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1. 发明申请

WO2012174154A1 MODULATION OF INFLAMMATORY RESPONSES BY FACTOR VII 审中-公开
标题翻译：由因子VII引起的炎症反应调节
公开(公告)号：WO2012174154A1
公开(公告)日：2012-12-20
申请号：PCT/US2012/042307
申请日：2012-06-13
申请人： ISIS PHARMACEUTICALS, INC. , CROSBY, Jeffrey, R. , REVENKO, Alexey , MONIA, Brett, P. , MACLEOD, Robert, A.
发明人： CROSBY, Jeffrey, R. , REVENKO, Alexey , MONIA, Brett, P. , MACLEOD, Robert, A.
IPC分类号： A61K31/7088
CPC分类号： A61K31/7088
摘要： Disclosed herein are antisense compounds and methods for modulating Factor VII and modulating an inflammatory disease, disorder or condition in an individual in need thereof. Inflammatory diseases in an individual such as arthritis and colitis can be treated, ameliorated or prevented with the administration of antisense compounds targeted to Factor VII. Provided herein are methods, compounds, and compositions for modulating levels of Factor VII mRNA and/or protein in an animal. Provided herein are methods, compounds, and compositions for modulating levels of Factor VII mRNA and/or protein in an animal in order to modulate an inflammatory response in the animal. Also provided herein are methods, compounds, and compositions for administering a therapeutically effective amount of a compound targeting Factor VII to an animal for ameliorating an inflammatory disease in an animal; treating an animal at risk for an inflammatory disease.
摘要翻译：本文公开了用于调节因子VII并调节有需要的个体的炎性疾病，病症或病症的反义化合物和方法。可以通过给予靶向因子VII的反义化合物来治疗，改善或预防个体中诸如关节炎和结肠炎的炎性疾病。本文提供了用于调节动物中因子VII mRNA和/或蛋白质水平的方法，化合物和组合物。本文提供了用于调节动物中因子VII mRNA和/或蛋白质水平的方法，化合物和组合物，以便调节动物中的炎症反应。本文还提供了用于向动物施用治疗有效量的靶向因子VII的化合物以改善动物的炎性疾病的方法，化合物和组合物; 治疗有风险的动物患有炎性疾病。

2. 发明申请

WO2010121074A8 MODULATION OF INFLAMMATORY RESPONSES BY FACTOR XI 审中-公开
公开(公告)号：WO2010121074A8
公开(公告)日：2010-10-21
申请号：PCT/US2010/031311
申请日：2010-04-15
申请人： ISIS PHARMACEUTICALS, INC. , MONIA, Brett, P. , CROSBY, Jeffrey, R. , MACLEOD, Robert, A. , FREIER, Susan, M.
发明人： MONIA, Brett, P. , CROSBY, Jeffrey, R. , MACLEOD, Robert, A. , FREIER, Susan, M.
IPC分类号： A61K48/00
摘要： Disclosed herein are antisense compounds and methods for modulating Factor XI and modulating an inflammatory disease, disorder or condition in an individual in need thereof. Inflammatory diseases in an individual such as arthritis and colitis can be ameliorated or prevented with the administration of antisense compounds targeted to Factor XI.

