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1. 发明申请

WO2010092176A3 NONTYPABLE HAEMOPHILUS INFLUENZAE ANTIGENS 审中-公开
标题翻译：不可替代的海马流感病毒抗体
公开(公告)号：WO2010092176A3
公开(公告)日：2011-02-17
申请号：PCT/EP2010051871
申请日：2010-02-15
申请人： INTERCELL AG , VON GABAIN ALEXANDER , NAGY ESZTER , MEINKE ANDREAS , SELAK SANJA , HANNER MARKUS , SMIDT MARGARITA , WEISSGRAM MICHAELA , NOIGES BIRGIT , SEIDEL STEFAN , BACHER JULIA , SATKE CHRISTINA , SCHUELER WOLFGANG , OLEKSIEWICZ MARTIN
发明人： VON GABAIN ALEXANDER , NAGY ESZTER , MEINKE ANDREAS , SELAK SANJA , HANNER MARKUS , SMIDT MARGARITA , WEISSGRAM MICHAELA , NOIGES BIRGIT , SEIDEL STEFAN , BACHER JULIA , SATKE CHRISTINA , SCHUELER WOLFGANG , OLEKSIEWICZ MARTIN
IPC分类号： A61K39/12 , C07K14/285 , C07K16/12 , C12R1/21
CPC分类号： C07K14/285 , A61K39/00 , A61K2039/53
摘要： The present invention relates to isolated nucleic acid molecules which encode an antigen from a nontypable Haemophilus influenzae (H. influenzae) species, a vector which comprises such nucleic acid molecule, and a host cell comprising such vector. Furthermore, the invention provides antigens from a nontypable Haemophilus influenzae species, as well as fragments and variants thereof, a process for producing such antigens, and a process for producing a cell, which expresses such antigen. More specifically such antigens are produced by or associated with bacterial infections caused by nontypable Haemophilus influenzae. Moreover, the present invention provides antibodies binding to such antigen, a hybridoma cell producing such antibodies, methods for producing such antibodies, a pharmaceutical composition comprising such nucleic acid molecule, antigen, vector or antibody, the use of such nucleic acid molecule, antigen, vector or antibody for the preparation of a pharmaceutical composition, methods for identifying an antagonist capable of binding such antigen or of reducing or inhibiting the interaction activity of such antigen, methods for diagnosing an infection with nontypable Haemophilus influenzae and methods for the treatment or prevention of an infection with nontypable Haemophilus influenzae.
摘要翻译：本发明涉及编码来自不可流行的流感嗜血杆菌（流感嗜血杆菌）物种的抗原的分离的核酸分子，包含该核酸分子的载体和包含该载体的宿主细胞。此外，本发明提供了来自不可渗透的流感嗜血杆菌物种的抗原，以及其片段和变体，产生这种抗原的方法，以及表达这种抗原的细胞的制备方法。更具体地说，这种抗原由不流行的流感嗜血杆菌引起的细菌感染产生或与其相关。此外，本发明提供了与这种抗原结合的抗体，产生这种抗体的杂交瘤细胞，产生这种抗体的方法，包含这种核酸分子，抗原，载体或抗体的药物组合物，使用这种核酸分子，抗原，用于制备药物组合物的载体或抗体，用于鉴定能够结合此类抗原的拮抗剂或降低或抑制该抗原的相互作用活性的方法，用于诊断不可流行的流感嗜血杆菌的感染的方法和用于治疗或预防感染非典型流感嗜血杆菌。

