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1. 发明申请

WO2008070120A2 INTRAVASCULAR IMPLANTABLE DEVICE HAVING SUPERIOR ANCHORING ARRANGEMENT 审中-公开
标题翻译：具有超级锚固装置的血管内植入装置
公开(公告)号：WO2008070120A2
公开(公告)日：2008-06-12
申请号：PCT/US2007/024912
申请日：2007-12-04
申请人： INNERPULSE, INC. , RANSBURY, Terrance , HOLBROOK, Kevin
发明人： RANSBURY, Terrance , HOLBROOK, Kevin
IPC分类号： A61F2/06
CPC分类号： A61N1/057
摘要： Methods, systems and devices are provided for anchoring an intravascular implantable device within a vessel that is located superior to the heart, i.e. above the heart in a direction toward the head of a patient. Also provided is a method of providing an intravascular device and instructions for implanting the intravascular device, comprising providing an intravascular device having an elongate device body with a proximal end and a distal end that is adapted for chronic implantation within the vasculature of a patient and that includes a distal portion of the intravascular device proximate the distal end of the elongate device body, and providing instructions for chronically implanting the intravascular device substantially wholly within the vasculature of a patient in a target vessel superior to the heart of the patient.
摘要翻译：提供了方法，系统和装置，用于将血管内可植入装置锚定在位于心脏上方的容器内，即在朝向患者头部的方向上方的心脏上方。还提供了一种提供血管内装置和用于植入血管内装置的说明书的方法，其包括提供具有细长装置主体的血管内装置，所述细长装置主体具有近端和远端，所述近端和远端适于在患者脉管系统内慢慢植入，并且包括靠近细长装置主体的远端的血管内装置的远端部分，以及提供用于将血管内装置基本上全部置于患者脉管系统内的指令，用于高于患者心脏的目标血管。

2. 发明申请

WO2009073754A2 IMPLANTATION METHODS, SYSTEMS AND TOOLS FOR INTRAVASCULAR IMPLANTABLE DEVICES 审中-公开
标题翻译：静脉注射装置的植入方法，系统和工具
公开(公告)号：WO2009073754A2
公开(公告)日：2009-06-11
申请号：PCT/US2008/085448
申请日：2008-12-03
申请人： INNERPULSE , RANSBURY, Terrance , HOLBROOK, Kevin
发明人： RANSBURY, Terrance , HOLBROOK, Kevin
IPC分类号： A61B17/34 , A61M1/10 , A61M25/08
CPC分类号： A61N1/056 , A61B17/064 , A61B17/068 , A61B2017/0649 , A61M39/0613 , A61N1/0573 , A61N1/372 , A61N2001/0578
摘要： Methods, systems and tools for implanting long-term active therapeutic medical devices referred to as intravascular implantable devices (HD) within a patient's vasculature are disclosed. In one embodiment, the implantation techniques and instruments of the present invention are adapted for implanting an IID having only a single anchoring arrangement positioned proximate a distal portion of the device for anchoring within a vessel located superior to the heart, i.e. above the heart in a direction toward the head of a patient. Other embodiments of the invention include various methods and tools for delivering and implanting an IID, delivering and securing an anchor, and delivering and implanting one or more leads.
摘要翻译：公开了用于植入长期活跃治疗医疗装置的方法，系统和工具，称为患者脉管系统内的血管内可植入装置（HD）。在一个实施例中，本发明的植入技术和仪器适于植入仅具有靠近装置的远端部分定位的单个锚固装置的IID，用于锚定在位于心脏上方的容器内，即位于心脏上方的血管朝向患者头部的方向。本发明的其它实施例包括用于递送和植入IID，递送和固定锚定器以及递送和植入一个或多个引线的各种方法和工具。

