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1. 发明申请

WO2005123113A2 INTERFERON COMPOSITIONS AND METHODS OF USE THEREOF 审中-公开
标题翻译：干扰素组合物及其使用方法
公开(公告)号：WO2005123113A2
公开(公告)日：2005-12-29
申请号：PCT/US2005/021050
申请日：2005-06-14
申请人： INTERMUNE, INC. , SEIWERT, Scott D. , BLATT, Lawrence M. , TAN, Hua , DERRICK, Jena Rey , HONG, Jin , RADHAKRISHNAN, Ramachandran
发明人： SEIWERT, Scott D. , BLATT, Lawrence M. , TAN, Hua , DERRICK, Jena Rey , HONG, Jin , RADHAKRISHNAN, Ramachandran
IPC分类号： A61K38/21
CPC分类号： A61K38/212 , A61K38/21 , A61K38/217 , A61K2300/00
摘要： The present invention provides compositions, including pharmaceutical compositions, comprising IFN-α and IFN-γ. The present invention further provides methods of treating various disorders, the methods comprising administering an effective amount of a subject composition.
摘要翻译：本发明提供包含IFN-α和IFN-γ的组合物，包括药物组合物。本发明还提供了治疗各种疾病的方法，所述方法包括施用有效量的受试者组合物。

2. 发明申请

WO2007092537A2 SYNTHETIC HYPERGLYCOSYLATED, AND HYPERGLYCOSYLATED PROTEASE-RESISTANT POLYPEPTIDE VARIANTS, ORAL FORMULATIONS AND METHODS OF USING THE SAME 审中-公开
标题翻译：合成高效液相色谱法和超高效抗菌多肽变体，口服制剂及其使用方法
公开(公告)号：WO2007092537A2
公开(公告)日：2007-08-16
申请号：PCT/US2007/003333
申请日：2007-02-07
申请人： ALIOS BIOPHARMA, INC. , BLATT, Lawrence M. , SEIWERT, Scott D. , HONG, Jin
发明人： BLATT, Lawrence M. , SEIWERT, Scott D. , HONG, Jin
IPC分类号： C07K14/555 , C07K14/56 , C07K14/565 , C07K14/57 , A61K38/21
CPC分类号： C07K14/555 , A61K38/00 , C07K14/56 , C07K14/565 , C07K14/57 , Y02A50/385 , Y02A50/387 , Y02A50/393
摘要： The present invention provides synthetic Type I interferon receptor polypeptide agonists comprising consensus or hybrid Type I interferon receptor polypeptide agonists, containing one or more native or non-native glycosylation sites. The present invention provides synthetic Type I interferon receptor polypeptide agonists comprising consensus or hybrid Type I interferon receptor polypeptide agonists, containing one or more native or non-native glycosylation sites, as well as erythropoietin and darbepoetin alfa, each of which are linked to a penetrating peptide that facilitates translocation of a substance across a biological barrier as well as pharmaceutical compositions, including oral formulations, of the same. The present invention further provides oral formulations of hyperglycosylated or protease-resistant, hyperglycosylated polypeptide variants, which polypeptide variants lack at least one protease cleavage site found in a parent polypeptide, and thus exhibit increased protease resistance compared to the parent polypeptide, which polypeptide variants further include (1) a carbohydrate moiety covalently linked to at least one non-native glycosylation site not found in the parent protein therapeutic or (2) a carbohydrate moiety covalently linked to at least one native glycosylation site found but not glycosylated in the parent protein therapeutic. The present invention further provides compositions, including oral pharmaceutical compositions, comprising the synthetic Type I interferon receptor polypeptide agonist, the hyperglycosylated polypeptide variant, or the hyperglycosylated, protease-resistant polypeptide variant. The present invention further provides containers, devices, and kits comprising the synthetic Type I interferon receptor polypeptide agonist, the hyperglycosylated polypeptide variant, or the hyperglycosylated, protease-resistant polypeptide variant. The present invention further provides therapeutic methods involving administering an effective amount of an oral pharmaceutical composition comprising a synthetic Type I interferon receptor polypeptide agonist, a hyperglycosylated polypeptide variant, or a hyperglycosylated, protease-resistant polypeptide variant to an individual in need thereof.
摘要翻译：本发明提供含有一个或多个天然或非天然糖基化位点的含有共有或混合型I型干扰素受体多肽激动剂的合成的I型干扰素受体多肽激动剂。本发明提供合成的I型干扰素受体多肽激动剂，其包含含有一个或多个天然或非天然糖基化位点的共有或混合型I型干扰素受体多肽激动剂，以及红细胞生成素和达比泊汀α，其各自与渗透性促进物质穿过生物屏障移位的肽以及包含口服制剂的药物组合物。本发明进一步提供高糖基化或蛋白酶抗性，高糖基化多肽变体的口服制剂，该多肽变体在母体多肽中缺少至少一个蛋白酶切割位点，因此与亲本多肽相比表现出增加的蛋白酶抗性，该多肽变体进一步包括（1）与亲本蛋白质治疗剂中未发现的至少一个非天然糖基化位点共价连接的碳水化合物部分，或（2）与母体蛋白质治疗中发现但未糖基化的至少一个天然糖基化位点共价连接的碳水化合物部分。本发明还提供包含口服药物组合物的组合物，其包含合成的I型干扰素受体多肽激动剂，高糖基化多肽变体或高糖基化的，蛋白酶抗性多肽变体。本发明还提供了包含合成的I型干扰素受体多肽激动剂，高糖基化多肽变体或高糖基化的蛋白酶抗性多肽变体的容器，装置和试剂盒。本发明进一步提供治疗方法，其涉及向有需要的个体施用有效量的包含合成的I型干扰素受体多肽激动剂，高糖基化多肽变体或高糖基化的，蛋白酶抗性多肽变体的口服药物组合物。

