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1. 发明申请

WO2007108621A1 SIRNA FOR INHIBITING NF-KB/RELA EXPRESSION 审中-公开
标题翻译： SIRNA抑制NF-KB / RELA表达
公开(公告)号：WO2007108621A1
公开(公告)日：2007-09-27
申请号：PCT/KR2007/001319
申请日：2007-03-17
申请人： BIONEER CORPORATION , CHOI, Young Chul , PARK, Han Oh , CHOUNG, So Rim , KIM, Seon Hoe , KIM, Ji Young , LEE, Eun Ju , LEE, Mi Young , KIM, Young Joo , LEE, Ui Jin , HAN, Chang Whan
发明人： CHOI, Young Chul , PARK, Han Oh , CHOUNG, So Rim , KIM, Seon Hoe , KIM, Ji Young , LEE, Eun Ju , LEE, Mi Young , KIM, Young Joo , LEE, Ui Jin , HAN, Chang Whan
IPC分类号： C12N15/11 , A61K48/00
CPC分类号： C12N15/113 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/346 , C12N2310/3521
摘要： The present invention relates to siRNA for inhibiting NF-κB/RelA and a pharmaceutical composition for treating rheumatoid arthritis. The pharmaceutical composition for treating rheumatoid arthritis of present invention comprises an active ingredient of siRNA which binds with mRNA transcribed from a gene coding for NF-κB/RelA to inhibit NF-κB/RelA expression in a cell. The pharmaceutical composition for treating rheumatoid arthritis can directly inhibit NF-κB/RelA expression in the gene level as well as induce the death of abnormally proliferated synovial cells, which makes possible its practical application for the treatment of rheumatoid arthritis in a more efficient manner.
摘要翻译：本发明涉及用于抑制NF-κB/ RelA的siRNA和用于治疗类风湿性关节炎的药物组合物。用于治疗本发明类风湿性关节炎的药物组合物包含与编码NF-κB/ RelA的基因转录的mRNA结合以抑制细胞中NF-κB/ RelA表达的siRNA活性成分。用于治疗类风湿性关节炎的药物组合物可以直接抑制基因水平的NF-κB/ RelA表达，并诱导异常增殖的滑膜细胞死亡，这使其成为可能以更有效的方式治疗类风湿性关节炎的实际应用。

2. 发明申请

WO2006129982A1 WASHING MACHINE HAVING SILVER COLLOIDAL SOLUTION GENERATING APPARATUS USING SILVER-FOAM 审中-公开
标题翻译：具有银色胶体溶液的洗衣机使用银发泡产生装置
公开(公告)号：WO2006129982A1
公开(公告)日：2006-12-07
申请号：PCT/KR2006/002125
申请日：2006-06-02
申请人： CHOI, Young Chul
发明人： CHOI, Young Chul
IPC分类号： D06F35/00
CPC分类号： D06F35/003
摘要： The present invention provides a washing machine having a silver colloidal suspension-producing apparatus, which enhances the efficiency with which detergent and bacteria are removed from laundry, thus increasing the washing performance of the washing machine. The silver colloidal suspension-producing apparatus of the present invention includes a housing (23) , which is provided between a washing tub (15) and a water supply hose (17) and has a positive terminal (41) and a negative terminal (45) therein. The silver colloidal suspension-producing apparatus further includes a plurality of electrode plates (75), which are provided in the housing, and a piece of silver foam (55), which is provided between the electrode plates. A plurality of pores is formed in the piece of silver foam. The piece of silver foam is electrically connected to the positive terminal, and the electrode plates are electrically connected to the negative terminal.
摘要翻译：本发明提供了一种具有银胶体悬浮液生产装置的洗衣机，其提高洗涤剂和细菌从衣物中去除的效率，从而提高洗衣机的洗涤性能。本发明的银胶体悬浮液制造装置包括设置在洗涤桶（15）和供水软管（17）之间并具有正极端子（41）和负极端子（45）的壳体（23））。银胶体悬浮液制造装置还包括设置在壳体中的多个电极板（75）和设置在电极板之间的一块银泡沫（55）。在该泡沫块中形成多个孔。该泡沫块与正极端子电连接，电极板与负极端子电连接。

