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1. 发明申请

WO2011009941A1 PROBES FOR SPECIFIC ANALYSIS OF NUCLEIC ACIDS 审中-公开
标题翻译：具体分析核酸的探讨
公开(公告)号：WO2011009941A1
公开(公告)日：2011-01-27
申请号：PCT/EP2010/060715
申请日：2010-07-23
申请人： OLINK GENOMICS AB , ERICSSON, Olof , ISAKSSON, Magnus , JOHANSSON, Henrik , LANDEGREN, Ulf
发明人： ERICSSON, Olof , ISAKSSON, Magnus , JOHANSSON, Henrik , LANDEGREN, Ulf
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6855
摘要： The present invention provides a method for detecting or enriching for a target deoxyribonucleic acid (DNA) present in a nucleic acid sample, said method comprising: (a) fragmenting a nucleic acid sample to generate nucleic acid fragments including a target fragment containing said target DNA; (b) rendering said fragments, including said target fragment, at least partially single-stranded, wherein the single- stranded portion includes an end portion and wherein the length of said single- stranded portion is sufficient to allow hybridisation of at least part of the single- stranded portion of said target fragment to the probe of step (c); (c) contacting the at least partially single-stranded fragments of step (b) with oligonucleotides A and B of a single target-specific nucleic acid probe, wherein: (i) oligonucleotide A is a single- stranded oligonucleotide comprising at one end a first target-specific part comprising at least 10 nucleotides complementary in sequence to at least part of said single- stranded portion of said target fragment, and comprising at the other end a second non-target-specific part which comprises a nucleotide sequence complementary to at least a portion, including one end, of oligonucleotide B of the probe, and (ii) oligonucleotide B is a single-stranded oligonucleotide which may contain or carry at least one element for detection and/or enrichment of said target fragment, and of which at least a portion, including one end, is complementary in sequence to the second non-target-specific part of oligonucleotide A, such that said target fragment becomes annealed to said probe through hybridisation to the first target-specific part of oligonucleotide A resulting in only one target-specific probe-binding event per target fragment; (d) ligating oligonucleotide B of said probe to the part of the single- stranded portion of said target fragment which is hybridised to oligonucleotide A of said probe to produce a probe-target fragment hybrid; and (e) detecting or enriching for said probe-target fragment hybrid. Kits for use in the method of the invention are also provided.
摘要翻译：本发明提供了用于检测或富集存在于核酸样品中的靶脱氧核糖核酸（DNA）的方法，所述方法包括：（a）将核酸样品分段以产生包含含有所述靶DNA的靶片段的核酸片段 ; （b）使包含所述靶片段的所述片段至少部分单链，其中所述单链部分包含端部，并且其中所述单链部分的长度足以允许杂交的至少一部分所述靶片段的单链部分与步骤（c）的探针结合; （c）将步骤（b）的至少部分单链片段与单个靶特异性核酸探针的寡核苷酸A和B接触，其中：（i）寡核苷酸A是单链寡核苷酸，其包含一端第一靶特异性部分包含与所述靶片段的所述单链部分的至少部分序列至少互补的10个核苷酸，并且在另一端包含第二非靶特异性部分，其包含与探针的寡核苷酸B的至少一部分（包括一端），和（ii）寡核苷酸B是可以含有或携带至少一种用于检测和/或富集所述靶片段的元件的单链寡核苷酸，其中包括一端的至少一部分在序列上与寡核苷酸A的第二非目标特异性部分互补，使得所述靶片段通过杂交退火至所述探针到寡核苷酸A的第一靶特异性部分，导致每个靶片段仅一个靶特异性探针结合事件; （d）将所述探针的寡核苷酸B连接到与所述探针的寡核苷酸A杂交的所述靶片段的单链部分的部分，以产生探针 - 靶片段杂交体; 和（e）检测或富集所述探针 - 靶片段杂交体。还提供了用于本发明方法的试剂盒。

