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1. 发明申请

WO2010052676A3 CONVERTER ELEMENT FOR A RADIATION DETECTOR 审中-公开
标题翻译：辐射探测器的转换器元件
公开(公告)号：WO2010052676A3
公开(公告)日：2010-10-28
申请号：PCT/IB2009054955
申请日：2009-11-09
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS INTELLECTUAL PROPERTY , STEADMAN BOOKER ROGER , SIMON MATTHIAS , HERRMANN CHRISTOPH , MENSER BERND , WIEGERT JENS , ENGEL KLAUS J , BAEUMER CHRISTIAN , MUELHENS OLIVER
发明人： STEADMAN BOOKER ROGER , SIMON MATTHIAS , HERRMANN CHRISTOPH , MENSER BERND , WIEGERT JENS , ENGEL KLAUS J , BAEUMER CHRISTIAN , MUELHENS OLIVER
IPC分类号： G01T1/29
CPC分类号： G01T1/249 , G01T1/24 , G01T1/2928
摘要： The invention relates to converter element (100) for a radiation detector, particularly for a Spectral CT scanner. The converter element (100) comprises at least two conversion cells (131) that are at least partially separated from each other by intermediate separation walls (135) which affect the spreading of electrical signals generated by incident radiation (X). The conversion cells (131) may particularly consist of a crystal of CdTe and/or CdZnTe. Said crystal is preferably grown by e.g. vapor deposition between preformed separation walls.
摘要翻译：本发明涉及用于辐射检测器的转换器元件（100），特别是用于光谱CT扫描仪。转换器元件（100）包括至少两个转换单元（131），所述至少两个转换单元（131）通过影响由入射辐射（X）产生的电信号的扩展的中间分隔壁（135）至少部分地彼此分离。转换电池（131）可以特别地由CdTe和/或CdZnTe的晶体组成。所述晶体优选通过例如预成型分隔壁之间的气相沉积。

2. 发明申请

WO2008012723A3 A DETECTOR FOR AND A METHOD OF DETECTING ELECTROMAGNETIC RADIATION 审中-公开
标题翻译：一种用于检测电磁辐射的检测器和方法
公开(公告)号：WO2008012723A3
公开(公告)日：2008-03-27
申请号：PCT/IB2007052783
申请日：2007-07-12
申请人： PHILIPS INTELLECTUAL PROPERTY , KONINK PHILIPS ELECRONICS N V , RUETTEN WALTER , SIMON MATTHIAS , KIEWITT RAINER , HERRMANN CHRISTOPH , MENSER BERND
发明人： RUETTEN WALTER , SIMON MATTHIAS , KIEWITT RAINER , HERRMANN CHRISTOPH , MENSER BERND
IPC分类号： G01T1/24 , H01L27/146
CPC分类号： H01L27/14658 , H01L27/14676
摘要： A detector unit (301) for detecting electromagnetic radiation (106), the detector unit (301) comprising a conversion material (332) adapted for converting impinging electromagnetic radiation (106) into electric charge carriers, a charge collection electrode (331) adapted for collecting the converted electric charge carriers, a shielding electrode (334, 335) adapted to form a capacitance with the charge collection electrode (331), and an evaluation circuit (312 to 315) electrically coupled with the charge collection electrode (331) and adapted for evaluating the electromagnetic radiation (106) based on the collected electric charge carriers.
摘要翻译：一种用于检测电磁辐射（106）的检测器单元（301），所述检测器单元（301）包括适于将入射电磁辐射（106）转换成电荷载流子的转换材料（332），适于收集转换的电荷载体，适于与电荷收集电极（331）形成电容的屏蔽电极（334,335），以及与电荷收集电极（331）电耦合的评估电路（312至315），并且适于用于基于收集的电荷载流子来评估电磁辐射（106）。

3. 发明申请

WO2011055277A3 DETECTOR UNIT FOR DETECTING ELECTROMAGNETIC RADIATION 审中-公开
标题翻译：用于检测电磁辐射的检测器单元
公开(公告)号：WO2011055277A3
公开(公告)日：2011-12-29
申请号：PCT/IB2010054863
申请日：2010-10-27
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS INTELLECTUAL PROPERTY , SIMON MATTHIAS , RUETTEN WALTER
发明人： SIMON MATTHIAS , RUETTEN WALTER
IPC分类号： G01T1/24 , H04N5/32
CPC分类号： G01T1/247 , H04N5/32 , H04N5/35545 , H04N5/3559 , H04N5/3745
摘要： According to an exemplary embodiment of the invention a detector unit 301 for detecting electro -magnetic radiation may be provided. The detector unit 301 may comprise a conversion material 332 adapted for converting impinging electro -magnetic radiation into electric charge carriers. Moreover, the detector unit 301 may comprise a charge collection electrode 331 adapted for collecting the converted electric charge carriers and an evaluation circuit 312, 313, 314 adapted for evaluating the electro -magnetic radiation based on the collected electric charge carriers. Moreover, the detector unit 301 may comprise a semiconductor 373 which may be electrically coupled between the charge collection electrode 331 and the evaluation circuit 312, 313, 314.
摘要翻译：根据本发明的示例性实施例，可以提供用于检测电磁辐射的检测器单元301。检测器单元301可以包括适于将撞击的电磁辐射转换成电荷载流子的转换材料332。此外，检测器单元301可以包括适于收集转换的电荷载流子的电荷收集电极331以及适用于基于收集的电荷载流子来评估电磁辐射的评估电路312,313,314。此外，检测器单元301可以包括可以电耦合在电荷收集电极331和评估电路312,313,314之间的半导体373。

