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1. 发明申请

WO2008111717A1 FE BASED ALLOY HAVING CORROSION RESISTANCE AND ABRASION RESISTANCE AND PREPARATION METHOD THEREOF 审中-公开
标题翻译：具有耐腐蚀性和耐磨性的基于有限元的合金及其制备方法
公开(公告)号：WO2008111717A1
公开(公告)日：2008-09-18
申请号：PCT/KR2007/005673
申请日：2007-11-12
申请人： IUCF-HYU , KIM, Seon Jin , KIM, Gyung Guk , KIM, Ji Hui , KIM, Ki Nam , KIM, Ji Young
发明人： KIM, Seon Jin , KIM, Gyung Guk , KIM, Ji Hui , KIM, Ki Nam , KIM, Ji Young
IPC分类号： C22C38/28
CPC分类号： C22C38/28
摘要： A corrosion and wear resistant iron (Fe) -based alloy is provided. The Fe-based alloy consists essentially of 14.1 to 14.7% by weight of chromium (Cr), 1.41 to 1.47% by weight of carbon (C), 1.78 to 5.46% by weight of titanium (Ti), 0.11 to 0.39% by weight of aluminum (Al), 0.07 to 0.27% by weight of vanadium (V) and the balance of iron (Fe). The Fe-based alloy is highly resistant to corrosion and wear. In addition, since the Fe-based alloy is prepared using titanium alloy scrap at reduced cost, it is economically advantageous. Furthermore, the Fe-based alloy is environmentally friendly in terms of resource recycling. Further provided is a method for preparing the Fe-based alloy.
摘要翻译：提供耐腐蚀和耐磨铁（Fe）基合金。 Fe基合金主要由14.1至14.7重量％的铬（Cr），1.41至1.47重量％的碳（C），1.78至5.46重量％的钛（Ti），0.11至0.39重量％的铝（Al），0.07〜0.27重量％的钒（V）和余量的铁（Fe）。铁基合金高度耐腐蚀和耐磨损。另外，由于以低成本的钛合金废料制备了Fe基合金，所以在经济上是有利的。此外，Fe基合金在资源回收方面是环保的。还提供了制备Fe基合金的方法。

2. 发明申请

WO2007108621A1 SIRNA FOR INHIBITING NF-KB/RELA EXPRESSION 审中-公开
标题翻译： SIRNA抑制NF-KB / RELA表达
公开(公告)号：WO2007108621A1
公开(公告)日：2007-09-27
申请号：PCT/KR2007/001319
申请日：2007-03-17
申请人： BIONEER CORPORATION , CHOI, Young Chul , PARK, Han Oh , CHOUNG, So Rim , KIM, Seon Hoe , KIM, Ji Young , LEE, Eun Ju , LEE, Mi Young , KIM, Young Joo , LEE, Ui Jin , HAN, Chang Whan
发明人： CHOI, Young Chul , PARK, Han Oh , CHOUNG, So Rim , KIM, Seon Hoe , KIM, Ji Young , LEE, Eun Ju , LEE, Mi Young , KIM, Young Joo , LEE, Ui Jin , HAN, Chang Whan
IPC分类号： C12N15/11 , A61K48/00
CPC分类号： C12N15/113 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/346 , C12N2310/3521
摘要： The present invention relates to siRNA for inhibiting NF-κB/RelA and a pharmaceutical composition for treating rheumatoid arthritis. The pharmaceutical composition for treating rheumatoid arthritis of present invention comprises an active ingredient of siRNA which binds with mRNA transcribed from a gene coding for NF-κB/RelA to inhibit NF-κB/RelA expression in a cell. The pharmaceutical composition for treating rheumatoid arthritis can directly inhibit NF-κB/RelA expression in the gene level as well as induce the death of abnormally proliferated synovial cells, which makes possible its practical application for the treatment of rheumatoid arthritis in a more efficient manner.
摘要翻译：本发明涉及用于抑制NF-κB/ RelA的siRNA和用于治疗类风湿性关节炎的药物组合物。用于治疗本发明类风湿性关节炎的药物组合物包含与编码NF-κB/ RelA的基因转录的mRNA结合以抑制细胞中NF-κB/ RelA表达的siRNA活性成分。用于治疗类风湿性关节炎的药物组合物可以直接抑制基因水平的NF-κB/ RelA表达，并诱导异常增殖的滑膜细胞死亡，这使其成为可能以更有效的方式治疗类风湿性关节炎的实际应用。

