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1. 发明申请

WO2009115508A2 PEPTIDES PROTECTIVE AGAINST S. PNEUMONIAE AND COMPOSITIONS, METHODS AND USES RELATING THERETO 审中-公开
标题翻译：抗生素保护措施
公开(公告)号：WO2009115508A2
公开(公告)日：2009-09-24
申请号：PCT/EP2009/053119
申请日：2009-03-17
申请人： INTERCELL AG , MEINKE, Andreas , TEUBENBACHER, Astrid , SENN, Beatrice , ZERBS, Manuel , HANNER, Markus , PIKALO, Jutta , NAGY, Eszter , GIEFING, Carmen , VON GABAIN, Alexander
发明人： MEINKE, Andreas , TEUBENBACHER, Astrid , SENN, Beatrice , ZERBS, Manuel , HANNER, Markus , PIKALO, Jutta , NAGY, Eszter , GIEFING, Carmen , VON GABAIN, Alexander
IPC分类号： C07K14/315 , C07K16/12 , G01N33/68 , A61K39/09
CPC分类号： A61K39/092 , C07K14/3156 , G01N33/56944 , G01N2333/3156 , G01N2469/20
摘要： The present invention relates to a protective peptide of Streptococcus pneumoniae (S. pneumoniae) or a functionally active variant of the protective peptide; a composition comprising at least two protective peptides or functionally active variants thereof; a composition comprising at least two proteins selected from the group consisting of i) a first type of protective peptide or functionally active variant thereof, ii) a second type of protective peptide or functionally active variant thereof and iii) a supportive peptide or a functionally active variant thereof; one or more nucleic acid(s) encoding the protective peptide or functionally active variant thereof or the at least two proteins comprised in the composition; a pharmaceutical composition comprising the protective peptide or functionally active variant thereof, the composition, or the nucleic acid(s); a method of producing an antibody using the protective peptide or functionally active variant thereof or the composition; the use of the protective peptide or functionally active variant thereof and/or the composition and/or the nucleic acid(s) for the manufacture of a medicament for the immunization or treatment of a subject; a method of diagnosing a S. pneumoniae infection using the protective peptide or a functionally active variant thereof, the composition or a primer and/or probe specific for the nucleic acid(s); a method for identifying a ligand capable of binding to a protective peptide or functionally active variant thereof; and the use of a protective peptide or functionally active variant thereof for the isolation and/or purification and/or identification of an interaction partner of the peptide.
摘要翻译：本发明涉及肺炎链球菌（Streptococcus pneumoniae）（肺炎链球菌）的保护肽或保护性肽的功能活性变体; 包含至少两种保护性肽或其功能活性变体的组合物; 包含至少两种选自i）第一类保护性肽或其功能活性变体的蛋白质的组合物，ii）第二类型的保护性肽或其功能活性变体，和iii）支持肽或功能活性其变体; 一种或多种编码保护性肽或其功能活性变体的核酸或组合物中包含的至少两种蛋白质; 包含保护性肽或其功能活性变体，组合物或核酸的药物组合物; 使用保护性肽或其功能活性变体或组合物制备抗体的方法; 保护性肽或其功能活性变体和/或组合物和/或核酸在制备用于免疫或治疗受试者的药物中的用途; 使用保护性肽或其功能活性变体来诊断肺炎链球菌感染的方法，所述组合物或对所述核酸特异性的引物和/或探针; 用于鉴定能够结合保护性肽或其功能活性变体的配体的方法; 以及使用保护性肽或其功能活性变体来分离和/或纯化和/或鉴定肽的相互作用配偶体。