2. 发明申请

WO2010136562A3 MORAXELLA CATARRHALIS ANTIGENS 审中-公开
标题翻译： MORAXELLA CATARRHALIS抗原
公开(公告)号：WO2010136562A3
公开(公告)日：2011-11-17
申请号：PCT/EP2010057414
申请日：2010-05-28
申请人： INTERCELL AG , VON GABAIN ALEXANDER , NAGY ESZTER , MEINKE ANDREAS , SELAK SANJA , HANNER MARKUS , SMIDT MARGARITA , FLOR JULIA , NOIGES BIRGIT , SCHUELER WOLFGANG , SCHIRMER ULRIKE , SALLETMAYER VERENA , NEZHYBA MARIO , SEIDEL STEFAN , OLEKSIEWICZ MARTIN
发明人： VON GABAIN ALEXANDER , NAGY ESZTER , MEINKE ANDREAS , SELAK SANJA , HANNER MARKUS , SMIDT MARGARITA , FLOR JULIA , NOIGES BIRGIT , SCHUELER WOLFGANG , SCHIRMER ULRIKE , SALLETMAYER VERENA , NEZHYBA MARIO , SEIDEL STEFAN , OLEKSIEWICZ MARTIN
IPC分类号： A61K38/04 , C07K14/21 , C07K16/12
CPC分类号： C07K14/212 , A61K39/00
摘要： The present invention relates to isolated nucleic acid molecules which encode an antigen from a Moraxella catarrhalis (Meat) species, a vector which comprises such nucleic acid molecule, and a host cell comprising such vector. Furthermore, the invention provides antigens from a Moraxella catarrhalis species, as well as fragments and variants thereof, a process for producing such antigens, and a process for producing a cell which expresses such antigen. More specifically, such antigens are produced by or associated with bacterial infections caused by Moraxella catarrhalis. Moreover, the present invention provides antibodies binding to such antigen, a hybridoma cell producing such antibodies, methods for producing such antibodies, a pharmaceutical composition comprising such nucleic acid molecule, antigen, vector or antibody, the use of such nucleic acid molecule, antigen, vector or antibody for the preparation of a pharmaceutical composition, methods for identifying an antagonist capable of binding such antigen or of reducing or inhibiting the interaction activity of such antigen, methods for diagnosing an infection with Moraxella catarrhalis and methods for the treatment or prevention of an infection with Moraxella catarrhalis.
摘要翻译：本发明涉及编码来自卡他莫拉菌（肉）物种的抗原的分离的核酸分子，包含该核酸分子的载体和包含该载体的宿主细胞。此外，本发明提供了卡他莫拉菌属物种的抗原，以及其片段和变体，产生这种抗原的方法，以及用于产生表达这种抗原的细胞的方法。更具体地说，这些抗原是由卡他莫拉菌引起的细菌感染产生或与之相关的。此外，本发明提供了与这种抗原结合的抗体，产生此类抗体的杂交瘤细胞，产生此类抗体的方法，包含该核酸分子，抗原，载体或抗体的药物组合物，使用此类核酸分子，抗原，用于制备药物组合物的载体或抗体，用于鉴定能够结合此类抗原的拮抗剂或降低或抑制此类抗原的相互作用活性的方法，用于诊断卡他莫拉菌的感染的方法和用于治疗或预防感染卡他莫拉菌。

