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1. 发明申请

WO2009027937A2 CLUSTERED MAGNETIC PARTICLES AS TRACERS FOR MAGNETIC PARTICLE IMAGING 审中-公开
标题翻译：聚集磁性粒子作为磁粉粒子成像的示踪剂
公开(公告)号：WO2009027937A2
公开(公告)日：2009-03-05
申请号：PCT/IB2008/053461
申请日：2008-08-28
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , GRUELL, Holger , BOEVE, Hans, M., B. , MARKOV, Denis
发明人： GRUELL, Holger , BOEVE, Hans, M., B. , MARKOV, Denis
IPC分类号： A61K49/18
CPC分类号： A61K49/1812 , A61K49/1887 , B82Y5/00
摘要： The invention provides a magnetic tracer material for use in magnetic particle imaging and a manufacturing method thereof. The magnetic tracer material comprises clusters of a plurality of magnetic particles that are clustered in a controlled way to form individual entities, for example, stabilized oil droplets, solid emulsion particles, liposomes, polymersomes or vesicles, or naturally occurring biological entities such as cells or viruses.
摘要翻译：本发明提供了用于磁性粒子成像的磁性示踪剂材料及其制造方法。磁性示踪物材料包括以受控方式聚集以形成单独实体的多个磁性颗粒的簇，例如稳定的油滴，固体乳液颗粒，脂质体，聚合物囊泡或囊泡，或天然存在的生物实体如细胞或病毒

2. 发明申请

WO2008099346A1 METHOD AND SEPARATOR SYSTEM FOR SEPARATING MAGNETIC PARTICLES, SEPARATOR COLUMN FOR USE IN A SEPARATOR SYSTEM 审中-公开
标题翻译：用于分离磁体的方法和分离器系统，用于分离器系统的分离器柱
公开(公告)号：WO2008099346A1
公开(公告)日：2008-08-21
申请号：PCT/IB2008/050512
申请日：2008-02-13
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , MARKOV, Denis , BOEVE, Hans, M., B.
发明人： MARKOV, Denis , BOEVE, Hans, M., B.
IPC分类号： B03C1/029 , B03C1/034 , B03C1/28
CPC分类号： B03C1/029 , A61B5/0515 , B03C1/034 , B03C1/288
摘要： Magnetic Particle Imaging (MPI) requires high-performing tracer materials that are highly magnetic monodispersed particles with fast remagnetization behaviour. Known separation techniques only allow for fractionation of magnetic particles based on differences in magnetic volume. Proposed is a separation method, which allows for separation of magnetic particles with respect to their dynamic response onto an oscillating high gradient magnetic field.
摘要翻译：磁性粒子成像（MPI）需要高性能示踪材料，它们是具有快速再磁化行为的高磁性单分散颗粒。已知的分离技术仅允许基于磁体积的差异分离磁性颗粒。提出了一种分离方法，其允许将磁性颗粒相对于它们的动态响应分离到振荡的高梯度磁场上。

3. 发明申请

WO2008090500A2 METHOD FOR INFLUENCING AND/OR DETECTING MAGNETIC PARTICLES IN A REGION OF ACTION, MAGNETIC PARTICLES AND THE USE OF MAGNETIC PARTICLES 审中-公开
标题翻译：在动作区域，磁性颗粒和磁性颗粒的使用中影响和/或检测磁性颗粒的方法
公开(公告)号：WO2008090500A2
公开(公告)日：2008-07-31
申请号：PCT/IB2008/050186
申请日：2008-01-18
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , BOEVE, Hans, M., B. , MARKOV, Denis
发明人： BOEVE, Hans, M., B. , MARKOV, Denis
IPC分类号： A61B5/00 , A61K49/00 , H01F1/00
CPC分类号： A61B5/05 , A61B5/0515 , A61K49/1818 , A61K49/1869 , B82Y25/00 , H01F1/0054 , H01F1/344
摘要： A method for influencing and/or detecting magnetic particles in a region of action, magnetic particles and the use of magnetic particles is disclosed, which method comprises the steps of: - introducing magnetic particles into a region of action, - generating a magnetic selection field having a pattern in space of its magnetic field strength such that a first sub-zone having a low magnetic field strength and a second sub-zone having a higher magnetic field strength are formed in the region of action - changing the position in space of the two sub-zones in the region of action by means of a magnetic drive field so that the magnetization of the magnetic particles change locally, - acquiring signals, which signals depend on the magnetization in the region of action, which magnetization is influenced by the change in the position in space of the first and second sub-zone, wherein the magnetic particles comprise a core region and a shell region, the core region comprising a magnetic material, wherein the magnetic material of the core region is provided as a mainly metallic material of comparably high saturation magnetization, wherein the shell region comprises mainly a metal oxide material or a nobel metal material.
摘要翻译：公开了一种用于影响和/或检测磁性颗粒的作用区域，磁性颗粒和使用磁性颗粒的方法，该方法包括以下步骤：将磁性颗粒引入到动作区域中，产生磁选择场在其磁场强度的空间中具有图案，使得具有低磁场强度的第一子区域和具有较高磁场强度的第二子区域在作用区域中形成 - 改变位置通过磁驱动场在动作区域中的两个子区域，使得磁性颗粒的磁化在局部变化， - 获取信号，该信号取决于作用区域中的磁化强度，该磁化受到变化的影响在所述第一和第二子区域的空间中的位置处，其中所述磁性颗粒包括芯区域和壳体区域，所述芯区域包括磁性材料其中芯区的磁性材料被提供为具有相当高饱和磁化强度的主要金属材料，其中壳区主要包括金属氧化物材料或诺贝尔金属材料。

