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1. 发明申请

WO0071995A3 ENCODING AND DECODING OF ARRAY SENSORS UTILIZING NANOCRYSTALS 审中-公开
标题翻译：编码和解码使用纳米晶体的阵列传感器
公开(公告)号：WO0071995A3
公开(公告)日：2001-02-22
申请号：PCT/US0013940
申请日：2000-05-22
申请人： ILLUMINA INC , CHEE MARK S , BARNARD STEVEN M , ZHAO CHANFENG
发明人： CHEE MARK S , BARNARD STEVEN M , ZHAO CHANFENG
IPC分类号： G01N21/64 , G01N33/58
CPC分类号： G01N33/587 , B82Y15/00 , G01N21/6428 , G01N33/588 , Y10S436/805 , Y10S436/823 , Y10S977/70 , Y10S977/776 , Y10S977/789 , Y10S977/792 , Y10S977/795 , Y10S977/898 , Y10S977/902 , Y10S977/904 , Y10S977/915
摘要： Described herein are assays and components for encoding and decoding microspheres. Each assay or component described utilizes at least one nanocrystal.
摘要翻译：本文描述了用于编码和解码微球的测定和组分。描述的每个测定或组分都使用至少一种纳米晶体。

2. 发明申请

WO02101358A9 MULTIPLEXED DETECTION METHODS 审中-公开
标题翻译：多重检测方法
公开(公告)号：WO02101358A9
公开(公告)日：2003-03-27
申请号：PCT/US0218634
申请日：2002-06-11
申请人： ILLUMINA INC , FAN JIAN-BING , STUELPNAGEL JOHN R , CHEE MARK S
发明人： FAN JIAN-BING , STUELPNAGEL JOHN R , CHEE MARK S
IPC分类号： C12Q1/68 , G01N
CPC分类号： C12Q1/6809 , C12Q2563/179 , C12Q2525/15
摘要： The present invention permits highly multiplexed detection of target molecules in a sample. The method includes contacting target analytes with a composition comprising an amplification enzyme and first and second target probes. The first and second target probes comprise first and second bioactive agent respectively, that specifically bind to the first and second target molecules. The probes may also comprise first and second adapter sequences, respectively, such and that the first adapter sequence identifies the first target molecule and the second adapter sequence identifies the second target molecule, and first and section upstream universal priming sequences, respectively. Finally, following amplification the method includes detecting the first and second amplicons, whereby the first and second target molecules, respectively are detected.
摘要翻译：本发明允许样品中靶分子的高度多重检测。该方法包括使目标分析物与包含扩增酶和第一和第二靶标探针的组合物接触。第一和第二靶探针分别包含特异性结合第一和第二靶分子的第一和第二生物活性剂。探针还可以分别包含第一和第二衔接子序列，并且第一衔接子序列分别标识第一靶分子，第二衔接子序列分别标识第二靶分子以及第一和部分上游通用引物序列。最后，扩增后，该方法包括检测第一和第二扩增子，由此分别检测第一和第二靶分子。

3. 发明申请

WO2004001062A2 MULTIPLEX NUCLEIC ACID REACTIONS 审中-公开
标题翻译：多重核酸反应
公开(公告)号：WO2004001062A2
公开(公告)日：2003-12-31
申请号：PCT/US0319680
申请日：2003-06-20
申请人： ILLUMINA INC , SHEN MIN-JUI RICHARD , OLIPHANT ARNOLD , BUTLER SCOTT L , STUELPNAGEL JOHN R , CHEE MARK S , KUHN KENNETH M , FAN JIAN-BING
发明人： SHEN MIN-JUI RICHARD , OLIPHANT ARNOLD , BUTLER SCOTT L , STUELPNAGEL JOHN R , CHEE MARK S , KUHN KENNETH M , FAN JIAN-BING
IPC分类号： C12P19/34 , C12Q1/68 , C12Q
CPC分类号： C12Q1/6827 , C12Q1/6858 , C12Q2535/125 , C12Q2537/143 , C12Q2561/125 , C12Q2565/515
摘要： The invention is directed to a variety of multiplexing methods used to amplify and/or genotype a variety of samples simultaneously.
摘要翻译：本发明涉及用于同时扩增和/或基因型多种样品的多种多样化方法。