3. 发明申请

WO2008135446A3 KLEBSIELLA ANTIGENS 审中-公开
标题翻译： KLEBSIELLA抗原
公开(公告)号：WO2008135446A3
公开(公告)日：2009-03-12
申请号：PCT/EP2008055214
申请日：2008-04-29
申请人： INTERCELL AG , BAKSHI SHARMILA , CIPPS THOMAS , HANNER MARKUS , PIKALO JUTTA , SATKE CHRISTINA , NAGY ESZTER , LUNDBERG URBAN , ZIERER DAGMAR , MEINKE ANDREAS , NOIGES BIRGIT , STIERSCHNEIDER ULRIKE , VON GABAIN ALEXANDER
发明人： BAKSHI SHARMILA , CIPPS THOMAS , HANNER MARKUS , PIKALO JUTTA , SATKE CHRISTINA , NAGY ESZTER , LUNDBERG URBAN , ZIERER DAGMAR , MEINKE ANDREAS , NOIGES BIRGIT , STIERSCHNEIDER ULRIKE , VON GABAIN ALEXANDER
IPC分类号： C07K14/26 , A61K39/395 , A61P31/04 , C07K16/12
CPC分类号： C07K14/26 , A61K39/00 , A61K39/0266 , A61K45/06 , A61K2039/505 , A61K2039/55505 , A61K2039/55566 , C07K16/1228 , C07K2317/21
摘要： The present invention relates to isolated nucleic acid molecules which encode an antigen, a vector which comprises such nucleic acid molecule, and a host cell comprising such vector. Furthermore, the invention provides antigens from a Klebsiella species, as well as fragments and variants thereof, a process for producing such antigens, and a process for producing a cell, which expresses such antigen. Moreover, the present invention provides antibodies binding to such antigen, a hybridoma cell producing such antibodies, methods for producing such antibodies, a pharmaceutical composition comprising such nucleic acid molecule, antigen, vector or antibody, the use of such nucleic acid molecule, antigen, vector or antibody for the preparation of a pharmaceutical composition, methods for identifying an antagonist capable of binding such antigen or of reducing or inhibiting the interaction activity of such antigen, methods for diagnosing an infection and methods for the treatment or prevention of an infection. More specifically such antigens are produced by or associated with bacterial pathogens causing nosocomial infections or bacterial infections caused by Klebsiella pneumoniae.
摘要翻译：本发明涉及编码抗原的分离的核酸分子，包含该核酸分子的载体和包含该载体的宿主细胞。此外，本发明提供了来自克雷伯氏菌属物种的抗原，以及其片段和变体，产生这种抗原的方法，以及表达这种抗原的细胞的制备方法。此外，本发明提供了与这种抗原结合的抗体，产生此类抗体的杂交瘤细胞，产生此类抗体的方法，包含该核酸分子，抗原，载体或抗体的药物组合物，使用此类核酸分子，抗原，用于制备药物组合物的载体或抗体，用于鉴定能够结合此类抗原的拮抗剂或降低或抑制该抗原的相互作用活性的方法，用于诊断感染的方法以及用于治疗或预防感染的方法。更具体地，这样的抗原由导致院内感染或由肺炎克雷伯杆菌引起的细菌感染的细菌病原体产生或与之相关。

4. 发明申请

WO2007042326A2 NEISSERIA MENINGITIDIS ANTIGENS 审中-公开
公开(公告)号：WO2007042326A2
公开(公告)日：2007-04-19
申请号：PCT/EP2006009934
申请日：2006-10-13
申请人： INTERCELL AG , NAGY ESZTER , MEINKE ANDREAS , VON GABAIN ALEXANDER , HANNER MARKUS , NOIGES BIRGIT , GELBMANN DIETER , SENN BEATRICE , LINGNAU KAREN
发明人： NAGY ESZTER , MEINKE ANDREAS , VON GABAIN ALEXANDER , HANNER MARKUS , NOIGES BIRGIT , GELBMANN DIETER , SENN BEATRICE , LINGNAU KAREN
IPC分类号： C07K14/22 , A61K39/095 , C07K19/00 , C12N15/11 , C12N15/62
CPC分类号： C07K14/22 , A61K39/00
摘要： The present invention relates to a peptide consisting of antigen of N. meningitidis of any of the SEQ ID NOS: 1 to 184 or a functional active fragment or derivative thereof, optionally further consisting of additional amino acid residue(s); a nucleic acid coding for the same; a pharmaceutical composition, especially a vaccine, containing a polypeptide comprising or consisting of said peptide or said nucleic acid; a nucleic acid coding for said polypeptide or a nucleic acid complementary to the same; an antibody or functional active fragment thereof; a hybridoma cell line which produces said antibody; a method for producing said antibody; a pharmaceutical composition comprising said antibody; the use of said peptide or said nucleic acid for the manufacture of a medicament for the immunization of a subject; the use of said antibody or functional fragment thereof for the manufacture of a medicament for the treatment of an infection; a method of diagnosing a N. meningitidis infection; a method for identifying a ligand capable of binding to said peptide; and the use said peptide for the isolation and/or purification and/or identification of an interaction partner of the peptide.
摘要翻译：本发明涉及由SEQ ID NOS：1至184中任一项的脑膜炎奈瑟氏球菌的抗原或其功能活性片段或衍生物组成的肽，所述肽任选进一步由另外的氨基酸残基组成; 编码它的核酸; 含有包含所述肽或所述核酸或由所述肽或所述核酸组成的多肽的药物组合物，特别是疫苗; 编码所述多肽的核酸或与其互补的核酸; 抗体或其功能活性片段; 产生所述抗体的杂交瘤细胞系; 生产所述抗体的方法; 包含所述抗体的药物组合物; 所述肽或所述核酸用于制造用于免疫受试者的药物的用途; 所述抗体或其功能片段在制备用于治疗感染的药物中的用途; 诊断脑膜炎奈瑟氏球菌感染的方法; 鉴定能够结合所述肽的配体的方法; 并且使用所述肽用于肽的相互作用配偶体的分离和/或纯化和/或鉴定。