3. 发明申请

WO2005077450A2 INTRAVASCULAR DELIVERY SYSTEM FOR THERAPEUTIC AGENTS 审中-公开
标题翻译：治疗剂的血管内输送系统
公开(公告)号：WO2005077450A2
公开(公告)日：2005-08-25
申请号：PCT/US2005/004063
申请日：2005-02-10
申请人： SYNECOR, LLC , WILLIAMS, Michael, S. , HOLBROOK, Kevin , RANSBURY, Terrance
发明人： WILLIAMS, Michael, S. , HOLBROOK, Kevin , RANSBURY, Terrance
IPC分类号： A61M31/00
CPC分类号： A61M25/04 , A61B5/0215 , A61B5/145 , A61B5/14532 , A61F2/82 , A61F2250/0068 , A61M5/14216 , A61M5/14232 , A61M5/14236 , A61M5/14276 , A61M5/172 , A61M2205/3523
摘要： Described herein is a system for intravascular drug delivery system, which includes a reservoir implantable a blood vessel, an intravascular pump fluidly coupled to the reservoir and an anchor expandable into contact with a wall of the blood vessel to retain the system within the vasculature. Delivery conduits may be extend from the reservoir and are positionable at select locations within the vasculature for target drug delivery to select organs or tissues.
摘要翻译：本文描述了用于血管内药物递送系统的系统，其包括可植入血管的储存器，流体地联接至储存器的血管内泵和可膨胀成与血管壁接触的锚，将系统保留在脉管系统内。输送导管可以从储存器延伸并且可以定位在脉管系统内的选定位置以用于靶向药物递送以选择器官或组织。

4. 发明申请

WO2005000398A3 INTRAVASCULAR ELECTROPHYSIOLOGICAL SYSTEM AND METHODS 审中-公开
公开(公告)号：WO2005000398A3
公开(公告)日：2005-01-06
申请号：PCT/US2004/017650
申请日：2004-06-04
申请人： SYNECOR , RANSBURY, Terrance , WILLIAMS, Michael, S. , GLENN, Richard, A. , FIFER, Dan , HOLBROOK, Kevin
发明人： RANSBURY, Terrance , WILLIAMS, Michael, S. , GLENN, Richard, A. , FIFER, Dan , HOLBROOK, Kevin
IPC分类号： A61N1/375
摘要： The present application describes an intravascular implantable pacing and/or defibrillation system. The described system includes a pulse generator that is implantable within a blood vessel and proportioned to blood flow through the blood vessel, and at least one electrode attachable to the pulse generator. During implantation, the pulse generator is introduced into a patient's vasculature, advanced to a desired vessel and anchored in place within the vessel. The electrode or electrodes are placed within the heart or surrounding vessels as needed to deliver electrical pulses to the appropriate location.

5. 发明申请

WO2010144916A3 METHODS AND SYSTEMS FOR ANTI-THROMBOTIC INTRAVASCULAR IMPLANTABLE DEVICES 审中-公开
公开(公告)号：WO2010144916A3
公开(公告)日：2010-12-16
申请号：PCT/US2010/038544
申请日：2010-06-14
申请人： INNERPULSE, INC. , RANSBURY, Terrance
发明人： RANSBURY, Terrance
IPC分类号： A61F2/02 , A61F2/06
摘要： An implantable intravascular medical device, and methods related to the implantable intravascular device, includes a plurality of containers connected by flex couplers which are configured for implantation in such a manner as to improve vascular response and reduce thrombosis resulting from chronic implantation of the device.

6. 发明申请

WO2007117538A3 FLEXIBLE INTERCONNECT ASSEMBLY FOR IMPLANTABLE MEDICAL DEVICES 审中-公开
公开(公告)号：WO2007117538A3
公开(公告)日：2007-10-18
申请号：PCT/US2007/008467
申请日：2007-04-03
申请人： INNERPULSE, INC. , RANSBURY, Terrance , PURCELL, Stephen
发明人： RANSBURY, Terrance , PURCELL, Stephen
IPC分类号： A61N1/00
摘要： A modular implantable medical device having first and second component containers and a flexible connector for connecting the first and second containers. The connector can include a pair of end members and a flexible portion extending therebetween to define an internal passage between the end members. Each of the end members can include a receptacle configured to communicate with the containers. The connector further includes a conduit extending between the pair of end members in the internal passage to provide a communication path between the first and second containers such that the first and second component containers are in communication.

