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1. 发明申请

WO2008034580A3 USES OF CRIPOWELLINS AND THE DERIVATIVES THEREOF FOR THE TREATMENT OF TUMOR DISEASES 审中-公开
标题翻译： CRIPOWELLINEN学报TUMÖRERKRANKUNGEN的处理使用及其衍生物
公开(公告)号：WO2008034580A3
公开(公告)日：2008-08-07
申请号：PCT/EP2007008110
申请日：2007-09-17
申请人： INTERMED DISCOVERY GMBH , GEHLING MATTHIAS , WEBER OLAF
发明人： GEHLING MATTHIAS , WEBER OLAF
IPC分类号： A61K31/55 , A61K31/7052 , A61P35/00 , A61P35/02 , A61P35/04
CPC分类号： A61K31/55 , A61K31/7052
摘要： The invention relates to the use of cripowellins and the derivatives thereof for producing medicaments utilized for treating tumor diseases.
摘要翻译：本发明涉及使用Cripowellinen的和用于制备药物的肿瘤疾病的治疗及其衍生物。

2. 发明申请

WO2006063813A3 3-ARYLALKYL-SUBSTITUTED AND 3-HETEROARYLALKYL-SUBSTITUTED-1,2,4-TRIAZIN-5(2H)-ONES 审中-公开
标题翻译： 3-芳基烷基-AND-3-杂芳基烷基取代-1,2,4-三嗪-5（2H） - 酮
公开(公告)号：WO2006063813A3
公开(公告)日：2006-09-21
申请号：PCT/EP2005013434
申请日：2005-12-14
申请人： BAYER HEALTHCARE AG , HENDRIX MARTIN , ZIMMERMANN KATJA , HIRTH-DIETRICH CLAUDIA , KARIG GUNTER , KARTHAUS DAGMAR , RAABE MARTIN , WEBER OLAF , ZAISS SIEGFRIED
发明人： HENDRIX MARTIN , ZIMMERMANN KATJA , HIRTH-DIETRICH CLAUDIA , KARIG GUNTER , KARTHAUS DAGMAR , RAABE MARTIN , WEBER OLAF , ZAISS SIEGFRIED
IPC分类号： C07D253/06 , A61K31/53 , C07D403/12 , C07D409/12
CPC分类号： C07D409/06 , C07D253/07 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/12 , C07D409/14 , C07D451/14
摘要： The invention relates to 3-arylalkyl-substituted and 3-heteroarylalkyl-substituted-1,2,4-triazin-5(2H)-ones, to a method for the production thereof, and to their use for producing medicaments for treating and/or preventing diseases, particularly chronic inflammatory diseases for example, rheumatoid diseases and cardiovascular diseases, such as dyslipidaemias, arteriosclerosis, and coronary heart diseases.
摘要翻译：本发明涉及3-芳基烷基和杂3-取代-1,2,4-三嗪-5（2H） - 酮和它们的制备方法和它们用于制备药物用于治疗和/或预防疾病的用途，特别流程慢性炎性疾病，如疾病类风湿性疾病，和心血管疾病，如血脂异常，动脉粥样硬化和冠心病心脏疾病。

3. 发明申请

WO0102350A3 NOVEL AMINO SULFONAMIDES AND AMIDO SULFONAMIDES AS ANTIVIRAL AGENTS 审中-公开
标题翻译：新氨基和氨基磺酰胺类抗病毒药物
公开(公告)号：WO0102350A3
公开(公告)日：2001-03-29
申请号：PCT/EP0005614
申请日：2000-06-19
申请人： BAYER AG , BENDER WOLFGANG , ECKENBERG PETER , GOLDMANN SIEGFRIED , HAERTER MICHAEL , HALLENBERGER SABINE , REEFSCHLAEGER JUERGEN , TRAPPE JOERG , WEBER OLAF
发明人： BENDER WOLFGANG , ECKENBERG PETER , GOLDMANN SIEGFRIED , HAERTER MICHAEL , HALLENBERGER SABINE , REEFSCHLAEGER JUERGEN , TRAPPE JOERG , WEBER OLAF
IPC分类号： C07C311/44 , C07C311/46 , C07C311/47 , C07C335/16 , C07D213/61 , C07D213/75 , C07D213/81 , C07D213/82 , C07D231/14 , C07D261/18 , C07D295/215 , C07D307/68 , C07D333/38 , C07D417/04 , A61K31/18 , A61P31/12 , C07D213/30 , C07D233/36
CPC分类号： C07D213/75 , C07C311/44 , C07C311/46 , C07C311/47 , C07C335/16 , C07D213/61 , C07D213/81 , C07D213/82 , C07D231/14 , C07D261/18 , C07D295/215 , C07D307/68 , C07D333/38 , C07D417/04
摘要： The invention relates to novel compounds of general formula (I) that are suitable as medicaments, to a method for the production thereof and to their utilization as medicaments, particularly as antiviral agents.
摘要翻译：本发明涉及适合作为药物的通式（I）的新化合物，其制备方法及其作为药物，特别是作为抗病毒剂的用途。

