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    • 4. 发明申请
    • CALIBRATION OF OPTICAL ANALYSIS MAKING USE OF MULTIVARIATE OPTICAL ELEMENTS
    • 光学分析的校准使用多种光学元件
    • WO2006064446A1
    • 2006-06-22
    • PCT/IB2005/054176
    • 2005-12-12
    • KONINKLIJKE PHILIPS ELECTRONICS N.V.BAKKER, BernardusVAN BEEK, MichaelRENSEN, Wouter
    • BAKKER, BernardusVAN BEEK, MichaelRENSEN, Wouter
    • G01J3/28G01N21/27G01N21/35
    • G01N21/65G01J3/28G01N21/276G01N2021/1748G01N2201/1293
    • The invention provides a method of calibrating an optical analysis system that makes use of multivariate optical signal analysis allowing to realize cost-efficient and robust implementation of a spectral analysis of an optical signal. The calibration method makes use of determining a parameter of a reference sample by means of the optical analysis system and comparing the actually determined parameter with a reference parameter that represents a precise and real property of the reference sample. Based on this comparison a calibration value can be determined that is applicable to perform a calibration of the optical analysis system with respect to at least one compound or analyte of the reference sample. Parameters and reference parameters of a reference sample may refer to a concentration of an analyte dissolved in the sample, or to spectroscopic background signals that have to be taken into account when performing a spectral analysis based on optical signals obtained from the reference sample. Various different reference samples providing a reference with respect to different acquisition conditions and different analyte or compound concentrations can be universally used. Analyte-specific reference data is preferably stored in a calibration unit of the optical analysis system and allows a high degree of automation of the calibration process.
    • 本发明提供了一种校准光学分析系统的方法,其利用多变量光信号分析,从而实现光信号的光谱分析的成本有效且鲁棒的实现。 校准方法利用通过光学分析系统确定参考样本的参数,并将实际确定的参数与表示参考样本的精确和不变性的参考参数进行比较。 基于该比较,可以确定适用于相对于参考样品的至少一种化合物或分析物执行光学分析系统的校准的校准值。 参考样品的参数和参考参数可以指溶解在样品中的分析物的浓度,或者基于从参考样品获得的光学信号进行光谱分析时必须考虑的光谱背景信号。 可以普遍使用提供关于不同采集条件和不同分析物或化合物浓度的参考的各种不同参考样品。 分析物特异性参考数据优选地存储在光学分析系统的校准单元中,并允许校准过程的高度自动化。