4. 发明申请

WO2010066885A2 INDEXING OF NUCLEIC ACID POPULATIONS 审中-公开
标题翻译：核酸族群的指数
公开(公告)号：WO2010066885A2
公开(公告)日：2010-06-17
申请号：PCT/EP2009066949
申请日：2009-12-11
申请人： FEBIT HOLDING GMBH , STAEHLER PEER F , STAEHLER CORD F , BEIER MARKUS , CHEE MARK S , SCHRACKE NADINE
发明人： STAEHLER PEER F , STAEHLER CORD F , BEIER MARKUS , CHEE MARK S , SCHRACKE NADINE
IPC分类号： C12Q1/68 , C12M1/00
CPC分类号： C12Q1/6869 , C12Q2565/537 , C12Q2563/179 , C12Q2525/191 , C12Q2535/122
摘要： The invention relates to a method for acquisition of genetic information, in particular for personalized medicine.
摘要翻译：本发明涉及用于获取遗传信息的方法，特别是用于个性化医疗的方法。

5. 发明申请

WO2012139110A3 PEPTIDE CONSTRUCTS AND ASSAY SYSTEMS 审中-公开
标题翻译：肽结构和测定系统
公开(公告)号：WO2012139110A3
公开(公告)日：2012-12-27
申请号：PCT/US2012032759
申请日：2012-04-09
申请人： PROGNOSYS BIOSCIENCES INC , KOZLOV IGOR A , CHEE MARK S , CAPEK PETR , ROUTENBERG DAVID A
发明人： KOZLOV IGOR A , CHEE MARK S , CAPEK PETR , ROUTENBERG DAVID A
IPC分类号： C40B40/08 , C40B40/10 , C40B50/06
CPC分类号： G01N33/6803 , C12N15/1062 , C12N15/1075 , C12Q2521/537
摘要： The disclosure provides methods for constructing peptide construct sets and methods of use of these peptide construct sets in assay systems for peptide analysis, and in particular for use in high throughput peptide analysis. The methods allow for analysis of large sets of peptide constructs in a cost-effective manner, employing molecular biological techniques that are both robust and easily parallelized. Thus, the methods allow for the construction of peptide construct sets encompassing, e.g., the human proteome.
摘要翻译：本公开提供了用于构建肽构建体组的方法以及用于肽分析的测定系统中这些肽构建体组的使用方法，特别是用于高通量肽分析。该方法允许以成本有效的方式分析大量肽构建体，使用分子生物学技术，其稳健且容易并行化。因此，所述方法允许构建包括例如人类蛋白质组的肽构建体组。

6. 发明申请

WO2011014879A3 ASSAY TOOLS AND METHODS OF USE 审中-公开
标题翻译：测定工具和使用方法
公开(公告)号：WO2011014879A3
公开(公告)日：2011-05-05
申请号：PCT/US2010044134
申请日：2010-08-02
申请人： PROGNOSYS BIOSCIENCES INC , CHEE MARK S , KOZLOV IGOR A
发明人： CHEE MARK S , KOZLOV IGOR A
IPC分类号： G01N33/573 , C12Q1/34 , C12Q1/37 , G01N33/543
CPC分类号： G01N33/54366 , C12Q1/34 , C12Q1/37 , G01N33/573
摘要： The present invention provides assay tools for the detection of biological or chemical activity in a sample. The assay tools of the invention provide direct detection using a positive signal generated on a surface of the assay tool. These assay tools provide improved methods for detection and/or identification of multiple agents (e.g., enzymes) in a sample, analysis of substrate specificity of such agents, and binding affinities and specificities of such agents. Upon activity a component is released from a first immobilised construct and then captured by a capture surface. At least two different immobilised constructs are used.
摘要翻译：本发明提供了用于检测样品中生物或化学活性的测定工具。本发明的测定工具使用在测定工具的表面上产生的阳性信号提供直接检测。这些测定工具提供了用于样品中多个试剂（例如酶）的检测和/或鉴定的改进方法，这些试剂的底物特异性的分析以及这些试剂的结合亲和力和特异性。在活动时，将组分从第一固定化构建物释放，然后由捕获表面捕获。使用至少两种不同的固定化构建体。

