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1. 发明申请

WO2010136562A3 MORAXELLA CATARRHALIS ANTIGENS 审中-公开
标题翻译： MORAXELLA CATARRHALIS抗原
公开(公告)号：WO2010136562A3
公开(公告)日：2011-11-17
申请号：PCT/EP2010057414
申请日：2010-05-28
申请人： INTERCELL AG , VON GABAIN ALEXANDER , NAGY ESZTER , MEINKE ANDREAS , SELAK SANJA , HANNER MARKUS , SMIDT MARGARITA , FLOR JULIA , NOIGES BIRGIT , SCHUELER WOLFGANG , SCHIRMER ULRIKE , SALLETMAYER VERENA , NEZHYBA MARIO , SEIDEL STEFAN , OLEKSIEWICZ MARTIN
发明人： VON GABAIN ALEXANDER , NAGY ESZTER , MEINKE ANDREAS , SELAK SANJA , HANNER MARKUS , SMIDT MARGARITA , FLOR JULIA , NOIGES BIRGIT , SCHUELER WOLFGANG , SCHIRMER ULRIKE , SALLETMAYER VERENA , NEZHYBA MARIO , SEIDEL STEFAN , OLEKSIEWICZ MARTIN
IPC分类号： A61K38/04 , C07K14/21 , C07K16/12
CPC分类号： C07K14/212 , A61K39/00
摘要： The present invention relates to isolated nucleic acid molecules which encode an antigen from a Moraxella catarrhalis (Meat) species, a vector which comprises such nucleic acid molecule, and a host cell comprising such vector. Furthermore, the invention provides antigens from a Moraxella catarrhalis species, as well as fragments and variants thereof, a process for producing such antigens, and a process for producing a cell which expresses such antigen. More specifically, such antigens are produced by or associated with bacterial infections caused by Moraxella catarrhalis. Moreover, the present invention provides antibodies binding to such antigen, a hybridoma cell producing such antibodies, methods for producing such antibodies, a pharmaceutical composition comprising such nucleic acid molecule, antigen, vector or antibody, the use of such nucleic acid molecule, antigen, vector or antibody for the preparation of a pharmaceutical composition, methods for identifying an antagonist capable of binding such antigen or of reducing or inhibiting the interaction activity of such antigen, methods for diagnosing an infection with Moraxella catarrhalis and methods for the treatment or prevention of an infection with Moraxella catarrhalis.
摘要翻译：本发明涉及编码来自卡他莫拉菌（肉）物种的抗原的分离的核酸分子，包含该核酸分子的载体和包含该载体的宿主细胞。此外，本发明提供了卡他莫拉菌属物种的抗原，以及其片段和变体，产生这种抗原的方法，以及用于产生表达这种抗原的细胞的方法。更具体地说，这些抗原是由卡他莫拉菌引起的细菌感染产生或与之相关的。此外，本发明提供了与这种抗原结合的抗体，产生此类抗体的杂交瘤细胞，产生此类抗体的方法，包含该核酸分子，抗原，载体或抗体的药物组合物，使用此类核酸分子，抗原，用于制备药物组合物的载体或抗体，用于鉴定能够结合此类抗原的拮抗剂或降低或抑制此类抗原的相互作用活性的方法，用于诊断卡他莫拉菌的感染的方法和用于治疗或预防感染卡他莫拉菌。