3. 发明申请

WO2006057833A2 METHOD OF SYNTHESIZING Y-JUNCTION SINGLE-WALLED CARBON NANOTUBES AND PRODUCTS FORMED THEREBY 审中-公开
标题翻译：合成Y-型单壁碳纳米管和形成的产物的方法
公开(公告)号：WO2006057833A2
公开(公告)日：2006-06-01
申请号：PCT/US2005/040995
申请日：2005-11-14
申请人： THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES , CHOI, Young, Chul , CHOI, Wonbong
发明人： CHOI, Young, Chul , CHOI, Wonbong
IPC分类号： C01B31/02 , H01L51/30
CPC分类号： H01L51/0048 , B82Y10/00 , B82Y30/00 , B82Y40/00 , C01B32/162 , C01B2202/02 , C01B2202/20 , C01B2202/22 , H01L51/0595 , Y10T428/31678
摘要： A method has been developed of synthesizing Y-SWNTs with controlled density, position, and growth direction. The process includes patterning a substrate with a solvent solution of catalyst metal ions, dopant metal ions and metal oxide ions, having in a molar ratio of catalyst to dopant in the range of 0.1 to 0.5 moles of catalyst metal per mole of dopant metal, prior to heating to 600-1200°C with a flow of hydrocarbon gas. A Y-SWNT can be used as a building component of nanoscale two- and three-terminal electronic devices, such as interconnects, diodes, and transistors. This development has a profound impact on nanoscale semiconductor industry, since it is certain that the market share of nanoscale devices using Y-SWNTs will be increased to a great extent.
摘要翻译：已经开发出合成具有受控密度，位置和生长方向的Y-SWNTs的方法。该方法包括用催化剂金属离子，掺杂剂金属离子和金属氧化物离子的溶剂溶液对催化剂与掺杂剂的摩尔比在每摩尔掺杂剂金属0.1-0.5摩尔催化剂金属的范围内图案化衬底用烃气体加热至600-1200℃。 Y-SWNT可用作纳米尺寸的两端和三端电子器件（如互连，二极管和晶体管）的构建部件。这一发展对纳米半导体产业产生了深远的影响，因为使用Y-SWNTs的纳米尺度器件的市场份额将在很大程度上得到提升。

4. 发明申请

WO2005007584A1 A STERILIZATION WATER TANK 审中-公开
标题翻译：灭菌水箱
公开(公告)号：WO2005007584A1
公开(公告)日：2005-01-27
申请号：PCT/KR2004/001837
申请日：2004-07-22
申请人： CHOI, Young Chul
发明人： CHOI, Young Chul
IPC分类号： C02F1/50
CPC分类号： C02F1/505 , C02F1/005 , C02F2307/04
摘要： The invention relates to a sterilization water tank which may maximize the water sterilization effect and may improve the quality of water. According to an aspect of the invention, there is provided a sterilization water tank comprising a tank body where water is contained 20, and a silver foam 30 which is formed in a foam pattern having a plurality of holes and is contained in the tank body 20, and wherein the water in the tank body 20 may be sterilized by the silver foam 30.
摘要翻译：本发明涉及杀菌水箱，其可以最大限度地提高水的杀菌效果并且可以提高水的质量。根据本发明的一个方面，提供了一种灭菌水箱，其包括容纳水的罐体20，以及形成为具有多个孔并且容纳在罐体20中的泡沫图案的银泡沫30 ，并且其中罐体20中的水可以被银泡沫30消毒。

