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1. 发明申请

WO2006014466A3 NOVEL CARBAMYLATED EPO AND METHOD FOR ITS PRODUCTION 审中-公开
标题翻译：新型碳酸酯EPO及其生产方法
公开(公告)号：WO2006014466A3
公开(公告)日：2006-06-29
申请号：PCT/US2005023910
申请日：2005-07-01
申请人： KENNETH S WARREN INST INC , LUNDBECK H AS , BRINES MICHAEL , CERAMI ANTHONY , HAND CARLA CERAMI , XIE QIAO-WEN , CHRISTENSEN SOREN , FOLDAGER J , VLABJORN M H , THEUSEN A H , PEDERSEN M , MUNK M
发明人： BRINES MICHAEL , CERAMI ANTHONY , HAND CARLA CERAMI , XIE QIAO-WEN , CHRISTENSEN SOREN , FOLDAGER J , VLABJORN M H , THEUSEN A H , PEDERSEN M , MUNK M
IPC分类号： A61K38/00
CPC分类号： C07K14/505 , A61K38/00
摘要： The present invention comprises an optimal process for carbamylation yielding a product with a low degree of polymerisation and aggregation. The fully carbamylated erythropoietin with all of the N-terminal and all lysine residues was obtained. The resulting fully carbamylated pure EPO is along with pharmaceutical compositions comprising the compound are part of the invention.
摘要翻译：本发明包括氨基甲酰化的最佳方法，产生具有低聚合度和聚集度的产物。获得具有所有N-末端和所有赖氨酸残基的完全氨基甲酰化促红细胞生成素。所得完全氨基甲酰化的纯EPO以及包含该化合物的药物组合物是本发明的一部分。

2. 发明申请

WO2006014349A3 METHOD OF PRODUCING FULLY CARBAMYLATED ERYTHROPOIETIN 审中-公开
标题翻译：生产完全氨基甲酰化红细胞生成素的方法
公开(公告)号：WO2006014349A3
公开(公告)日：2006-07-20
申请号：PCT/US2005023505
申请日：2005-07-01
申请人： KENNETH S WARREN INST INC , CERAMI ANTHONY , HAND CARLA CERAMI , XIE QIAO WEN , BRINES MICHAEL
发明人： BRINES MICHAEL
IPC分类号： A61K38/00
CPC分类号： C07K14/505 , A61K38/00
摘要： The present invention relates to a method of carbamylating an erythropoietin such that the resulting carbamylated erythropoietin has less that about 10% free primary amines on the lysines and the N-terminal amino acids, is not digested when exposed to Lys-C proteolysis, exhibits no erythropoietic activity in a TF-1 or UT-7/EPOR cell viability assay at a concentration of 1 µg/ml, and demonstrates a static sciatic index of less than about .65 within a Sciatic Nerve Assay. Additionally, the invention is related to pharmaceutical compositions containing carbamylated erythropoietins of the invention and the use of the pharmaceutical compositions for the treatment of conditions and diseases of excitable tissues.
摘要翻译：本发明涉及使促红细胞生成素氨基甲酰化的方法，使得所得的氨基甲酰化促红细胞生成素具有少于赖氨酸上约10％的游离伯胺和N端氨基酸，当暴露于Lys-C蛋白水解时不被消化，在浓度为1μg/ ml的TF-1或UT-7 / EPOR细胞活力测定中的促红细胞生成活性，并且在坐骨神经分析中显示小于约.65的静态坐骨指数。此外，本发明涉及含有本发明的氨基甲酰化促红细胞生成素的药物组合物以及该药物组合物用于治疗可兴奋组织的病症和疾病的用途。

