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1. 发明申请

WO2004022577A3 LONG ACTING ERYTHROPOIETINS THAT MAINTAIN TISSUE PROTECTIVE ACTIVITY OF ENDOGENOUS ERYTHROPOIETIN 审中-公开
标题翻译：长期维持内源性ERYTHROPOIETIN组织保护活性的抗氧化活性
公开(公告)号：WO2004022577A3
公开(公告)日：2004-09-16
申请号：PCT/US0328073
申请日：2003-09-09
申请人： WARREN PHARMACEUTICALS INC , CERAMI ANTHONY , SMART JOHN , BRINES MICHAEL , CERAMI CARLA , KENNETH S WARREN INST INC
发明人： CERAMI ANTHONY , SMART JOHN , BRINES MICHAEL , CERAMI CARLA
IPC分类号： A61K38/18 , A61K47/48 , C07K14/505 , A61K38/16 , A61K38/22 , C07K1/10
CPC分类号： C07K14/505 , A61K38/1816 , A61K47/549 , A61K47/60
摘要： Methods for increasing the hematocrit of an individual while maintaining the tissue protective activities of endogenous through the administration of a pharmaceutical compound containing chemically modified long acting erythropoietin. Also disclosed are the new chemically modified long acting erythropoietins, methods of producing the chemically modified long acting erythropoietins, and compositions comprising the chemically modified long acting erythropoietins.
摘要翻译：通过施用含有化学改性的长效促红细胞生成素的药物化合物来维持个体的血细胞比容的方法，同时维持内源的组织保护活性。还公开了新的化学改性的长效促红细胞生成素，生产化学改性的长效促红细胞生成素的方法和包含化学改性的长效促红细胞生成素的组合物。

2. 发明申请

WO2004004656A3 TISSUE PROTECTIVE CYTOKINES FOR THE PROTECTION, RESTORATION, AND ENHANCEMENT OF RESPONSIVE CELLS, TISSUES AND ORGANS 审中-公开
标题翻译：用于保护，恢复和增强反应性细胞，组织和器官的组织保护性细胞因子
公开(公告)号：WO2004004656A3
公开(公告)日：2006-06-01
申请号：PCT/US0321350
申请日：2003-07-03
申请人： KENNETH S WARREN INST INC , BRINES MICHAEL , CERAMI ANTHONY , CERAMI CARLA
发明人： BRINES MICHAEL , CERAMI ANTHONY , CERAMI CARLA
IPC分类号： A61K38/00 , A61K45/00 , A61K31/00 , A61K38/16 , A61K38/18 , A61K38/19 , A61K38/24 , A61K38/27 , A61K45/06 , A61P3/10 , A61P7/00 , A61P9/00 , A61P9/04 , A61P9/10 , A61P21/04 , A61P25/00 , A61P25/02 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/28 , A61P25/32 , A61P27/02 , A61P27/06 , A61P29/00 , A61P43/00 , C07K14/00 , C07K14/505 , C07K14/52 , C07K14/575
CPC分类号： A61K31/00 , A61K31/5377 , A61K31/573 , A61K31/65 , A61K31/66 , A61K38/00 , A61K45/06 , C07K14/505 , A61K2300/00
摘要： Methods and compositions are provided for treating a mammal having inflammation by protecting or enhancing a responsive cell, tissue, organ or body part exhibiting or associated with the inflammation, by systemic or local administration of a composition comprising a tissue protective cytokine. The invention also encompasses combination treatments comprising administering a composition comprising a tissue protective cytokine of the invention and administering at least one anti-inflammatory or least one immunomodulatory agent.
摘要翻译：提供了通过全身或局部施用包含组织保护性细胞因子的组合物来治疗具有炎症的哺乳动物，通过保护或增强显示或与炎症相关的反应性细胞，组织，器官或身体部位来治疗炎症。本发明还包括组合治疗，其包括施用包含本发明的组织保护性细胞因子的组合物并施用至少一种抗炎或至少一种免疫调节剂。