4. 发明申请

WO02076976A3 RHO-KINASE INHIBITORS 审中-公开
标题翻译： RHO-激酶抑制剂
公开(公告)号：WO02076976A3
公开(公告)日：2002-12-12
申请号：PCT/US0208659
申请日：2002-03-22
申请人： BAYER AG , NAGARATHNAM DHANAPALAN , ASGARI DAVOUD , SHAO JIANXING , LIU XIAO-GAO , KHIRE UDAY , WANG CHUNGUANG , HART BARRY , BOYER STEPHEN , WEBER OLAF , LYNCH MARK , BANKSTON DONALD
发明人： NAGARATHNAM DHANAPALAN , ASGARI DAVOUD , SHAO JIANXING , LIU XIAO-GAO , KHIRE UDAY , WANG CHUNGUANG , HART BARRY , BOYER STEPHEN , WEBER OLAF , LYNCH MARK , BANKSTON DONALD
IPC分类号： A61K31/517 , A61K31/5377 , A61P1/00 , A61P7/04 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/08 , A61P15/00 , A61P15/10 , A61P19/10 , A61P25/00 , A61P27/06 , A61P35/00 , A61P43/00 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
CPC分类号： C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
摘要翻译：公开了化合物及其衍生物，它们的合成及其作为Rho激酶抑制剂的用途。本发明的这些化合物可用于抑制肿瘤生长，治疗勃起功能障碍以及治疗Rho激酶（例如冠心病）介导的其它适应症。

5. 发明申请

WO0204019A3 USE OF STRAINS OF THE PARAPOX OVIS VIRUS AGAINST ORGAN FIBROSIS 审中-公开
标题翻译：使用羊副痘病毒侵害器官纤维化株
公开(公告)号：WO0204019A3
公开(公告)日：2002-08-01
申请号：PCT/EP0107978
申请日：2001-07-11
申请人： BAYER AG , HIRTH-DIETRICH CLAUDIA , SCHLAPP TOBIAS , SIEGLING ANGELA , KNORR ANDREAS , WEBER OLAF , THEISS GUDRUN
发明人： HIRTH-DIETRICH CLAUDIA , SCHLAPP TOBIAS , SIEGLING ANGELA , KNORR ANDREAS , WEBER OLAF , THEISS GUDRUN
IPC分类号： C12N7/00 , A61K35/76 , A61K39/275 , A61K48/00 , A61P1/16 , A61P19/04 , A61P25/32 , A61P31/12 , A61P37/04 , A61P43/00 , C12N7/08
CPC分类号： A61K35/76 , A61K2039/5252 , C12N2710/24232
摘要： The invention relates to the human use of inactivated parapox viruses for the prophylaxis and the treatment of illnesses associated with increased collagen deposition, said illnesses affecting inner organs, e.g. the liver, and also skin and the appendages thereof. Liver fibrosis or liver cirrhosis resulting from viral hepatitis or ethanol-induced liver diseases such as cystic fibrosis are especially relevant.
摘要翻译：本发明涉及的具有增加胶原沉积，其中两个内部器官，如相关的疾病的预防和治疗人类使用灭活parapoxviruses的肝脏，皮肤及其附件可能会受到影响。特别受影响的肝纤维化或肝硬化在病毒性肝炎或乙醇诱导的肝脏疾病和囊性纤维化的唤醒。

6. 发明申请

WO0076966A3 INDOLINYLAMIDE DERIVATIVES AND THE USE THEREOF AS ANTIVIRAL DRUGS 审中-公开
标题翻译： INDOLINYLAMIDDERIVATE及其作为抗病毒药物
公开(公告)号：WO0076966A3
公开(公告)日：2001-07-19
申请号：PCT/EP0005114
申请日：2000-06-05
申请人： BAYER AG , HANDKE GABRIELE , BAUMEISTER JUDITH , BENDER WOLFGANG , BETZ ULRICH , BRANDS MICHAEL , ECKENBERG PETER , FISCHER RUEDIGER , HENDRIX MARTIN , HENNINGER KERSTIN , JENSEN AXEL , KELDENICH JOERG , KLEYMANN GERALD , MAESSEN JUTTA , SCHNEIDER UDO , WEBER OLAF
发明人： HANDKE GABRIELE , BAUMEISTER JUDITH , BENDER WOLFGANG , BETZ ULRICH , BRANDS MICHAEL , ECKENBERG PETER , FISCHER RUEDIGER , HENDRIX MARTIN , HENNINGER KERSTIN , JENSEN AXEL , KELDENICH JOERG , KLEYMANN GERALD , MAESSEN JUTTA , SCHNEIDER UDO , WEBER OLAF
IPC分类号： C07D209/08 , C07D401/12 , C07D403/12 , C07D405/12 , A61K31/404 , A61P31/12
CPC分类号： C07D401/12 , C07D209/08 , C07D403/12 , C07D405/12
摘要： The invention relates to compounds of general formula (I), to a method for the production thereof and to the use of said compounds as medicaments, particularly as antiviral drugs.
摘要翻译：本发明betrifftneue通式（I）化合物，它们的制备方法以及它们作为药物的用途，尤其是作为抗病毒药物的方法。

