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1. 发明申请

WO2011112229A2 THERAPEUTIC AGENT PREPARATIONS FOR DELIVERY INTO A LUMEN OF THE INTESTINAL TRACT USING A SWALLOWABLE DRUG DELIVERY DEVICE 审中-公开
标题翻译：使用易于使用的药物递送装置将治疗剂用于输送入真菌感染物的制剂
公开(公告)号：WO2011112229A2
公开(公告)日：2011-09-15
申请号：PCT/US2010/062073
申请日：2010-12-23
申请人： INCUBE LABS, LLC , IMRAN, Mir A.
发明人： IMRAN, Mir A.
IPC分类号： A61K9/48 , A61K9/22 , A61K9/20 , A61K38/28 , A61P3/10
CPC分类号： A61K38/28 , A61K9/0097 , A61K9/4816 , A61M31/002
摘要： Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade within the wall to release the drug to produce a therapeutic effect. The preparation can be coupled to an actuator having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.
摘要翻译：本发明的实施方案提供了可在胃肠道内递送药物和其它治疗剂的吞咽装置，制剂和方法。许多实施例提供了用于递送药剂的吞咽装置。具体实施方案提供了可吞咽的装置，例如用于将药物输送到肠壁或其它胃肠腔中的胶囊。实施方案还提供了各种药物制剂，其被配置为容纳在胶囊内，从胶囊进入肠壁并在壁内降解以释放药物以产生治疗效果。制剂可以联接到具有第一配置的致动器，其中制剂被包含在胶囊中，并且第二配置将制剂从胶囊推出到肠壁中。本发明的实施方案对于递送胃肠道内吸收不良，耐受和/或降解的药物特别有用。

2. 发明申请

WO2012075337A2 DIRECTED DELIVERY OF AGENTS TO NEURAL ANATOMY 审中-公开
标题翻译：指导性地向神经解剖学提供代理
公开(公告)号：WO2012075337A2
公开(公告)日：2012-06-07
申请号：PCT/US2011/062958
申请日：2011-12-01
申请人： SPINAL MODULATION, INC. , KRAMER, Jeffery , IMRAN, Mir A.
发明人： KRAMER, Jeffery , IMRAN, Mir A.
IPC分类号： A61N1/34 , A61K9/00 , A61N1/05
CPC分类号： A61N1/0551 , A61K9/0009 , A61K9/0085
摘要： The present invention is directed generally to systems, devices and methods for direct delivery of agents, e.g., pharmaceutical agents, to target spinal and neuronal anatomies, e.g., the dorsal root ganglia (DRG), for the treatment of various disorders, particularly pain and pain related disorders, such as chronic itch, sensory disorders, multiple sclerosis, post-herpetic neuralgia and the like. The system, devices and methods of the invention encompass the agents to be delivered to the target anatomy alone or in combination with electrical stimulation. The delivery device and systems and methods as disclosed herein place the distal end of the delivery element, which comprises at least one agent delivery structure, and optionally at least one electrode, in close proximity, or in contact with or next to the target spinal anatomy, e.g., DRG. A variety of agents can be delivered using the device, including sodium channel blockers, biologics, neuroinflammatory modulators, toxins etc., to selectively neuromodulate the neurons. Agent delivery and/or electrical stimulation can be automated and/or can be controlled automatically or by a pre-determined program, or by a patient control pump (PCA).
摘要翻译：本发明一般涉及用于直接递送药剂（例如药剂）以靶向脊髓和神经元解剖结构（例如背根神经节（DRG））的系统，装置和方法，用于治疗各种疾病，特别是疼痛和疼痛相关疾病，如慢性瘙痒，感觉障碍，多发性硬化，疱疹后神经痛等。本发明的系统，装置和方法包括单独或与电刺激组合递送至目标解剖结构的药剂。如本文所公开的递送装置和系统和方法将包括至少一个药剂递送结构的输送元件的远端和可选地至少一个电极置于目标脊柱解剖结构的紧密接近或接近或接近，例如DRG。可以使用包括钠通道阻断剂，生物制剂，神经炎症调节剂，毒素等的装置递送各种药剂以选择性神经调节神经元。药剂递送和/或电刺激可以自动化和/或可以由预先确定的程序或患者控制泵（PCA）自动控制。

