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1. 发明申请

WO2007133147A1 METHOD AND MEANS FOR TREATING INFLAMMATORY BOWEL DISEASE 审中-公开
标题翻译：治疗炎症性皮肤病的方法和手段
公开(公告)号：WO2007133147A1
公开(公告)日：2007-11-22
申请号：PCT/SE2007/000459
申请日：2007-05-14
申请人： IBD COLUMN THERAPIES INTERNATIONAL AB , THÖRN, Magnus , WINQVIST, Ola
发明人： THÖRN, Magnus , WINQVIST, Ola
IPC分类号： A61K39/395 , A61M1/36 , A61P1/04
CPC分类号： C07K16/28 , A61M1/3679
摘要： A method of treating inflammatory bowel disease (IBD) comprises providing an intestinal biopsy sample obtained from inflamed tissue of a patient; mechanically treating the sample to obtain a cell suspension; identifying cell surface markers of activated leukocytes selected from T lymphocytes, neutrophil granulocytes, and eosinophil granulocytes in the suspension; raising antibodies against one of more of the activated cells and immobilizing them on a support; providing a column loaded with the support; diverting a portion of the patient's peripheral blood to make it pass through the column before re-infusing it to the patient to make the activated leukocytes couple with antibodies on the support, thereby eliminating them from the blood stream. Also disclosed are corresponding columns and supports, and their use in the method.
摘要翻译：治疗炎性肠病（IBD）的方法包括提供从患者的发炎组织获得的肠活检样品; 机械处理样品以获得细胞悬浮液; 鉴定悬浮液中选自T淋巴细胞，嗜中性粒细胞和嗜酸粒细胞粒细胞的活化白细胞的细胞表面标志物; 提高针对一种或多种活化细胞的抗体并将其固定在载体上; 提供装载有支撑件的柱子; 转移患者外周血的一部分使其通过柱，然后将其再次注入患者，使活化的白细胞与载体上的抗体偶联，从而从血液中除去它们。还公开了相应的列和支持，以及它们在该方法中的使用。

2. 发明申请

WO2010029317A2 TREATING INFLAMMATORY CONDITIONS 审中-公开
标题翻译：处理危害条件
公开(公告)号：WO2010029317A2
公开(公告)日：2010-03-18
申请号：PCT/GB2009/002196
申请日：2009-09-10
申请人： IBD COLUMN THERAPIES INTERNATIONAL AB , WINQVIST, Ola , COTTON, Graham
发明人： WINQVIST, Ola , COTTON, Graham
IPC分类号： C07K14/52 , A61M1/36 , B01J20/32
CPC分类号： A61M1/3679 , A61M1/3618 , B01J20/262 , B01J20/267 , B01J20/28004 , B01J20/28009 , B01J20/28016 , B01J20/3085 , B01J20/3212 , B01J20/3219 , B01J20/3242 , B01J20/3272 , B01J20/3274 , B01J2220/58 , C07K14/52 , C07K14/521 , C07K17/06 , C07K17/10
摘要： An apheresis column loaded with a solid support comprises one or more chemokines, in particular biotinylated chemokines, immobilized directly or indirectly on the support, in particular on a support carrying streptavidin. Also disclosed are uses of the column and the support and a method of depleting cells, in particular leukocytes, from the peripheral blood of a person suffering from an inflammatory condition such as Inflammatory Bowel Disease (IBD).
摘要翻译：负载有固体支持物的单采血液柱包含一个或多个趋化因子，特别是生物素化的趋化因子，其直接或间接地固定在载体上，特别是在携带链霉亲和素的载体上。还公开了柱和载体的使用以及从患有炎症性肠炎（IBD）的人的外周血中消耗细胞，特别是白细胞的方法。