5. 发明申请

WO2010104751A1 SYSTEM AND METHOD FOR USING CARBON DIOXIDE SEQUESTERED FROM SEAWATER IN THE REMINERALIZATION OF PROCESS WATER 审中-公开
标题翻译：在海水循环过程中使用从海水中排出的二氧化碳的系统和方法
公开(公告)号：WO2010104751A1
公开(公告)日：2010-09-16
申请号：PCT/US2010/026289
申请日：2010-03-05
申请人： DOOSAN HEAVY INDUSTRIES & CONSTRUCTION CO., LTD. , CHOI, Young, Chul , LEE, Chunwoo , SANCHIS, Elvira, Fernandez
发明人： CHOI, Young, Chul , LEE, Chunwoo , SANCHIS, Elvira, Fernandez
IPC分类号： C02F9/04 , C02F1/44
CPC分类号： B01D61/025 , B01D53/22 , B01D61/58 , B01D2311/04 , B01D2311/06 , B01D2311/12 , C02F1/441 , C02F1/66 , C02F1/68 , C02F2103/08 , Y02A20/128 , Y02A20/131 , Y02A20/134
摘要： Disclosed is an improved method for the remineralization of process water in a desalination system. The method sequesters carbon dioxide gas (CO2) from seawater or concentrate (brine) of desalination process via a gas transfer membrane. The sequestered carbon dioxide gas (CO2) is thereafter used in the production of soluble calcium bicarbonate (Ca (HCO3) 2). The calcium bicarbonate (Ca (HCO3) 2) adds hardness and alkalinity to the resulting process water.
摘要翻译：公开了一种改进的脱盐系统中工艺水再矿化的方法。该方法通过气体转移膜从脱盐过程的海水或浓缩物（盐水）中隔离二氧化碳气体（CO 2）。此后将隔离的二氧化碳气体（CO 2）用于生产可溶性碳酸氢钙（Ca（HCO 3）2）。碳酸氢钙（Ca（HCO 3）2）为所得到的工艺水添加硬度和碱度。

6. 发明申请

WO2007145458A1 METHOD OF PREPARING siRNAs FOR SELECTIVE INHIBITION OF TARGET mRNA ISOTYPES 审中-公开
标题翻译：制备用于选择性抑制靶标mRNA同功酶的siRNA的方法
公开(公告)号：WO2007145458A1
公开(公告)日：2007-12-21
申请号：PCT/KR2007/002827
申请日：2007-06-12
申请人： BIONEER CORPORATION , PARK, Seong Min , KIM, Young Joo , CHOI, Young Chul , PARK, Han Oh , CHOUNG, So Rim
发明人： PARK, Seong Min , KIM, Young Joo , CHOI, Young Chul , PARK, Han Oh , CHOUNG, So Rim
IPC分类号： C12N15/10 , C12N15/11 , C12N15/00
CPC分类号： C12N15/111 , C12N2320/10
摘要： A method of preparing siRNAs for selective inhibition of target mRNA isotypes comprises: dividing target mRNA isotypes intended to inhibit the expression thereof and non-target mRNA isotypes from the mRNA isotypes of a gene; allotting a common location information region (A) of exons on genome DNA corresponding to the target mRNA isotypes; allotting a location information region (B) present specifically in exons of genome DNA corresponding to target mRNAs by excluding the location information region of exons on genome DNA corresponding to non-target mRNA from the location information region (A); determining base sequences in the target mRNAs corresponding to the location information region (B); and obtaining siRNA sequences for inhibiting the determined base sequences specifically. The method of the present invention can be used to prepare siRNAs for selective inhibition of specific target mRNA isotypes in a gene having several isotypes by alternative splicing, and enables siRNA design for all the genes in genome, making good tool for functional genomics study.
摘要翻译：制备用于选择性抑制靶mRNA同种型的siRNA的方法包括：从基因的mRNA同种型分离旨在抑制其表达的靶mRNA同种型和非靶mRNA同种型; 在对应于靶mRNA同种型的基因组DNA上分配外显子的共同位置信息区（A）; 通过从所述位置信息区域（A）中排除与非靶mRNA相对应的基因组DNA上的外显子的位置信息区域，分配特定存在于与靶mRNA相对应的基因组DNA外显子中的位置信息区（B）确定对应于位置信息区域（B）的目标mRNA中的碱基序列; 并获得特异性抑制所确定的碱基序列的siRNA序列。本发明的方法可用于制备用于通过选择性剪接在具有多个同种型的基因中特异性靶mRNA同种型的选择性抑制的siRNA，并且使得能够对基因组中所有基因进行siRNA设计，为功能基因组学研究提供了良好的工具。