7. 发明申请

WO0047996A9 ARRAYS COMPRISING A FIDUCIAL AND AUTOMATED INFORMATION PROCESSING IN RANDOMLY ORDERED ARRAYS 审中-公开
标题翻译：包含随机序列中的FIDUCIAL和自动信息处理的阵列
公开(公告)号：WO0047996A9
公开(公告)日：2002-04-11
申请号：PCT/US0003375
申请日：2000-02-09
申请人： ILLUMINA INC
发明人： STUELPNAGEL JOHN R , CHEE MARK S , DICKINSON TODD A , GUNDERSON KEVIN
IPC分类号： G01N33/53 , B01J19/00 , C40B70/00 , G01N21/64 , G01N21/77 , G01N21/78 , G01N33/566 , G01N37/00 , G06T7/00
CPC分类号： G01N21/6456 , B01J19/0046 , B01J2219/00317 , B01J2219/005 , B01J2219/00572 , B01J2219/00585 , B01J2219/00596 , B01J2219/00648 , B01J2219/00659 , B01J2219/00689 , B01J2219/00704 , B01J2219/00707 , B01J2219/0072 , C40B70/00 , G01N21/553 , G01N21/6428 , G01N21/6458 , G01N21/658 , G01N21/7703 , G01N2021/6484
摘要： The present invention provides array compositions comprising a substrate with a surface comprising discrete sites, at least one fiducial, and a population of microspheres comprising at least a first and a second subpopulation, each comprising a bioactive agent, and distributed on said surface. Each subpopulation may optionally comprise a unique optical signature, an identifier binding ligand, or both. The invention further provides compositions comprising a computer readable memory, comprising data acquisition, registration, and comparison modules to direct a computer to function in a specified manner. The registration module may utilize any number of fiducials, including a fiducial fiber, a fiducial microsphere, or a fiducial template generated from the random array. In further aspects, the invention provided methods of making the array compositions of the invention, for comparing separate data images of a random array, for decoding a random array composition, and for determining the presence of a target analyte in a sample.
摘要翻译：本发明提供了阵列组合物，其包含具有包括离散位点的表面的底物，至少一个基准和一组微球，其包含至少第一和第二亚群，每个亚群包含生物活性剂并分布在所述表面上。每个亚群可以任选地包含独特的光学特征，标识符结合配体或两者。本发明还提供了包括计算机可读存储器的组合物，其包括数据获取，注册和比较模块，以引导计算机以指定的方式起作用。注册模块可以利用任何数量的基准，包括基准光纤，基准微球体或从随机阵列产生的基准模板。在另外的方面，本发明提供了制备本发明的阵列组合物的方法，用于比较随机阵列的单独数据图像，用于解码随机阵列组成，以及用于确定样品中目标分析物的存在。

8. 发明申请

WO0200336A3 COMPOSITE ARRAYS UTILIZING MICROSPHERES WITH A HYBRIDIZATION CHAMBER 审中-公开
标题翻译：使用混合室的复合微阵列
公开(公告)号：WO0200336A3
公开(公告)日：2003-03-06
申请号：PCT/US0120801
申请日：2001-06-28
申请人： ILLUMINA INC
发明人： STUELPNAGEL JOHN R , CHEE MARK S , AUGER STEVEN R , WANG GAN G , CASAS LAURA S , BAKER SHAWN CHRISTOPHER , KAIN ROBERT C
IPC分类号： G01N33/543 , B01J19/00 , C12M1/00 , C12Q1/68 , C40B40/06 , G01N33/48 , G01N33/53 , G01N33/566 , G01N37/00
CPC分类号： B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/005 , B01J2219/00511 , B01J2219/00524 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , C40B40/06 , G01N35/028
摘要： The invention relates to sensor compositions comprising a composite array of individual arrays, to allow for simultaneous processing of a number of samples. The invention further provides methods of making and using the composite arrays. The invention further provides a hybridization chamber for use with a composite array.
摘要翻译：本发明涉及包括单独阵列的复合阵列的传感器组合物，以允许同时处理多个样品。本发明还提供了制备和使用复合阵列的方法。本发明还提供了一种与复合阵列一起使用的杂交室。