3. 发明申请

WO2008069497A1 STRESS SPECIFIC PROMOTERS 审中-公开
标题翻译：应力特定推进器
公开(公告)号：WO2008069497A1
公开(公告)日：2008-06-12
申请号：PCT/KR2007/006122
申请日：2007-11-30
申请人： PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION , LEE, Choon-Hwan , MOON, Yong-Hwan , KIM, Ji Young , HAN, Ji-Sung , PARK, Hee-Yeon , KIM, Minkyun , NAHM, Beak Hie , KIM, Yeon Ki , KIM, Min Jeong , LEE, Dong-Hun
发明人： LEE, Choon-Hwan , MOON, Yong-Hwan , KIM, Ji Young , HAN, Ji-Sung , PARK, Hee-Yeon , KIM, Minkyun , NAHM, Beak Hie , KIM, Yeon Ki , KIM, Min Jeong , LEE, Dong-Hun
IPC分类号： C12N15/63 , C12N15/67
CPC分类号： C12N15/8237
摘要： The present invention relates to promoters, which are linked to target genes in stress environments such as anoxia so as to normally promote the expression of the target genes. According to the disclosed invention, it is possible to obtain transgenic plants having tolerance to stresses such as anoxia.
摘要翻译：本发明涉及在应激环境如缺氧中与靶基因相连的启动子，以便通常促进靶基因的表达。根据所公开的发明，可以获得对胁迫如缺氧具有耐受性的转基因植物。

4. 发明申请

WO2006104356A1 DIPEPTIDYL PEPTIDASE-IV INHIBITING COMPOUNDS, METHODS OF PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE AGENT 审中-公开
标题翻译： DIPEPTIDYL PEPTIDASE-IV抑制化合物，其制备方法和含有它们的药物组合物作为活性剂
公开(公告)号：WO2006104356A1
公开(公告)日：2006-10-05
申请号：PCT/KR2006/001169
申请日：2006-03-30
申请人： LG LIFE SCIENCES, LTD. , LEE, Chang-Seok , KOH, Jong Sung , KOO, Ki Dong , KIM, Geun Tae , KIM, Kyoung-Hee , HONG, Sang Yong , KIM, Sungsub , KIM, Min-Jung , YIM, Hyeon Joo , LIM, Dongchul , KIM, Hye Jin , HAN, Hee Oon , BU, Seong Cheol , KWON, Oh Hwan , KIM, Sung Ho , HUR, Gwong-Cheung , KIM, Ji Young , YEOM, Zi-Ho , YEO, Dong-Jun
发明人： LEE, Chang-Seok , KOH, Jong Sung , KOO, Ki Dong , KIM, Geun Tae , KIM, Kyoung-Hee , HONG, Sang Yong , KIM, Sungsub , KIM, Min-Jung , YIM, Hyeon Joo , LIM, Dongchul , KIM, Hye Jin , HAN, Hee Oon , BU, Seong Cheol , KWON, Oh Hwan , KIM, Sung Ho , HUR, Gwong-Cheung , KIM, Ji Young , YEOM, Zi-Ho , YEO, Dong-Jun
IPC分类号： C07D471/04
CPC分类号： C07D487/04 , C07D401/06 , C07D413/06 , C07D471/04 , C07D498/04 , C07D513/04
摘要： The present invention relates to novel compounds exhibiting good inhibitory activity versus Dipeptidyl Peptidase-IV(DPP-IV), methods of preparing the same and pharmaceutical compositions containing the same as an active agent.
摘要翻译：本发明涉及相对于二肽基肽酶-IV（DPP-IV）显示出良好抑制活性的新化合物，其制备方法和含有该活性剂的药物组合物。

