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1. 发明申请

WO2010121074A1 MODULATION OF INFLAMMATORY RESPONSES BY FACTOR XI 审中-公开
标题翻译：由因子XI引起的炎症反应调节
公开(公告)号：WO2010121074A1
公开(公告)日：2010-10-21
申请号：PCT/US2010031311
申请日：2010-04-15
申请人： ISIS PHARMACEUTICALS INC , MONIA BRETT P , CROSBY JEFFREY R , MACLEOD ROBERT A , SIWKOWSKI ANDREW M , FREIER SUSAN M , ZHANG HONG , ZHAO CHENGUANG
发明人： MONIA BRETT P , CROSBY JEFFREY R , MACLEOD ROBERT A , SIWKOWSKI ANDREW M , FREIER SUSAN M , ZHANG HONG , ZHAO CHENGUANG
IPC分类号： A61K48/00
CPC分类号： C12N15/113 , A61K31/7115 , A61K31/712 , A61K31/7125 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y304/21027 , C12N2310/3521
摘要： Disclosed herein are antisense compounds and methods for modulating Factor XI and modulating an inflammatory disease, disorder or condition in an individual in need thereof. Inflammatory diseases in an individual such as arthritis and colitis can be ameliorated or prevented with the administration of antisense compounds targeted to Factor XI.
摘要翻译：本文公开了用于调节因子XI并调节有需要的个体的炎性疾病，病症或病症的反义化合物和方法。通过施用针对因子XI的反义化合物，可以改善或预防个体如关节炎和结肠炎中的炎性疾病。

2. 发明申请

WO2010045509A3 MODULATION OF FACTOR 11 EXPRESSION 审中-公开
标题翻译：因子11表达的调节
公开(公告)号：WO2010045509A3
公开(公告)日：2010-07-15
申请号：PCT/US2009060922
申请日：2009-10-15
申请人： ISIS PHARMACEUTICALS INC , FREIER SUSAN M , MONIA BRETT P , ZHANG HONG , ZHAO CHENGUANG , CROSBY JEFFREY R , SIWKOWSKI ANDREW M
发明人： FREIER SUSAN M , MONIA BRETT P , ZHANG HONG , ZHAO CHENGUANG , CROSBY JEFFREY R , SIWKOWSKI ANDREW M
IPC分类号： A61K31/70
CPC分类号： A61K31/7125 , A61K31/366 , A61K31/4365 , A61K31/4545 , A61K31/713 , A61K31/727 , A61K31/737 , C07H21/00 , C12N15/1137 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y304/21027
摘要： Disclosed herein are antisense compounds and methods for decreasing Factor 11 and treating or preventing thromboembolic complications in an individual in need thereof. Examples of disease conditions that can be ameliorated with the administration of antisense compounds targeted to Factor 11 include thrombosis, embolism, and thromboembolism, such as, deep vein thrombosis, pulmonary embolism, myocardial infarction, and stroke. Antisense compounds targeting Factor 11 can also be used as a prophylactic treatment to prevent individuals at risk for thrombosis and embolism.
摘要翻译：本文公开了用于降低需要其的个体中的因子11并治疗或预防血栓栓塞并发症的反义化合物和方法。施用靶向因子11的反义化合物可改善的疾病状况的实例包括血栓形成，栓塞和血栓栓塞，如深静脉血栓形成，肺栓塞，心肌梗塞和中风。靶向因子11的反义化合物也可用作预防性治疗以预防有血栓形成和栓塞风险的个体。