7. 发明申请

WO2007145385A1 SILVER COLLOIDAL SOLUTION STEAM CLEANER 审中-公开
标题翻译：银离子溶液蒸汽清洁剂
公开(公告)号：WO2007145385A1
公开(公告)日：2007-12-21
申请号：PCT/KR2006/002264
申请日：2006-06-14
申请人： CHOI, Young Chul
发明人： CHOI, Young Chul
IPC分类号： A47L11/34
CPC分类号： A47L11/34 , A47L11/4086 , A61L2/07 , A61L2/22 , A61L2/238
摘要： The present invention provides a silver colloidal suspension steam cleaner, which discharges high-temperature silver colloidal suspension steam during a cleaning process, thus eliminating bacteria from an object surface, and imparting a bactericidal property to the object surface which endures after the cleaning process has been completed. The silver colloidal suspension steam cleaner of the present invention includes a cleaner body (1), which has a vacuum suction port body 2, to which a steam nozzle (24) is mounted, and conducts a vacuum suction operation. The silver colloidal suspension steam cleaner further includes a silver colloidal suspension steam generating unit, which is provided on a rear surface of the cleaner body (1) and generates silver colloidal suspension steam to be sprayed outside through the steam nozzle (24).
摘要翻译：本发明提供了一种银胶体悬浮蒸汽清洁剂，其在清洁过程中排出高温银胶体悬浮液蒸汽，从而从物体表面除去细菌，并且在清洁过程之后持续的物体表面赋予杀菌性完成。本发明的银胶体悬浮蒸汽清洗机包括具有真空吸入口主体2的清洁器主体（1），安装有蒸汽喷嘴（24）并进行真空抽吸操作。银胶体悬浮蒸汽清洗剂还包括银胶体悬浮液蒸汽发生单元，其设置在吸尘器主体（1）的后表面上，并产生通过蒸汽喷嘴（24）喷射到外部的银胶体悬浮蒸汽。

8. 发明申请

WO2006057833A9 METHOD OF SYNTHESIZING Y-JUNCTION SINGLE-WALLED CARBON NANOTUBES AND PRODUCTS FORMED THEREBY 审中-公开
公开(公告)号：WO2006057833A9
公开(公告)日：2006-10-05
申请号：PCT/US2005040995
申请日：2005-11-14
申请人： FLORIDA INTERNAT UNIVERSITY BO , CHOI YOUNG CHUL , CHOI WONBONG
发明人： CHOI YOUNG CHUL , CHOI WONBONG
IPC分类号： C01B31/02 , H01L51/30
CPC分类号： H01L51/0048 , B82Y10/00 , B82Y30/00 , B82Y40/00 , C01B32/162 , C01B2202/02 , C01B2202/20 , C01B2202/22 , H01L51/0595 , Y10T428/31678
摘要： A method has been developed of synthesizing Y-SWNTs with controlled density, position, and growth direction. The process includes patterning a substrate with a solvent solution of catalyst metal ions, dopant metal ions and metal oxide ions, having in a molar ratio of catalyst to dopant in the range of 0.1 to 0.5 moles of catalyst metal per mole of dopant metal, prior to heating to 600-1200°C with a flow of hydrocarbon gas. A Y-SWNT can be used as a building component of nanoscale two- and three-terminal electronic devices, such as interconnects, diodes, and transistors. This development has a profound impact on nanoscale semiconductor industry, since it is certain that the market share of nanoscale devices using Y-SWNTs will be increased to a great extent.

