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1. 发明申请

WO2021180781A1 UP-SCALED PRODUCTION OF MICROGLIA-LIKE/-PRECURSOR CELLS AND MACROPHAGE CELLS USING MESH MACROCARRIERS 审中-公开
公开(公告)号：WO2021180781A1
公开(公告)日：2021-09-16
申请号：PCT/EP2021/056037
申请日：2021-03-10
申请人： LIFE & BRAIN GMBH , RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITÄT BONN
发明人： MATHEWS-AJENDRA, Mona Ann , HAUPT, Simone , BRÜSTLE, Oliver
IPC分类号： C12N5/079 , C12N5/073 , C12N5/00 , C12M1/12
摘要： The present invention relates to methods allowing adherence and outgrowth of embryoid bodies (EBs) using macrocarriers. The methods of the invention are useful for an up-scaled production of myeloid cells, such as macrophage- and microglia-like/-precursor cells, in a bioreactor system. The invention further relates to microglia-like cells or microglial precursor cells obtainable by these methods that are cryopreservable. The invention also concerns a porous macrocarrier coated with a material facilitating cell adherence.

2. 发明申请

WO2011051401A1 IN-VIVO STIMULATIONS-MESSSONDE 审中-公开
标题翻译：体内刺激-PROBE
公开(公告)号：WO2011051401A1
公开(公告)日：2011-05-05
申请号：PCT/EP2010/066392
申请日：2010-10-28
申请人： LIFE & BRAIN GMBH , RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITÄT , FORSCHUNGSZENTRUM CAESAR , BECK, Heinz , REMY, Stefan , KRÜPPEL, Roland , LACHER, Manfred , BÄR, Marion , SCHMITZ, Sam , SCHEIDING, Bernd , HOLIK, Peter , KOCH, Michael
发明人： BECK, Heinz , REMY, Stefan , KRÜPPEL, Roland , LACHER, Manfred , BÄR, Marion , SCHMITZ, Sam , SCHEIDING, Bernd , HOLIK, Peter , KOCH, Michael
IPC分类号： A61N5/06 , A61B5/04
CPC分类号： A61N5/0601 , A61B5/04001 , A61B5/4041 , A61B5/4064 , A61B5/6849 , A61B2018/00839 , A61B2503/40 , A61N5/0622 , A61N2005/0612 , A61N2005/063 , A61N2005/0651
摘要： Beschrieben wird eine Messsonde und ein System zur gezielten optischen in-vivo Stimulation von Nervenzellen und zur elektrischen Messung von Nervenzellenimpulsen. Die Messsonde umfasst mindestens eine Messnadel zum automatisch gesteuerten, motorischen in-vivo Einführen in ein Gehirn eines Wirbeltieres, wobei an der Nadel mindestens ein elektrischer Messaufnehmer zum Kontaktieren mit mindestens einer Nervenzelle des Gehirns angebracht ist, um deren Aktivität zu messen. Zudem umfasst die Messsonde mindestens eine Lichtquelle, mit deren emittiertem Licht die mindestens eine Nervenzelle optisch stimuliert werden kann.
摘要翻译：中描述了一种测量探头和用于靶向用于脉冲的电测量神经细胞和神经细胞的体刺激的光学系统。所述探针包括至少一个测量销用于自动地控制，机动的体内插入脊椎动物的脑，其中在所述针的至少一个电传感器被安装成与脑的至少一个神经元接触，以测量它们的活性。此外，所述探针包括至少一个光源，所述至少一个神经细胞可以与他们的发射的光被光学刺激。