2. 发明申请

WO2009115508A3 PEPTIDES PROTECTIVE AGAINST S. PNEUMONIAE AND COMPOSITIONS, METHODS AND USES RELATING THERETO 审中-公开
标题翻译：抗菌肽抗菌素及其组合物，方法和用途
公开(公告)号：WO2009115508A3
公开(公告)日：2009-11-12
申请号：PCT/EP2009053119
申请日：2009-03-17
申请人： INTERCELL AG , MEINKE ANDREAS , TEUBENBACHER ASTRID , SENN BEATRICE , ZERBS MANUEL , HANNER MARKUS , PIKALO JUTTA , NAGY ESZTER , GIEFING CARMEN , VON GABAIN ALEXANDER
发明人： MEINKE ANDREAS , TEUBENBACHER ASTRID , SENN BEATRICE , ZERBS MANUEL , HANNER MARKUS , PIKALO JUTTA , NAGY ESZTER , GIEFING CARMEN , VON GABAIN ALEXANDER
IPC分类号： C07K14/315 , A61K39/09 , C07K16/12 , G01N33/68
CPC分类号： A61K39/092 , C07K14/3156 , G01N33/56944 , G01N2333/3156 , G01N2469/20
摘要： The present invention relates to a protective peptide of Streptococcus pneumoniae (S. pneumoniae) or a functionally active variant of the protective peptide; a composition comprising at least two protective peptides or functionally active variants thereof; a composition comprising at least two proteins selected from the group consisting of i) a first type of protective peptide or functionally active variant thereof, ii) a second type of protective peptide or functionally active variant thereof and iii) a supportive peptide or a functionally active variant thereof; one or more nucleic acid(s) encoding the protective peptide or functionally active variant thereof or the at least two proteins comprised in the composition; a pharmaceutical composition comprising the protective peptide or functionally active variant thereof, the composition, or the nucleic acid(s); a method of producing an antibody using the protective peptide or functionally active variant thereof or the composition; the use of the protective peptide or functionally active variant thereof and/or the composition and/or the nucleic acid(s) for the manufacture of a medicament for the immunization or treatment of a subject; a method of diagnosing a S. pneumoniae infection using the protective peptide or a functionally active variant thereof, the composition or a primer and/or probe specific for the nucleic acid(s); a method for identifying a ligand capable of binding to a protective peptide or functionally active variant thereof; and the use of a protective peptide or functionally active variant thereof for the isolation and/or purification and/or identification of an interaction partner of the peptide.
摘要翻译：本发明涉及肺炎链球菌（Streptococcus pneumoniae）（肺炎链球菌）的保护肽或保护性肽的功能活性变体; 包含至少两种保护性肽或其功能活性变体的组合物; 包含至少两种选自i）第一类保护性肽或其功能活性变体的蛋白质的组合物，ii）第二类型的保护性肽或其功能活性变体，和iii）支持肽或功能活性其变体; 一种或多种编码保护性肽或其功能活性变体的核酸或组合物中包含的至少两种蛋白质; 包含保护性肽或其功能活性变体，组合物或核酸的药物组合物; 使用保护性肽或其功能活性变体或组合物制备抗体的方法; 保护性肽或其功能活性变体和/或组合物和/或核酸在制备用于免疫或治疗受试者的药物中的用途; 使用保护性肽或其功能活性变体来诊断肺炎链球菌感染的方法，所述组合物或对所述核酸特异性的引物和/或探针; 用于鉴定能够结合保护性肽或其功能活性变体的配体的方法; 以及使用保护性肽或其功能活性变体来分离和/或纯化和/或鉴定肽的相互作用配偶体。

3. 发明申请

WO2008061953A1 PEPTIDES PROTECTIVE AGAINST S. PNEUMONIAE AND COMPOSITIONS, METHODS AND USES RELATING THERETO 审中-公开
标题翻译：抗菌肽抗菌素及其组合物，方法和用途
公开(公告)号：WO2008061953A1
公开(公告)日：2008-05-29
申请号：PCT/EP2007/062493
申请日：2007-11-19
申请人： INTERCELL AG , NAGY, Eszter , GIEFING, Carmen , VON GABAIN, Alexander , HANNER, Markus , PIKALO, Jutta , SENN, Beatrice , SCHUNN, Michael , SWATOSCH, Gabriele , ZERBS, Manuel
发明人： NAGY, Eszter , GIEFING, Carmen , VON GABAIN, Alexander , HANNER, Markus , PIKALO, Jutta , SENN, Beatrice , SCHUNN, Michael , SWATOSCH, Gabriele , ZERBS, Manuel
IPC分类号： A61K39/09 , C07K14/315 , G01N33/569
CPC分类号： G01N33/56944 , G01N2469/20
摘要： The present invention relates to a protective peptide or a functionally active variant of the protective peptide; a composition comprising at least two proteins selected from the group consisting of i) a first type of protective peptide or functionally active variant thereof, ii) a second type of protective peptide or functionally active variant thereof and iii) a supportive peptide or a functionally active variant thereof; one or more nucleic acid(s) encoding the protective peptide or functionally active variant thereof or the at least two proteins comprised in the composition; a pharmaceutical composition comprising the protective peptide or functionally active variant thereof, the composition, or the nucleic acid(s); a method of producing an antibody using the protective peptide or functionally active variant thereof or the composition; the use of the protective peptide or functionally active variant thereof and/or the composition and/or the nucleic acid(s) for the manufacture of a medicament for the immunization or treatment of a subject; a method of diagnosing a S. pneumoniae infect ion using the protective peptide or a functionally active variant thereof, the composition or a primer and/or probe specific for the nucleic acid(s); a method for identifying a ligand capable of binding to a protective peptide or variant thereof; and the use of a protective peptide or variant thereof for the isolation and/or purification and/or identification of an interaction partner of the peptide.
摘要翻译：本发明涉及保护性肽或保护性肽的功能活性变体; 包含至少两种选自i）第一类保护性肽或其功能活性变体的蛋白质的组合物，ii）第二类型的保护性肽或其功能活性变体，和iii）支持肽或功能活性其变体; 一种或多种编码保护性肽或其功能活性变体的核酸或组合物中包含的至少两种蛋白质; 包含保护性肽或其功能活性变体，组合物或核酸的药物组合物; 使用保护性肽或其功能活性变体或组合物制备抗体的方法; 保护性肽或其功能活性变体和/或组合物和/或核酸在制备用于免疫或治疗受试者的药物中的用途; 使用保护性肽或其功能活性变体诊断肺炎链球菌感染的方法，所述组合物或对核酸特异性的引物和/或探针; 用于鉴定能够结合保护性肽或其变体的配体的方法; 以及使用保护性肽或其变体来分离和/或纯化和/或鉴定该肽的相互作用配偶体。

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