2. 发明申请

WO2010092176A3 NONTYPABLE HAEMOPHILUS INFLUENZAE ANTIGENS 审中-公开
标题翻译：不可替代的海马流感病毒抗体
公开(公告)号：WO2010092176A3
公开(公告)日：2011-02-17
申请号：PCT/EP2010051871
申请日：2010-02-15
申请人： INTERCELL AG , VON GABAIN ALEXANDER , NAGY ESZTER , MEINKE ANDREAS , SELAK SANJA , HANNER MARKUS , SMIDT MARGARITA , WEISSGRAM MICHAELA , NOIGES BIRGIT , SEIDEL STEFAN , BACHER JULIA , SATKE CHRISTINA , SCHUELER WOLFGANG , OLEKSIEWICZ MARTIN
发明人： VON GABAIN ALEXANDER , NAGY ESZTER , MEINKE ANDREAS , SELAK SANJA , HANNER MARKUS , SMIDT MARGARITA , WEISSGRAM MICHAELA , NOIGES BIRGIT , SEIDEL STEFAN , BACHER JULIA , SATKE CHRISTINA , SCHUELER WOLFGANG , OLEKSIEWICZ MARTIN
IPC分类号： A61K39/12 , C07K14/285 , C07K16/12 , C12R1/21
CPC分类号： C07K14/285 , A61K39/00 , A61K2039/53
摘要： The present invention relates to isolated nucleic acid molecules which encode an antigen from a nontypable Haemophilus influenzae (H. influenzae) species, a vector which comprises such nucleic acid molecule, and a host cell comprising such vector. Furthermore, the invention provides antigens from a nontypable Haemophilus influenzae species, as well as fragments and variants thereof, a process for producing such antigens, and a process for producing a cell, which expresses such antigen. More specifically such antigens are produced by or associated with bacterial infections caused by nontypable Haemophilus influenzae. Moreover, the present invention provides antibodies binding to such antigen, a hybridoma cell producing such antibodies, methods for producing such antibodies, a pharmaceutical composition comprising such nucleic acid molecule, antigen, vector or antibody, the use of such nucleic acid molecule, antigen, vector or antibody for the preparation of a pharmaceutical composition, methods for identifying an antagonist capable of binding such antigen or of reducing or inhibiting the interaction activity of such antigen, methods for diagnosing an infection with nontypable Haemophilus influenzae and methods for the treatment or prevention of an infection with nontypable Haemophilus influenzae.
摘要翻译：本发明涉及编码来自不可流行的流感嗜血杆菌（流感嗜血杆菌）物种的抗原的分离的核酸分子，包含该核酸分子的载体和包含该载体的宿主细胞。此外，本发明提供了来自不可渗透的流感嗜血杆菌物种的抗原，以及其片段和变体，产生这种抗原的方法，以及表达这种抗原的细胞的制备方法。更具体地说，这种抗原由不流行的流感嗜血杆菌引起的细菌感染产生或与其相关。此外，本发明提供了与这种抗原结合的抗体，产生这种抗体的杂交瘤细胞，产生这种抗体的方法，包含这种核酸分子，抗原，载体或抗体的药物组合物，使用这种核酸分子，抗原，用于制备药物组合物的载体或抗体，用于鉴定能够结合此类抗原的拮抗剂或降低或抑制该抗原的相互作用活性的方法，用于诊断不可流行的流感嗜血杆菌的感染的方法和用于治疗或预防感染非典型流感嗜血杆菌。

3. 发明申请

WO2008135446A3 KLEBSIELLA ANTIGENS 审中-公开
标题翻译： KLEBSIELLA抗原
公开(公告)号：WO2008135446A3
公开(公告)日：2009-03-12
申请号：PCT/EP2008055214
申请日：2008-04-29
申请人： INTERCELL AG , BAKSHI SHARMILA , CIPPS THOMAS , HANNER MARKUS , PIKALO JUTTA , SATKE CHRISTINA , NAGY ESZTER , LUNDBERG URBAN , ZIERER DAGMAR , MEINKE ANDREAS , NOIGES BIRGIT , STIERSCHNEIDER ULRIKE , VON GABAIN ALEXANDER
发明人： BAKSHI SHARMILA , CIPPS THOMAS , HANNER MARKUS , PIKALO JUTTA , SATKE CHRISTINA , NAGY ESZTER , LUNDBERG URBAN , ZIERER DAGMAR , MEINKE ANDREAS , NOIGES BIRGIT , STIERSCHNEIDER ULRIKE , VON GABAIN ALEXANDER
IPC分类号： C07K14/26 , A61K39/395 , A61P31/04 , C07K16/12
CPC分类号： C07K14/26 , A61K39/00 , A61K39/0266 , A61K45/06 , A61K2039/505 , A61K2039/55505 , A61K2039/55566 , C07K16/1228 , C07K2317/21
摘要： The present invention relates to isolated nucleic acid molecules which encode an antigen, a vector which comprises such nucleic acid molecule, and a host cell comprising such vector. Furthermore, the invention provides antigens from a Klebsiella species, as well as fragments and variants thereof, a process for producing such antigens, and a process for producing a cell, which expresses such antigen. Moreover, the present invention provides antibodies binding to such antigen, a hybridoma cell producing such antibodies, methods for producing such antibodies, a pharmaceutical composition comprising such nucleic acid molecule, antigen, vector or antibody, the use of such nucleic acid molecule, antigen, vector or antibody for the preparation of a pharmaceutical composition, methods for identifying an antagonist capable of binding such antigen or of reducing or inhibiting the interaction activity of such antigen, methods for diagnosing an infection and methods for the treatment or prevention of an infection. More specifically such antigens are produced by or associated with bacterial pathogens causing nosocomial infections or bacterial infections caused by Klebsiella pneumoniae.
摘要翻译：本发明涉及编码抗原的分离的核酸分子，包含该核酸分子的载体和包含该载体的宿主细胞。此外，本发明提供了来自克雷伯氏菌属物种的抗原，以及其片段和变体，产生这种抗原的方法，以及表达这种抗原的细胞的制备方法。此外，本发明提供了与这种抗原结合的抗体，产生此类抗体的杂交瘤细胞，产生此类抗体的方法，包含该核酸分子，抗原，载体或抗体的药物组合物，使用此类核酸分子，抗原，用于制备药物组合物的载体或抗体，用于鉴定能够结合此类抗原的拮抗剂或降低或抑制该抗原的相互作用活性的方法，用于诊断感染的方法以及用于治疗或预防感染的方法。更具体地，这样的抗原由导致院内感染或由肺炎克雷伯杆菌引起的细菌感染的细菌病原体产生或与之相关。