3. 发明申请

WO9944583A3 METHODS AND DEVICES FOR MODULATING THE IMMUNE RESPONSE 审中-公开
标题翻译：用于调节免疫应答的方法和装置
公开(公告)号：WO9944583A3
公开(公告)日：1999-11-11
申请号：PCT/US9904637
申请日：1999-03-02
申请人： APPLIED VACCINE TECHNOLOGIES C , CERAMI ANTHONY , CERAMI CARLA , GELBER COHAVA , DOVE DAVID
发明人： CERAMI ANTHONY , CERAMI CARLA , GELBER COHAVA , DOVE DAVID
IPC分类号： A61K9/00 , A61K39/00
CPC分类号： A61K9/0024
摘要： The present invention provides methods and devices for inducing, stimulating, blocking and reducing the immune response of a mammal to an antigen, using an implantable device which exposes the antigen in a controlled fashion to cells of the immune system. The device comprises a porous matrix contained within a perforated, impermeable container. By manipulating the bioavailability of antigen within the device, and the timing of introduction of antigen into the device relative to the time of implantation of the device within the mammal, a robust and long-term response can be induced against an antigen, or an existing or potential immune response can be down regulated or blocked. The methods and devices can be used for therapeutic vaccination, and in non-exposed mammals for prophylactic vaccination. Immunity can be cellular, humoral, or mucosal. Suppression of the immune response is useful for the treatment or prophylaxis of such conditions as allergies, autoimmune disease, and in tolerizing mammals to suppress an immune response to transplant antigens. The device can also be used for harvesting immune cells for later reintroduction into the mammal, and for preparing immune serum and hybridomas.
摘要翻译：本发明提供了使用以受控方式将抗原暴露于免疫系统的细胞的可植入装置来诱导，刺激，阻断和减少哺乳动物对抗原的免疫应答的方法和装置。该装置包含容纳在穿孔的不可渗透容器内的多孔基质。通过操纵装置内抗原的生物利用度以及将装置中的抗原引入装置的时间相对于哺乳动物内装置的时间，可以诱导针对抗原或现有抗原的稳健和长期响应或潜在的免疫应答可被下调或阻断。该方法和装置可以用于治疗性疫苗接种，并且用于未暴露的哺乳动物用于预防性疫苗接种。免疫可以是细胞的，体液的或粘膜的。抑制免疫应答可用于治疗或预防诸如变态反应，自身免疫疾病和耐受哺乳动物的疾病以抑制针对移植抗原的免疫应答。该装置还可以用于收获免疫细胞以供以后重新引入哺乳动物中，并用于制备免疫血清和杂交瘤。

4. 发明申请

WO03020161A3 IMMUNE MODULATION DEVICE FOR USE IN ANIMALS 审中-公开
标题翻译：用于动物的免疫调节装置
公开(公告)号：WO03020161A3
公开(公告)日：2003-06-05
申请号：PCT/US0214759
申请日：2002-05-09
申请人： APPLIED VACCINE TECHNOLOGIES C , CERAMI ANTHONY , CERAMI CARLA , XIE QIAO-WEN , TENHUISEN KEVOR S , ROSENBLATT JOEL , KOYFMAN ILYA S
发明人： CERAMI ANTHONY , CERAMI CARLA , XIE QIAO-WEN , TENHUISEN KEVOR S , ROSENBLATT JOEL , KOYFMAN ILYA S
IPC分类号： A61K9/00 , A61K9/16 , A61K35/14 , A61K38/00 , A61K39/00 , C07K14/00 , C12N5/06 , C12Q1/06 , G01N33/53 , G01N33/543 , A61K45/05
CPC分类号： A61K9/0024 , A61K9/1641 , A61K9/1647 , Y10T442/2525
摘要： The present invention is directed to an implantable immune modulation device (Figure 1) that is useful for modulating an immune response in mammals, comprising a plurality of fibers, within a porous shell. The fiber filling is loaded with single or multiple antigens, and optionally one or more biologically active compounds such as cytokines (e.g. lymphokines, chemokines etc.), attachment factors, genes, peptides, proteins, nucleotides, carbohydrates or cells depending on the application.
摘要翻译：本发明涉及可用于在多孔壳内调节包含多种纤维的哺乳动物的免疫应答的可植入免疫调节装置（图1）。取决于应用，纤维填充物装载有单个或多个抗原，以及任选地一种或多种生物活性化合物，例如细胞因子（例如淋巴因子，趋化因子等），附着因子，基因，肽，蛋白质，核苷酸，碳水化合物或细胞。