3. 发明申请

WO2004096148A3 TISSUE PROTECTIVE CYTOKINE RECEPTOR COMPLEX, ASSAYS FOR IDENTIFYING TISSUE PROTECTIVE COMPOUNDS AND USES THEREOF 审中-公开
标题翻译：组织保护性细胞因子受体复合物，用于鉴定组织保护性化合物的方法及其用途
公开(公告)号：WO2004096148A3
公开(公告)日：2006-03-02
申请号：PCT/US2004013099
申请日：2004-04-26
申请人： KENNETH S WARREN INST INC , BRINES MICHAEL , CERAMI ANTHONY , GHEZZI PIETRO , FIORDALISO FBIO , FRATELLI MADDALENA , LEIST MARCEL , NIELSEN METTE , SAGER THOMAS , PEDERSEN LARS OSTERGAARD , GERWIEN JENS , COLEMAN THOMAS
发明人： BRINES MICHAEL , CERAMI ANTHONY , GHEZZI PIETRO , FIORDALISO FBIO , FRATELLI MADDALENA , LEIST MARCEL , NIELSEN METTE , SAGER THOMAS , PEDERSEN LARS OSTERGAARD , GERWIEN JENS , COLEMAN THOMAS
IPC分类号： A61K20060101 , G01N33/50 , G01N33/68 , A61K38/19 , A61K39/00 , C07K14/505 , C07K14/52 , C12N5/00 , C12N15/00 , G01N33/53
CPC分类号： G01N33/5088 , A61K38/00 , G01N33/6863
摘要： The present invention is directed methods for identifying compounds that have a tissue protective activity using a heteromultimer receptor complex that mediates the tissue protective activities. The complex consists of at least one EPO-R in complex with at least one ßc Receptor. These compounds used in the assays to identify tissue protective compounds include, but are not limited to, small molecules and biologics. The compounds identified using these assays can be used to treat or prevent various diseases, disorders, or conditions of the central and peripheral nervous systems as well as those of other erythropoietin-responsive or excitable cells, tissues, and organs.
摘要翻译：本发明涉及使用介导组织保护活性的异源多聚体受体复合物来鉴定具有组织保护活性的化合物的方法。该复合物由至少一种与至少一种β受体复合物的EPO-R组成。用于鉴定组织保护性化合物的测定中使用的这些化合物包括但不限于小分子和生物制剂。使用这些测定法鉴定的化合物可用于治疗或预防中枢和周围神经系统以及其它促红细胞生成素反应或兴奋细胞，组织和器官的各种疾病，病症或病症。

4. 发明申请

WO2004022577A3 LONG ACTING ERYTHROPOIETINS THAT MAINTAIN TISSUE PROTECTIVE ACTIVITY OF ENDOGENOUS ERYTHROPOIETIN 审中-公开
标题翻译：长期维持内源性ERYTHROPOIETIN组织保护活性的抗氧化活性
公开(公告)号：WO2004022577A3
公开(公告)日：2004-09-16
申请号：PCT/US0328073
申请日：2003-09-09
申请人： WARREN PHARMACEUTICALS INC , CERAMI ANTHONY , SMART JOHN , BRINES MICHAEL , CERAMI CARLA , KENNETH S WARREN INST INC
发明人： CERAMI ANTHONY , SMART JOHN , BRINES MICHAEL , CERAMI CARLA
IPC分类号： A61K38/18 , A61K47/48 , C07K14/505 , A61K38/16 , A61K38/22 , C07K1/10
CPC分类号： C07K14/505 , A61K38/1816 , A61K47/549 , A61K47/60
摘要： Methods for increasing the hematocrit of an individual while maintaining the tissue protective activities of endogenous through the administration of a pharmaceutical compound containing chemically modified long acting erythropoietin. Also disclosed are the new chemically modified long acting erythropoietins, methods of producing the chemically modified long acting erythropoietins, and compositions comprising the chemically modified long acting erythropoietins.
摘要翻译：通过施用含有化学改性的长效促红细胞生成素的药物化合物来维持个体的血细胞比容的方法，同时维持内源的组织保护活性。还公开了新的化学改性的长效促红细胞生成素，生产化学改性的长效促红细胞生成素的方法和包含化学改性的长效促红细胞生成素的组合物。