7. 发明申请

WO2012149511A2 NEUROMODULATION SYSTEMS AND METHODS FOR TREATING ACUTE HEART FAILURE SYNDROMES 审中-公开
标题翻译：神经系统和治疗急性心力衰竭综合征的方法
公开(公告)号：WO2012149511A2
公开(公告)日：2012-11-01
申请号：PCT/US2012/035712
申请日：2012-04-28
申请人： SYNECOR LLC , RANSBURY, Terrance , SANDERS, William, E. , STACK, Richard, S. , STACK, Colleen
发明人： RANSBURY, Terrance , SANDERS, William, E. , STACK, Richard, S. , STACK, Colleen
IPC分类号： A61N1/362 , A61N1/04 , A61M25/088 , A61B18/00 , A61B17/34
CPC分类号： A61N1/3621 , A61B5/01 , A61B5/0215 , A61B5/024 , A61M25/0074 , A61M25/0125 , A61M25/0147 , A61M25/04 , A61M2025/0175 , A61N1/056 , A61N1/057 , A61N1/36114 , A61N1/3627
摘要： A neuromodulation system for treating acute heart failure syndromes includes a first catheter having a parasympathetic therapy element adapted for positioning within a first blood vessel such as a superior vena cava, and a second catheter sympathetic therapy element adapted for positioning with a second, different, blood vessel such as the pulmonary artery. The catheters comprise a system in which one of catheters is slidably disposed over the other of the catheters. The system may further be slidably disposed over a third elongate element such as a Swan-Ganz catheter positionable within a pulmonary artery, such that the Swan- Ganz may be used for monitoring parameters such as blood pressure and cardiac output during neuromodulation therapy. The parasympathetic therapy element is energized to deliver neuromodulation therapy to a parasympathetic nerve fiber such as a vagus nerve, while the sympathetic therapy element is energized to deliver neuromodulation therapy to a sympathetic nerve fiber such as a sympathetic cardiac nerve fiber. For treatment of acute heart failure syndromes, the neuromodulation therapy may be used to lower heart rate and increase cardiac inotropy.
摘要翻译：用于治疗急性心力衰竭综合征的神经调节系统包括具有适于定位在诸如上腔静脉的第一血管内的副交感神经治疗元件的第一导管和适于与第二不同血液定位的第二导管交感神经治疗元件血管如肺动脉。导管包括其中一个导管可滑动地设置在另一个导管上的系统。系统还可以可滑动地设置在第三细长元件（例如可定位在肺动脉内的Swan-Ganz导管）之上，使得Swan-Ganz可用于监测神经调节治疗期间的血压和心输出量等参数。副交感神经治疗元件被激励以将神经调节治疗递送到副交感神经纤维例如迷走神经，而交感神经治疗元件通电以将神经调节治疗递送至交感神经纤维如交感神经纤维。对于急性心力衰竭综合征的治疗，神经调节治疗可用于降低心率并增加心脏内向性。

8. 发明申请

WO2007022192A2 ELECTRODES FOR IMPLANTABLE MEDICAL DEVICES 审中-公开
标题翻译：用于植入式医疗设备的电极
公开(公告)号：WO2007022192A2
公开(公告)日：2007-02-22
申请号：PCT/US2006/031859
申请日：2006-08-15
申请人： SYNECOR, LLC , FIFER, Daniel, W. , RANSBURY, Terrance
发明人： FIFER, Daniel, W. , RANSBURY, Terrance
IPC分类号： A61N1/05
CPC分类号： A61N1/056
摘要： A device for implantation in the vasculature of a patient can include discrete but electrically connected electrodes that, along with the device body, form a substantially smooth exterior surface that allows for easy insertion and removal. Any interstices between the electrodes can be back-filled with a flexible elastomer such as silicone to ensure a smooth surface. The individual electrode segments, such as ring or disc segments, can be connected by an appropriate conductive connection, such as a flexible u-joint, thru-cable, or end-to-end connection including a coupler spring.
摘要翻译：用于植入患者的脉管系统中的装置可以包括离散但电连接的电极，其与装置主体一起形成允许易于插入和移除的基本光滑的外表面。电极之间的任何空隙都可以用柔性弹性体例如硅树脂回填以确保表面光滑。单个电极段，例如环形或盘形段，可以通过适当的导电连接，例如柔性U形接头，贯通电缆或包括耦合器弹簧的端到端连接来连接。