4. 发明申请

WO2009122330A3 BIOCOMPATIBLE PRODUCTS FOR MAGNETIC PARTICLE IMAGING 审中-公开
公开(公告)号：WO2009122330A3
公开(公告)日：2009-10-08
申请号：PCT/IB2009/051274
申请日：2009-03-26
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , MARKOV, Denis , BOEVE, Hans, M., B.
发明人： MARKOV, Denis , BOEVE, Hans, M., B.
IPC分类号： A61L27/50
摘要： The present invention relates to materials and methods for non-invasive imaging of biocompatible products. Biocompatible products are provided that can be visualized in vivo and in vitro using magnetic particle imaging methods. It was found that these materials can be employed for monitoring development, remodeling or degradation of biocompatible products. In another aspect, the inventive products enable substance delivery tracking and can be used to visualize targeted delivery of active agents.

5. 发明申请

WO2009057022A2 SEPARATOR COLUMN, SEPARATOR SYSTEM, METHOD OF FRACTIONATING MAGNETIC PARTICLES, METHOD OF MANUFACTURING A SEPARATOR COLUMN AND USE OF A SEPARATOR COLUMN 审中-公开
标题翻译：分离柱，分离器系统，分离磁性颗粒的方法，制造分离柱的方法和分离柱的使用
公开(公告)号：WO2009057022A2
公开(公告)日：2009-05-07
申请号：PCT/IB2008/054393
申请日：2008-10-24
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N.V. , MARKOV, Denis , BOEVE, Hans, M., B. , GLEICH, Bernhard , WEIZENECKER, Juergen
发明人： MARKOV, Denis , BOEVE, Hans, M., B. , GLEICH, Bernhard , WEIZENECKER, Juergen
IPC分类号： B03C1/28 , B03C1/033
CPC分类号： B03C1/286 , A61B5/0515 , B03C1/01 , B03C1/0335 , B03C2201/18
摘要： A separator system with a separator column and a method of fractionating magnetic particles, preferably using field-flow fractionation is proposed, which allows for more effective fractionation of magnetic particles with respect to their dynamic magnetic response in a wide frequency and amplitude range of an applied magnetic field, in particular relevant for magnetic particle imaging (MPI).
摘要翻译：提出了具有分离器柱的分离器系统和优选使用场流分馏的分馏磁性粒子的方法，其允许磁性粒子相对于其动态磁响应的更有效的分级应用磁场的宽频率和幅度范围，特别是与磁性粒子成像（MPI）有关。