2. 发明申请

WO2008153492A1 METHOD FOR INTRODUCING COMMON AND/OR INDIVIDUAL SEQUENCE ELEMENTS IN A TARGET NUCLEIC ACID MOLECULE 审中-公开
标题翻译：在目标核酸分子中引入通用和/或个体序列元件的方法
公开(公告)号：WO2008153492A1
公开(公告)日：2008-12-18
申请号：PCT/SE2008/050694
申请日：2008-06-11
申请人： JOHANSSON, Henrik , ERICSSON, Olof
发明人： JOHANSSON, Henrik , ERICSSON, Olof
IPC分类号： C12Q1/68
CPC分类号： C12N15/1065 , C12N15/10
摘要： The invention relates to a method for introducing common and/or individual sequence elements in a target nucleic acid molecule in a sample containing sample nucleic acid molecules, comprising the steps i) denaturing the sample nucleic acid molecules, if the sample nucleic acid molecules are double-stranded, to obtain single stranded sample nucleic acid molecules ii) bringing the sample nucleic acid molecules in contact with primary, secondary and tertiary probe nucleic acid molecules, wherein the 3 '-end of the tertiary probe comprise a part complementary to the primary probe and the 5 '-end of the tertiary probe comprise a part complementary to a 5 '-part of the target nucleic acid molecule; the 3 '-end of the secondary probe is complementary to a 3 '-part of the target nucleic acid molecule and the 5 '-end of the secondary probe is not complementary to the target nucleic acid molecule; wherein said primary, secondary and tertiary probes comprise said common and/ or individual sequence elements; iii) ligating the 3 '-end of the primary probe to the 5 '-end of the target nucleic acid molecule; and iv) elongating the 3 '-end of the secondary probe by means of a nucleic acid polymerase; or iv') elongating the 3'-end of the target nucleic acid molecule.
摘要翻译：本发明涉及在含有样品核酸分子的样品中引入靶核酸分子中的常见和/或单个序列元件的方法，其包括以下步骤：i）如果样品核酸分子是双重的，则使样品核酸分子变性以获得单链样品核酸分子ii）使样品核酸分子与初级，次级和第三级探针核酸分子接触，其中第三级探针的3'末端包含与主要探针互补的部分并且第三探针的5'末端包含与靶核酸分子的5'部分互补的部分; 第二探针的3'末端与靶核酸分子的3'部分互补，并且第二探针的5'末端与靶核酸分子不互补; 其中所述初级，次级和第三级探针包括所述共同和/或单个序列元件; iii）将主要探针的3'端连接到靶核酸分子的5'末端; 和iv）通过核酸聚合酶延伸第二探针的3'末端; 或iv'）延伸靶核酸分子的3'末端。