9. 发明申请

WO2013028274A2 SYSTEM AND METHOD FOR NEUROMODULATION 审中-公开
标题翻译：神经修复的系统和方法
公开(公告)号：WO2013028274A2
公开(公告)日：2013-02-28
申请号：PCT/US2012/046329
申请日：2012-07-11
申请人： SYNECOR LLC , SANDERS, William, E. , MASSON, Stephen, C. , RANSBURY, Terrance , STACK, Richard, S.
发明人： SANDERS, William, E. , MASSON, Stephen, C. , RANSBURY, Terrance , STACK, Richard, S.
CPC分类号： A61N1/36114 , A61N1/0551 , A61N1/056 , A61N1/36053 , A61N1/36135 , A61N1/36139
摘要： A method of treating autonomic imbalance in a patient includes energizing a first therapeutic element disposed in a superior vena cava of the patient to deliver therapy to a parasympathetic nerve fiber such as a vagus nerve, and energizing a second therapeutic element disposed within the superior vena cava to deliver therapy to a sympathetic cardiac nerve fiber. A neuromodulation system includes a parasympathetic therapy element adapted for positioning within a blood vessel, a sympathetic therapy element adapted for positioning with the blood vessel; and a stimulator configured to energize the parasympathetic therapy element to deliver parasympathetic therapy to a parasympathetic nerve fiber disposed external to the blood vessel and energize the sympathetic therapy element within the blood vessel to deliver sympathetic therapy to a sympathetic nerve fiber disposed external to the blood vessel. Delivery of the parasympathetic and sympathetic therapy decreases the patient's heart rate and elevates or maintains the blood pressure of the patient.
摘要翻译：一种治疗患者自主性不平衡的方法包括激励设置在患者上腔静脉中的第一治疗元件，以将治疗递送至副交感神经纤维如迷走神经，以及激励位于上腔静脉内的第二治疗元件为交感神经纤维提供治疗。神经调节系统包括适于定位在血管内的副交感神经治疗元件，适于与血管定位的交感治疗元件; 以及刺激器，其构造成激励所述副交感神经治疗元件以将副交感神经治疗递送至设置在所述血管外部的副交感神经纤维，并且激励所述血管内的所述交感神经治疗元件，以向位于所述血管外部的交感神经纤维递送交感神经治疗。副交感神经和交感神经治疗的交付减少患者的心率，提高或维持患者的血压。

10. 发明申请

WO2007022180A1 LEAD FIXATION AND EXTRACTION 审中-公开
标题翻译：铅固定和提取
公开(公告)号：WO2007022180A1
公开(公告)日：2007-02-22
申请号：PCT/US2006/031829
申请日：2006-08-15
申请人： SYNECOR, LLC , FIFER, Daniel, W. , RANSBURY, Terrance
发明人： FIFER, Daniel, W. , RANSBURY, Terrance
IPC分类号： A61N1/05
CPC分类号： A61N1/0565 , A61N1/057 , A61N1/0573 , A61N2001/0578
摘要： A device for implantation in the vasculature of a patient can include a fixation mechanism for anchoring the device in place while allowing for easy removal of the device. The fixation mechanism can include a detachable and/or biodegradable portion that can allow for removal from the bulk of the device in order to allow for the bulk to simply be pulled from the body without likelihood of injury. These devices also can include electrode assemblies that do not promote fibrous ingrowth, further reducing the likelihood for injury upon extraction of the device.
摘要翻译：用于植入患者脉管系统中的装置可以包括用于将装置固定在适当位置的固定机构，同时允许容易地移除装置。固定机构可以包括可拆卸的和/或可生物降解的部分，其可以允许从装置的大部分移除，以便容易地将本体从身体拉出而不会受到伤害。这些装置还可以包括不促进纤维向内生长的电极组件，进一步降低在提取装置时损伤的可能性。

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