3. 发明申请

WO2010006808A1 COMPOSITION COMPRISING IN VITRO EXPANDED T-LYMPHOCYTES AND VESSEL FORMATION INHIBITORS SUITABLE IN THE TREATMENT OF CANCER 审中-公开
标题翻译：包含体外扩增的T淋巴细胞的组合物和适用于治疗癌症的血管形成抑制剂
公开(公告)号：WO2010006808A1
公开(公告)日：2010-01-21
申请号：PCT/EP2009/005216
申请日：2009-07-17
申请人： SENTOCLONE AB , WINQVIST, Ola , THÖRN, Magnus
发明人： WINQVIST, Ola , THÖRN, Magnus
IPC分类号： C12N5/08 , A61K38/18
CPC分类号： C12N5/0636 , A61K2039/5158 , C12N5/0651 , C12N2501/23
摘要： Improved cancer therapy using a combination treatment with tumour-reactive T-lymphocytes obtained by an in vitro method for expansion and activation of tumour-reactive lymphocytes, in particular CD4+ helper and/or CD8+ T-lymphocytes and inhibitors of vessel formation inhibitors, notably inhibitors of VEGF.
摘要翻译：使用通过体外扩增和激活肿瘤反应性淋巴细胞，特别是CD4 +辅助和/或CD8 + T淋巴细胞和血管形成抑制剂抑制剂的体外方法获得的肿瘤反应性T淋巴细胞的组合治疗改进的癌症治疗，特别是抑制剂的VEGF。

4. 发明申请

WO2007027132A1 TREATMENT OF INFLAMMATORY BOWEL DISEASE 审中-公开
标题翻译：炎症性皮肤病的治疗
公开(公告)号：WO2007027132A1
公开(公告)日：2007-03-08
申请号：PCT/SE2006/000959
申请日：2006-08-22
申请人： ITH IMMUNE THERAPY HOLDINGS AB , WINQVIST, Ola , THÖRN, Magnus
发明人： WINQVIST, Ola , THÖRN, Magnus
IPC分类号： A61K35/26 , C12N5/08 , A61P37/06
CPC分类号： A61K35/26 , A61K2035/124 , C12N5/0636 , C12N2501/10 , C12N2501/15 , C12N2501/23 , C12N2501/24 , C12N2501/25 , C12N2501/51 , C12N2501/515
摘要： A method of treating inflammatory bowel disease (IBD) comprises collecting regulatory T cells in an activated or non-activated state from a patient's sentinel lypmph nodes draining bowel segments with or without IBD, optionally activating the cells by contacting them with a cytokine and an antigen extract obtained from an inflamed bowel segment, expanding the T cells in vitro, and re-infusing the expanded T cells to the patient. Also disclosed are methods for obtaining sentinel nodes, for expanding T cells, for re-establishing the T H 1/T H 2 balance in the patient suffering from Crohn's disease, and corresponding uses of the expanded T cells, the cytokines and of antigen extract, as well as of correspondingly activated and expanded T cells.
摘要翻译：一种治疗炎症性肠病（IBD）的方法包括从有或没有IBD引流肠段的患者前哨淋巴结收集处于活化或非活化状态的调节性T细胞，任选地通过使细胞与细胞因子和抗原接触而激活细胞从发炎肠段获得的提取物，在体外扩增T细胞，并将扩张的T细胞重新注入患者体内。还公开了用于获得前哨淋巴结的方法，用于扩增T细胞，用于重建患有克罗恩病的患者中的T H 1 H 2 / H 2 H 2平衡，以及扩增的T细胞，细胞因子和抗原提取物的相应用途，以及相应的活化和扩增的T细胞。

5. 发明申请

WO2009017444A3 DIAGNOSIS, STAGING AND MONITORING OF INFLAMMATORY BOWEL DISEASE 审中-公开
公开(公告)号：WO2009017444A3
公开(公告)日：2009-02-05
申请号：PCT/SE2008/000464
申请日：2008-07-29
申请人： ISS IMMUNE SYSTEM STIMULATION AB , THÖRN, Magnus , WINQVIST, Ola
发明人： THÖRN, Magnus , WINQVIST, Ola
IPC分类号： G01N33/68 , C07K14/525 , C07K14/54 , C07K14/57 , C07K14/705 , C07K14/72
摘要： A method of differentiating between active and inactive IBD in a gastrointestinal mucosa sample or a sample from a sentinel lymph node draining gastrointestinal mucosa comprises preparing a suspension of single cells from the sample, analyzing the suspension for expression of the inflammation activation marker CD69 on CD4+ T helper cells using directly labelled fluorescent DC69 antibody; comparing the number of T helper cells expressing DC69 in the sample with that obtained from a corresponding sample of a healthy person, a significantly increased level of T helper cells expressingCDD69 signifying the presence of active IBD and a less than significantly increased level of T helper cells signifying the presence of inactive IBD. Also disclosed are methods of differentiating between ulcerative colitis (UC) and Crohn's disease (CD), of detecting UC and CD, and of determining the susceptibility of an IBD patient to steroid treatment.