3. 发明申请

WO2011067378A1 METHOD FOR AMPLIFICATION OF TARGET NUCLEIC ACID 审中-公开
标题翻译：放射性核酸的方法
公开(公告)号：WO2011067378A1
公开(公告)日：2011-06-09
申请号：PCT/EP2010/068837
申请日：2010-12-03
申请人： OLINK GENOMICS AB , ERICSSON, Olof , ISAKSSON, Magnus , JOHANSSON, Henrik , ROOS, Fredrik , FREDRIKSSON, Simon , NILSSON, Mats
发明人： ERICSSON, Olof , ISAKSSON, Magnus , JOHANSSON, Henrik , ROOS, Fredrik , FREDRIKSSON, Simon , NILSSON, Mats
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12Q2565/519 , C12Q2531/125 , C12Q2563/131 , C12Q2525/161 , C12Q2521/501
摘要： The present invention provides a method for amplifying at least one target nucleic acid in a nucleic acid sample, comprising:(a) fragmenting the nucleic acid sample to create at least one target fragment comprising said target nucleic acid and comprising two probe-complementary portions, wherein at least one of said two probe-complementary portions is located at an end of the target fragment; (b) contacting said fragmented nucleic acid sample with at least one probe which is provided with an immobilisation moiety and optionally is immobilised on a solid phase by means of said moiety, and which comprises two target fragment-complementary portions which are complementary in sequence to the probe- complementary portions of the target fragment, wherein said portions of the probe may be adjacent, or separated by an intervening non-target fragment-complementary portion; (c) rendering the fragmented nucleic acid sample single- stranded, wherein the step may occur before, contemporaneously with or after step (b); (d) allowing the probe-complementary portions of the target fragment to hybridise with the target-fragment complementary portions of the probe; (e) if the probe provided in step (b) is not immobilised, immobilising the probe-target fragment hybrid on a solid phase by means of said immobilisation moiety; (f) separating non-immobilised nucleic acid fragments from the solid phase; (g) contacting the solid phase with a ligase to ligate, directly or indirectly, ligatable 5' and 3' ends of the target fragment whereby the target fragment is circularised, wherein where one of said probe-complementary portions of the target fragment is not located at an end of the target fragment, the ligatable end, other than that at which a probe-complementary portion is located, is created by the action of a flap endonuclease or an exonuclease; and (h) amplifying said circularised target fragment. Kits for use in the method of the invention are also provided.
摘要翻译：本发明提供了用于扩增核酸样品中的至少一种靶核酸的方法，其包括：（a）使核酸样品片段化以产生至少一个包含所述靶核酸的靶片段并且包含两个探针互补部分，其中所述两个探针互补部分中的至少一个位于所述靶片段的末端; （b）使所述片段化的核酸样品与至少一个具有固定部分的探针接触，并且任选地通过所述部分固定在固相上，并且其包含两个靶序列互补部分，其与序列互补所述靶片段的探针互补部分，其中所述探针的所述部分可以相邻，或由介入的非靶片段互补部分分开; （c）使所述片段化的核酸样品单链，其中所述步骤可以在步骤（b）之前或之后发生; （d）允许靶片段的探针互补部分与探针的靶 - 片段互补部分杂交; （e）如果步骤（b）中提供的探针未被固定，则通过所述固定部分将探针 - 靶片段杂交体固定在固相上; （f）从固相中分离未固定的核酸片段; （g）使固相与连接酶接触直接或间接连接目标片段的5'和3'末端，由此靶片段是环化的，其中靶片段的所述探针互补部分之一不是位于靶片段的末端，通过翼片内切核酸酶或外切核酸酶的作用产生除了探针互补部分所位于之外的可连接末端; 和（h）扩增所述环化的靶片段。还提供了用于本发明方法的试剂盒。

4. 发明申请

WO2012126504A1 METHOD AND DEVICE FOR LINEARIZING A TRANSFORMER 审中-公开
标题翻译：用于线性化变压器的方法和装置
公开(公告)号：WO2012126504A1
公开(公告)日：2012-09-27
申请号：PCT/EP2011/054165
申请日：2011-03-18
申请人： ABB RESEARCH LTD , BENGTSSON, Tord , JOHANSSON, Henrik , ROXENBORG, Stefan , MENEZES, Joseph , NAGY, Zoltan , SEHLSTEDT, Mikael
发明人： BENGTSSON, Tord , JOHANSSON, Henrik , ROXENBORG, Stefan , MENEZES, Joseph , NAGY, Zoltan , SEHLSTEDT, Mikael
IPC分类号： G01R15/18 , H01F27/42 , G05F7/00 , H02H1/00
CPC分类号： H01F27/42
摘要： The present invention relates to a method for linearizing voltage transmission through a transformer including a magnetic core and, input and output windings. A measurement signal is supplied to the input winding at a first frequency and an output signal is measured at the output winding of the transformer, wherein the voltage of the measurement signal may be so low that the transformer operates in a non-linear region. The method comprises, for a conditioning signal, selecting a second frequency different from the first frequency (100), defining an amplitude value of the conditioning signal (110) and supplying the conditioning signal to the input winding at the second frequency with the defined amplitude value so that the transformer operates in its linear region (120).
摘要翻译：本发明涉及通过包括磁芯和输入和输出绕组的变压器线性化电压传输的方法。测量信号以第一频率提供给输入绕组，并且在变压器的输出绕组处测量输出信号，其中测量信号的电压可能非常低以致变压器在非线性区域中工作。该方法包括：对于调节信号，选择不同于第一频率（100）的第二频率，定义调节信号（110）的振幅值，并将调节信号以限定的幅度以第二频率提供给输入绕组使得变压器在其线性区域（120）中工作。