3. 发明申请

WO2009061851A3 MODULATION OF FACTOR 7 EXPRESSION 审中-公开
标题翻译：因子7的表达式的调制
公开(公告)号：WO2009061851A3
公开(公告)日：2009-07-16
申请号：PCT/US2008082526
申请日：2008-11-05
申请人： ISIS PHARMACEUTICALS INC , FREIER SUSAN M , MONIA BRETT P , ZHANG HONG , CROSBY JEFFREY R , ZHAO CHENGUANG
发明人： FREIER SUSAN M , MONIA BRETT P , ZHANG HONG , CROSBY JEFFREY R , ZHAO CHENGUANG
IPC分类号： A61K31/7088 , A61P7/02 , C12N15/113
CPC分类号： C12N15/1137 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12Y304/21021 , C12N2310/3525
摘要： Disclosed herein are antisense compounds and methods for decreasing Factor 7 and treating or preventing thromboembolic complications, hyperproliferative disorders, or inflammatory conditions in an individual in need thereof. Examples of disease conditions that can be ameliorated with the administration of antisense compounds targeted to Factor 7 include thrombosis, embolism, and thromboembolism, such as, deep vein thrombosis, pulmonary embolism, myocardial infarction, stroke, cancer, rheumatoid arthritis, and fibrosis.
摘要翻译：本文公开了用于减少因子7并在需要其的个体中治疗或预防血栓栓塞并发症，过度增殖性疾病或炎性病症的反义化合物和方法。通过施用靶向因子7的反义化合物可以改善的疾病状况的实例包括血栓形成，栓塞和血栓栓塞，例如深静脉血栓形成，肺栓塞，心肌梗塞，中风，癌症，类风湿性关节炎和纤维化。

4. 发明申请

WO2009061852A3 MODULATION OF FACTOR 9 EXPRESSION 审中-公开
标题翻译：因子9表达的调节
公开(公告)号：WO2009061852A3
公开(公告)日：2009-09-24
申请号：PCT/US2008082527
申请日：2008-11-05
申请人： ISIS PHARMACEUTICALS INC , FREIER SUSAN M , MONIA BRETT P , ZHANG HONG , ZHAO CHENGUANG
发明人： FREIER SUSAN M , MONIA BRETT P , ZHANG HONG , ZHAO CHENGUANG
IPC分类号： A61K31/7088 , A61P7/02 , A61P9/04 , A61P11/00 , C07H21/00 , C12N15/113
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Disclosed herein are antisense compounds and methods for decreasing Factor 9 and increasing clotting time in an individual in need thereof. Examples of disease conditions that can be ameliorated with the administration of antisense compounds targeted to Factor 9 include thrombosis, embolism, thromoboembolism such as deep vein thrombosis, pulmonary embolism, myocardial infarction, and stroke.
摘要翻译：本文公开了用于减少有需要的个体中的因子9和增加凝血时间的反义化合物和方法。施用靶向因子9的反义化合物可改善疾病状况的例子包括血栓形成，栓塞，血栓栓塞如深静脉血栓形成，肺栓塞，心肌梗塞和中风。

5. 发明申请

WO2009061841A3 MODIFIED POLYNUCLEOTIDES AS ANTIDOTES TO ANTISENSE COMPOUNDS 审中-公开
标题翻译：改性多核苷酸作为抗体化合物的抗体
公开(公告)号：WO2009061841A3
公开(公告)日：2009-08-06
申请号：PCT/US2008082511
申请日：2008-11-05
申请人： ISIS PHARMACEUTICALS INC , MONIA BRETT P , SIWKOWSKI ANDREW M , ZHANG HONG
发明人： MONIA BRETT P , SIWKOWSKI ANDREW M , ZHANG HONG
IPC分类号： A61P43/00 , C12N15/11 , C12N15/113 , G01N33/00
CPC分类号： C12N15/11 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/321 , C12N2310/341 , C12N2320/50 , C12N2310/3525
摘要： The present invention relates to antisense antidote compounds and uses thereof. Such antidote compounds reduce the magnitude and/or duration of the antisense activity of an antisense compound.
摘要翻译：本发明涉及反义解毒剂化合物及其用途。这样的解毒剂化合物降低了反义化合物的反义活性的大小和/或持续时间。

6. 发明申请

WO0248314A3 ANTISENSE MODULATION OF RAIDD EXPRESSION 审中-公开
标题翻译： RAIDD表达式的防伪调制
公开(公告)号：WO0248314A3
公开(公告)日：2009-06-11
申请号：PCT/US0150914
申请日：2001-10-29
申请人： ISIS PHARMACEUTICALS INC , ZHANG HONG , FREIER SUSAN M , WATT ANDREW T
发明人： ZHANG HONG , FREIER SUSAN M , WATT ANDREW T
IPC分类号： C07H21/04 , A61K38/00 , A61K48/00 , C12N15/00 , C12N15/09 , C12N15/113
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of RAIDD. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding RAIDD. Methods of using these compounds for modulation of RAIDD expression and for treatment of diseases associated with expression of RAIDD are provided.
摘要翻译：提供反义化合物，组合物和方法用于调节RAIDD的表达。组合物包含靶向编码RAIDD的核酸的反义化合物，特别是反义寡核苷酸。提供了使用这些化合物调节RAIDD表达和治疗与RAIDD表达相关疾病的方法。