6. 发明申请

WO2008007260A2 NFC ENABLED POINTING WITH A MOBILE DEVICE 审中-公开
标题翻译：使用移动设备NFC启用指向
公开(公告)号：WO2008007260A2
公开(公告)日：2008-01-17
申请号：PCT/IB2007/052293
申请日：2007-06-15
申请人： NXP B.V. , BOEVE, Hans, M., B. , IKKINK, Teunis, J. , WOUDA, Kornelis, J.
发明人： BOEVE, Hans, M., B. , IKKINK, Teunis, J. , WOUDA, Kornelis, J.
IPC分类号： G06F3/033 , G06F3/0346
CPC分类号： G06F3/0346 , H04W84/10 , H04W88/02 , H04W88/06
摘要： A system comprises a communication terminal (CT1) which has a near field communication unit (10) for near field communication with a mobile device (MD1) when in range of the near field communication unit (10). An output device (OD1; OD2) is positioned outside the range of the near field communication unit (10) to provide output to a user of the mobile device (MD1). A controller (11) controls the output device (OD1; OD2) to provide the output dependent on an orientation (D1) of the mobile device (MD1).
摘要翻译：一种系统包括：通信终端（CT1），其具有用于在近场通信单元（10）的范围内时与移动设备（MD1）进行近场通信的近场通信单元（10）。输出设备（OD1; OD2）位于近场通信单元（10）的范围之外，以向移动设备（MD1）的用户提供输出。控制器（11）控制输出设备（OD1; OD2）以提供取决于移动设备（MD1）的取向（D1）的输出。

7. 发明申请

WO2006117731A1 DEVICE COMPRISING A SENSOR ARRANGEMENT AND AN ESTIMATOR 审中-公开
标题翻译：包含传感器布置的设备和估计器
公开(公告)号：WO2006117731A1
公开(公告)日：2006-11-09
申请号：PCT/IB2006/051317
申请日：2006-04-27
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , IKKINK, Teunis, J. , BOEVE, Hans, M., B. , VAN DE WALLE, Gerjan
发明人： IKKINK, Teunis, J. , BOEVE, Hans, M., B. , VAN DE WALLE, Gerjan
IPC分类号： G01C17/38
CPC分类号： G01C17/38
摘要： Devices (1) comprising sensor arrangements (2) for providing first field information defining at least parts of first fields and for providing second field information defining first parts of second fields are provided with estimators (4) for estimating second parts of the second fields as functions of mixtures of the first and second field information, to become more reliable and user friendly. The fields may be earth gravitational fields and/or earth magnetic fields and/or further fields. The mixtures comprise dot products of the first and second fields and/or first products of first components of the first and second fields in first directions and/or second products of second components of the first and second fields in second directions. The second parts of the second field comprise third components of the second field in third directions. The estimators (4) can further estimate third components of the first field in third directions as further functions of the first field information.
摘要翻译：设置有用于提供定义第一场的至少一部分的第一场信息和用于提供定义第二场的第一部分的第二场信息的传感器装置（2），用于将第二场的第二部分估计为第一和第二场信息的混合功能变得更加可靠和用户友好。场可以是地球引力场和/或地球磁场和/或其它场。混合物包括第一和第二场中的第一和第二场的第一和第二场的第一组分和/或第二方向上的第一和第二场的第二组分的第二组分的第一产物和/或第一组分的第一产物的第一产物。第二场的第二部分包括在第三方向上的第二场的第三分量。估计器（4）可以进一步估计第三方向的第一场的第三分量作为第一场信息的另外的功能。

8. 发明申请

WO2005114671A1 DIGITAL MAGNETIC CURRENT SENSOR AND LOGIC 审中-公开
标题翻译：数字磁电流传感器和逻辑
公开(公告)号：WO2005114671A1
公开(公告)日：2005-12-01
申请号：PCT/IB2005/051552
申请日：2005-05-11
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BOEVE, Hans, M., B.
发明人： BOEVE, Hans, M., B.
IPC分类号： G11C11/15
CPC分类号： G11C11/15 , G01R15/205 , G01R33/09 , G01R33/098 , Y10T29/49002
摘要： A sensor for sensing magnetic field strength has a sensor element, and detection circuitry for detecting a level of resistance of the sensor element, the level of resistance varying with magnetic field under test and having hysteresis, so that upon electromagnetic excitation the resistance can switch between two or more stable levels as the magnetic field under test varies. The sensor outputs a digital signal according to the level of resistance. The sensor output may further be interpreted in terms of a change-of-state upon electromagnetic excitation. As the sensor no longer needs a different characteristic from magnetic memory cells, it can be much easier to construct and to integrate with magnetic memory cells than an analog sensor. An excitation signal varies a threshold for the magnetic field under test at which the resistance switches, to enable multiple measurements with different thresholds. Multiple sensor elements can have different thresholds, by having differing geometry or size. It has applications in current sensing, and programmable magnetic logic, when multiple input currents are sensed. Changing the threshold can change the logic operation between AND and OR.
摘要翻译：用于感测磁场强度的传感器具有传感器元件，以及用于检测传感器元件的电阻水平的检测电路，电阻值随着测试中的磁场而变化并具有迟滞，从而在电磁激励时，电阻可以在随着被测磁场的变化，两个或更多个稳定的水平。传感器根据电阻水平输出数字信号。传感器输出可以进一步根据电磁激励时的状态变化来解释。由于传感器不再需要与磁存储单元不同的特性，因此与模拟传感器相比，可以轻松构建和集成磁存储单元。激励信号改变电阻开关处的被测磁场的阈值，以便能够以不同的阈值进行多次测量。多个传感器元件可以具有不同的阈值，具有不同的几何形状或尺寸。当感应到多个输入电流时，它具有电流检测和可编程磁逻辑的应用。更改阈值可以改变AND和OR之间的逻辑运算。