4. 发明申请

WO2007042326A2 NEISSERIA MENINGITIDIS ANTIGENS 审中-公开
公开(公告)号：WO2007042326A2
公开(公告)日：2007-04-19
申请号：PCT/EP2006009934
申请日：2006-10-13
申请人： INTERCELL AG , NAGY ESZTER , MEINKE ANDREAS , VON GABAIN ALEXANDER , HANNER MARKUS , NOIGES BIRGIT , GELBMANN DIETER , SENN BEATRICE , LINGNAU KAREN
发明人： NAGY ESZTER , MEINKE ANDREAS , VON GABAIN ALEXANDER , HANNER MARKUS , NOIGES BIRGIT , GELBMANN DIETER , SENN BEATRICE , LINGNAU KAREN
IPC分类号： C07K14/22 , A61K39/095 , C07K19/00 , C12N15/11 , C12N15/62
CPC分类号： C07K14/22 , A61K39/00
摘要： The present invention relates to a peptide consisting of antigen of N. meningitidis of any of the SEQ ID NOS: 1 to 184 or a functional active fragment or derivative thereof, optionally further consisting of additional amino acid residue(s); a nucleic acid coding for the same; a pharmaceutical composition, especially a vaccine, containing a polypeptide comprising or consisting of said peptide or said nucleic acid; a nucleic acid coding for said polypeptide or a nucleic acid complementary to the same; an antibody or functional active fragment thereof; a hybridoma cell line which produces said antibody; a method for producing said antibody; a pharmaceutical composition comprising said antibody; the use of said peptide or said nucleic acid for the manufacture of a medicament for the immunization of a subject; the use of said antibody or functional fragment thereof for the manufacture of a medicament for the treatment of an infection; a method of diagnosing a N. meningitidis infection; a method for identifying a ligand capable of binding to said peptide; and the use said peptide for the isolation and/or purification and/or identification of an interaction partner of the peptide.
摘要翻译：本发明涉及由SEQ ID NOS：1至184中任一项的脑膜炎奈瑟氏球菌的抗原或其功能活性片段或衍生物组成的肽，所述肽任选进一步由另外的氨基酸残基组成; 编码它的核酸; 含有包含所述肽或所述核酸或由所述肽或所述核酸组成的多肽的药物组合物，特别是疫苗; 编码所述多肽的核酸或与其互补的核酸; 抗体或其功能活性片段; 产生所述抗体的杂交瘤细胞系; 生产所述抗体的方法; 包含所述抗体的药物组合物; 所述肽或所述核酸用于制造用于免疫受试者的药物的用途; 所述抗体或其功能片段在制备用于治疗感染的药物中的用途; 诊断脑膜炎奈瑟氏球菌感染的方法; 鉴定能够结合所述肽的配体的方法; 并且使用所述肽用于肽的相互作用配偶体的分离和/或纯化和/或鉴定。

5. 发明申请

WO2008155291A3 CHLAMYDIA ANTIGENS 审中-公开
标题翻译： CHLAMYDIA抗原
公开(公告)号：WO2008155291A3
公开(公告)日：2009-03-05
申请号：PCT/EP2008057456
申请日：2008-06-13
申请人： INTERCELL AG , MEINKE ANDREAS , NAGY ESZTER , NOIGES BIRGIT , ASKLIN JOHANNA , VON GABAIN ALEXANDER
发明人： MEINKE ANDREAS , NAGY ESZTER , NOIGES BIRGIT , ASKLIN JOHANNA , VON GABAIN ALEXANDER
IPC分类号： C07K14/295
CPC分类号： C07K14/295 , A61K39/118 , G01N33/56927 , G01N2469/20
摘要： The present invention relates to isolated nucleic acid molecules which encode an antigen from a Chlamydia species, a vector which comprises such nucleic acid molecule, and a host cell comprising such vector. Furthermore, the invention provides antigens from a Chlamydia species, as well as fragments and variants thereof, a process for producing such antigens, and a process for producing a cell, which expresses such antigen. More specifically such antigens are produced by or associated with bacterial infections caused by Chlamydia pneumoniae. Moreover, the present invention provides antibodies binding to such antigen, a hybridoma cell producing such antibodies, methods for producing such antibodies, a pharmaceutical composition comprising such nucleic acid molecule, antigen, vector or antibody, the use of such nucleic acid molecule, antigen, vector or antibody for the preparation of a pharmaceutical composition, methods for identifying an antagonist capable of binding such antigen or of reducing or inhibiting the interaction activity of such antigen, methods for diagnosing an infection with Chlamydia and methods for the treatment or prevention of an infection with Chlamydia.
摘要翻译：本发明涉及编码来自衣原体物种的抗原的分离的核酸分子，包含该核酸分子的载体和包含该载体的宿主细胞。此外，本发明提供了来自衣原体物种的抗原，以及其片段和变体，产生这种抗原的方法，以及表达这种抗原的细胞的制备方法。更具体地，这种抗原由肺炎衣原体引起的细菌感染产生或与细菌感染有关。此外，本发明提供了与这种抗原结合的抗体，产生此类抗体的杂交瘤细胞，产生此类抗体的方法，包含该核酸分子，抗原，载体或抗体的药物组合物，使用此类核酸分子，抗原，用于制备药物组合物的载体或抗体，用于鉴定能够结合此类抗原的拮抗剂或降低或抑制此类抗原的相互作用活性的方法，用于诊断衣原体感染的方法以及用于治疗或预防感染的方法与衣原体。