4. 发明申请

WO2008032241A3 SCINTILLATOR BASED X-RAY SENSITIVE INTEGRATED CIRCUIT ELEMENT WITH DEPLETED ELECTRON DRIFT REGION 审中-公开
标题翻译：基于扫描仪的X射线敏感集成电路元件与电子脱落区域
公开(公告)号：WO2008032241A3
公开(公告)日：2008-06-26
申请号：PCT/IB2007053597
申请日：2007-09-06
申请人： PHILIPS INTELLECTUAL PROPERTY , KONINKL PHILIPS ELECTRONICS NV , SONSKY JAN , SIMON MATTHIAS
发明人： SONSKY JAN , SIMON MATTHIAS
IPC分类号： G01T1/20
CPC分类号： G01T1/2018
摘要： It is described an integrated circuit design and a method to fabricate the same for a high-efficiency, low-noise, position sensitive X-ray detection in particular for medical applications. The device (350) is based on deep recesses (354) filled with an X-ray sensitive scintillator material. A shallow first electrode (360) is formed on the surface of the substrate (352) sidewalls separating two neighboring recesses (354). This sidewall electrode (360) in combination with particular frontside wafer electrode (363) structure results in a full depletion of the entire device (350) and a removal of signal charge towards the low capacitance readout electrode (363). The described integrated circuit element (350) ensures high and not depth dependent light collection efficiency.
摘要翻译：描述了用于高效，低噪声，位置敏感的X射线检测的集成电路设计和制造方法，特别是用于医疗应用。装置（350）基于填充有X射线敏感闪烁体材料的深凹部（354）。在分离两个相邻的凹部（354）的基板（352）的侧壁的表面上形成浅的第一电极（360）。该侧壁电极（360）与特定的前侧晶片电极（363）结构相结合导致整个器件（350）的完全耗尽以及向低电容读出电极（363）去除信号电荷。所描述的集成电路元件（350）确保高且不依赖于深度的光收集效率。

5. 发明申请

WO2008126009A3 REDUCING TRAP EFFECTS IN A SCINTILLATOR BY APPLICATION OF SECONDARY RADIATION 审中-公开
标题翻译：通过应用二次辐射降低扫描仪中的陷阱效应
公开(公告)号：WO2008126009A3
公开(公告)日：2009-05-22
申请号：PCT/IB2008051329
申请日：2008-04-08
申请人： PHILIPS INTELLECTUAL PROPERTY , KONINKL PHILIPS ELECTRONICS NV , SNOEREN RUDOLPH M , STEINHAUSER HEIDRUN , NOORDHOEK NICOLAAS J , SIMON MATTHIAS
发明人： SNOEREN RUDOLPH M , STEINHAUSER HEIDRUN , NOORDHOEK NICOLAAS J , SIMON MATTHIAS
IPC分类号： G01T1/20
CPC分类号： G01T1/2018 , G01T1/20
摘要： According to an embodiment of the invention, a radiation detector device (10) for detecting a primary radiation (6) comprises a scintillator (12) which generates a converted primary radiation in response to incoming primary radiation (6) and a photo detector (14) for detecting the converted primary radiation. The radiation detector device (10) further comprises a secondary radiation source (20) for irradiating the scintillator (12) with a secondary radiation (22) which has a wavelength different from a wavelength of the first radiation (6) and which is capable of producing a spatially more uniform response of the scintillator (12) to primary radiation. In an embodiment of the invention, the radiation detector device (10) is an X-ray detector of an X-ray imaging apparatus where the primary radiation is X-ray radiation and the secondary radiation has a wavelength between 350 nm and 450 nm. According to an embodiment, the irradiation with the secondary radiation, e.g. UV radiation, produces a uniform gain distribution of the X-ray detector (10).
摘要翻译：根据本发明的实施例，用于检测初级辐射（6）的辐射检测器装置（10）包括闪烁体（12），其响应于入射的主辐射（6）和光检测器（14）产生转换的一次辐射）用于检测转换的一次辐射。辐射检测器装置（10）还包括用于用闪光体（12）照射具有与第一辐射（6）的波长不同的波长的次辐射（22）的次辐射源（20）产生闪烁体（12）对初级辐射的空间上更均匀的响应。在本发明的一个实施例中，辐射检测器装置（10）是X射线成像装置的X射线检测器，其中初级辐射是X射线辐射，二次辐射具有在350nm和450nm之间的波长。根据一个实施例，用二次辐射的照射，例如， UV辐射，产生X射线检测器（10）的均匀增益分布。