3. 发明申请

WO2010120524A2 METHODS OF MODULATING AN IMMUNE RESPONSE TO A VIRAL INFECTION 审中-公开
标题翻译：调节对病毒感染的免疫应答的方法
公开(公告)号：WO2010120524A2
公开(公告)日：2010-10-21
申请号：PCT/US2010/029408
申请日：2010-03-31
申请人： ALTAIR THERAPEUTICS, INC. , ISIS PHARMACEUTICALS, INC. , GREGORY, Susan , KARRAS, James, G. , CROSBY, Jeffrey, R. , YU, Zhengrong , GEARY, Richard, S.
发明人： GREGORY, Susan , KARRAS, James, G. , CROSBY, Jeffrey, R. , YU, Zhengrong , GEARY, Richard, S.
IPC分类号： C12N15/113 , C07K14/715 , A61K48/00
CPC分类号： C07K14/7155 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Disclosed herein are methods for treating respiratory disorders via administration of antisense compounds targeting IL-4Rα. Provided herein, for example, are compositions and methods of modulating immune responses to a viral infection in a subject. Also provided, for example, are compositions and methods for managing, treating, ameliorating, preventing and/or delaying the onset of pulmonary inflammation, airway hyperreactivity and/or loss of lung function, or a symptom thereof in a subject during the course of or resulting from a viral infection. Further provided, for example, are compositions and methods of inducing or augmenting hypo-responsiveness, non-responsiveness or tolerance to a virus in a subject. Also provided, for example, are compositions and methods of enhancing the efficacy of a viral vaccine in a subject. In certain embodiments, the compositions and methods provided herein utilize an antisense compound 12 to 35 nucleobases in length targeted to a nucleic acid molecule encoding human IL-4 receptor alpha IL-4Rα, wherein said antisense compound inhibits expression of human IL-4Rα protein and/or expression of functional IL-4 and IL- 13 receptors.
摘要翻译：本文公开了通过施用靶向IL-4Rα的反义化合物来治疗呼吸病症的方法。例如，本文提供了调节受试者对病毒感染的免疫应答的组合物和方法。例如，还提供了组合物和方法，所述组合物和方法用于在患者的过程期间管理，治疗，改善，预防和/或延迟肺部炎症发作，气道高反应性和/或肺功能丧失或其症状，由病毒感染引起。例如，进一步提供了诱导或增强对象中病毒的低反应性，无反应性或耐受性的组合物和方法。例如，还提供了增强病人疫苗在受试者中的功效的组合物和方法。在某些实施方案中，本文提供的组合物和方法利用靶向编码人IL-4受体αIL-4Rα的核酸分子长度为12至35个核碱基的反义化合物，其中所述反义化合物抑制人IL-4Rα蛋白的表达并且 /或功能性IL-4和IL-13受体的表达。

4. 发明申请

WO2009061851A3 MODULATION OF FACTOR 7 EXPRESSION 审中-公开
标题翻译：因子7的表达式的调制
公开(公告)号：WO2009061851A3
公开(公告)日：2009-07-16
申请号：PCT/US2008082526
申请日：2008-11-05
申请人： ISIS PHARMACEUTICALS INC , FREIER SUSAN M , MONIA BRETT P , ZHANG HONG , CROSBY JEFFREY R , ZHAO CHENGUANG
发明人： FREIER SUSAN M , MONIA BRETT P , ZHANG HONG , CROSBY JEFFREY R , ZHAO CHENGUANG
IPC分类号： A61K31/7088 , A61P7/02 , C12N15/113
CPC分类号： C12N15/1137 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12Y304/21021 , C12N2310/3525
摘要： Disclosed herein are antisense compounds and methods for decreasing Factor 7 and treating or preventing thromboembolic complications, hyperproliferative disorders, or inflammatory conditions in an individual in need thereof. Examples of disease conditions that can be ameliorated with the administration of antisense compounds targeted to Factor 7 include thrombosis, embolism, and thromboembolism, such as, deep vein thrombosis, pulmonary embolism, myocardial infarction, stroke, cancer, rheumatoid arthritis, and fibrosis.
摘要翻译：本文公开了用于减少因子7并在需要其的个体中治疗或预防血栓栓塞并发症，过度增殖性疾病或炎性病症的反义化合物和方法。通过施用靶向因子7的反义化合物可以改善的疾病状况的实例包括血栓形成，栓塞和血栓栓塞，例如深静脉血栓形成，肺栓塞，心肌梗塞，中风，癌症，类风湿性关节炎和纤维化。

5. 发明申请

WO2006091841A2 COMPOSITIONS AND THEIR USES DIRECTED TO IL-4R ALPHA 审中-公开
标题翻译：组合物及其与IL-4R ALPHA相关的用途
公开(公告)号：WO2006091841A2
公开(公告)日：2006-08-31
申请号：PCT/US2006006645
申请日：2006-02-24
申请人： ISIS PHARMACEUTICALS INC , KARRAS JAMES G , GREGORY SUSAN , CROSBY JEFFREY R , WEDEL MARK K , TUNG DAVID
发明人： KARRAS JAMES G , GREGORY SUSAN , CROSBY JEFFREY R , WEDEL MARK K , TUNG DAVID
IPC分类号： A61K31/7088 , A61P11/00 , C12N15/113
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/3525
摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of IL- 4R alpha in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders related to expression of IL 4R-a, airway hyperresponsiveness, and/or pulmonary inflammation.
摘要翻译：本文公开了用于调节细胞，组织或动物中IL-4Rα的表达的化合物，组合物和方法。还提供了目标验证的方法。还提供了所公开的化合物和组合物在制备用于治疗与IL 4R-α的表达，气道高反应性和/或肺部炎症相关的疾病和病症的药物中的用途。