6. 发明申请

WO2008031133A3 BORRELIA ANTIGENS 审中-公开
标题翻译： BORRELIA抗原
公开(公告)号：WO2008031133A3
公开(公告)日：2008-05-29
申请号：PCT/AT2007000439
申请日：2007-09-14
申请人： INTERCELL AG , LUNDBERG URBAN , MEINKE ANDREAS , NAGY ESZTER , VON GABAIN ALEXANDER , NOIGES BIRGIT , GELBMANN DIETER , POLJAK ALBINA , TRISKA CHRISTINE
发明人： LUNDBERG URBAN , MEINKE ANDREAS , NAGY ESZTER , VON GABAIN ALEXANDER , NOIGES BIRGIT , GELBMANN DIETER , POLJAK ALBINA , TRISKA CHRISTINE
IPC分类号： C07K14/20
CPC分类号： C07K7/08 , A61K39/00 , A61K2039/53 , C07K7/06 , C07K14/20
摘要： The present invention relates to isolated nucleic acid molecules which encode a protein, isolated nucleic acid molecules which encode a hyperimmune serum reactive antigen, a vector which comprises such nucleic acid molecule, a host cell comprising such vector, a hyperimmune reactive antigen from Borrelia species, proteins which are preferably hyperimmune serum reactive antigens, hyperimmune serum reactive antigens, antigens, a process for producing such proteins, hyperimmune serum reactive antigens or antigens, a process for producing a cell which expresses such protein, hyperimmune serum reactive antigen or antigen, an antibody binding to such protein, hyperimmune serum reactive antigen or antigen, a hybridoma cell producing such antibody, methods for producing such antibody, a pharmaceutical composition comprising such nucleic acid molecule, protein, hyperimmune serum reactive antigen, antigen or antibody, the use of such nucleic acid molecule, protein, hyperimmune serum reactive antigen, antigen or antibody for the manufacture of a medicament, methods for identifying an antagonist capable of reducing or inhibiting the interaction activity of such protein, hyperimmune serum reactive antigen or antigen, methods for diagnosing an infection and methods for the treatment of an infection. More specifically such proteins, hyperimmune serum reactive antigens or antigens are produced by or associated with bacterial pathogens causing Lyme disease or bacterial infections caused by Borrelia burgdorferi s.l.
摘要翻译：本发明涉及编码蛋白质的分离的核酸分子，编码超免疫血清反应性抗原的分离的核酸分子，包含此类核酸分子的载体，包含此类载体的宿主细胞，来自疏螺旋体属物种的超免疫反应性抗原，优选超免疫血清反应性抗原的蛋白质，超免疫血清反应性抗原，抗原，生产这种蛋白质的方法，超免疫血清反应性抗原或抗原，表达该蛋白质的细胞的生产方法，超免疫血清反应性抗原或抗原，抗体与这样的蛋白质结合，超免疫血清反应性抗原或抗原，产生此类抗体的杂交瘤细胞，产生此类抗体的方法，包含此类核酸分子的药物组合物，蛋白质，超免疫血清反应性抗原，抗原或抗体，酸分子，蛋白质，超免疫血清反应性蚂蚁 igen，用于制造药物的抗原或抗体，用于鉴定能够降低或抑制此类蛋白质的相互作用活性的拮抗剂的方法，超免疫血清反应性抗原或抗原，用于诊断感染的方法和用于治疗感染的方法。更具体地说，这些蛋白质，超免疫血清反应性抗原或抗原由细菌病原体产生或与细菌病原体相关，所述细菌病原体引起莱姆病或伯氏疏螺旋体引起的细菌感染。

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