5. 发明申请

WO2011139210A1 GYRATORY CRUSHER COMPRISING A DUST SEAL AND METHOD OF FITTING 审中-公开
标题翻译：包括一个密封件和装配方法的打磨机
公开(公告)号：WO2011139210A1
公开(公告)日：2011-11-10
申请号：PCT/SE2011/050486
申请日：2011-04-20
申请人： SANDVIK INTELLECTUAL PROPERTY AB , JOHANSSON, Henrik
发明人： JOHANSSON, Henrik
IPC分类号： B02C2/06
CPC分类号： B02C2/06 , B02C2/00
摘要： A gyratory crusher comprises a crusher head (12) on which a first crushing shell is mounted; a frame (4) on which a second crushing shell is mounted and forms in conjunction with the first crushing shell a crushing aperture; a drive device adapted to rotating an eccentric to which the crusher head (12) is so connected as to be adapted to being caused, during rotation of the eccentric, to perform a gyratory movement for crushing of material which is introduced into the crushing aperture; and a dust seal (30) which is adapted to sealing a gap between the frame (4) and a fastening portion (37; 52) situated close to the crusher head (12) and which comprises a seal bellows (32) and a seal slide ring (34) which is connected sealingly to a lower portion of the seal bellows (32) and has a lower slide surface (42) adapted to sliding along, and to abutting sealingly, with a substantially vertical abutment pressure determined by the inherent weight of the seal slide ring (34) and by the influence of the seal bellows (32), against an upper slide surface (44) provided on the frame (4), with an upper portion (36) of the seal bellows (32) sealingly connected to said fastening portion (37; 52), so that rotation of the crusher head (12) causes rotation of the seal slide ring (34) about a substantially vertical axis of rotation.
摘要翻译：回转式破碎机包括：破碎机头（12），其上安装有第一破碎壳; 框架（4），其上安装有第二破碎壳并与第一破碎壳结合形成破碎孔; 驱动装置，其适于使所述破碎机头部（12）连接的偏心轮旋转，以适于在所述偏心件的旋转期间被引起，以执行用于破碎引入到所述破碎孔中的材料的回转运动; 以及防尘密封件（30），其适于密封所述框架（4）与位于所述破碎机头部（12）附近的紧固部分（37; 52）之间的间隙，并且包括密封波纹管（32）和密封件滑动环（34），其密封地连接到密封波纹管（32）的下部，并且具有下滑动表面（42），其适于沿着密封地以由固有重量确定的基本垂直的邻接压力滑动（34）的上部（36）与密封波纹管（32）的影响相对应的位于框架（4）上的上部滑动表面（44）上，密封地连接到所述紧固部分（37; 52），使得破碎机头部（12）的旋转导致密封滑动环（34）围绕基本垂直的旋转轴线旋转。

6. 发明申请

WO2009036791A1 INFLATABLE CURTAIN AIRBAG 审中-公开
标题翻译：充气窗帘安全气囊
公开(公告)号：WO2009036791A1
公开(公告)日：2009-03-26
申请号：PCT/EP2007/008243
申请日：2007-09-21
申请人： AUTOLIV DEVELOPMENT AB , JORLÖV, Andreas , JOHANSSON, Henrik , KJELL, Fredrik
发明人： JORLÖV, Andreas , JOHANSSON, Henrik , KJELL, Fredrik
IPC分类号： B60R21/231 , B60R21/20
CPC分类号： B60R21/201 , B60R21/232
摘要： Inflatable curtain airbag for a vehicle comprising an airbag body (1) rolled or folded to form a longitudinal airbag package with several attachment portions (6) and an indication element (2) for indicating a twisted attachment status of the airbag at the vehicle structure, wherein the indication element (2) is arranged in a releasable manner along at least parts of the longitudinal extension of the package.
摘要翻译：一种用于车辆的充气帘式气囊，其包括滚动或折叠以形成具有多个安装部分（6）的纵向安全气囊包装的气囊本体（1）和用于指示安全气囊在车辆结构处的扭转安装状态的指示元件（2）其中所述指示元件（2）沿着所述包装的纵向延伸部的至少一部分以可释放的方式布置。