3. 发明申请

WO2010125110A1 METHOD FOR OBTAINING HUMAN MICROGLIAL PRECURSOR CELLS FROM PLURIPOTENT STEM CELLS 审中-公开
标题翻译：从大脑干细胞中获得人类微血管前体细胞的方法
公开(公告)号：WO2010125110A1
公开(公告)日：2010-11-04
申请号：PCT/EP2010/055731
申请日：2010-04-28
申请人： LIFE & BRAIN GmbH , RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITÄT , NEUMANN, Harald , ROY, Kristin , BRÜSTLE, Oliver , PEITZ, Michael
发明人： NEUMANN, Harald , ROY, Kristin , BRÜSTLE, Oliver , PEITZ, Michael
IPC分类号： C12N5/07
CPC分类号： A61K35/30 , A61K35/12 , C12N5/0622 , C12N2500/25 , C12N2500/32 , C12N2500/38 , C12N2500/44 , C12N2500/50 , C12N2501/22 , C12N2501/2303 , C12N2501/235 , C12N2501/58 , C12N2506/02
摘要： The present invention relates to a method for obtaining human microglial precursor cells, comprising: (a) providing a ceil population comprising neural precursor cells, wherein the cell population is obtainable from embryoid bodies differentiated from human pluripotent stem cells; (b) differentiating the cell population comprising neural precursor cells into microglial precursor cells by culturing in medium comprising a growth factor selected from the group consisting of insulin and insulin-like growth factors; (c) expanding and enriching microglial precursor cells in medium comprising a growth factor selected from the group consisting of insulin and insulin-iike growth factors and 10 to 150 ng/ml GM-CSF; and (d) isolating microglial precursor cells comprising CD45-positive cells.
摘要翻译：本发明涉及一种获得人小胶质细胞前体细胞的方法，包括：（a）提供包含神经前体细胞的细胞群，其中所述细胞群可从人多能干细胞分化的胚状体获得; （b）通过在包含选自胰岛素和胰岛素样生长因子的生长因子的培养基中培养将包含神经前体细胞的细胞群分化为小胶质前体细胞; （c）在包含选自胰岛素和胰岛素生长因子和10至150ng / ml GM-CSF的生长因子的培养基中扩增和富集小神经胶质前体细胞; 和（d）分离包含CD45阳性细胞的小胶质细胞前体细胞。

4. 发明申请

WO2010108665A1 PROMOTION OF NEURONAL INTEGRATION IN NEURAL STEM CELL GRAFTS 审中-公开
标题翻译：神经干细胞移植中神经元整合的促进
公开(公告)号：WO2010108665A1
公开(公告)日：2010-09-30
申请号：PCT/EP2010/001841
申请日：2010-03-24
申请人： LIFE & BRAIN GMBH , BRUSTLE, Oliver , KOCH, Philipp , LADEWIG, Julia
发明人： BRUSTLE, Oliver , KOCH, Philipp , LADEWIG, Julia
IPC分类号： A61K38/00 , A61K35/30 , C07K16/18
CPC分类号： A61K35/30 , C07K16/2863 , C07K2317/76
摘要： The invention relates to the treatment of diseases or disorders of the nervous system. In particular, the invention relates to the treatment of diseases or disorders of the nervous system by stem cell therapy, in particular therapy with neural precursor cells. In preferred aspects of the invention, inhibitors of chemoattraction are administered prior to, concomitantly with, or subsequently to the administration of neural precursor cells.
摘要翻译：本发明涉及治疗神经系统疾病或病症。特别地，本发明涉及通过干细胞疗法治疗神经系统疾病或病症，特别是用神经前体细胞治疗。在本发明的优选方面，在给予神经前体细胞之前，伴随或随后给予化学吸引抑制剂。

