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1. 发明申请

WO2008155291A3 CHLAMYDIA ANTIGENS 审中-公开
标题翻译： CHLAMYDIA抗原
公开(公告)号：WO2008155291A3
公开(公告)日：2009-03-05
申请号：PCT/EP2008057456
申请日：2008-06-13
申请人： INTERCELL AG , MEINKE ANDREAS , NAGY ESZTER , NOIGES BIRGIT , ASKLIN JOHANNA , VON GABAIN ALEXANDER
发明人： MEINKE ANDREAS , NAGY ESZTER , NOIGES BIRGIT , ASKLIN JOHANNA , VON GABAIN ALEXANDER
IPC分类号： C07K14/295
CPC分类号： C07K14/295 , A61K39/118 , G01N33/56927 , G01N2469/20
摘要： The present invention relates to isolated nucleic acid molecules which encode an antigen from a Chlamydia species, a vector which comprises such nucleic acid molecule, and a host cell comprising such vector. Furthermore, the invention provides antigens from a Chlamydia species, as well as fragments and variants thereof, a process for producing such antigens, and a process for producing a cell, which expresses such antigen. More specifically such antigens are produced by or associated with bacterial infections caused by Chlamydia pneumoniae. Moreover, the present invention provides antibodies binding to such antigen, a hybridoma cell producing such antibodies, methods for producing such antibodies, a pharmaceutical composition comprising such nucleic acid molecule, antigen, vector or antibody, the use of such nucleic acid molecule, antigen, vector or antibody for the preparation of a pharmaceutical composition, methods for identifying an antagonist capable of binding such antigen or of reducing or inhibiting the interaction activity of such antigen, methods for diagnosing an infection with Chlamydia and methods for the treatment or prevention of an infection with Chlamydia.
摘要翻译：本发明涉及编码来自衣原体物种的抗原的分离的核酸分子，包含该核酸分子的载体和包含该载体的宿主细胞。此外，本发明提供了来自衣原体物种的抗原，以及其片段和变体，产生这种抗原的方法，以及表达这种抗原的细胞的制备方法。更具体地，这种抗原由肺炎衣原体引起的细菌感染产生或与细菌感染有关。此外，本发明提供了与这种抗原结合的抗体，产生此类抗体的杂交瘤细胞，产生此类抗体的方法，包含该核酸分子，抗原，载体或抗体的药物组合物，使用此类核酸分子，抗原，用于制备药物组合物的载体或抗体，用于鉴定能够结合此类抗原的拮抗剂或降低或抑制此类抗原的相互作用活性的方法，用于诊断衣原体感染的方法以及用于治疗或预防感染的方法与衣原体。

2. 发明申请

WO2008155291A2 CHLAMYDIA ANTIGENS 审中-公开
标题翻译： CHLAMYDIA抗原
公开(公告)号：WO2008155291A2
公开(公告)日：2008-12-24
申请号：PCT/EP2008/057456
申请日：2008-06-13
申请人： INTERCELL AG , MEINKE, Andreas , NAGY, Eszter , NOIGES, Birgit , ASKLIN, Johanna , VON GABAIN, Alexander
发明人： MEINKE, Andreas , NAGY, Eszter , NOIGES, Birgit , ASKLIN, Johanna , VON GABAIN, Alexander
IPC分类号： C07K14/295
CPC分类号： C07K14/295 , A61K39/118 , G01N33/56927 , G01N2469/20
摘要： The present invention relates to isolated nucleic acid molecules which encode an antigen from a Chlamydia species, a vector which comprises such nucleic acid molecule, and a host cell comprising such vector. Furthermore, the invention provides antigens from a Chlamydia species, as well as fragments and variants thereof, a process for producing such antigens, and a process for producing a cell, which expresses such antigen. More specifically such antigens are produced by or associated with bacterial infections caused by Chlamydia pneumoniae . Moreover, the present invention provides antibodies binding to such antigen, a hybridoma cell producing such antibodies, methods for producing such antibodies, a pharmaceutical composition comprising such nucleic acid molecule, antigen, vector or antibody, the use of such nucleic acid molecule, antigen, vector or antibody for the preparation of a pharmaceutical composition, methods for identifying an antagonist capable of binding such antigen or of reducing or inhibiting the interaction activity of such antigen, methods for diagnosing an infection with Chlamydia and methods for the treatment or prevention of an infection with Chlamydia .
摘要翻译：本发明涉及编码来自衣原体物种的抗原的分离的核酸分子，包含该核酸分子的载体和包含该载体的宿主细胞。此外，本发明提供了来自衣原体物种的抗原，以及其片段和变体，产生这种抗原的方法，以及表达这种抗原的细胞的制备方法。更具体地，这样的抗原由衣原体引起的细菌感染产生或与其相关

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