9. 发明申请

WO2006072842A1 DIELECTRIC ANTIFUSE FOR ELECTRO-THERMALLY PROGRAMMABLE DEVICE 审中-公开
标题翻译：用于电热可编程器件的电介质抗体
公开(公告)号：WO2006072842A1
公开(公告)日：2006-07-13
申请号：PCT/IB2005/053898
申请日：2005-11-24
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BOEVE, Hans, M., B. , ATTENBOROUGH, Karen , HURKX, Godefridus, A., M. , AGARWAL, Prabhat , HUIZING, Hendrik G., A. , IN 'T ZANDT, Michael, A., A. , SLOTBOOM, Jan, W.
发明人： BOEVE, Hans, M., B. , ATTENBOROUGH, Karen , HURKX, Godefridus, A., M. , AGARWAL, Prabhat , HUIZING, Hendrik G., A. , IN 'T ZANDT, Michael, A., A. , SLOTBOOM, Jan, W.
IPC分类号： H01L45/00 , H01L27/24
CPC分类号： G11C11/5678 , G11C13/0004 , H01L27/2409 , H01L45/06 , H01L45/1233 , H01L45/1246 , H01L45/144
摘要： A thermally programmable memory has a programmable element (20) of a thermally programmable resistance preferably of phase change material, material and a blown antifuse (80) located adjacent to the programmable material. Such a blown antiiuse has a dielectric layer (100) surrounded by conductive layers (90,110) to enable a brief high voltage to be applied across the dielectric to blow a small hole in the dielectric during manufacture to form a small conductive path which can be used as a tiny electrical heater for programming the material. Due to the current confinement by the hole, the volume of the material that must be heated in order to switch to a highly- resistive state is very small. As a result the programming power can be low.
摘要翻译：热可编程存储器具有可编程电阻的可编程电阻（20），优选地是相变材料的材料和位于可编程材料附近的吹制反熔丝（80）。这种吹制的抗氧化剂具有由导电层（90,110）包围的电介质层（100），以使得能够在制造期间在电介质两端施加短暂的高电压以吹出电介质中的小孔，以形成可以使用的小导电路径作为用于编程材料的微小电加热器。由于孔的电流限制，必须加热以切换到高阻态的材料的体积非常小。因此，编程功率可能很低。

10. 发明申请

WO2005050660A1 METHOD AND DEVICE FOR PERFORMING ACTIVE FIELD COMPENSATION DURING PROGRAMMING OF A MAGNETORESISTIVE MEMORY DEVICE 审中-公开
标题翻译：用于在磁记录存储器件编程期间执行主动补偿的方法和装置
公开(公告)号：WO2005050660A1
公开(公告)日：2005-06-02
申请号：PCT/IB2004/052467
申请日：2004-11-17
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BOEVE, Hans, M., B.
发明人： BOEVE, Hans, M., B.
IPC分类号： G11C11/16
CPC分类号： G11C11/16
摘要： The present invention provides an array (20) og magnetoresistive memory elements (10). The array (20) comprises: means for applying a current or voltage for generating a programming magnetic field at a selected magnetoresistive memory element (10s), a magnetic field sensor unit (50) for measuring an external magnetic field in the vicinity of the selected magnetoresistive memory element (10s), and means (52) for tuning the current or voltage for compensating locally for the measured external magnetic field during a programming operation. The present invention also provides a corresponding method.
摘要翻译：本发明提供一种阵列（20）磁阻存储元件（10）。阵列（20）包括：用于在所选择的磁阻存储元件（10s）处施加用于产生编程磁场的电流或电压的装置，用于测量所选择的磁阻存储元件附近的外部磁场的磁场传感器单元（50）磁阻存储元件（10s）以及用于在编程操作期间调谐用于补偿所测量的外部磁场的电流或电压的装置（52）。本发明还提供了相应的方法。

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