3. 发明申请

WO2010045481A2 METHODS, DEVICES AND SYSTEMS FOR PROGRAMMING NEUROSTIMULATION 审中-公开
标题翻译：用于编程神经调节的方法，装置和系统
公开(公告)号：WO2010045481A2
公开(公告)日：2010-04-22
申请号：PCT/US2009/060880
申请日：2009-10-15
申请人： SPINAL MODULATION, INC. , IMRAN, Mir A. , MOSSOP, Brian J. , KISHAWI, Eyad
发明人： IMRAN, Mir A. , MOSSOP, Brian J. , KISHAWI, Eyad
IPC分类号： A61N1/372
CPC分类号： A61N1/37247 , A61N1/0551 , A61N1/3605 , A61N1/36071 , A61N1/36146 , A61N1/36185
摘要： Methods, devices and systems are provided to efficiently identify one or more preferred neurostimulation parameter sets that treat a targeted pain of a patient. Each neurostimulation parameter set defines electrode parameters and neurostimulation signal parameters. A plurality of different neurostimulation parameter sets are tested on the patient to thereby identify those sets that treat the targeted pain. Each of the tested neurostimulation parameter sets defines an electrode configuration that differs from the other tested sets. All of the tested neurostimulation parameter sets comprise a same value for a specific neurostimulation signal parameter (e.g., pulse width) that if reduced reduces power consumption. If more than one of the tested neurostimulation parameter sets are identified as treating the targeted pain, then sets identified as treating the targeted pain are retested, with the value for the specific neurostimulation signal parameter reduced by a same amount for each of the retested sets, to thereby identify those neurostimulation parameter sets that treat the targeted pain at the reduced level.
摘要翻译：提供了用于有效识别治疗患者的目标疼痛的一个或多个优选神经刺激参数组的方法，设备和系统。每个神经刺激参数集定义了电极参数和神经刺激信号参数。对患者测试多个不同的神经刺激参数集，从而识别治疗目标疼痛的那些组。每个测试的神经刺激参数集定义了不同于其他测试集的电极配置。所有测试的神经刺激参数集对于特定的神经刺激信号参数（例如，脉冲宽度）包括相同的值，如果减小则降低功耗。如果被测试的神经刺激参数组的一个以上的被识别为处理目标的疼痛，然后设置鉴定为治疗目标疼痛重新测试，以相同的量减少对每个重新测试集合中的用于特定神经刺激信号参数的值，从而识别那些在降低水平治疗目标疼痛的神经刺激参数集。

4. 发明申请

WO2009006114A1 SENSOR DRIVEN GASTRIC STIMULATION FOR PATIENT MANAGEMENT 审中-公开
标题翻译：传感器驱动胃肠道刺激患者管理
公开(公告)号：WO2009006114A1
公开(公告)日：2009-01-08
申请号：PCT/US2008/068045
申请日：2008-06-24
申请人： INTRAPACE, INC. , BRYNELSEN, Charles R. , IMRAN, Mir A. , BASHYAM, Jacob A.
发明人： BRYNELSEN, Charles R. , IMRAN, Mir A. , BASHYAM, Jacob A.
IPC分类号： A61N1/00
CPC分类号： A61N1/36007 , A61N1/05 , G06F19/00
摘要： Gastric stimulation systems and methods are provided for treating a patient, particularly by modifying behavior of the patient leading to excess weight loss. In some embodiments, such weight loss is achieved with a combination approach which includes two or more of the following: acute screening of the potential patients, gastric stimulation, induction of symptoms or specific behaviors and integration of patient management data into the treatment plan. Gastric stimulation is provided to portions of the gastrointestinal tract, particularly the stomach, with the use of at least one electrode. A variety of gastric stimulation systems may be used, including stimulators that are endoscopically placed, laparoscopically placed or placed by modified or combination methods.
摘要翻译：提供胃刺激系统和方法用于治疗患者，特别是通过改变导致多余体重减轻的患者的行为。在一些实施方案中，通过组合方法实现这种体重减轻，其包括以下两个或更多个：潜在患者的急性筛选，胃刺激，诱导症状或特定行为以及将患者管理数据整合到治疗计划中。使用至少一个电极将胃刺激提供给胃肠道的部分，特别是胃。可以使用各种胃刺激系统，包括通过内窥镜放置的腹腔镜放置或通过修改或组合方法放置的刺激器。