5. 发明申请

WO2004004656A3 TISSUE PROTECTIVE CYTOKINES FOR THE PROTECTION, RESTORATION, AND ENHANCEMENT OF RESPONSIVE CELLS, TISSUES AND ORGANS 审中-公开
标题翻译：用于保护，恢复和增强反应性细胞，组织和器官的组织保护性细胞因子
公开(公告)号：WO2004004656A3
公开(公告)日：2006-06-01
申请号：PCT/US0321350
申请日：2003-07-03
申请人： KENNETH S WARREN INST INC , BRINES MICHAEL , CERAMI ANTHONY , CERAMI CARLA
发明人： BRINES MICHAEL , CERAMI ANTHONY , CERAMI CARLA
IPC分类号： A61K38/00 , A61K45/00 , A61K31/00 , A61K38/16 , A61K38/18 , A61K38/19 , A61K38/24 , A61K38/27 , A61K45/06 , A61P3/10 , A61P7/00 , A61P9/00 , A61P9/04 , A61P9/10 , A61P21/04 , A61P25/00 , A61P25/02 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/28 , A61P25/32 , A61P27/02 , A61P27/06 , A61P29/00 , A61P43/00 , C07K14/00 , C07K14/505 , C07K14/52 , C07K14/575
CPC分类号： A61K31/00 , A61K31/5377 , A61K31/573 , A61K31/65 , A61K31/66 , A61K38/00 , A61K45/06 , C07K14/505 , A61K2300/00
摘要： Methods and compositions are provided for treating a mammal having inflammation by protecting or enhancing a responsive cell, tissue, organ or body part exhibiting or associated with the inflammation, by systemic or local administration of a composition comprising a tissue protective cytokine. The invention also encompasses combination treatments comprising administering a composition comprising a tissue protective cytokine of the invention and administering at least one anti-inflammatory or least one immunomodulatory agent.
摘要翻译：提供了通过全身或局部施用包含组织保护性细胞因子的组合物来治疗具有炎症的哺乳动物，通过保护或增强显示或与炎症相关的反应性细胞，组织，器官或身体部位来治疗炎症。本发明还包括组合治疗，其包括施用包含本发明的组织保护性细胞因子的组合物并施用至少一种抗炎或至少一种免疫调节剂。

6. 发明申请

WO2005117927A3 TISSUE PROTECTIVE CYTOKINES WITH AN EXTENDED THERAPEUTIC WINDOW 审中-公开
标题翻译：组织保护性细胞因子与延伸的治疗窗口
公开(公告)号：WO2005117927A3
公开(公告)日：2006-05-11
申请号：PCT/US2004015863
申请日：2004-05-20
申请人： KENNETH S WARREN INST INC , LUNDBECK & CO AS H , CERAMI ANTHONY , BRINES MICHAEL , COLEMAN THOMAS
发明人： CERAMI ANTHONY , BRINES MICHAEL , COLEMAN THOMAS
IPC分类号： A61K38/00 , A61K38/18
CPC分类号： A61K38/1816
摘要： Methods and uses are provided for a pharmaceutical composition with an erythropoietin or a tissue protective cytokine for protecting or restoring function to a responsive cell, tissue, organ or body part function or viability in mammals when administered outside of the therapeutic window of previously approved therapeutics.
摘要翻译：为具有促红细胞生成素或组织保护性细胞因子的药物组合物提供方法和用途，用于当在先前认可的治疗剂的治疗窗口之外施用时，用于保护或恢复对哺乳动物的响应细胞，组织，器官或身体部位功能或活力的功能。

