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    • 1. 发明申请
    • MODULATION OF INFLAMMATORY RESPONSES BY FACTOR VII
    • 由因子VII引起的炎症反应调节
    • WO2012174154A1
    • 2012-12-20
    • PCT/US2012/042307
    • 2012-06-13
    • ISIS PHARMACEUTICALS, INC.CROSBY, Jeffrey, R.REVENKO, AlexeyMONIA, Brett, P.MACLEOD, Robert, A.
    • CROSBY, Jeffrey, R.REVENKO, AlexeyMONIA, Brett, P.MACLEOD, Robert, A.
    • A61K31/7088
    • A61K31/7088
    • Disclosed herein are antisense compounds and methods for modulating Factor VII and modulating an inflammatory disease, disorder or condition in an individual in need thereof. Inflammatory diseases in an individual such as arthritis and colitis can be treated, ameliorated or prevented with the administration of antisense compounds targeted to Factor VII. Provided herein are methods, compounds, and compositions for modulating levels of Factor VII mRNA and/or protein in an animal. Provided herein are methods, compounds, and compositions for modulating levels of Factor VII mRNA and/or protein in an animal in order to modulate an inflammatory response in the animal. Also provided herein are methods, compounds, and compositions for administering a therapeutically effective amount of a compound targeting Factor VII to an animal for ameliorating an inflammatory disease in an animal; treating an animal at risk for an inflammatory disease.
    • 本文公开了用于调节因子VII并调节有需要的个体的炎性疾病,病症或病症的反义化合物和方法。 可以通过给予靶向因子VII的反义化合物来治疗,改善或预防个体中诸如关节炎和结肠炎的炎性疾病。 本文提供了用于调节动物中因子VII mRNA和/或蛋白质水平的方法,化合物和组合物。 本文提供了用于调节动物中因子VII mRNA和/或蛋白质水平的方法,化合物和组合物,以便调节动物中的炎症反应。 本文还提供了用于向动物施用治疗有效量的靶向因子VII的化合物以改善动物的炎性疾病的方法,化合物和组合物; 治疗有风险的动物患有炎性疾病。
    • 6. 发明申请
    • METHODS OF MODULATING AN IMMUNE RESPONSE TO A VIRAL INFECTION
    • 调节对病毒感染的免疫应答的方法
    • WO2010120524A3
    • 2010-12-09
    • PCT/US2010029408
    • 2010-03-31
    • ALTAIR THERAPEUTICS INCISIS PHARMACEUTICALS INCGREGORY SUSANKARRAS JAMES GCROSBY JEFFREY RYU ZHENGRONGGEARY RICHARD S
    • GREGORY SUSANKARRAS JAMES GCROSBY JEFFREY RYU ZHENGRONGGEARY RICHARD S
    • C12N15/113A61K48/00C07K14/715
    • C07K14/7155C12N15/1138C12N2310/11C12N2310/315C12N2310/321C12N2310/3341C12N2310/341C12N2310/346C12N2310/3525
    • Disclosed herein are methods for treating respiratory disorders via administration of antisense compounds targeting IL-4Ra. Provided herein, for example, are compositions and methods of modulating immune responses to a viral infection in a subject. Also provided, for example, are compositions and methods for managing, treating, ameliorating, preventing and/or delaying the onset of pulmonary inflammation, airway hyperreactivity and/or loss of lung function, or a symptom thereof in a subject during the course of or resulting from a viral infection. Further provided, for example, are compositions and methods of inducing or augmenting hypo-responsiveness, non-responsiveness or tolerance to a virus in a subject. Also provided, for example, are compositions and methods of enhancing the efficacy of a viral vaccine in a subject. In certain embodiments, the compositions and methods provided herein utilize an antisense compound 12 to 35 nucleobases in length targeted to a nucleic acid molecule encoding human IL-4 receptor alpha IL-4Ra, wherein said antisense compound inhibits expression of human IL-4Ra protein and/or expression of functional IL-4 and IL- 13 receptors.
    • 本文公开了通过施用靶向IL-4Ra的反义化合物来治疗呼吸系统疾病的方法。 例如,本文提供调节受试者中病毒感染的免疫应答的组合物和方法。 还提供了例如用于在过程中管理,治疗,改善,预防和/或延迟受试者的肺部炎症发作,气道高反应性和/或肺功能丧失或其症状的组合物和方法, 由病毒感染引起。 进一步提供的是例如诱导或增加受试者中对病毒的低反应性,非反应性或耐受性的组合物和方法。 还提供了例如增强受试者中病毒疫苗功效的组合物和方法。 在某些实施方案中,本文提供的组合物和方法利用长度为靶向编码人IL-4受体α-IL-4Ra的核酸分子的反义化合物12至35个核碱基,其中所述反义化合物抑制人IL-4Ra蛋白的表达和 /或功能性IL-4和IL-13受体的表达。