3. 发明申请

WO2009059021A2 HCV GENOTYPING AND PHENOTYPING 审中-公开
标题翻译： HCV基因分型和表型
公开(公告)号：WO2009059021A2
公开(公告)日：2009-05-07
申请号：PCT/US2008/081816
申请日：2008-10-30
申请人： INTERMUNE, INC. , HONG, Jin , SEIWERT, Scott , LIM, Sharlene , QIN, Xiaoli
发明人： HONG, Jin , SEIWERT, Scott , LIM, Sharlene , QIN, Xiaoli
IPC分类号： C12Q1/70
CPC分类号： C12Q1/707
摘要： The present invention includes methods of genotyping and phenotyping HCV. In one embodiment, the methods of the invention can be used to determine whether a HCV isolate is resistant to an antiviral drug. The invention also includes primers for amplifying a HCV NS3 region and kits.
摘要翻译：本发明包括HCV的基因分型和表型分型的方法。在一个实施方案中，本发明的方法可用于确定HCV分离物是否对抗病毒药物具有抗性。本发明还包括用于扩增HCV NS3区和引物的引物。

4. 发明申请

WO2009038323A3 SOLAR CELL AND METHOD FOR MANUFACTURING THE SAME 审中-公开
公开(公告)号：WO2009038323A3
公开(公告)日：2009-03-26
申请号：PCT/KR2008/005462
申请日：2008-09-16
申请人： JUSUNG ENGINEERING CO., LTD. , HONG, Jin , KIM, Joungsik
发明人： HONG, Jin , KIM, Joungsik
IPC分类号： H01L31/042
摘要： A solar cell and a method for manufacturing the same is disclosed, wherein the solar cell comprises a first cell comprised of a semiconductor wafer with a PN structure; a second cell comprised of a thin film semiconductor layer with a PIN structure, formed on one surface of the first cell; a first electrode layer formed on one surface of the second cell; and a second electrode layer formed on the other surface of the first cell. Unlike the related art solar cell, the solar cell according to the present invention can absorb the light of long-wavelength range in the first cell, and the light of short-wavelength range in the second cell. As a result, it is possible for the solar cell according to the present invention to absorb the light of all ranges, thereby realizing the high efficiency of 20% or above. Also, the entire process time becomes shortened since there is no requirement for the procedure of forming the silicon thin film for a long period of time.

5. 发明申请

WO2009008674A2 SOLAR CELL AND METHOD OF MANUFACTURING THE SAME 审中-公开
标题翻译：太阳能电池及其制造方法
公开(公告)号：WO2009008674A2
公开(公告)日：2009-01-15
申请号：PCT/KR2008/004061
申请日：2008-07-10
申请人： JUSUNG ENGINEERING CO., LTD. , HONG, Jin , KIM, Jae Ho , YANG, Chang Sil
发明人： HONG, Jin , KIM, Jae Ho , YANG, Chang Sil
IPC分类号： H01L31/042
CPC分类号： H01L31/18 , H01L31/02167 , H01L31/022433 , H01L31/02363 , H01L31/035281 , H01L31/0468 , H01L31/075 , H01L31/202 , Y02E10/52 , Y02E10/548 , Y02P70/521
摘要： Provided are a solar cell and a method of manufacturing the same. The solar cell includes a transparent substrate. A first electrode and a transparent insulating layer are sequentially stacked over a plurality of first regions of the transparent substrate. A first electrode, a light-converting layer, a transparent insulating layer, and a second electrode are sequentially stacked over a second region of the transparent substrate other than the first regions. Therefore, light incident from the substrate can penetrate between the light-converting layers spaced apart from each other, thus manufacturing a transparent solar cell. Also, since light scattered by the transparent insulating layer is also incident into the side of the light-converting layer, the light-receiving area is not reduced and thus the efficiency of the solar cell can be increased.
摘要翻译：提供一种太阳能电池及其制造方法。太阳能电池包括透明基板。第一电极和透明绝缘层依次层叠在透明基板的多个第一区域上。第一电极，光转换层，透明绝缘层和第二电极依次层叠在除了第一区域之外的透明基板的第二区域上。因此，从基板入射的光可以穿透彼此间隔开的光转换层，从而制造透明的太阳能电池。此外，由于透明绝缘层散射的光也入射到光转换层的侧面，因此不会降低光接收面积，能够提高太阳能电池的效率。