5. 发明申请

WO2015082721A1 MEANS AND METHODS FOR ESTABLISHING A CLINICAL PROGNOSIS OF DISEASES ASSOCIATED WITH THE FORMATION OF AGGREGATES OF Aβ1-42 审中-公开
标题翻译：建立与Aβ1-42聚集相关的疾病临床预防的手段和方法
公开(公告)号：WO2015082721A1
公开(公告)日：2015-06-11
申请号：PCT/EP2014/076907
申请日：2014-12-08
申请人： LIFE & BRAIN GMBH , RHEINISCHE FRIEDRICH-WILHELMS UNIVERSITÄT BONN
发明人： BECKER, Tim , HENEKA, Michael Thomas , KUNZ, Wolfram , ZUNIGA, Alfredo Ramirez , NÖTHEN, Markus
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/156
摘要： The present invention relates to novel means and methods for establishing the prediction of the course of neurodegenerative diseases such as Alzheimer's disease based on genotyping single nucleotide polymorphism rs62256378 and or at least one SNP in linkage disequilibrium therewith. Moreover a novel method for screening pharmaceutical compounds which may be useful for the treatment of AD are disclosed.
摘要翻译：本发明涉及基于基因分型单核苷酸多态性rs62256378和至少一个与其连锁不平衡的SNP来建立神经变性疾病如阿尔茨海默氏病过程预测的新方法和方法。此外，公开了一种用于筛选可用于治疗AD的药物化合物的新方法。

6. 发明申请

WO2012076974A1 8-TRIAZOLYLXANTHINE DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS ADENOSINE RECEPTOR ANTAGONISTS 审中-公开
标题翻译： 8-三唑并噻吩衍生物，其生产方法及其用作腺苷受体拮抗剂
公开(公告)号：WO2012076974A1
公开(公告)日：2012-06-14
申请号：PCT/IB2011/002987
申请日：2011-12-08
申请人： LIFE & BRAIN GMBH , MÜLLER, Christa , ZIMMER, Andreas , LABS, Stefanie , BUCHHOLZ, Stephanie , HINZ, Sonja
发明人： MÜLLER, Christa , ZIMMER, Andreas , LABS, Stefanie , BUCHHOLZ, Stephanie , HINZ, Sonja
IPC分类号： C07D473/06 , C07D473/08 , C07D473/12 , A61K31/522 , A61P25/28
CPC分类号： C07D473/08 , C07D473/12
摘要： The invention relates to derivatives of the general formulae (I) and (II) to processes for the production thereof, to pharmaceutical preparations containing said compounds and/or physiologically compatible salts or solvates or prodrugs which can be produced therefrom as well as to the pharmaceutical use of said compounds, the salts or solvates thereof as adenosine receptor antagonists, in particular for the treatment of neurodegenerative disorders, e.g. stroke, amylotrophic lateral sclerosis, dementia, Alzheimer's disease, Parkinson's disease, ischemia/reperfusion injury, inflammation, and/or neurological disorder. The blockade of adenosine receptors could also be useful for other indications regarding the metabolism, e.g. diabetic retinopathy, diabetes mellitus, hyperbaric oxygen - induced retinopathy and/or obesity. Applications could also be the treatment of allergic diseases and autoimmune diseases, including mast cell degranulation, asthma, bronchoconstriction, pulmonary fibrosis, inflammatory or obstructive airways disease and/or chronic obstructive pulmonary disease (COPD). In addition, they could be used to treat cancer. The diseases associated with adenosine receptors are also diabetes, diarrhea, inflammatory bowel disease and/or gastrointestinal tract disorders. Adenosine receptor antagonists could be effective for treating a hepatic disease or condition for reducing fat deposition in the liver or fibrosis of the liver. The use of compounds of general formulae I or II can be associated with many applications e.g., scleroderm arthritis, atherosclerosis, urticaria, myocardial infarction, myocardial reperfusion after ischemia, vasodilation, hypertension, hypersensitivity, myocardial ischemia, heart attack and/or retinopathy of prematurity.
摘要翻译：本发明涉及通式（I）和（II）的衍生物及其制备方法，含有所述化合物和/或可由其制备的生理上相容的盐或溶剂化物或前药的药物制剂以及药物使用所述化合物，其盐或溶剂化物作为腺苷受体拮抗剂，特别是用于治疗神经变性疾病，例如中风，肌萎缩性侧索硬化，痴呆，阿尔茨海默病，帕金森病，缺血/再灌注损伤，炎症和/或神经障碍。腺苷受体的阻断也可用于其他有关代谢的适应症，例如，糖尿病性视网膜病变，糖尿病，高压氧诱导的视网膜病变和/或肥胖。应用还可以是治疗过敏性疾病和自身免疫性疾病，包括肥大细胞脱粒，哮喘，支气管收缩，肺纤维化，炎性或阻塞性气道疾病和/或慢性阻塞性肺疾病（COPD）。此外，它们可以用于治疗癌症。与腺苷受体相关的疾病也是糖尿病，腹泻，炎性肠病和/或胃肠道疾病。腺苷受体拮抗剂可有效治疗肝脏疾病或病症，以减少肝脏中的脂肪沉积或肝纤维化。使用通式I或II的化合物可与许多应用相关联，例如硬皮病关节炎，动脉粥样硬化，荨麻疹，心肌梗死，缺血后心肌再灌注，血管舒张，高血压，超敏反应，心肌缺血，心脏病发作和/或早产儿视网膜病变。