7. 发明申请

WO02062301A3 METHOD AND COMPOSITION FOR REJUVINATING CELLS, TISSUES, ORGANS, HAIR AND NAILS 审中-公开
标题翻译：重组细胞，组织，器官，头发和指甲的方法和组合
公开(公告)号：WO02062301A3
公开(公告)日：2002-10-17
申请号：PCT/US0203714
申请日：2002-02-07
申请人： FARRINGTON PHARMACEUTICALS LLC , ULRICH PETER C , FANG SHENG DING , BRINES MICHAEL , XIE QIAO WEN , CERAMI ANTHONY
发明人： ULRICH PETER C , FANG SHENG DING , BRINES MICHAEL , XIE QIAO WEN , CERAMI ANTHONY
IPC分类号： C07D233/60 , A61K8/49 , A61K31/415 , A61K31/4174 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/44 , A61K31/452 , A61K31/495 , A61K31/496 , A61K31/50 , A61K31/505 , A61K31/519 , A61K31/535 , A61K31/5377 , A61K31/5383 , A61P3/10 , A61P9/00 , A61P9/10 , A61P9/12 , A61P13/02 , A61P13/12 , A61P17/00 , A61P19/02 , A61P25/02 , A61P25/28 , A61P27/02 , A61P27/12 , A61P27/16 , A61P43/00 , A61Q3/00 , A61Q3/02 , A61Q5/00 , A61Q5/12 , A61Q19/00 , A61Q19/08 , C07D213/20 , C07D213/50 , C07D213/57 , C07D213/73 , C07D233/54 , C07D239/26 , C07D239/42 , C07D265/36 , C07D277/22 , C07D277/24 , C07D277/84 , C07D417/06 , C07D487/04 , C07D498/02 , C07D513/04 , C07D521/00 , C07D213/02 , C07D239/02 , C07D277/20 , C07D277/30 , C07D277/60 , C07D401/00 , C07D403/02 , C07D413/02 , C07D417/00
CPC分类号： C07D213/20 , A61K8/49 , A61K8/4986 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/495 , A61K31/50 , A61K31/505 , A61K31/535 , A61Q3/00 , A61Q3/02 , A61Q5/00 , A61Q5/02 , A61Q5/12 , A61Q7/00 , A61Q19/08 , A61Q19/10 , C07D213/50 , C07D213/57 , C07D213/73 , C07D231/12 , C07D233/54 , C07D233/56 , C07D233/64 , C07D239/26 , C07D239/42 , C07D249/08 , C07D277/22 , C07D277/24 , C07D277/84 , C07D417/06 , C07D487/04 , C07D513/04
摘要： In one embodiment, the present invention relates to compounds and compositions including pharmaceutical compositions containing the compounds and associated methods that uncouple sugar-mediated coupling of proteins, lipids, nucleic acids, and other biomaterials, and any combination thereof. In another embodiment, the compositions and associated methods have utility in vivo to reduce the deleterious effects of sugar-mediated coupling processes in an organism, when the organism is exposed to the compound or composition internally, by ingestion, transdermal application, or other means. In yet another embodiment, the compositions and associated methods are useful for the ex-vivo treatment of organs, cells and tissues and external treatment of hair, nails and skin to rejuvenate them by changing deformability and increase the tissue fissuion coefficient. In a further embodiment, the present invention relates to novel compounds and pharmaceutical compositions.
摘要翻译：在一个实施方案中，本发明涉及包含药物组合物的化合物和组合物，所述药物组合物含有化合物和解离糖介导的蛋白质，脂质，核酸和其他生物材料偶联的相关方法及其任何组合。在另一个实施方案中，组合物和相关方法在体内通过摄入，经皮施用或其它方式在生物体内部暴露于化合物或组合物时，有效地降低糖介导的生物体中的偶联过程的有害作用。在另一个实施方案中，组合物和相关方法可用于器官，细胞和组织的离体处理以及毛发，指甲和皮肤的外部治疗，以通过改变变形性和增加组织裂隙系数来使其恢复活力。在另一个实施方案中，本发明涉及新化合物和药物组合物。

8. 发明申请

WO0170196A3 SUSTAINED RELEASE DELIVERY SYSTEMS FOR SOLUTES 审中-公开
标题翻译：可持续发布的解决方案系统
公开(公告)号：WO0170196A3
公开(公告)日：2002-03-21
申请号：PCT/US0108955
申请日：2001-03-21
申请人： FARRINGTON PHARMACEUTICALS LLC , BRINES MICHAEL , CERAMI ANTHONY , WUERTH JEAN PAUL
发明人： BRINES MICHAEL , CERAMI ANTHONY , WUERTH JEAN-PAUL
IPC分类号： A61J3/00 , A61K9/00 , A61K9/20 , A61K9/22 , A61K31/4706 , A61K38/00 , A61P7/06 , A61P33/06
CPC分类号： A61K9/2072
摘要： The present invention relates to devices that allow for linear, sustained-release of solutes with adjustable initial-release kinetics. In particular, the present invention relates to devices for delivering substances to the body of an animal. The present invention also relates to methods for delivering solutes in a constant, sustained-release fashion using the devices of the invention.
摘要翻译：本发明涉及允许具有可调节的初始释放动力学的溶质线性，持续释放的装置。特别地，本发明涉及用于将物质输送到动物身体的装置。本发明还涉及使用本发明的装置以恒定的持续释放方式输送溶质的方法。