6. 发明申请

WO2007071409A1 METHOD FOR TREATING COLON CANCER 审中-公开
标题翻译：治疗结肠癌的方法
公开(公告)号：WO2007071409A1
公开(公告)日：2007-06-28
申请号：PCT/EP2006/012338
申请日：2006-12-20
申请人： SENTOCLONE THERAPEUTICS AB , WINQVIST, Ola , THÖRN, Magnus
发明人： WINQVIST, Ola , THÖRN, Magnus
IPC分类号： A61K35/12 , A61P35/00
CPC分类号： A61K35/26
摘要： The present invention discloses an immunotherapeutic method for treating patients suffering from colon cancer, by administering expanded tumour-reactive CD4+ helper and/or CD8+ T-lymphocytes obtainable from one or more sentinel or metinel lymph nodes draining a tumour in the colon or a metastasis arising from a tumour in the colon. The present invention provides a new effective method for treating colon cancer and metastatic colon cancer, without adverse side effects associated with the known treatments. The method comprises identification of in a patient one or more sentinel and/or metinel lymph nodes draining a tumour in the colon or a metastasis from a tumour in the colon, resection of the one or more nodes and, optionally all or part of the tumour or metastasis, isolation of tumour-reactive T-lymphocytes from said lymph nodes, in vitro expansion of said tumour-reactive T-lymphocytes, and administration of the thus obtained tumour-reactive T-lymphocytes to the patient, wherein the T- lymphocytes are CD4+ helper and/or CD8+ T-lymphocytes.
摘要翻译：本发明公开了一种用于治疗患有结肠癌的患者的免疫治疗方法，其通过施用扩增的肿瘤反应性CD4 +辅助细胞和/或CD8 + T淋巴细胞，所述淋巴细胞可以从引流结肠中的一个或多个前哨淋巴结或met淋巴结或转移出现从结肠肿瘤。本发明提供了一种治疗结肠癌和转移性结肠癌的新型有效方法，没有与已知治疗相关的副作用。该方法包括在患者中识别排出结肠中肿瘤的一个或多个哨兵和/或met淋巴结或来自结肠肿瘤的转移，切除一个或多个淋巴结，以及任选的全部或部分肿瘤或转移，从所述淋巴结分离肿瘤反应性T淋巴细胞，所述肿瘤反应性T淋巴细胞的体外扩增，以及由此获得的肿瘤反应性T淋巴细胞给予患者，其中所述T淋巴细胞为 CD4 +辅助和/或CD8 + T淋巴细胞。

7. 发明申请

WO2007071390A1 METHOD FOR TREATING MALIGNANT MELANOMA 审中-公开
标题翻译：治疗恶性肿瘤的方法
公开(公告)号：WO2007071390A1
公开(公告)日：2007-06-28
申请号：PCT/EP2006/012306
申请日：2006-12-20
申请人： SENTOCLONE THERAPEUTICS AB , WINQVIST, Ola , THÖRN, Magnus
发明人： WINQVIST, Ola , THÖRN, Magnus
IPC分类号： A61K35/14 , A61K35/26 , A61K38/20 , A61K38/21 , A61K39/00 , C12N5/06 , G01N33/50
CPC分类号： A61K39/0011 , A61K38/21 , A61K2039/5158 , C12N5/0636 , C12N2501/23 , G01N2333/57
摘要： The present invention discloses an immunotherapeutic method for treating patients suffering from malignant melanoma, by administering expanded tumour-reactive CD4+ helper and/or CD8+ T-lymphocytes obtainable from one or more sentinel or metinel lymph nodes draining a malignant melanoma or a metastasis arising from malignant melanoma. The present invention provides a new effective method for treating malignant melanoma and metastatic malignant melanoma, without adverse side effects associated with the known treatments. The method comprises identification of in a patient one or more sentinel and/or metinel lymph nodes draining a malignant melanoma or a metastasis there from, resection of the one or more nodes and, optionally all or part of the tumour or metastasis, isolation of tumour-reactive T- lymphocytes from said lymph nodes, in vitro expansion of said tumour-reactive T- lymphocytes, and administration of the thus obtained tumour-reactive T-lymphocytes to the patient, wherein the T-lymphocytes are CD4+ helper and/or CD8+ T-lymphocytes.
摘要翻译：本发明公开了一种用于治疗患恶性黑素瘤患者的免疫治疗方法，其通过施用扩增的肿瘤反应性CD4 +辅助细胞和/或CD8 + T淋巴细胞，所述淋巴细胞可从一个或多个排除恶性黑素瘤的前哨淋巴结或met淋巴结获得，或由恶性黑素瘤引起的转移黑色素瘤。本发明提供了治疗恶性黑素瘤和转移性恶性黑色素瘤的新型有效方法，与已知治疗无关的副作用。该方法包括在患者中识别排出恶性黑素瘤或其中的转移的一个或多个前哨淋巴结和/或met淋巴结，切除一个或多个淋巴结，以及任选全部或部分肿瘤或转移，分离肿瘤 - 来自所述淋巴结的反应性T-淋巴细胞，所述肿瘤反应性T淋巴细胞的体外扩增，以及由此获得的肿瘤反应性T淋巴细胞给予患者，其中所述T淋巴细胞是CD4 +辅助细胞和/或CD8 + T淋巴细胞。

