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    • 6. 发明申请
    • METHODS AND COMPOSITIONS FOR TREATING METABOLIC BONE DISEASES RELATING TO HUMAN ENDOKINE ALPHA
    • 用于治疗与人内皮素ALPHA相关的代谢性骨髓疾病的方法和组合物
    • WO2003070763A1
    • 2003-08-28
    • PCT/US2002/025809
    • 2002-08-15
    • HUMAN GENOME SCIENCES, INC.YU, Guo-LiangNI, JianROSEN, Craig, A.NARDELLI, Bernadetta
    • YU, Guo-LiangNI, JianROSEN, Craig, A.NARDELLI, Bernadetta
    • C07K14/52
    • C07K14/5255A61K38/00
    • The present invention concerns methods for diagnosis and treatment of metabolic bone diseases and disorders using a novel member of the tumor necrosis factor (TNF) family of cytokines. In particular the invention provides methods of using the Endokine alpha protein and/or homomultimeric and/or heteromultimeric polypeptide complexes containing Endokine alpha, in the diagnosis, prognosis and treatment of metabolic bone diseases and disorders. Also provided by the invention are methods of using the Endokine alpha protein and/or homomultimeric and/or heteromultimeric polypeptide complexes containing Endokine alpha, in the diagnosis, prognosis and treatment of diseases and/or disorders associated with aberrant osteoclast development and/or activity. The present invention also provides isolated polynucleotides encoding polypeptides of the invention, antibodies thereto, and agonists and antagonists thereof, for use in the diagnosis, prognosis and treatment of metabolic bone diseases and disorders.
    • 本发明涉及使用细胞因子的肿瘤坏死因子(TNF)家族的新成员诊断和治疗代谢性骨疾病和病症的方法。 特别地,本发明提供了在代谢性骨疾病和病症的诊断,预后和治疗中使用含有内因激酶α的内因子α蛋白和/或同源多聚体和/或异源多聚体多肽复合物的方法。 本发明还提供了使用含有内因激酶α的内含子α蛋白和/或同源多聚体和/或异源多聚体多肽复合物在与异常破骨细胞发育和/或活性相关的疾病和/或病症的诊断,预后和治疗中的方法。 本发明还提供编码本发明的多肽的分离的多核苷酸,其抗体及其激动剂和拮抗剂,用于代谢性骨疾病和病症的诊断,预后和治疗。
    • 7. 发明申请
    • NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES
    • 核酸,蛋白质和抗体
    • WO2002072763A2
    • 2002-09-19
    • PCT/US2002/006990
    • 2002-03-08
    • HUMAN GENOME SCIENCES, INC.SHI, YangguNI, JianRUBEN, Steven, M.
    • SHI, YangguNI, JianRUBEN, Steven, M.
    • C12N
    • C07K14/47A61K38/00A61K48/00
    • The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
    • 本发明涉及新蛋白质。 更具体而言,提供了编码新多肽的分离的核酸分子。 提供了与这些多肽结合的新多肽和抗体。 还提供了载体,宿主细胞,以及用于生产人多核苷酸和/或多肽以及抗体的重组和合成方法。 本发明进一步涉及用于诊断,治疗,预防和/或预测与这些新多肽有关的病症的诊断和治疗方法。 本发明进一步涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还涉及用于抑制或增强本发明多肽的产生和功能的方法和/或组合物。
    • 9. 发明申请
    • HUMAN CHEMOTACTIC CYTOKINE I
    • 人类化学细胞因子
    • WO1997023640A1
    • 1997-07-03
    • PCT/US1995016871
    • 1995-12-26
    • HUMAN GENOME SCIENCES, INC.
    • HUMAN GENOME SCIENCES, INC.NI, JianYU, Guo-LiangALFONSO, PedroGENTZ, ReinerSU, Jeffrey, Y.
    • C12P21/02
    • C07K14/52A61K38/00
    • Human chemotactic cytokine I polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptide in a host.
    • 公开了人类趋化性细胞因子I多肽和编码这种趋化性细胞因子的DNA(RNA)和通过重组技术产生这种多肽的方法。 还公开了利用这种趋化性细胞因子治疗白血病,肿瘤,慢性感染,自身免疫疾病,纤维化病症,伤口愈合和牛皮癣的方法。 还公开了抗这种趋化性细胞因子的拮抗剂及其作为治疗类风湿性关节炎,自身免疫,慢性和急性炎症和感染性疾病,过敏反应,前列腺素不依赖性发烧和骨髓衰竭的治疗剂的用途。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码趋化性细胞因子的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定。