6. 发明申请

WO2010120524A3 METHODS OF MODULATING AN IMMUNE RESPONSE TO A VIRAL INFECTION 审中-公开
标题翻译：调节对病毒感染的免疫应答的方法
公开(公告)号：WO2010120524A3
公开(公告)日：2010-12-09
申请号：PCT/US2010029408
申请日：2010-03-31
申请人： ALTAIR THERAPEUTICS INC , ISIS PHARMACEUTICALS INC , GREGORY SUSAN , KARRAS JAMES G , CROSBY JEFFREY R , YU ZHENGRONG , GEARY RICHARD S
发明人： GREGORY SUSAN , KARRAS JAMES G , CROSBY JEFFREY R , YU ZHENGRONG , GEARY RICHARD S
IPC分类号： C12N15/113 , A61K48/00 , C07K14/715
CPC分类号： C07K14/7155 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Disclosed herein are methods for treating respiratory disorders via administration of antisense compounds targeting IL-4Ra. Provided herein, for example, are compositions and methods of modulating immune responses to a viral infection in a subject. Also provided, for example, are compositions and methods for managing, treating, ameliorating, preventing and/or delaying the onset of pulmonary inflammation, airway hyperreactivity and/or loss of lung function, or a symptom thereof in a subject during the course of or resulting from a viral infection. Further provided, for example, are compositions and methods of inducing or augmenting hypo-responsiveness, non-responsiveness or tolerance to a virus in a subject. Also provided, for example, are compositions and methods of enhancing the efficacy of a viral vaccine in a subject. In certain embodiments, the compositions and methods provided herein utilize an antisense compound 12 to 35 nucleobases in length targeted to a nucleic acid molecule encoding human IL-4 receptor alpha IL-4Ra, wherein said antisense compound inhibits expression of human IL-4Ra protein and/or expression of functional IL-4 and IL- 13 receptors.
摘要翻译：本文公开了通过施用靶向IL-4Ra的反义化合物来治疗呼吸系统疾病的方法。例如，本文提供调节受试者中病毒感染的免疫应答的组合物和方法。还提供了例如用于在过程中管理，治疗，改善，预防和/或延迟受试者的肺部炎症发作，气道高反应性和/或肺功能丧失或其症状的组合物和方法，由病毒感染引起。进一步提供的是例如诱导或增加受试者中对病毒的低反应性，非反应性或耐受性的组合物和方法。还提供了例如增强受试者中病毒疫苗功效的组合物和方法。在某些实施方案中，本文提供的组合物和方法利用长度为靶向编码人IL-4受体α-IL-4Ra的核酸分子的反义化合物12至35个核碱基，其中所述反义化合物抑制人IL-4Ra蛋白的表达和 /或功能性IL-4和IL-13受体的表达。

7. 发明申请

WO2010121074A1 MODULATION OF INFLAMMATORY RESPONSES BY FACTOR XI 审中-公开
标题翻译：由因子XI引起的炎症反应调节
公开(公告)号：WO2010121074A1
公开(公告)日：2010-10-21
申请号：PCT/US2010031311
申请日：2010-04-15
申请人： ISIS PHARMACEUTICALS INC , MONIA BRETT P , CROSBY JEFFREY R , MACLEOD ROBERT A , SIWKOWSKI ANDREW M , FREIER SUSAN M , ZHANG HONG , ZHAO CHENGUANG
发明人： MONIA BRETT P , CROSBY JEFFREY R , MACLEOD ROBERT A , SIWKOWSKI ANDREW M , FREIER SUSAN M , ZHANG HONG , ZHAO CHENGUANG
IPC分类号： A61K48/00
CPC分类号： C12N15/113 , A61K31/7115 , A61K31/712 , A61K31/7125 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y304/21027 , C12N2310/3521
摘要： Disclosed herein are antisense compounds and methods for modulating Factor XI and modulating an inflammatory disease, disorder or condition in an individual in need thereof. Inflammatory diseases in an individual such as arthritis and colitis can be ameliorated or prevented with the administration of antisense compounds targeted to Factor XI.
摘要翻译：本文公开了用于调节因子XI并调节有需要的个体的炎性疾病，病症或病症的反义化合物和方法。通过施用针对因子XI的反义化合物，可以改善或预防个体如关节炎和结肠炎中的炎性疾病。