6. 发明申请

WO2011075605A2 HYPERGLYCOSYLATED INTERFERON VARIANTS AND METHODS OF USE 审中-公开
标题翻译：高效液相色谱法及其使用方法
公开(公告)号：WO2011075605A2
公开(公告)日：2011-06-23
申请号：PCT/US2010/060884
申请日：2010-12-16
申请人： ALIOS BIOPHARMA, INC. , HONG, Jin , BLATT, Lawrence
发明人： HONG, Jin , BLATT, Lawrence
IPC分类号： C07K14/555 , C07K14/56 , A61K38/21
CPC分类号： C07K14/555 , A61K38/00
摘要： Disclosed herein are hyperglycosylated interferon variants, pharmaceutical compositions comprising the hyperglycosylated interferon variants described herein, and method of ameliorating and/or treating diseases and/or conditions with the hyperglycosylated interferon variants described herein.
摘要翻译：本文公开了高糖基化干扰素变体，包含本文所述的高糖蛋白化干扰素变体的药物组合物，以及本文所述的高糖基化干扰素变体改善和/或治疗疾病和/或病症的方法。

7. 发明申请

WO2008147116A3 SOLAR CELL AND METHOD OF FABRICATING THE SAME 审中-公开
公开(公告)号：WO2008147116A3
公开(公告)日：2008-12-04
申请号：PCT/KR2008/003010
申请日：2008-05-29
申请人： JUSUNG ENGINEERING CO., LTD , HONG, Jin , KIM, Jae Ho , SHIN, Yong Woo
发明人： HONG, Jin , KIM, Jae Ho , SHIN, Yong Woo
IPC分类号： H01L31/04 , H01L31/042
摘要： A solar cell includes a first electrode on a substrate; a plurality of pillars on the first electrode; a semiconductor layer on the first electrode, wherein a surface area of the semiconductor layer is greater than a surface area of the first electrode; and a second electrode over the semiconductor layer.

8. 发明申请

WO2006020580A2 SYNTHETIC HYPERGLYCOSYLATED, PROTEASE-RESISTANT POLYPEPTIDE VARIANTS, ORAL FORMULATIONS AND METHODS OF USING THE SAME 审中-公开
标题翻译：合成的低聚肽，抗蛋白酶的多肽变体，口服制剂和使用它们的方法
公开(公告)号：WO2006020580A2
公开(公告)日：2006-02-23
申请号：PCT/US2005/028165
申请日：2005-08-08
申请人： INTERMUNE, INC.
发明人： HONG, Jin , SEIWERT, Scott D. , BLATT, Lawrence M.
IPC分类号： A61K38/14 , A61K38/17
CPC分类号： A61K38/212
摘要： The present invention provides synthetic Type I interferon receptor polypeptide agonists comprising consensus or hybrid Type I interferon receptor polypeptide agonists, containing one or more native or non-native glycosylation sites. The present invention further provides oral formulations of protease-resistant or protease-resistant, hyperglycosylated polypeptide variants, which polypeptide variants lack at least one protease cleavage site found in a parent polypeptide, and thus exhibit increased protease resistance compared to the parent polypeptide, which polypeptide variants further include (1) a carbohydrate moiety covalently linked to at least one non-native glycosylation site not found in the parent protein therapeutic or (2) a carbohydrate moiety covalently linked to at least one native glycosylation site found but not glycosylated in the parent protein therapeutic. The present invention further provides compositions, including oral pharmaceutical compositions, comprising the synthetic Type I interferon receptor polypeptide agonist, the hyperglycosylated polypeptide variant, the protease-resistant polypeptide variant, or the hyperglycosylated, protease-resistant polypeptide variant. The present invention further provides containers, devices, and kits comprising the synthetic Type I interferon receptor polypeptide agonist, the hyperglycosylated polypeptide variant, the protease-resistant polypeptide variant, or the hyperglycosylated, protease-resistant polypeptide variant. The present invention further provides therapeutic methods involving administering an effective amount of an oral pharmaceutical composition comprising a synthetic Type I interferon receptor polypeptide agonist, a hyperglycosylated polypeptide variant, a protease-resistant polypeptide variant, or a hyperglycosylated, protease-resistant polypeptide variant to an individual in need thereof.
摘要翻译：本发明提供了包含共有或杂合I型干扰素受体多肽激动剂的合成I型干扰素受体多肽激动剂，其含有一个或多个天然或非天然糖基化位点。本发明进一步提供了蛋白酶抗性或蛋白酶抗性的高糖基化多肽变体的口服制剂，所述多肽变体缺少在亲本多肽中发现的至少一个蛋白酶切割位点，并因此表现出与亲本多肽相比增加的蛋白酶抗性，所述多肽变体还包括（1）共价连接至亲本蛋白质治疗剂中未发现的至少一个非天然糖基化位点的碳水化合物部分，或（2）共价连接至在亲本蛋白质中发现但未糖基化的至少一个天然糖基化位点的碳水化合物部分蛋白质治疗。本发明进一步提供包含合成的I型干扰素受体多肽激动剂，高糖基化的多肽变体，蛋白酶抗性多肽变体或高糖基化的蛋白酶抗性多肽变体的组合物，包括口服药物组合物。本发明进一步提供了包含合成的I型干扰素受体多肽激动剂，高糖基化的多肽变体，蛋白酶抗性多肽变体或高糖基化的蛋白酶抗性多肽变体的容器，装置和试剂盒。本发明进一步提供了治疗方法，其包括将有效量的包含合成的I型干扰素受体多肽激动剂，高糖基化的多肽变体，蛋白酶抗性多肽变体或高糖基化的蛋白酶抗性多肽变体的口服药物组合物施用于有需要的个人。