7. 发明申请

WO2007089565A8 MIXING UNIT FOR LOW PRESSURE-EGR CONDENSATE INTO THE COMPRESSOR 审中-公开
标题翻译：低压EGR混合机混合到压缩机中
公开(公告)号：WO2007089565A8
公开(公告)日：2009-02-19
申请号：PCT/US2007002140
申请日：2007-01-26
申请人： BORGWARNER INC , JOERGL VOLKER , KIENER TIMM , WEBER OLAF
发明人： JOERGL VOLKER , KIENER TIMM , WEBER OLAF
IPC分类号： F02M25/07
CPC分类号： F02M26/35 , F02M26/06 , F02M26/15 , F02M26/19
摘要： The present invention is a an exhaust gas return system (10) for reintroducing condensate generated in exhaust gas from an engine (14) into a compressor (36) of a turbocharger (18), having a turbocharger unit (18) having a turbine (20) and a compressor (36), and a compressor wheel (42) located inside the compressor (36). The present invention also includes a mixing pipe (52) located inside an intake tube (44) for receiving exhaust gas with droplets (54) from an EGR-tube (46), wherein the EGR-tube (46) delivers the exhaust gas with droplets (54) to the mixing pipe (52), mixing the air (41) and the exhaust gas with droplets (54) forming a mixture (64) containing droplets (50), and introducing the mixture (64) and the droplets (50) onto the compressor wheel (42) in an area of low circumferential speed, preventing damage to the compressor wheel (42).
摘要翻译：本发明是一种用于将从发动机（14）排出的废气中产生的冷凝物重新引入涡轮增压器（18）的压缩机（36）的废气返回系统（10），该涡轮增压器具有涡轮增压器单元（18） 20）和压缩机（36）以及位于压缩机（36）内的压缩机叶轮（42）。本发明还包括位于进气管（44）内部的用于从EGR管（46）接收具有液滴（54）的废气的混合管（52），其中EGR管（46）将排气与将液滴（54）分配到混合管（52），将空气（41）和废气与形成含有液滴（50）的混合物（64）的液滴（54）混合，并引入混合物（64）和液滴 50）在低圆周速度的区域内压缩在压缩机叶轮（42）上，防止对压缩机叶轮（42）的损坏。

8. 发明申请

WO2007111926A3 INTEGRATED CHARGE AIR AND EGR VALVE 审中-公开
标题翻译：集成充气空气和EGR阀
公开(公告)号：WO2007111926A3
公开(公告)日：2007-12-06
申请号：PCT/US2007007092
申请日：2007-03-22
申请人： BORGWARNER INC , JOERGL VOLKER , KIENER TIMM , WEBER OLAF , CZARNOWSKI ROBERT S
发明人： JOERGL VOLKER , KIENER TIMM , WEBER OLAF , CZARNOWSKI ROBERT S
IPC分类号： F02M25/07
CPC分类号： F02B29/0418 , F02D2009/0276 , F02M26/05 , F02M26/06 , F02M26/07 , F02M26/15 , F02M26/16 , F02M26/24 , F02M26/26 , F02M26/64 , Y02T10/146
摘要： An engine assembly (10) comprising an engine, a plurality of coolers, a plurality of bypasses, and at least one actuator (32). The engine has an exhaust manifold and an intake manifold. The gaseous fluid exiting the exhaust manifold is recirculated to the intake manifold. The exhaust gas passes through either an air cooler or a bypass. At least one actuator is operably connected to the plurality of bypasses. The bypasses have a valve (28, 30) which is actuated to control the flow of the gaseous fluid through the bypass as both the bypass and the cooler. Therefore, when a single actuator is used to control the valves in both bypasses, the valves in the bypasses have the same relationship with the inlets so that a single actuator movement will control both valves in the same manner.
摘要翻译：包括发动机，多个冷却器，多个旁路以及至少一个致动器（32）的发动机组件（10）。发动机具有排气歧管和进气歧管。离开排气歧管的气体流体再循环到进气歧管。废气通过空气冷却器或旁路。至少一个致动器可操作地连接到多个旁路。旁路具有阀（28,30），其被致动以控制气体流体通过旁路作为旁路和冷却器的流动。因此，当使用单个致动器来控制两个旁路中的阀时，旁路中的阀与入口具有相同的关系，使得单个致动器运动将以相同的方式控制两个阀。

