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1. 发明申请

WO2010109357A1 MARKER ADAPTED NORMAL TISSUE COMPLICATION PROBABILITY 审中-公开
标题翻译：标记适应正常组织综合概率
公开(公告)号：WO2010109357A1
公开(公告)日：2010-09-30
申请号：PCT/IB2010/050732
申请日：2010-02-18
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , WEIBRECHT, Martin , GEORGI, Jens, Christoph , RIBBING, Carolina, M.
发明人： WEIBRECHT, Martin , GEORGI, Jens, Christoph , RIBBING, Carolina, M.
IPC分类号： A61N5/10
CPC分类号： A61N5/103 , A61N5/1038 , G06F19/00 , G06Q50/22
摘要： A therapy system includes a diagnostic image scanner (12) that acquires a diagnostic image of a target region to be treated. A planning processor (70) is configured to generate a patient specific adaptive radiation therapy plan based on patient specific biomarkers before and during therapy. A first set of patient specific biomarkers is determined then used for the determination of a first normal tissue complication probability (NTCP) model and a first tumor control probability (TCP) model. A radiation therapy device (40) administers a first dose of radiation to the target region with a protocol based on the first NTCP model and the first TCP model. A second set of patient specific biomarkers is determined. A relationship between the first set and second set of patient specific biomarkers is used to determine a second NTCP model and a second TCP model. The radiation therapy device (40) administers a second dose of radiation to the target region with a protocol based on the second NTCP model and second TCP model.
摘要翻译：治疗系统包括：诊断图像扫描器（12），其获取待治疗的对象区域的诊断图像。规划处理器（70）被配置为在治疗之前和期间基于患者特异性生物标志物产生患者特异性自适应放射治疗计划。确定第一组患者特异性生物标志物，然后用于确定第一正常组织并发症概率（NTCP）模型和第一肿瘤控制概率（TCP）模型。辐射治疗装置（40）使用基于第一NTCP模型和第一TCP模型的协议向目标区域施加第一剂量的辐射。确定第二组患者特异性生物标志物。使用第一组和第二组患者特异性生物标志物之间的关系来确定第二NTCP模型和第二TCP模型。辐射治疗装置（40）使用基于第二NTCP模型和第二TCP模型的协议向目标区域施加第二剂量的辐射。

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