7. 发明申请

WO2009149956A3 FUSION PROTEIN AND USE THEREOF 审中-公开
标题翻译：融合蛋白及其用途
公开(公告)号：WO2009149956A3
公开(公告)日：2010-06-10
申请号：PCT/EP2009004287
申请日：2009-06-15
申请人： LIFE & BRAIN GMBH , EDENHOFER FRANK , BOSNALI MANAL , PEITZ MICHAEL , THIER MARC-CHRISTIAN
发明人： EDENHOFER FRANK , BOSNALI MANAL , PEITZ MICHAEL , THIER MARC-CHRISTIAN
IPC分类号： C12N15/64 , C12N5/074
CPC分类号： C12N5/0696 , C07K2319/80 , C12N15/62 , C12N2501/602 , C12N2501/603
摘要： The invention relates to a fusion protein and a method for the generation of the fusion protein of the invention. Further, the invention relates to the use of the fusion protein of the invention for the generation of induced pluripotent cells. Moreover, the invention relates to a composition comprising at least one fusion protein of the invention.
摘要翻译：本发明涉及融合蛋白和产生本发明的融合蛋白的方法。此外，本发明涉及本发明的融合蛋白用于产生诱导多能细胞的用途。此外，本发明涉及包含本发明的至少一种融合蛋白的组合物。

8. 发明申请

WO2010028820A2 PERIPHERAL ZONE TUMOR CELLS, METHODS FOR THEIR PREPARATION AND USE 审中-公开
标题翻译：周围区肿瘤细胞及其制备和使用方法
公开(公告)号：WO2010028820A2
公开(公告)日：2010-03-18
申请号：PCT/EP2009/006547
申请日：2009-09-09
申请人： LIFE & BRAIN GMBH , SCHEFFLER, Björn , SIMON, Matthias , BRÜSTLE, Oliver , HERRLINGER, Ulrich, Johannes , GLAS, Martin
发明人： SCHEFFLER, Björn , SIMON, Matthias , BRÜSTLE, Oliver , HERRLINGER, Ulrich, Johannes , GLAS, Martin
CPC分类号： G01N33/5011 , C12N5/0618 , C12N5/0622 , C12N5/0693 , G01N33/5017 , G01N33/502 , G01N33/5058 , G01N33/574 , G01N2333/705 , G01N2333/70596 , G01N2500/10
摘要： The present invention relates to a tumor cell of the peripheral zone of a tumor and methods of providing such a tumor cell. Further provided is a method for identifying a molecular marker diagnostic for an infiltrative cancer, an antibody, which specifically binds to such molecular marker, a method for identifying a therapeutic compound effective against a metastatic/infiltrative cancer disease and the use of a tumor cell according to the invention.
摘要翻译：本发明涉及肿瘤外周区的肿瘤细胞和提供这种肿瘤细胞的方法。还提供了用于鉴定诊断浸润性癌症的分子标志物的方法，与该分子标志物特异性结合的抗体，鉴定对转移性/浸润性癌症有效的治疗性化合物的方法，以及使用肿瘤细胞发明。