9. 发明申请

WO2006122306A3 ENGINE AIR MANAGEMENT SYSTEM 审中-公开
标题翻译：发动机空气管理系统
公开(公告)号：WO2006122306A3
公开(公告)日：2007-03-01
申请号：PCT/US2006018418
申请日：2006-05-11
申请人： BORGWARNER INC , JOERGL VOLKER , KIENER TIMM , WEBER OLAF
发明人： JOERGL VOLKER , KIENER TIMM , WEBER OLAF
IPC分类号： F02M25/07 , F01N13/08
CPC分类号： F02B29/0406 , F01N3/021 , F01N2340/06 , F02B37/00 , F02M26/05 , F02M26/06 , F02M26/15 , F02M26/24 , F02M26/25 , Y02T10/146
摘要： An air management assembly (10) for use in an engine (12) with an exhaust manifold (14) that outputs an exhaust gas and an intake manifold (16), with a filter (18) in fluid communication between the exhaust manifold (14) and turbocharger (20). The air management assembly (10) provides a compressor (22), a turbine (24), at least one gaseous fluid cooler (32, 36, 44), at least one bypass (28, 28)' and a housing (30) where the compressor (22), turbine (24), at least one gaseous fluid cooler (32), (36, 44), bypass (28, 28'), or combination thereof are integrated into the housing (30). The compressor (22) is in fluid communication with the intake manifold (16). The turbine (24) is in fluid communication with the exhaust manifold (14). The turbine (24) and the compressor (22) are moveably coupled and move in conjunction with one another. The gaseous fluid coolers (32, 36, 44) are in fluid communication with the compressor (32), turbine (24), or combination thereof. The bypass (28') is in fluid communication with an output of the turbine (24) and an input of the compressor (22) for selective bypassing of the gaseous fluid cooler (44).
摘要翻译：一种用于具有排气歧管（14）的发动机（12）的空气管理组件（10），所述排气歧管输出废气和进气歧管（16），其中过滤器（18）在排气歧管（14）之间流体连通）和涡轮增压器（20）。空气管理组件（10）提供压缩机（22），涡轮机（24），至少一个气态流体冷却器（32,36,44），至少一个旁路（28,28）和壳体（30）其中压缩机（22），涡轮机（24），至少一个气态流体冷却器（32），（36,44），旁路（28,28'）或其组合被集成到壳体（30）中。压缩机22与进气歧管16流体连通。涡轮（24）与排气歧管（14）流体连通。涡轮（24）和压缩机（22）可移动地联接并且彼此结合地移动。气态流体冷却器（32,36,44）与压缩机（32），涡轮机（24）或其组合流体连通。旁路（28'）与涡轮机（24）的输出端和压缩机（22）的输入端流体连通，用于选择性旁路气体流体冷却器（44）。

10. 发明申请

WO9947696A2 ASSAYS FOR DETECTING SUBSTANCES WITH AN ANTI-HIV ACTION 审中-公开
标题翻译：测定法搜索具有抗HIV活性剂
公开(公告)号：WO9947696A2
公开(公告)日：1999-09-23
申请号：PCT/EP9901512
申请日：1999-03-09
申请人： BAYER AG , WEBER OLAF , HUG HUBERT
发明人： WEBER OLAF , HUG HUBERT
IPC分类号： C12Q1/00 , C12Q1/68 , C12Q1/70 , G01N33/15 , G01N33/50 , G01N33/569
CPC分类号： G01N33/5008 , C12Q1/6897 , C12Q1/70 , G01N2510/00
摘要： The invention relates to new assays for detecting substances influencing apoptosis for a new treatment of the disease caused by the human immunodeficiency virus (HIV). The invention is based on the discovery in the human immunodeficiency virus (HIV) of a new region homologous to the "death effector domain" (DED) and on a new antiviral strategy, based on said discovery, for eliminating HIV-infected cells from the body and preventing the acquired immune deficiency syndrome (AIDS).
摘要翻译：本发明涉及用于检测细胞凋亡影响的物质用于由人免疫缺陷病毒的新疗法新颖测定（HIV）引起的疾病。本发明是一种新的“死亡效应域”（DED）的发现同系物的人类免疫缺陷病毒（HIV）的区域，并基于对消除身体和预防获得性免疫缺陷综合征的HIV感染细胞中，这种新的抗病毒策略（AIDS）根据。

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