7. 发明申请

WO2007030061A1 NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES 审中-公开
标题翻译：新西兰双倍体药物及其用于治疗CCR8介导性疾病的用途
公开(公告)号：WO2007030061A1
公开(公告)日：2007-03-15
申请号：PCT/SE2006/001012
申请日：2006-09-04
申请人： ASTRAZENECA AB , BÖRJESSON, Lena , CONNOLLY, Stephen , JOHANSSON, Henrik , KRISTOFFERSSON, Anna , LINNANEN, Tero , SHAMOVSKY, Igor , SKRINJAR, Marco
发明人： BÖRJESSON, Lena , CONNOLLY, Stephen , JOHANSSON, Henrik , KRISTOFFERSSON, Anna , LINNANEN, Tero , SHAMOVSKY, Igor , SKRINJAR, Marco
IPC分类号： C07D471/10 , A61K31/407 , A61K31/438 , A61P11/00 , A61P11/06 , C07D487/10
CPC分类号： C07D487/10 , C07D471/10
摘要： The invention provides compounds of general formula (I) wherein A, B, p, w, x, y, and z are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译：本发明提供了通式（I）的化合物，其中A，B，p，w，x，y和z如说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗中的用途。

8. 发明申请

WO2012116757A1 METHOD FOR ADAPTATION OF GROUND FAULT DETECTION 审中-公开
标题翻译：接地故障检测方法
公开(公告)号：WO2012116757A1
公开(公告)日：2012-09-07
申请号：PCT/EP2011/053232
申请日：2011-03-03
申请人： ABB RESEARCH LTD , JOHANSSON, Henrik , MENEZES, Joseph , ROXENBORG, Stefan , BENGTSSON, Tord
发明人： JOHANSSON, Henrik , MENEZES, Joseph , ROXENBORG, Stefan , BENGTSSON, Tord
IPC分类号： G01R31/02 , G01R31/06 , G01R31/34
CPC分类号： G01R31/025 , G01R31/343 , H02H1/003 , H02H3/08 , H02H7/00 , H02H7/0822
摘要： The present invention relates to a method for adapting a ground fault detection to a change of an electrical machine condition, wherein the machine includes a winding. The electrical machine is in a first machine condition, a first reference value being defined for measured values of an electrical quantity. The ground fault detection comprises continuously measuring the electrical quantity in the winding and detecting a ground fault based on the measured values of the electrical quantity and the first reference value. The method comprises receiving a signal (101, 102), detecting a change of machine condition based on the received signal (120), and changing to a second reference value for the measured values of the electrical quantity, the second reference value being different from the first reference value (100) when the change of machine condition is detected.
摘要翻译：本发明涉及一种用于使接地故障检测适应于电机状态变化的方法，其中机器包括绕组。电机处于第一机器状态，为电量的测量值定义第一参考值。接地故障检测包括连续测量绕组中的电量，并根据电量和第一参考值的测量值检测接地故障。该方法包括接收信号（101,102），根据接收到的信号（120）检测机器状态的变化，并将电量的测量值改变为第二参考值，第二参考值不同于当检测到机器状态的变化时的第一参考值（100）。