5. 发明申请

WO2010089340A3 PEPTIDES PROTECTIVE AGAINST E. FAECALIS, METHODS AND USES RELATING THERETO 审中-公开
标题翻译：肽对E.Facalis有保护作用，方法和与其相关的用途
公开(公告)号：WO2010089340A3
公开(公告)日：2010-12-09
申请号：PCT/EP2010051341
申请日：2010-02-04
申请人： INTERCELL AG , NAGY ESZTER , SENN BEATRICE , HANNER MARKUS , BERGER MANFRED , MEINKE ANDREAS , VON GABAIN ALEXANDER , MURRAY BARBARA , SINGH KAVINDRA V
发明人： NAGY ESZTER , SENN BEATRICE , HANNER MARKUS , BERGER MANFRED , MEINKE ANDREAS , VON GABAIN ALEXANDER , MURRAY BARBARA , SINGH KAVINDRA V
IPC分类号： C07K14/315 , C07K16/12 , G01N33/569
CPC分类号： C07K14/335 , A61K39/012 , A61K2039/55566 , C07K16/1267 , G01N33/56916
摘要： The present invention relates to a protective peptide of Enterococcus faecalis (E. faecalis) or a functional active variant thereof, optionally further consisting of additional amino acid residue(s); a nucleic acid coding for the same; a pharmaceutical composition comprising said peptide or said nucleic acid; an antibody or functional active fragment thereof specifically binding to the antigen; a hybridoma cell line which produces said antibody; a method for producing said antibody; a pharmaceutical composition comprising said antibody; the use of said peptide or said nucleic acid for the manufacture of a medicament for the immunization or treatment of a subject; the use of said antibody or functional fragment thereof for the manufacture of a medicament for the treatment of an infection; a method of diagnosing an E. faecalis infection; and the use of said peptide for the isolation and/or purification and/or identification of an interaction partner of the peptide.
摘要翻译：本发明涉及粪肠球菌（粪肠球菌）的保护性肽或其功能活性变体，任选进一步由额外的氨基酸残基组成; 编码它的核酸; 包含所述肽或所述核酸的药物组合物; 特异性结合抗原的抗体或其功能活性片段; 产生所述抗体的杂交瘤细胞系; 生产所述抗体的方法; 包含所述抗体的药物组合物; 所述肽或所述核酸用于制造用于免疫或治疗受试者的药物的用途; 所述抗体或其功能片段在制备用于治疗感染的药物中的用途; 诊断粪肠球菌感染的方法; 以及所述肽用于肽的相互作用配偶体的分离和/或纯化和/或鉴定的用途。