9. 发明申请

WO2011075606A2 HYPERGLYCOSYLATED POLYPEPTIDE VARIANTS AND METHODS OF USE 审中-公开
标题翻译：超高效多肽变体及其使用方法
公开(公告)号：WO2011075606A2
公开(公告)日：2011-06-23
申请号：PCT/US2010/060891
申请日：2010-12-16
申请人： ALIOS BIOPHARMA, INC. , HONG, Jin , BLATT, Lawrence
发明人： HONG, Jin , BLATT, Lawrence
IPC分类号： C07K14/435 , C07K16/18 , A61K38/17 , A61K39/395 , C12N15/85
CPC分类号： C07K14/61 , A61K38/00 , C07K14/505 , C07K14/535 , C07K14/62 , C07K14/65 , C07K2319/31 , C07K2319/91
摘要： Disclosed herein are hyperglycosylated polypeptide variants, pharmaceutical compositions comprising the hyperglycosylated polypeptide variants described herein, and method of ameliorating and/or treating diseases and/or conditions with the hyperglycosylated polypeptide variants described herein.
摘要翻译：本文公开的是高糖基化多肽变体，包含本文所述的高糖基化多肽变体的药物组合物，以及本文所述的高糖基化多肽变体改善和/或治疗疾病和/或病症的方法。

10. 发明申请

WO2009082137A2 THIN FILM TYPE SOLAR CELL AND METHOD FOR MANUFACTURING THE SAME 审中-公开
标题翻译：薄膜型太阳能电池及其制造方法
公开(公告)号：WO2009082137A2
公开(公告)日：2009-07-02
申请号：PCT/KR2008/007554
申请日：2008-12-19
申请人： JUSUNG ENGINEERING Co., Ltd. , HONG, Jin , YANG, Chang Sil , KWON, Gi Chung
发明人： HONG, Jin , YANG, Chang Sil , KWON, Gi Chung
IPC分类号： H01L31/042
CPC分类号： H01L31/0236 , H01L31/02366 , H01L31/046 , Y02E10/50
摘要： A thin film type solar cell and a method for manufacturing the same is disclosed, which is capable of improving solar-ray transmittance and dispersion efficiency by the increased effective area for absorbing the solar ray through the use of substrate with a predetermined pattern having protrusions and depressions, wherein the method comprises preparing a substrate with a predetermined pattern having protrusions and depressions on its one surface; forming a front electrode on the substrate; forming a semiconductor layer on the front electrode; and forming a rear electrode on the semiconductor layer.
摘要翻译：公开了一种薄膜型太阳能电池及其制造方法，其能够通过使用具有突起的预定图案的基板的使用来增加用于吸收太阳光线的有效面积来提高太阳光线透射率和分散效率，凹陷，其中所述方法包括在其一个表面上制备具有突起和凹陷的预定图案的基底; 在所述基板上形成前电极; 在前电极上形成半导体层; 以及在所述半导体层上形成后电极。

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