9. 发明申请

WO2010121660A1 A METHOD AND A DEVICE FOR SUPERVISING THE SENSITIVITY OF A PROTECTION FUNCTION 审中-公开
标题翻译：一种用于监控保护功能灵敏度的方法和装置
公开(公告)号：WO2010121660A1
公开(公告)日：2010-10-28
申请号：PCT/EP2009/054971
申请日：2009-04-24
申请人： ABB RESEARCH LTD , THORBURN, Stefan , JOHANSSON, Henrik , ROXENBORG, Stefan , BENGTSSON, Tord
发明人： THORBURN, Stefan , JOHANSSON, Henrik , ROXENBORG, Stefan , BENGTSSON, Tord
IPC分类号： H02H3/00 , H02H3/04
CPC分类号： H02H3/006 , H02H3/044
摘要： The present invention relates to a method and a device for supervising the sensitivity of a protection function in an electrical power system comprising a metering device for measuring values of a feature, said protection function being configured to initialize an action based on a test value and a threshold value for the feature, wherein said test value is either a measured value or derived from the said measured values, the device (9) comprising a computing unit (3) configured to receive the test values and, repeatedly during the operation of the protection function, to calculate a mean value and a deviation of the test values, to determine the probability of a false action based on the calculated mean value, the threshold value and the calculated deviation, and to indicate that the sensitivity is too high when the probability of a false action exceeds a first limit value for the probability of a false action.
摘要翻译：本发明涉及一种用于监控电力系统中的保护功能的灵敏度的方法和装置，包括用于测量特征值的计量装置，所述保护功能被配置为基于测试值初始化动作，以及所述特征的阈值，其中所述测试值是测量值或从所述测量值导出，所述设备（9）包括被配置为接收测试值的计算单元（3），并且在所述保护操作期间重复函数，以计算测试值的平均值和偏差，以基于所计算的平均值，阈值和计算的偏差来确定误动作的概率，并且当概率为高时，表示灵敏度太高的虚假动作超过了错误行为的概率的第一个限制值。

10. 发明申请

WO2012004083A1 POWER-SUPPLY CIRCUIT 审中-公开
标题翻译：电源电路
公开(公告)号：WO2012004083A1
公开(公告)日：2012-01-12
申请号：PCT/EP2011/059632
申请日：2011-06-09
申请人： ST-ERICSSON SA , JOHANSSON, Henrik
发明人： JOHANSSON, Henrik
IPC分类号： G05F1/577 , H02M3/335
CPC分类号： G05F1/577 , H02M1/44 , H02M3/156 , H02M2001/0045 , H02M2001/0048 , Y02B70/1491
摘要： A power-supply circuit (10) for an electronic circuit (2) having a plurality of functional units (5-1,...,5-N) is disclosed. The power-supply circuit (10) comprises a plurality of supply-voltage regulators (30-1,...,30-N), each adapted to provide an output supply voltage to a corresponding one of the functional units (5-1,...,5-N) and each having a disabled and an enabled state. Furthermore, the power-supply circuit (10) comprises a preregulator (20) adapted to provide a common intermediate supply voltage to all of the supply-voltage regulators (30-1,...,30-N), wherein the preregulator (20) is adapted to generate the intermediate supply voltage such that it follows a reference level of the preregulator. Moreover, the power-supply circuit (10) comprises a control unit (40) adapted to control the reference level of the preregulator (20) at least based on which of the supply-voltage regulators (30-1,...,30-N) are currently in the enabled state and which of the supply-voltage regulators (30-1,...,30-N) are currently in the disabled state. A related method of operating the power-supply circuit (10), a related computer program product, and a related computer-readable medium are also disclosed.
摘要翻译：公开了一种具有多个功能单元（5-1，...，5-N）的电子电路（2）的电源电路（10）。电源电路（10）包括多个供电电压调节器（30-1，...，30-N），每个电源电压调节器适于向相应的一个功能单元（5-1）提供输出电源电压，...，5-N），并且每个具有禁用和启用状态。此外，电源电路（10）包括预调节器（20），其适于向所有电源电压调节器（30-1，...，30-N）提供公共的中间供电电压，其中预调节器 20）适于产生中间电源电压，使得其遵循前置调节器的参考电平。此外，电源电路（10）包括控制单元（40），该控制单元（40）至少基于哪个电源 - 稳压器（30-1，...，30）来控制预调节器（20）的参考电平 -N）当前处于使能状态，哪个电源电压调节器（30-1，...，30-N）当前处于禁用状态。还公开了操作电源电路（10）的相关方法，相关的计算机程序产品和相关的计算机可读介质。

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