6. 发明申请

WO2008126012A3 DETERMINATION OF A SPATIAL GAIN DISTRIBUTION OF A SCINTILLATOR 审中-公开
标题翻译：确定扫描仪空间增益分布
公开(公告)号：WO2008126012A3
公开(公告)日：2009-05-22
申请号：PCT/IB2008051339
申请日：2008-04-09
申请人： PHILIPS INTELLECTUAL PROPERTY , KONINK PHILIPS ELECTZRONICS N , SNOEREN RUDOLPH M , STEINHAUSER HEIDRUN , NOORDHOEK NICOLAAS J , SIMON MATTHIAS
发明人： SNOEREN RUDOLPH M , STEINHAUSER HEIDRUN , NOORDHOEK NICOLAAS J , SIMON MATTHIAS
IPC分类号： G01T1/20
CPC分类号： G01T1/2018 , G01T1/2928
摘要： A method for providing information about a spatial gain distribution of a scintillator for a primary radiation is provided which does not require the irradiation of the scintillator with the primary radiation. The method comprises the step of irradiating the scintillator with a secondary radiation for generating an image of a spatial secondary gain distribution of the scintillator for said second radiation. The spatial secondary gain distribution image corresponds to an image of the spatial primary gain distribution for the primary radiation. In an embodiment of the invention, i.e. in an X-rayimaging device where the primary radiation is X-rayradiation, the invention provides for an accurate calibration of the X-raydetector without irradiating the X-raydetector with X- rayradiation. Rather, irradiation with UV radiation as the secondary radiation provides the desired spatial secondary gain distribution image which can be used for calibration.
摘要翻译：提供了一种用于提供关于主辐射的闪烁体的空间增益分布的信息的方法，其不需要用初级辐射照射闪烁体。该方法包括用二次辐射照射闪烁体的步骤，用于产生用于所述第二辐射的闪烁体的空间二次增益分布的图像。空间二次增益分布图像对应于初级辐射的空间初级增益分布的图像。在本发明的一个实施例中，即在主辐射是X射线照射的X射线成像装置中，本发明提供了X射线检测器的精确校准，而不用X射线照射X射线检测器。相反，用UV辐射作为辅助辐射的照射提供了可用于校准的期望的空间二次增益分布图像。

7. 发明申请

WO2010028820A3 PERIPHERAL ZONE TUMOR CELLS, METHODS FOR THEIR PREPARATION AND USE 审中-公开
标题翻译：外周区域肿瘤细胞，其制备和使用方法
公开(公告)号：WO2010028820A3
公开(公告)日：2010-06-17
申请号：PCT/EP2009006547
申请日：2009-09-09
申请人： LIFE & BRAIN GMBH , SCHEFFLER BJOERN , SIMON MATTHIAS , BRUESTLE OLIVER , HERRLINGER ULRICH JOHANNES , GLAS MARTIN
发明人： SCHEFFLER BJOERN , SIMON MATTHIAS , BRUESTLE OLIVER , HERRLINGER ULRICH JOHANNES , GLAS MARTIN
IPC分类号： C12N5/095 , G01N33/50
CPC分类号： G01N33/5011 , C12N5/0618 , C12N5/0622 , C12N5/0693 , G01N33/5017 , G01N33/502 , G01N33/5058 , G01N33/574 , G01N2333/705 , G01N2333/70596 , G01N2500/10
摘要： The present invention relates to a tumor cell of the peripheral zone of a tumor and methods of providing such a tumor cell. Further provided is a method for identifying a molecular marker diagnostic for an infiltrative cancer, an antibody, which specifically binds to such molecular marker, a method for identifying a therapeutic compound effective against a metastatic/infiltrative cancer disease and the use of a tumor cell according to the invention.
摘要翻译：本发明涉及肿瘤周边区域的肿瘤细胞和提供这种肿瘤细胞的方法。进一步提供一种用于鉴定渗透性癌症的分子标记物的诊断方法，特异性结合该分子标记物的抗体，鉴定对转移性/浸润性癌症有效的治疗化合物的方法以及肿瘤细胞的用途涉及本发明。

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