8. 发明申请

WO2010120511A3 METHOD OF TREATING RESPIRATORY DISORDERS 审中-公开
公开(公告)号：WO2010120511A3
公开(公告)日：2010-10-21
申请号：PCT/US2010/029379
申请日：2010-03-31
申请人： ALTAIR THERAPEUTICS, INC. , ISIS PHARMACEUTICALS, INC. , GREGORY, Susan , KARRAS, James, G. , CROSBY, Jeffrey, R. , YU, Zhengrong , GEARY, Richard, S.
发明人： GREGORY, Susan , KARRAS, James, G. , CROSBY, Jeffrey, R. , YU, Zhengrong , GEARY, Richard, S.
IPC分类号： C12N15/113 , C07K14/715 , A61K48/00
摘要： Disclosed herein are methods for treating respiratory disorders via administration of antisense compounds targeting IL-4Rα. Provided herein, for example, are compositions and methods for managing, treating, ameliorating, preventing and/or delaying the onset of pulmonary inflammation, airway hyperreactivity and/or loss of lung function, or a symptom thereof in a subject. Further provided, for example, are compositions and methods of inducing or augmenting hypo-responsiveness, non-responsiveness or tolerance to an antigen in a subject. Also provided, for example, are compositions and methods of enhancing the efficacy of a vaccine in a subject. In certain embodiments, the compositions and methods provided herein utilize an antisense compound 12 to 35 nucleobases in length targeted to a nucleic acid molecule encoding human IL-4 receptor alpha IL-4Rα, wherein said antisense compound inhibits expression of human IL-4Rα protein and/or expression of functional IL-4 and IL- 13 receptors.

9. 发明申请

WO2006086821A1 ANTISENS MODULATION OF INTEGRIN α4 EXPRESSION 审中-公开
标题翻译： INTEGRIN的抗体调制a4表达
公开(公告)号：WO2006086821A1
公开(公告)日：2006-08-24
申请号：PCT/AU2005/001634
申请日：2005-10-20
申请人： ANTISENSE THERAPEUTICS LTD , TACHAS, George , KARRAS, James, G. , GREGORY, Susan , CROSBY, Jeffrey, R. , DOBIE, Kenneth, W. , BENNETT, C., Frank
发明人： TACHAS, George , KARRAS, James, G. , GREGORY, Susan , CROSBY, Jeffrey, R. , DOBIE, Kenneth, W. , BENNETT, C., Frank
IPC分类号： A61K31/711 , A61P11/00
CPC分类号： A61K31/711 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： A method for the treatment and/or prophylaxis of an animal having a respiratory disease or condition associated with airway hyperresponsiveness, eosinophilia, neutrophilia, leukocytes or overproduction of mucus and/or with the expression of integrin α4 comprising administering to the animal a composition comprising from. 0.001 to 1000 µg per kg body weight of the animal of an antisense compound targeted to a nucleic acid molecule encoding integrin α4.
摘要翻译：用于治疗和/或预防具有呼吸道疾病或与气道高反应性，嗜酸性粒细胞增多症，嗜中性粒细胞增多症，白细胞或过度产生粘液和/或与整联蛋白a4表达有关的呼吸系统疾病或病症的动物的方法，包括向动物施用包含。 0.001至1000μg/ kg体重的靶向编码整联蛋白a4的核酸分子的反义化合物的动物。

10. 发明申请

WO2012064758A2 METHODS FOR MODULATING FACTOR 12 EXPRESSION 审中-公开
标题翻译：调节因子12表达的方法
公开(公告)号：WO2012064758A2
公开(公告)日：2012-05-18
申请号：PCT/US2011/059804
申请日：2011-11-08
申请人： ISIS PHARMACEUTICALS, INC. , MONIA, Brett, P. , MACLEOD, Robert, A. , CROSBY, Jeffrey, R.
发明人： MONIA, Brett, P. , MACLEOD, Robert, A. , CROSBY, Jeffrey, R.
IPC分类号： A61K48/00
CPC分类号： C12N15/1137 , C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/321 , C12N2310/3525
摘要： Disclosed herein are methods for decreasing Factor 12 and treating or preventing thromboembolic conditions in an individual in need thereof. Examples of disease conditions that can be ameliorated with the administration of antisense compounds targeted to Factor 12 include thrombosis, embolism, and thromboembolism, such as, deep vein thrombosis, pulmonary embolism, myocardial infarction, stroke, and mesenteric thrombosis. Methods for inhibiting Factor 12 can also be used as a prophylactic treatment to prevent individuals at risk for thrombosis and embolism.
摘要翻译：本文公开了减少因子12并治疗或预防有此需要的个体血栓栓塞症状的方法。通过施用靶向因子12的反义化合物可以改善的疾病状况的实例包括血栓形成，栓塞和血栓栓塞，例如深静脉血栓形成，肺栓塞，心肌梗塞，中风和肠系膜血栓形成。抑制因子12的方法也可以用作预防性治疗以预防患有血栓形成和栓塞危险的个体。

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