5. 发明申请

WO02053580A3 PROTECTION, RESTORATION, AND ENHANCEMENT OF ERYTHROPOIETIN-RESPONSIVE CELLS, TISSUES AND ORGANS 审中-公开
标题翻译： ERYTHROPOIETIN-响应细胞，组织和器官的保护，恢复和增强
公开(公告)号：WO02053580A3
公开(公告)日：2004-02-12
申请号：PCT/US0149479
申请日：2001-12-28
申请人： KENNETH S WARREN INST INC
发明人： BRINES MICHAEL , CERAMI ANTHONY , CERAMI CARLA
IPC分类号： A61K45/00 , A61K38/00 , A61K38/16 , A61K38/18 , A61K38/19 , A61K38/24 , A61K38/27 , A61K45/06 , A61P3/10 , A61P7/00 , A61P9/00 , A61P9/04 , A61P9/10 , A61P21/04 , A61P25/00 , A61P25/02 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/28 , A61P25/32 , A61P27/02 , A61P27/06 , A61P29/00 , A61P43/00 , C07K14/52 , C07K14/575 , C07K14/00 , C07K14/505
CPC分类号： A61K45/06 , A61K38/1816 , A61K2300/00
摘要： Methods and compositions are provided for protecting or enhancing an erythropoietin-responsive cell, tissue, organ or body part function or viability in vivo, in situ or ex vivo in mammals, including human beings, by systemic or local administration of an erythropoietin receptor activity modulator, such as an erythropoietin or a modified erythropoeitin.
摘要翻译：提供了通过全身或局部施用促红细胞生成素受体活性调节剂，在哺乳动物（包括人）中原位或离体保护或增强促红细胞生成素反应性细胞，组织，器官或身体部位功能或活体活性的方法和组合物，如红细胞生成素或改良的红细胞生成素。

6. 发明申请

WO2004003176A9 RECOMBINANT TISSUE PROTECTIVE CYTOKINES AND ENCODING NUCLEIC ACIDS THEREOF FOR PROTECTION, RESTORATION, AND ENHANCEMENT OF RESPONSIVE CELLS, TISSUES, AND ORGANS 审中-公开
标题翻译：重组组织保护性细胞因子和编码其保护，恢复和增强反应性细胞，组织和器官的核酸
公开(公告)号：WO2004003176A9
公开(公告)日：2008-02-07
申请号：PCT/US0320964
申请日：2003-07-01
申请人： KENNETH S WARREN INST INC , LUNDBECK & CO AS H
发明人： NIELSEN JACOB , PEDERSEN JAN TORLEIF , GERWIEN JENS , BAY KATRINE , PEDERSEN LARS OSTERGAARD , LEIST MARCEL , GEIST MARIE AAVANG , KALLUNKI PEKKA , CHRISTENSEN SOREN , SAGER THOMAS , BRINES MICHAEL , CERAMI ANTHONY , CERAMI CARLA
IPC分类号： A61K38/00 , C07K14/505 , C12N5/00 , C12N15/00 , C12N15/87 , G01N33/53
CPC分类号： C07K14/505 , A61K38/00 , C07K2319/00 , C12N15/87
摘要： Methods and compositions are provided for protecting or enhancing a responsive cell, tissue, organ or body part function or viability in vivo, in situ o
摘要翻译：提供方法和组合物用于在原位o保护或增强反应性细胞，组织，器官或身体部位功能或体内存活力

7. 发明申请

WO2004003176A3 RECOMBINANT TISSUE PROTECTIVE CYTOKINES AND ENCODING NUCLEIC ACIDS THEREOF FOR PROTECTION, RESTORATION, AND ENHANCEMENT OF RESPONSIVE CELLS, TISSUES, AND ORGANS 审中-公开
标题翻译：重组组织保护性细胞因子和编码其保护，恢复和增强反应性细胞，组织和器官的核酸
公开(公告)号：WO2004003176A3
公开(公告)日：2004-10-28
申请号：PCT/US0320964
申请日：2003-07-01
申请人： KENNETH S WARREN INST INC , LUNDBECK & CO AS H
发明人： NIELSEN JACOB , PEDERSEN JAN TORLEIF , GERWIEN JENS , BAY KATRINE , PEDERSEN LARS OSTERGAARD , LEIST MARCEL , GEIST MARIE AAVANG , KALLUNKI PEKKA , CHRISTENSEN SOREN , SAGER THOMAS , BRINES MICHAEL , CERAMI ANTHONY , CERAMI CARLA
IPC分类号： A61K38/00 , C07K14/505 , C12N5/00 , C12N15/00 , C12N15/87 , G01N33/53
CPC分类号： C07K14/505 , A61K38/00 , C07K2319/00 , C12N15/87
摘要： Methods and compositions are provided for protecting or enhancing a responsive cell, tissue, organ or body part function or viability in vivo, in situ or ex vivo in mammals, including human beings, by systemic or local administration of an erythropoietin receptor activity modulator, such as an recombinant tissue protective cytokine.
摘要翻译：通过全身或局部给予促红细胞生成素受体活性调节剂，提供方法和组合物用于在哺乳动物（包括人类）中原位或离体保护或增强体内反应性细胞，组织，器官或身体部位功能或活力，作为重组组织保护性细胞因子。

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