9. 发明申请

WO2006057833A3 METHOD OF SYNTHESIZING Y-JUNCTION SINGLE-WALLED CARBON NANOTUBES AND PRODUCTS FORMED THEREBY 审中-公开
标题翻译：合成Y-结单壁碳纳米管的方法及由其形成的产品
公开(公告)号：WO2006057833A3
公开(公告)日：2006-07-13
申请号：PCT/US2005040995
申请日：2005-11-14
申请人： TEES THE FLORIDA INTERNAT UNIV , CHOI YOUNG CHUL , CHOI WONBONG
发明人： CHOI YOUNG CHUL , CHOI WONBONG
IPC分类号： C01B31/02 , H01L51/30
CPC分类号： H01L51/0048 , B82Y10/00 , B82Y30/00 , B82Y40/00 , C01B32/162 , C01B2202/02 , C01B2202/20 , C01B2202/22 , H01L51/0595 , Y10T428/31678
摘要： A method has been developed of synthesizing Y-SWNTs with controlled density, position, and growth direction. The process includes patterning a substrate with a solvent solution of catalyst metal ions, dopant metal ions and metal oxide ions, having in a molar ratio of catalyst to dopant in the range of 0.1 to 0.5 moles of catalyst metal per mole of dopant metal, prior to heating to 600-1200°C with a flow of hydrocarbon gas. A Y-SWNT can be used as a building component of nanoscale two- and three-terminal electronic devices, such as interconnects, diodes, and transistors. This development has a profound impact on nanoscale semiconductor industry, since it is certain that the market share of nanoscale devices using Y-SWNTs will be increased to a great extent.
摘要翻译：已经开发了一种合成具有可控密度，位置和生长方向的Y-SWNTs的方法。该方法包括用催化剂金属离子，掺杂剂金属离子和金属氧化物离子的溶剂溶液对基材进行图案化，其中催化剂与掺杂剂的摩尔比为每摩尔掺杂剂金属0.1-0.5摩尔催化剂金属，用烃气流加热到600-1200℃。 Y-SWNT可以用作纳米级二端和三端电子器件的构建组件，如互连，二极管和晶体管。这一发展对纳米级半导体产业产生了深远的影响，因为可以肯定的是，使用Y-SWNTs的纳米级器件的市场份额将得到很大程度的提高。

10. 发明申请

WO2006062369A1 METHOD OF INHIBITING EXPRESSION OF TARGET MRNA USING SIRNA CONSISTING OF NUCLEOTIDE SEQUENCE COMPLEMENTARY TO SAID TARGET MRNA 审中-公开
标题翻译：抑制靶向MRNA的表达的方法使用SIRNA包含核酸序列与鉴定目标MRNA相符
公开(公告)号：WO2006062369A1
公开(公告)日：2006-06-15
申请号：PCT/KR2005/004207
申请日：2005-12-08
申请人： BIONEER CORPORATION , CHOI, Young-chul , PARK, Han Oh , CHOUNG, Sorim , KIM, Young Joo , KIM, Sang Soo , PARK, Seong-min , KIM, Sang-cheol , YOON, Gyuman , CHOI, Kyoung Oak , KANG, Hyo Jin
发明人： CHOI, Young-chul , PARK, Han Oh , CHOUNG, Sorim , KIM, Young Joo , KIM, Sang Soo , PARK, Seong-min , KIM, Sang-cheol , YOON, Gyuman , CHOI, Kyoung Oak , KANG, Hyo Jin
IPC分类号： C12Q1/68
CPC分类号： C12N15/111 , C12N15/113 , C12N2310/14 , C12N2320/11 , G06F19/18
摘要： A inhibition method of target mRNA expression includes: (a) obtaining binding energy of a double combination section on a dsRNA sequence of all combination comprising complementary nucleotides to a random target mRNA; (b) dividing the binding energy into four sections on the dsRNA sequence of each combination to obtain a difference of the mean binding energy between each section and convert into a score of a relative combination energy pattern; (c) selecting siRNA whose inhibition efficiency to target mRNA is expected to be high by applying the converted score to the dsRNA sequence with other factors that affect the efficiency of siRNA; and (d) inhibiting target mRNA expression using the selected siRNA. As a result, a researcher or an experimenter can analyze patterns of a relative binding energy on base sequences of unknown siRNA without actual experiments to determine whether the siRNA is effective or ineffective rapidly, thereby design and production efficiency of siRNA can be maximized and target mRNA can be effectively inhibited with efficient siRNA to the target mRNA.
摘要翻译：靶mRNA表达的抑制方法包括：（a）获得双组合切片对包含与随机靶mRNA的互补核苷酸的所有组合的dsRNA序列的结合能; （b）将结合能分成每个组合的dsRNA序列上的四个部分，以获得每个部分之间的平均结合能的差异，并转换成相对组合能量模式的得分; （c）通过将影响siRNA效率的其它因素应用于dsRNA序列的转化得分，选择siRNA靶向mRNA的抑制效率高的siRNA; 和（d）使用所选择的siRNA抑制靶mRNA表达。因此，研究人员或实验者可以分析未知siRNA碱基序列上的相对结合能力的模式，而无需实际的实验来快速确定siRNA是否有效或无效，从而可以使siRNA的设计和生产效率最大化，靶mRNA 可以有效地抑制靶mRNA的有效siRNA。

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