5. 发明申请

WO2019056007A1 IONTOPHORETIC SYSTEMS, KITS AND METHODS FOR TRANSDERMAL DELIVERY OF COSMETIC AGENTS 审中-公开
公开(公告)号：WO2019056007A1
公开(公告)日：2019-03-21
申请号：PCT/US2018/051572
申请日：2018-09-18
申请人： INCUBE LABS LLC
发明人： IMRAN, Mir A.
IPC分类号： A61F13/02 , A61M37/00 , A61N1/18 , A61N1/04 , A61M35/00 , A61M31/00 , A61K9/06 , A61K9/70
摘要： Embodiments provide systems for delivering cosmetic agents (CA) into the skin. The system includes a power source and at least two electrode assemblies (EA) which may be attached or otherwise incorporated into a facemask assembly that fits over the users face. Each EA is configured to be held in contact with a facial or other skin layer. Additionally, each EA includes an electrode that is coupled to the power source to receive an output current from the power source. At least one of the EAs in the pair includes a medium that carries a CA, the medium being provided on the at least one electrode assembly to enable the output current to deliver the cosmetic agent into the epidermal dermal or other layer of the skin. Embodiments are particularly useful for delivering CAs into a selected layer of the skin to produce a desired cosmetic effect.

6. 发明申请

WO2023059487A1 SYSTEMS AND METHODS FOR CONCURRENT AND INDEPENDENT MULTI-CHANNEL NEUROMODULATION 审中-公开
公开(公告)号：WO2023059487A1
公开(公告)日：2023-04-13
申请号：PCT/US2022/044965
申请日：2022-09-28
申请人： INCUBE LABS, LLC
发明人： IMRAN, Mir A. , BUSTAMANTE, Gilbert , HONEYAGER, Kevin S. , HORLEN, Kyle , KHANWILKAR, Pratap S. , SPEHR, Paul , ZHENG, Xiaolu
IPC分类号： A61N1/04 , A61B18/00 , A61N1/05 , A61B18/14 , A61N1/36
摘要： An electrical neuromodulation system comprises signal output circuitry comprising an N number of channels. The electrical neuromodulation system further comprises at least an N-1 number of electrical isolators configured for respectively isolating an N-1 number of the independent channels, such that the N number of channels have different grounds. The electrical neuromodulation system further comprises processing circuitry configured for independently controlling the signal output circuitry to concurrently deliver neuromodulation energy in accordance with at least two different sets of neuromodulation parameters through the N number of channels to at least one anatomical site inside of a patient. The electrical neuromodulation system further comprises a biocompatible casing containing the signal output circuitry, and the N-1 number of electrical isolators.