9. 发明申请

WO2009094172A3 TISSUE PROTECTIVE PEPTIDES AND PEPTIDE ANALOGS FOR PREVENTING AND TREATING DISEASES AND DISORDERS ASSOCIATED WITH TISSUE DAMAGE 审中-公开
标题翻译：用于预防和治疗与组织损伤相关的疾病和病症的组织保护肽和肽类似物
公开(公告)号：WO2009094172A3
公开(公告)日：2009-12-10
申请号：PCT/US2009000424
申请日：2009-01-22
申请人： ARAIM PHARMACEUTICALS INC , CERAMI ANTHONY , BRINES MICHAEL
发明人： CERAMI ANTHONY , BRINES MICHAEL
IPC分类号： C07K14/505
CPC分类号： A61K38/1816 , A61K38/00 , A61K38/10 , A61K47/48215 , C07K7/06 , C07K14/505
摘要： The present invention provides peptides and peptide analogs that have tissue protective activities while having little or no potentially undesirable hematopoietic effects. The peptides and peptide analogs are useful in preventing and treating a variety of diseases and disorders associated with tissue damage.
摘要翻译：本发明提供具有组织保护活性同时具有很少或没有潜在的不期望的造血作用的肽和肽类似物。肽和肽类似物可用于预防和治疗与组织损伤相关的各种疾病和病症。

10. 发明申请

WO2007019545A3 TISSUE PROTECTIVE PEPTIDES AND USES THEREOF 审中-公开
标题翻译：组织保护性肽及其用途
公开(公告)号：WO2007019545A3
公开(公告)日：2008-10-02
申请号：PCT/US2006031061
申请日：2006-08-07
申请人： WARREN PHARMACEUTICALS INC , CERAMI ANTHONY , BRINES MICHAEL , COLEMAN THOMAS
发明人： CERAMI ANTHONY , BRINES MICHAEL , COLEMAN THOMAS
IPC分类号： A61K38/00
CPC分类号： C07K14/505 , A61K38/00 , C07K14/435 , C07K14/575 , C07K14/71 , C07K2319/00
摘要： The present invention is directed to novel tissue protective peptides. The tissue protective peptides of the invention may bind to a tissue protective receptor complex. In particular, the present invention is drawn to tissue protective peptides derived from or sharing consensus sequences with portions of cytokine receptor ligands, including Erythropoietin (EPO), that are not involved in the binding of the ligand to the receptor complex, e.g., to the EPO receptor homodimer. Accordingly, the tissue protective peptides of the invention are derived from the amino acid sequences of regions of cytokine receptor ligands that are generally located on or within the region of the ligand protein that is opposite of the receptor complex, i.e., are generally derived from amino acid sequences of regions of the ligand protein that face away from the receptor complex while the ligand is bound to the receptor. The invention is further directed to the consensus sequences for use in engineering a synthetic tissue protective peptide. These tissue protective peptides also include fragments, chimeras, as well as peptides designed to mimic the spatial localization of key amino acid residues within the tissue protective receptor ligands, e.g., EPO. The invention further encompasses methods for treating or preventing a disease or disorder using tissue protective peptides of the current invention. The invention also encompasses methods for enhancing excitable tissue function using tissue protective peptides of the current invention.
摘要翻译：本发明涉及新型组织保护肽。本发明的组织保护肽可以结合组织保护性受体复合物。特别地，本发明涉及来自或共享具有部分细胞因子受体配体（包括促红细胞生成素（EPO））的组织保护肽，其不参与配体与受体复合物的结合，例如与 EPO受体同二聚体。因此，本发明的组织保护肽衍生自通常位于与受体复合体相反的配体蛋白的区域上或内部的细胞因子受体配体的区域的氨基酸序列，即通常衍生自氨基当配体与受体结合时，配体蛋白的表面远离受体复合物的酸序列。本发明还涉及用于工程化合成组织保护肽的共有序列。这些组织保护肽还包括片段，嵌合体以及旨在模拟组织保护性受体配体例如EPO内的关键氨基酸残基的空间定位的肽。本发明还包括使用本发明的组织保护肽治疗或预防疾病或病症的方法。本发明还包括使用本发明的组织保护肽增强可兴奋组织功能的方法。

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