8. 发明申请

WO2007071389A1 METHOD FOR TREATING DISSEMINATED CANCER 审中-公开
标题翻译：治疗传染性癌症的方法
公开(公告)号：WO2007071389A1
公开(公告)日：2007-06-28
申请号：PCT/EP2006/012305
申请日：2006-12-20
申请人： SENTOCLONE THERAPEUTICS AB , WINQVIST, Ola , THÖRN, Magnus
发明人： WINQVIST, Ola , THÖRN, Magnus
IPC分类号： C12N5/06
CPC分类号： C12N5/0636 , A61K39/0011 , A61K2039/5158 , C12N5/0651 , C12N2501/23 , C12N2501/24
摘要： The present invention discloses an immunotherapeutic method for treating a patient suffering from a disseminated cancer by administering expanded tumour-reactive CD4+ helper and/or CD8+ T-lymphocytes obtainable from one or more metastasis-draining lymph nodes (metinel nodes) draining a metastasis. The method comprises identification of one or more metinel lymph nodes in a patient, resection of the one or more nodes and, optionally all or part of the metastases, isolation of metastasis-reactive T-lymphocytes from said lymph nodes, in vitro expansion of said metastasis-reactive T-lymphocytes, and administration of the thus obtained T-lymphocytes to the patient, wherein the T-lymphocytes are CD4+ helper and/or CD8+ T-lymphocytes.
摘要翻译：本发明公开了一种免疫治疗方法，用于通过施用从一个或多个排泄转移的转移性淋巴结（metinel node）获得的扩增的肿瘤反应性CD4 +辅助细胞和/或CD8 + T淋巴细胞来治疗患有弥漫性癌症的患者。该方法包括鉴定患者中的一个或多个el淋巴结，切除一个或多个淋巴结，以及任选全部或部分转移，从所述淋巴结中分离转移反应性T淋巴细胞，所述淋巴结的体外扩增转移反应性T淋巴细胞，以及由此获得的T淋巴细胞给予患者，其中T淋巴细胞是CD4 +辅助细胞和/或CD8 + T淋巴细胞。