9. 发明申请

WO0200336A9 COMPOSITE ARRAYS UTILIZING MICROSPHERES WITH A HYBRIDIZATION CHAMBER 审中-公开
标题翻译：用杂交室利用微球的复合阵列
公开(公告)号：WO0200336A9
公开(公告)日：2002-10-10
申请号：PCT/US0120801
申请日：2001-06-28
申请人： ILLUMINA INC
发明人： STUELPNAGEL JOHN R , CHEE MARK S , AUGER STEVEN R , WANG GAN G , CASAS LAURA S , BAKER SHAWN CHRISTOPHER , KAIN ROBERT C
IPC分类号： G01N33/543 , B01J19/00 , C12M1/00 , C12Q1/68 , C40B40/06 , G01N33/48 , G01N33/53 , G01N33/566 , G01N37/00
CPC分类号： B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/005 , B01J2219/00511 , B01J2219/00524 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , C40B40/06 , G01N35/028
摘要： The invention relates to sensor compositions comprising a composite array of individual arrays, to allow for simultaneous processing of a number of samples. The invention further provides methods of making and using the composite arrays. The invention further provides a hybridization chamber for use with a composite array.
摘要翻译：本发明涉及包括单个阵列的复合阵列的传感器组合物，以允许同时处理多个样本。本发明还提供了制造和使用复合阵列的方法。本发明还提供了与复合阵列一起使用的杂交室。

10. 发明申请

WO0063437A2 DETECTION OF NUCLEIC ACID REACTIONS ON BEAD ARRAYS 审中-公开
标题翻译：检测珠粒阵列上的核酸反应
公开(公告)号：WO0063437A2
公开(公告)日：2000-10-26
申请号：PCT/US0010716
申请日：2000-04-20
申请人： ILLUMINA INC
发明人： GUNDERSON KEVIN , STUELPNAGEL JOHN R , CHEE MARK S
IPC分类号： C12Q1/68 , C40B40/06
CPC分类号： C12Q1/6837 , B01J2219/005 , B01J2219/00596 , B01J2219/00648 , B01J2219/00659 , B01J2219/00707 , B01J2219/00722 , C12Q1/6813 , C12Q1/6834 , C12Q1/6869 , C40B40/06 , C12Q2565/301 , C12Q2533/101 , C12Q2521/543 , C12Q2533/107 , C12Q2525/161 , C12Q2561/125 , C12Q2565/518 , C12Q2565/607 , C12Q2537/143
摘要： The present invention is directed to methods and compositions for the use of microsphere arrays to detect and quantify a number of nucleic acid reactions. The invention finds use in genotyping, i.e. the determination of the sequence of nucleic acids, particularly alterations such as nucleotide substitutions (mismatches) and single nucleotide polymorphisms (SNPs). Similarly, the invention finds use in the detection and quantification of a nucleic acid target using a variety of amplification techniques, including both signal amplification and target amplification. The methods and compositions of the invention can be used in nucleic acid sequencing reactions as well. All applications can include the use of adapter sequences to allow for universal arrays.
摘要翻译：本发明涉及使用微球阵列来检测和定量许多核酸反应的方法和组合物。本发明用于基因分型，即确定核酸序列，特别是改变，例如核苷酸取代（错配）和单核苷酸多态性（SNP）。类似地，本发明用于使用多种扩增技术检测和定量核酸靶，包括信号放大和靶扩增两者。本发明的方法和组合物也可用于核酸测序反应。所有应用程序可以包括使用适配器序列来允许通用阵列。

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