7. 发明申请

WO2023003782A1 SYSTEMS AND METHODS FOR CONTROLLING AN OVERACTIVE BLADDER 审中-公开
公开(公告)号：WO2023003782A1
公开(公告)日：2023-01-26
申请号：PCT/US2022/037389
申请日：2022-07-15
申请人： INCUBE LABS, LLC
发明人： IMRAN, Mir A.
IPC分类号： A61N1/36 , A61N1/05 , A61B5/20
摘要： A system for treating a patient suffering from symptoms of an overactive bladder includes a signal generator, a bladder fullness monitoring apparatus (BFMA), and a controller. When in operation, the signal generator delivers a simulation signal to a peripheral nerve of the patient to stimulate the peripheral nerve and alleviate the patient's overactive bladder symptoms. The BFMA generates a data signal corresponding to a degree of filling of the patient's bladder, and the controller receives the data signal from the BFMA and from the data signal determines a total number of voiding events during one or more monitoring periods. The controller adjusts parameters of the stimulation signal when the determined total number of voiding episodes during the one or more monitoring periods is greater than a target number.

8. 发明申请

WO2020243275A1 DEVICES AND METHODS FOR ADMINISTERING A THERAPEUTIC PREPARATION 审中-公开
公开(公告)号：WO2020243275A1
公开(公告)日：2020-12-03
申请号：PCT/US2020/034883
申请日：2020-05-28
申请人： INCUBE LABS, LLC
发明人： IMRAN, Mir A. , CHANG, Arthur Hsu Chen
IPC分类号： A61M5/00 , A61M31/00 , A61K9/00
摘要： Systems, devices and methods are provided for administering a carrier incorporating a therapeutic preparation within a subject. A device includes a carrier, and a launch assembly to deploy the carrier by ejecting the carrier from the device and into internal tissue of the subject. The device detects a status of deployment of the carrier. A system includes a delivery device, a carrier disposed in the delivery device, a launch assembly, and detection circuitry. The launch assembly causes the carrier to exit the delivery device so as to penetrate internal tissue of the subject. The system determines a status of deployment of the carrier using the detection circuitry. A method includes introducing a launch assembly within the subject, the launch assembly coupled to a carrier; deploying, by the launch assembly, the carrier; and detecting a status of deployment of the carrier.

9. 发明申请

WO2020118181A1 METHOD AND APPARATUS FOR MANUFACTURING MICROTABLETS 审中-公开
公开(公告)号：WO2020118181A1
公开(公告)日：2020-06-11
申请号：PCT/US2019/064932
申请日：2019-12-06
申请人： INCUBE LABS, LLC
发明人： IMRAN, Mir A. , CHANG, Arthur Hsu Chen , ONG, Chang Jin , GRATTA, Delia Anna
IPC分类号： A61K9/20
摘要： Embodiments provide methods and apparatus for manufacturing a microtablet from a precursor material such as a pharmaceutical powder. Various embodiments provide a method which includes compressing the powder to form a compressed mass of a selected density and repeatedly compacting the compressed mass to increase the density of the compressed mass and form a microtablet. Related methods and apparatus are provided.

10. 发明申请

WO2020068842A1 INGESTIBLE DEVICE WITH EXPANDABLE ENCLOSURE 审中-公开
公开(公告)号：WO2020068842A1
公开(公告)日：2020-04-02
申请号：PCT/US2019/052718
申请日：2019-09-24
申请人： INCUBE LABS, LLC
发明人： IMRAN, Mir A.
IPC分类号： A61K9/20 , A61K9/28 , A61K9/48 , A61M25/16 , A61M31/00 , A61M37/00 , A61M99/00 , A61K9/0065 , A61M2025/105 , A61M2025/1054 , A61M25/10 , A61M31/002 , C07K16/241 , C07K16/244 , C07K16/283
摘要： An embodiment of an ingestible device for the delivery of a therapeutic agent includes a swallowable outer shell and a delivery mechanism within the outer shell. The delivery mechanism includes an expandable enclosure. The delivery mechanism is triggerable in situ within a gastrointestinal (GI) tract of a body to expand multiple regions of the expandable enclosure to an expanded state at a delivery location within the body. The multiple regions include a head region and a tail region with a protective recess defined between the head region and the tail region, and a retention region within the protective recess. A dimension of the retention region as expanded is less than a dimension of the head region as expanded and less than a dimension of the tail region as expanded. The ingestible device includes a shaped composition disposed at the retention region.

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