7. 发明申请

WO2011041719A3 METHOD AND APPARATUS FOR TRANSMIT POWER CONTROL FOR MULTIPLE ANTENNA TRANSMISSIONS IN THE UPLINK 审中-公开
标题翻译：用于上行链路中多个天线传输的发射功率控制的方法和装置
公开(公告)号：WO2011041719A3
公开(公告)日：2011-07-21
申请号：PCT/US2010051185
申请日：2010-10-01
申请人： INTERDIGITAL PATENT HOLDINGS , PELLETIER BENOIT , CAI LUJING , ZHANG HONG
发明人： PELLETIER BENOIT , CAI LUJING , ZHANG HONG
IPC分类号： H04W52/36
CPC分类号： H04W52/34 , H04B7/0413 , H04B7/0465 , H04B7/0615 , H04J13/00 , H04L1/1812 , H04W52/146 , H04W52/367 , H04W52/42 , H04W72/0473
摘要： Techniques for transmit power control for multiple antenna transmissions in an uplink are disclosed. A wireless transmit/receive unit (WTRU) generates at least one input stream for transmission and applies a gain factor to each channel. The gain factor is determined based on a reference channel power estimate. The WTRU generates at least two data streams from the input stream for transmission via a plurality of antennas and applies weights to the data streams. The gain factor and/or the weights are controlled such that a transmit power on each antenna is within a maximum allowed value. The WTRU may perform power scaling on a condition that a transmit power on any antenna exceeds the maximum allowed value. The WTRU may scale down an enhanced dedicated channel (E-DCH) dedicated physical data channel (E-DPDCH) first before other channels. For multiple E-DCH streams, the WTRU may calculate an E-DPDCH power offset based on an additional power offset factor due to multiple stream transmission.
摘要翻译：公开了用于上行链路中多天线传输的发射功率控制的技术。无线发射/接收单元（WTRU）生成至少一个用于传输的输入流，并将增益因子应用于每个信道。基于参考信道功率估计来确定增益因子。 WTRU从输入流生成至少两个数据流，以经由多个天线传输，并对数据流应用权重。控制增益因子和/或权重，使得每个天线上的发射功率在最大允许值内。 WTRU可以在任何天线上的发射功率超过最大允许值的条件下执行功率缩放。 WTRU可以在其他信道之前首先缩小增强型专用信道（E-DCH）专用物理数据信道（E-DPDCH）。对于多个E-DCH流，WTRU可以基于由于多流传输而引起的附加功率偏移因子来计算E-DPDCH功率偏移。

8. 发明申请

WO2009158189A8 DETECTING A STRUCTURE IN A WELL 审中-公开
标题翻译：检测一个好的结构
公开(公告)号：WO2009158189A8
公开(公告)日：2010-05-06
申请号：PCT/US2009046818
申请日：2009-06-10
申请人： SCHLUMBERGER CA LTD , SCHLUMBERGER TECHNOLOGY BV , PRAD RES & DEV LTD , SCHLUMBERGER SERVICES PETROL , SCHLUMBERGER HOLDINGS , ZHANG HONG , DEPAVIA LUIS E
发明人： ZHANG HONG , DEPAVIA LUIS E
IPC分类号： E21B47/09
CPC分类号： E21B47/0905 , G01V3/28
摘要： A tool for detecting a structure in a well includes a receiver coil having a first winding and a second winding, a first circuit to apply an input signal to the second winding, and a detection circuit to detect a response of the first winding to the input signal applied to the second winding. The response of the first winding indicates presence of the structure in the well if the receiver coil is positioned proximate the structure. The depths (or locations) of these structures are used to avoid placing receivers near these structures for EM induction surveys, such as cross-well, surface-to-wellbore, or single-wellbore induction loggings with receivers in metallic casing.
摘要翻译：用于检测井中的结构的工具包括具有第一绕组和第二绕组的接收器线圈，将输入信号施加到第二绕组的第一电路以及用于检测第一绕组对输入端的响应的检测电路信号施加到第二绕组。如果接收器线圈靠近结构定位，则第一绕组的响应指示井中存在结构。这些结构的深度（或位置）用于避免将接收器放置在这些结构附近用于EM感应测量，例如在金属外壳中具有接收器的交叉井，井对井眼或单井眼感应测井。