9. 发明申请

WO2009124720A1 ANDROGENETIC ALOPECIA 审中-公开
标题翻译：雄性ALOPECIA
公开(公告)号：WO2009124720A1
公开(公告)日：2009-10-15
申请号：PCT/EP2009/002564
申请日：2009-04-07
申请人： LIFE & BRAIN GMBH , HEINRICH-HEINE-UNIVERSITÄT DÜSSELDORF , RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITÄT , NÖTHEN, Markus, M. , BROCKSCHMIDT, Felix, F. , KRUSE, Roland , HILLMER, Axel
发明人： NÖTHEN, Markus, M. , BROCKSCHMIDT, Felix, F. , KRUSE, Roland , HILLMER, Axel
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/158 , C12Q2600/172
摘要： The present invention relates to methods for testing for a predisposition or presence of androgenetic alopecia comprising testing a sample obtained from a prospective patient or from a person suspected of carrying a predisposition for androgenetic alopecia. The invention also relates to a genetic marker for androgenetic alopecia characterised in that the genetic marker is located in a chromosomal region of human chromosome 20p11 and wherein the genetic marker is selected from the group consisting of a single nucleotide polymorphism (SNP), variable number of tandem repeat (VNTR), microsatellites or short tandem repeats (STR). Further, the invention relates to a diagnostic composition for the detection of androgenetic alopecia or a predisposition therefore as well as to a kit.
摘要翻译：本发明涉及用于测试雄激素性脱发的倾向或存在的方法，包括测试从预期患者或怀疑携带雄激素性脱发倾向的人获得的样品。本发明还涉及雄激素性脱发的遗传标记，其特征在于遗传标记位于人染色体20p11的染色体区域，其中所述遗传标记选自单核苷酸多态性（SNP），可变数目串联重复（VNTR），微卫星或短串联重复序列（STR）。此外，本发明涉及一种用于检测雄激素性脱发或易感性以及试剂盒的诊断组合物。

10. 发明申请

WO2014023732A1 NICLOSAMIDE AND ITS DERIVATIVES FOR USE IN THE TREATMENT OF SOLID TUMORS 审中-公开
标题翻译： NICLOSAMIDE及其衍生物用于治疗实体肿瘤
公开(公告)号：WO2014023732A1
公开(公告)日：2014-02-13
申请号：PCT/EP2013/066484
申请日：2013-08-06
申请人： LIFE & BRAIN GMBH , RHEINISCHE FRIEDRICH-WILHELMS UNIVERSITÄT
发明人： SCHEFFLER, Björn , GLAS, Martin
IPC分类号： A61K31/165 , A61K31/4188 , A61P35/00 , A61K45/06 , A61K31/167
CPC分类号： A61K31/167 , A61K31/4188 , A61K31/609 , A61K45/06 , C07C235/64 , C12Q1/6883 , C12Q2600/156 , C12Q2600/16 , G01N33/57484 , G01N2800/52 , A61K2300/00
摘要： The present invention relates to novel therapeutic uses of niclosamide for the treatment of cancer. In particular, a combination of niclosamide or one of its derivatives with an alkylating agent is provided for the treatment of solid tumors. Moreover, niclosamide or one of its derivatives can be used for the treatment of solid tumors characterized by underexpression of NFKBIA. Finally, the invention relates to diagnostic methods for determining whether treatment with niclosamide alone or in combination with an alkylating agent is suitable for a cancer patient.
摘要翻译：本发明涉及氯硝柳胺用于治疗癌症的新的治疗用途。具体而言，提供氯硝柳胺或其衍生物之一与烷化剂的组合用于治疗实体瘤。而且，氯硝柳胺或其衍生物之一可以用于治疗以NFκBIA的低表达为特征的实体瘤。最后，本发明涉及用于确定单独用氯硝柳胺或与烷化剂联合治疗是否适合于癌症患者的诊断方法。

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