6. 发明申请

WO2009115508A3 PEPTIDES PROTECTIVE AGAINST S. PNEUMONIAE AND COMPOSITIONS, METHODS AND USES RELATING THERETO 审中-公开
标题翻译：抗菌肽抗菌素及其组合物，方法和用途
公开(公告)号：WO2009115508A3
公开(公告)日：2009-11-12
申请号：PCT/EP2009053119
申请日：2009-03-17
申请人： INTERCELL AG , MEINKE ANDREAS , TEUBENBACHER ASTRID , SENN BEATRICE , ZERBS MANUEL , HANNER MARKUS , PIKALO JUTTA , NAGY ESZTER , GIEFING CARMEN , VON GABAIN ALEXANDER
发明人： MEINKE ANDREAS , TEUBENBACHER ASTRID , SENN BEATRICE , ZERBS MANUEL , HANNER MARKUS , PIKALO JUTTA , NAGY ESZTER , GIEFING CARMEN , VON GABAIN ALEXANDER
IPC分类号： C07K14/315 , A61K39/09 , C07K16/12 , G01N33/68
CPC分类号： A61K39/092 , C07K14/3156 , G01N33/56944 , G01N2333/3156 , G01N2469/20
摘要： The present invention relates to a protective peptide of Streptococcus pneumoniae (S. pneumoniae) or a functionally active variant of the protective peptide; a composition comprising at least two protective peptides or functionally active variants thereof; a composition comprising at least two proteins selected from the group consisting of i) a first type of protective peptide or functionally active variant thereof, ii) a second type of protective peptide or functionally active variant thereof and iii) a supportive peptide or a functionally active variant thereof; one or more nucleic acid(s) encoding the protective peptide or functionally active variant thereof or the at least two proteins comprised in the composition; a pharmaceutical composition comprising the protective peptide or functionally active variant thereof, the composition, or the nucleic acid(s); a method of producing an antibody using the protective peptide or functionally active variant thereof or the composition; the use of the protective peptide or functionally active variant thereof and/or the composition and/or the nucleic acid(s) for the manufacture of a medicament for the immunization or treatment of a subject; a method of diagnosing a S. pneumoniae infection using the protective peptide or a functionally active variant thereof, the composition or a primer and/or probe specific for the nucleic acid(s); a method for identifying a ligand capable of binding to a protective peptide or functionally active variant thereof; and the use of a protective peptide or functionally active variant thereof for the isolation and/or purification and/or identification of an interaction partner of the peptide.
摘要翻译：本发明涉及肺炎链球菌（Streptococcus pneumoniae）（肺炎链球菌）的保护肽或保护性肽的功能活性变体; 包含至少两种保护性肽或其功能活性变体的组合物; 包含至少两种选自i）第一类保护性肽或其功能活性变体的蛋白质的组合物，ii）第二类型的保护性肽或其功能活性变体，和iii）支持肽或功能活性其变体; 一种或多种编码保护性肽或其功能活性变体的核酸或组合物中包含的至少两种蛋白质; 包含保护性肽或其功能活性变体，组合物或核酸的药物组合物; 使用保护性肽或其功能活性变体或组合物制备抗体的方法; 保护性肽或其功能活性变体和/或组合物和/或核酸在制备用于免疫或治疗受试者的药物中的用途; 使用保护性肽或其功能活性变体来诊断肺炎链球菌感染的方法，所述组合物或对所述核酸特异性的引物和/或探针; 用于鉴定能够结合保护性肽或其功能活性变体的配体的方法; 以及使用保护性肽或其功能活性变体来分离和/或纯化和/或鉴定肽的相互作用配偶体。

7. 发明申请

WO2004099242A3 STREPTOCOCCUS AGALACTIAE ANTIGENS I + II 审中-公开
公开(公告)号：WO2004099242A3
公开(公告)日：2005-06-16
申请号：PCT/EP2004004856
申请日：2004-05-06
申请人： INTERCELL AG , MEINKE ANDREAS , NAGY ESZTER , HANNER MARKUS , HORKY MARKUS , KALLENDA SABINE , PRUSTOMERSKY SONJA
发明人： MEINKE ANDREAS , NAGY ESZTER , HANNER MARKUS , HORKY MARKUS , KALLENDA SABINE , PRUSTOMERSKY SONJA
IPC分类号： C07K14/315 , A61K39/09 , C07K16/12 , C12N15/11 , C12N15/31 , C12Q1/68 , G01N33/50
CPC分类号： C07K16/1275 , C07K14/315 , C07K2317/00
摘要： The present invention discloses isolated nucleic acid molecules encoding a hyperimmune serum reactive antigen or a fragment thereof as well as hyperimmune serum reactive antigens or fragments thereof from S. agalactiae, methods for isolating such antigens and specific uses thereof.
摘要翻译：本发明公开了编码超免疫血清反应性抗原或其片段的分离的核酸分子，以及来自无乳链球菌的超免疫血清反应性抗原或其片段，分离该抗原的方法及其具体用途。