9. 发明申请

WO2008064339A3 MOBILE SPEED AND DOPPLER FREQUENCY ESTIMATION USING CYCLOSTATIONARITY 审中-公开
标题翻译：移动速度和多普勒频率估计的循环平稳性
公开(公告)号：WO2008064339A3
公开(公告)日：2008-07-10
申请号：PCT/US2007085436
申请日：2007-11-21
申请人： NEW JERSEY TECH INST , ZHANG HONG , ABDI ALI
发明人： ZHANG HONG , ABDI ALI
IPC分类号： H04B7/01
CPC分类号： H04B7/01
摘要： Embodiments of the invention exploit cyclostationarity of linearly modulated signals, transmitted through fading channels, to provide robust blind and data-aided mobile speed estimators. Embodiments of the invention utilize at least two methods of cyclic-correlation- and cyclic-spectrum-based methods and extension to space-time speed estimation at the base station in macrocells. In comparison with background art methods, the new estimators of the embodiments of the invention can be used without any need for pilot tones, and are robust to additive stationary noise or interference of any color or distribution. In addition, embodiments of the invention can also be implemented blindly, which can increase the data throughput. Performance results of the estimators of the embodiments of the invention are illustrated via extensive Monte Carlo simulation results.
摘要翻译：本发明的实施例利用通过衰落信道传输的线性调制信号的循环平稳性，以提供鲁棒的盲和数据辅助的移动速度估计器。本发明的实施例利用基于循环相关和循环频谱的方法中的至少两种方法和对宏小区中的基站处的空间 - 时间速度估计的扩展。与背景技术方法相比，可以使用本发明实施例的新估计器而不需要任何导频音，并且对于附加的固定噪声或任何颜色或分布的干扰是稳健的。另外，本发明的实施例也可以盲目地实现，这可以增加数据吞吐量。通过广泛的蒙特卡洛模拟结果来说明本发明的实施例的估计器的性能结果。

10. 发明申请

WO2006121849A3 E-SERVICES TRANSLATION UTILIZING MACHINE TRANSLATION AND TRANSLATION MEMORY 审中-公开
标题翻译：电子翻译使用机器翻译和翻译记忆
公开(公告)号：WO2006121849A3
公开(公告)日：2007-11-08
申请号：PCT/US2006017398
申请日：2006-05-08
申请人： CHENG SHANG-CHE , PRESSMAN ALEXANDER , ZHANG HONG , MA PEI CHIANG , ZHANG SHUAN , HUMMEL JOCHEN
发明人： CHENG SHANG-CHE , PRESSMAN ALEXANDER , ZHANG HONG , MA PEI CHIANG , ZHANG SHUAN , HUMMEL JOCHEN
IPC分类号： G06F7/00 , G06F15/00 , G06F17/00 , G06F17/28 , G06F17/30
CPC分类号： G06F17/289 , G06F17/2827 , G06F17/2836 , G06F17/2854
摘要： A system and method for translating data from a source language to a target language is provided wherein machine generated target translation of a source sentence is compared to a database of human generated target sentences. If a matching human generated target sentence is found, the human generated target sentence may be used instead of the machine generated sentence, since the human generated target sentence is more likely to be a well-formed sentence than the machine generated sentence. The system and method does not rely on a translation memory containing pairs of sentences in both source and target languages, and minimizes the reliance on a human translator to correct a translation generated by machine translation.
摘要翻译：提供了一种用于将数据从源语言翻译成目标语言的系统和方法，其中将源语句的机器生成的目标翻译与人生成的目标句子的数据库进行比较。如果找到匹配的人类生成的目标句子，则可以使用人类生成的目标句子来代替机器生成的句子，因为人类生成的目标句子更可能是比机器产生的句子更好的句子。系统和方法不依赖于包含源语言和目标语言中的句子对的翻译记忆库，并且最小化对人类翻译器的依赖，以纠正机器翻译产生的翻译。

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