9. 发明申请

WO2007071388A1 IMPROVED METHOD FOR EXPANSION OF TUMOUR-REACTIVE T-LYMPHOCYTES FOR IMMUNOTHERAPY OF PATIENTS WITH CANCER 审中-公开
标题翻译：用于肿瘤患者免疫的肿瘤反应性T淋巴细胞扩增的改进方法
公开(公告)号：WO2007071388A1
公开(公告)日：2007-06-28
申请号：PCT/EP2006/012304
申请日：2006-12-20
申请人： SENTOCLONE THERAPEUTICS AB , WINQVIST, Ola , THÖRN, Magnus
发明人： WINQVIST, Ola , THÖRN, Magnus
IPC分类号： C12N5/06 , A61K39/00
CPC分类号： C12N5/0636 , A61K2039/5158 , C12N5/0651
摘要： The present invention discloses an improved method for expansion and activation of tumour-reactive lymphocytes, in particular CD4+ helper and/or CD8+ T-lymphocytes, which may be used for treating and/or preventing cancer. The method provides high numbers of tumour-reactive T-lymphocytes within a short time span and the possibility of directing development of tumour-reactive CD4+ helper and/or CD8+ T-lymphocytes towards specific subpopulations. The method comprises a first phase of stimulating tumour-reactive CD4+ T helper and/or CD8+ T-lymphocytes with tumour-derived antigen together with at least one substance having agonistic activity towards the IL-2 receptor to promote survival of tumour-reactive CD4+ T helper and/or CD8+ T-lymphocytes; and a second phase of activating and promoting growth of tumour-reactive CD4+ T helper and/or CD8+ T-lymphocytes, wherein the second phase is initiated when the CD25 cell surface marker (or IL-2R marker) is down-regulated on CD4+ T helper and/or CD8+ T-lymphocytes.
摘要翻译：本发明公开了可用于治疗和/或预防癌症的肿瘤反应性淋巴细胞，特别是CD4 +辅助和/或CD8 + T淋巴细胞的扩增和活化的改进方法。该方法在短时间内提供了大量的肿瘤反应性T淋巴细胞，以及将肿瘤反应性CD4 +辅助细胞和/或CD8 + T淋巴细胞向特定亚群发展的可能性。该方法包括用肿瘤衍生的抗原刺激肿瘤反应性CD4 + T辅助细胞和/或CD8 + T淋巴细胞的第一阶段以及至少一种对IL-2受体具有激动作用的物质以促进肿瘤反应性CD4 + T的存活辅助和/或CD8 + T淋巴细胞; 和激活和促进肿瘤反应性CD4 + T辅助细胞和/或CD8 + T淋巴细胞生长的第二阶段，其中当CD25细胞表面标志物（或IL-2R标志物）在CD4 + T上下调时，启动第二阶段辅助和/或CD8 + T淋巴细胞。

10. 发明申请

WO2007071410A1 METHOD FOR TREATING URINARY BLADDER CANCER 审中-公开
标题翻译：治疗尿路癌的方法
公开(公告)号：WO2007071410A1
公开(公告)日：2007-06-28
申请号：PCT/EP2006/012340
申请日：2006-12-20
申请人： SENTOCLONE THERAPEUTICS AB , WINQVIST, Ola , THÖRN, Magnus
发明人： WINQVIST, Ola , THÖRN, Magnus
IPC分类号： A61K35/26 , A61P35/00 , C12N5/06
CPC分类号： A61K39/0011 , C12N5/0636 , C12N2501/23 , C12N2501/505
摘要： The present invention discloses an immunotherapeutic method for treating a patient suffering from urinary bladder cancer by administering expanded tumour-reactive CD4+ helper and/or CD8+ T-lymphocytes obtainable from one or more sentinel or metinel lymph nodes draining a tumour in the bladder or a metastasis arising from a tumour in the bladder. The method provides a new effective method for treating urinary bladder cancer and metastatic bladder cancer, without adverse side effects associated with the known treatments. The method comprises identification of in a patient one or more sentinel and/or metinel lymph nodes draining a tumour in the bladder or a metastasis from a tumour in the bladder, resection of the one or more nodes and, optionally all or part of the tumour or metastasis, isolation of tumour-reactive T- lymphocytes from said lymph nodes, in vitro expansion of said tumour-reactive T- lymphocytes, and administration of the thus obtained tumour-reactive T-lymphocytes to the patient, wherein the T-lymphocytes are CD4+ helper and/or CD8+ T-lymphocytes.
摘要翻译：本发明公开了一种用于治疗患有膀胱癌的患者的免疫治疗方法，其通过施用扩增的肿瘤反应性CD4 +辅助细胞和/或CD8 + T淋巴细胞，所述扩增的肿瘤反应性CD4 +辅助细胞和/或CD8 + T淋巴细胞可从排出膀胱肿瘤或转移的一个或多个前哨淋巴结或met淋巴结由膀胱肿瘤引起。该方法提供了治疗膀胱癌和转移性膀胱癌的新型有效方法，没有与已知治疗相关的不良副作用。所述方法包括在患者中识别排出膀胱中的肿瘤或来自膀胱中的肿瘤的转移的一个或多个前哨和/或met淋巴结，切除一个或多个淋巴结，以及任选的全部或部分肿瘤或转移，从所述淋巴结分离肿瘤反应性T淋巴细胞，所述肿瘤反应性T淋巴细胞的体外扩增，以及由此获得的肿瘤反应性T淋巴细胞给予患者，其中T淋巴细胞为 CD4 +辅助和/或CD8 + T淋巴细胞。

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