTURE-REPRODUCING DEVICES 审中-公开
标题翻译：用于驱动图像传播设备的系统
公开(公告)号：WO2005020204A8
公开(公告)日：2006-04-13
申请号：PCT/IB2004051463
申请日：2004-08-16
申请人： PHILIPS INTELLECTUAL PROPERTY , KONINKL PHILIPS ELECTRONICS NV , SOLF TORSTEN , ECK KAI , WEIBRECHT MARTIN
发明人： SOLF TORSTEN , ECK KAI , WEIBRECHT MARTIN
IPC分类号： G09G3/36
CPC分类号： G09G3/3648 , G09G2320/0252 , G09G2320/0261 , G09G2320/0285 , G09G2340/16
摘要： In a system for driving inertia-prone picture-reproducing devices, in particular liquid-crystal displays, in which a correcting value that depends on changes in the video signals from frame to frame is added to incoming video signals to compensate for the inertial effects and in which the corrected video signals are passed to the picture-reproducing device to form the correcting value, a model of the picture-reproducing device is provided that has a state variable as an output variable, the video signals as a first input variable and the state variable from a preceding frame as a second input variable. Furthermore, to derive the correcting value, a function having the incoming video signals and the state variable of the preceding variable as input variables and the corrected video signals as an output variable.
摘要翻译：在用于驱动惯性倾向的图像再现装置的系统中，特别是液晶显示器，其中将依赖于帧间视频信号的变化的校正值加到输入视频信号上以补偿惯性效应，其中校正的视频信号被传送到图像再现装置以形成校正值，提供了具有状态变量作为输出变量的图像再现装置的模型，视频信号作为第一输入变量，并且状态变量作为第二个输入变量。此外，为了导出校正值，具有输入视频信号和前一变量的状态变量作为输入变量的函数和校正后的视频信号作为输出变量。

9. 发明申请

WO9828911A2 X-RAY EXAMINATION APPARATUS WITH X-RAY IMAGE SENSOR MATRIX AND CORRECTION UNIT 审中-公开
标题翻译： X射线图像传感器矩阵和校正单元的X射线检查装置
公开(公告)号：WO9828911A2
公开(公告)日：1998-07-02
申请号：PCT/IB9701595
申请日：1997-12-23
申请人： PHILIPS ELECTRONICS NV , PHILIPS NORDEN AB , CONRADS NORBERT , WEIBRECHT MARTIN , SCHIEBEL ULRICH , WIECZOREK HERFRIED KARL
发明人： CONRADS NORBERT , WEIBRECHT MARTIN , SCHIEBEL ULRICH , WIECZOREK HERFRIED KARL
IPC分类号： H04N5/32 , A61B6/00 , H04N5/325 , H04N5/359
CPC分类号： H04N5/325 , H04N5/3597
摘要： An x-ray examination apparatus comprises an x-ray image sensor matrix (1) for deriving an initial image signal from the x-ray image. The sensor elements of the x-ray sensor matrix convert incident x-rays into electric charges. These electric charges are read-out and converted into the initial image signal. Further a correction unit (2) is provided for correcting the initial image signal, notably for disturbances due to delayed transferred charges, that have been retained in the sensor elements for some time. The correction unit (2) is provided with a memory which stores correction values. Further the correction provided with a selection unit (5) for selecting appropriate correction values from the memory (3).
摘要翻译： X射线检查装置包括用于从X射线图像导出初始图像信号的x射线图像传感器矩阵（1）。 X射线传感器矩阵的传感器元件将入射的X射线转换成电荷。这些电荷被读出并转换成初始图像信号。此外，提供校正单元（2），用于校正已经保留在传感器元件中一段时间的初始图像信号，特别是用于由于延迟传送的电荷引起的干扰。校正单元（2）设置有存储校正值的存储器。此外，还提供了用于从存储器（3）中选择适当的校正值的选择单元（5）。

10. 发明申请

WO2011070461A3 DIAGNOSTIC TECHNIQUES FOR CONTINUOUS STORAGE AND JOINT ANALYSIS OF BOTH IMAGE AND NON-IMAGE MEDICAL DATA 审中-公开
标题翻译：用于连续存储和联合分析两个图像和非图像医学数据的诊断技术
公开(公告)号：WO2011070461A3
公开(公告)日：2011-12-08
申请号：PCT/IB2010055237
申请日：2010-11-17
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS INTELLECTUAL PROPERTY , RIBBING CAROLINA , WEIBRECHT MARTIN , BACHMANN PETER K
发明人： RIBBING CAROLINA , WEIBRECHT MARTIN , BACHMANN PETER K
IPC分类号： G06F19/00
CPC分类号： G06F19/321 , G16H50/20
摘要： An apparatus comprises: a database (30) storing medical data including image medical data and non-image medical data for a plurality of patients; a digital processor (40) configured to (i) generate a features vector (56) comprising features indicative of a patient derived from patient medical data stored in the database including both patient image medical data and patient non-image medical data and (ii) perform multivariate analysis (64) on a features vector generated for a patient of interest to determine a proposed diagnosis for the patient of interest; and a user interface (42) configured to output a human perceptible representation of the proposed diagnosis for the patient of interest.
摘要翻译：一种装置包括：数据库（30），存储包括用于多个患者的图像医疗数据和非图像医疗数据的医学数据; 数字处理器（40），被配置为（i）生成特征向量（56），其特征向量（56）包括表示从存储在数据库中的患者医疗数据导出的病人的特征，包括患者图像医疗数据和患者非图像医疗数据，以及（ii）对为感兴趣的患者生成的特征向量执行多变量分析（64）以确定对感兴趣的患者的建议诊断; 以及用户界面（42），其被配置为输出针对感兴趣的患者的所提出的诊断的人感知表示。

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