8. 发明申请

WO2004092209A3 S. PNEUMONIAE ANTIGENS 审中-公开
标题翻译： S.PONUMONIAE抗原
公开(公告)号：WO2004092209A3
公开(公告)日：2004-12-09
申请号：PCT/EP2004003984
申请日：2004-04-15
申请人： INTERCELL AG , MEINKE ANDREAS , NAGY ESZTER , HANNER MARKUS , DEWASTHALY SHAILESH , STIERSCHNEIDER ULRIKE
发明人： MEINKE ANDREAS , NAGY ESZTER , HANNER MARKUS , DEWASTHALY SHAILESH , STIERSCHNEIDER ULRIKE
IPC分类号： A61K39/00 , A61P31/04 , C07K14/315 , A61K39/09 , C07K16/12 , C07K16/46 , C07K19/00 , C12N5/12 , C12N15/02 , C12Q1/68 , G01N33/569
CPC分类号： C07K14/3156 , A61K39/00 , A61K39/092 , C12Q1/689 , C12Q2600/158
摘要： The present invention discloses isolated nucleic acid molecules encoding a hyperimmune serum reactive antigen or a fragment thereof as well as hyperimmune serum reactive antigens or fragments thereof from S. pneumoniae, methods for isolating such antigens and specific uses thereof.
摘要翻译：本发明公开了编码超免疫血清反应性抗原或其片段的分离的核酸分子以及来自肺炎链球菌的超免疫血清反应性抗原或其片段，分离此类抗原的方法及其特定用途。

9. 发明申请

WO2004092209A9 S. PNEUMONIAE ANTIGENS 审中-公开
公开(公告)号：WO2004092209A9
公开(公告)日：2008-11-27
申请号：PCT/EP2004003984
申请日：2004-04-15
申请人： INTERCELL AG , MEINKE ANDREAS , NAGY ESZTER , HANNER MARKUS , DEWASTHALY SHAILESH , STIERSCHNEIDER ULRIKE
发明人： MEINKE ANDREAS , NAGY ESZTER , HANNER MARKUS , DEWASTHALY SHAILESH , STIERSCHNEIDER ULRIKE
IPC分类号： A61K39/00 , A61P31/04 , C07K14/315
CPC分类号： C07K14/3156 , A61K39/00 , A61K39/092 , C12Q1/689 , C12Q2600/158
摘要： The present invention discloses isolated nucleic acid molecules encoding a hyperimmune serum reactive antigen or a fragment thereof as well as hyperimmune serum reactive antigens or fragments thereof from S. pneumoniae, methods for isolating such antigens and specific uses thereof.
摘要翻译：本发明公开了编码超免疫血清反应性抗原或其片段的分离的核酸分子以及来自肺炎链球菌的超免疫血清反应性抗原或其片段，分离这些抗原的方法及其具体用途。

10. 发明申请

WO2004106367A3 ENTEROCOCCUS ANTIGENS 审中-公开
标题翻译： ENTEROCOCCUS抗原
公开(公告)号：WO2004106367A3
公开(公告)日：2005-06-16
申请号：PCT/EP2004005664
申请日：2004-05-26
申请人： INTERCELL AG , MEINKE ANDREAS , NAGY ESZTER , HANNER MARKUS , GELBMANN DIETER
发明人： MEINKE ANDREAS , NAGY ESZTER , HANNER MARKUS , GELBMANN DIETER
IPC分类号： A61K39/00 , C07K14/315 , C07K16/12 , C12N15/31 , C12Q1/68 , G01N33/569
CPC分类号： C07K16/1267 , A61K39/00 , A61K2039/53 , C07K14/315 , C07K2317/21 , C12Q1/689 , C12Q2600/158 , G01N33/56916 , G01N2500/00
摘要： The present invention discloses isolated nucleic acid molecules encoding a hyperimmune serum reactive antigen or a fragment thereof as well as hyperimmune serum reactive antigens or fragments thereof from E.faecalis, methods for isolating such antigens and specific uses thereof.
摘要翻译：本发明公开了编码超免疫血清反应性抗原或其片段的分离的核酸分子以及来自粪肠球菌的超免疫血清反应性抗原或其片段，分离这些抗原的方法及其具体用途。

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