5. 发明申请

WO2009116840A2 CHEMICAL REAGENTS REGULATING STEM CELL FATE 审中-公开
标题翻译：化学试剂调节干细胞损伤
公开(公告)号：WO2009116840A2
公开(公告)日：2009-09-24
申请号：PCT/KR2009/001443
申请日：2009-03-20
申请人： INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY , KIM, Dong Wook , HWANG, Ki-Chul , KIM, Sung Hou , KIM, Ji Young , CHANG, Woo Chul
发明人： KIM, Dong Wook , HWANG, Ki-Chul , KIM, Sung Hou , KIM, Ji Young , CHANG, Woo Chul
IPC分类号： C12N5/02 , C12N5/06
CPC分类号： C12N5/0655 , C12N5/0619 , C12N2500/38 , C12N2500/44 , C12N2501/235 , C12N2501/727 , C12N2502/1394 , C12N2506/02
摘要： The present invention relates to a method for inducing differentiation of a stem cell, which comprises culturing the stem cell in the presence of an inhibitor to protein kinase A or Rho kinase. The present invention provides novel small molecules having isoquinolinesulfonamide scaffold to effectively induce differentiation of stem cells. The present invention allows for directed differentiation of stem cells to a specific cell type.
摘要翻译：本发明涉及诱导干细胞分化的方法，其包括在抑制剂存在下将蛋白激酶A或Rho激酶培养干细胞。本发明提供了具有异硫酚磺酰胺支架的新型小分子，以有效诱导干细胞的分化。本发明允许将干细胞定向分化为特定细胞类型。

6. 发明申请

WO2008093960A1 NOVEL DIPEPTIDYL PEPTIDASE-IV INHIBITORS 审中-公开
标题翻译：新型DIPEPTIDYL PEPTIDASE-IV抑制剂
公开(公告)号：WO2008093960A1
公开(公告)日：2008-08-07
申请号：PCT/KR2008/000428
申请日：2008-01-23
申请人： LG LIFE SCIENCES, LTD. , KOO, Ki Dong , JUNG, Hyejin , LEE, Chang-Seok , LEE, In Sang , YEO, Dong Jun , KWON, Oh Hwan , KIM, Kyoung-Hee , LIM, Dongchul , KIM, Youn hoa , CHANG, Minsun , KIM, Ji Young , KOH, Jong Sung
发明人： KOO, Ki Dong , JUNG, Hyejin , LEE, Chang-Seok , LEE, In Sang , YEO, Dong Jun , KWON, Oh Hwan , KIM, Kyoung-Hee , LIM, Dongchul , KIM, Youn hoa , CHANG, Minsun , KIM, Ji Young , KOH, Jong Sung
IPC分类号： C07D401/06
CPC分类号： C07D401/06 , C07D401/14 , C07D405/14 , C07D413/04 , C07D413/14
摘要： The present invention relates to novel compounds exhibiting excellent inhibitory activity versus Dipeptidyl Peptidase-IV (DPP-IV), methods of preparing the same and pharmaceutical compositions containing the same as an active agent.
摘要翻译：本发明涉及对二肽基肽酶-IV（DPP-IV）表现出优异抑制活性的新化合物，其制备方法和含有该活性剂的药物组合物。

7. 发明申请

WO2008085008A1 T-CELL INHIBITING COMPOUNDS AND THEIR USE FOR THE TREATMENT OF T-CELL-MEDIATED DISEASES 审中-公开
标题翻译： T细胞抑制化合物及其用于治疗T细胞介导性疾病的用途
公开(公告)号：WO2008085008A1
公开(公告)日：2008-07-17
申请号：PCT/KR2008/000195
申请日：2008-01-11
申请人： MOGAM BIOTECHNOLOGY RESEARCH INSTITUTE , WON, Jonghwa , JUNG, Eun Joo , HUR, Minkyu , KIM, Sungjoo , KIM, Young Lim , PARK, Doo-Hong , LEE, Ge Hyeong , KIM, Ikyon , YOO, Sung-Eun , KIM, Ji Young , WON, Hye Kyoung
发明人： WON, Jonghwa , JUNG, Eun Joo , HUR, Minkyu , KIM, Sungjoo , KIM, Young Lim , PARK, Doo-Hong , LEE, Ge Hyeong , KIM, Ikyon , YOO, Sung-Eun , KIM, Ji Young , WON, Hye Kyoung
IPC分类号： C07D235/18 , C07D235/26 , C07D401/12 , C07D413/12 , A61K31/416 , A61P37/00
CPC分类号： C07D233/90 , C07D233/84 , C07D401/06 , C07D405/04 , C07D409/04 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds of formula IA or IB. The present invention also concerned to a method of treating immunologic diseases or pathological conditions in association with T cell involving an immunologic component using T-cell inhibitors, optionally in combination with one or more other drugs selected from steroids, DMARDs, NSAIDs, immunosuppressive, and biological modifiers, pharmaceutical compositions comprising said compounds of formula IA or IB together with said other drugs, and the use of T-cell inhibitors for the manufacture of a pharmaceutical composition for the treatment of immunologic diseases or pathological conditions involving an immunologic component.
摘要翻译：本发明涉及式IA或IB的化合物。本发明还涉及一种使用T细胞抑制剂治疗与T细胞相关的免疫学疾病或病理状态的方法，所述T细胞抑制剂任选地与一种或多种其它选自类固醇，DMARD，NSAID，免疫抑制剂和生物改性剂，包含式IA或IB的所述化合物与所述其它药物的药物组合物，以及T细胞抑制剂在制备用于治疗免疫学疾病或涉及免疫组分的病理状况的药物组合物中的用途。

8. 发明申请

WO2007094601A1 EXTRACT OF STEWARTIA KOREANA AND USE THEREOF 审中-公开
标题翻译：禾本科植物提取物及其用途
公开(公告)号：WO2007094601A1
公开(公告)日：2007-08-23
申请号：PCT/KR2007/000763
申请日：2007-02-13
申请人： RNA INC. , KIM, Ji Young , CHUNG, Dae Kyun , LEE, Tae Hoon , LEE, Guy Wilhem , LEE, Jung Min
发明人： KIM, Ji Young , CHUNG, Dae Kyun , LEE, Tae Hoon , LEE, Guy Wilhem , LEE, Jung Min
IPC分类号： A61K36/82 , A61K8/97 , A61P17/02
CPC分类号： A61K8/97 , A61K36/82 , A61Q7/00 , A61Q19/00 , A61Q19/08
摘要： The present invention relates to an extract of Stewartia koreana and use thereof. More particularly, it relates to an extract of Stewartia koreana which is extracted with any one selected from the group consisting of water, a C1-4 low alcohol, a polar solvent, a non-polar solvent and a mixture thereof, and a pharmaceutical composition for promoting angiogenesis or tissue regeneration and a cosmetic for improving wrinkles comprising the same as an effective ingredient. The extract of Stewartia koreana according to the present invention promotes migration and multiplication of endothelial cell and shows excellent effect in angiogenesis and wound healing and thus, is useful in treatment or prevention of diseases which requires angiogenesis for healing of wounded and frostbitten region, wound healing after surgical operation, and treatment and prevention of gastric ulcer, ischaemic heart diseases and hair loss. Also, the extract shows the dermal tissue regenerating effect and thus, is useful as a cosmetic for improving wrinkles.
摘要翻译：本发明涉及白僵菌的提取物及其用途。更具体地说，本发明涉及使用选自水，C 1-4低级醇，极性溶剂，非极性溶剂及其混合物中的任何一种提取的白僵菌提取物和药物组合物用于促进血管发生或组织再生和用于改善包含其作为有效成分的皱纹的化妆品。根据本发明的白僵菌的提取物促进内皮细胞的迁移和增殖，并且在血管生成和伤口愈合中表现出优异的效果，因此可用于治疗或预防需要血管生成以治愈受伤和冻伤区域，伤口愈合的疾病手术后，治疗和预防胃溃疡，缺血性心脏病和脱发。此外，提取物显示真皮组织再生效果，因此可用作改善皱纹的化妆品。

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